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The map label for this gene is lysC [H]

Identifier: 218710533

GI number: 218710533

Start: 2765109

End: 2766296

Strand: Reverse

Name: lysC [H]

Synonym: VS_2582

Alternate gene names: 218710533

Gene position: 2766296-2765109 (Counterclockwise)

Preceding gene: 218710534

Following gene: 218710532

Centisome position: 83.84

GC content: 43.27

Gene sequence:

>1188_bases
GTGAAAATGCCTCTTATCGTGCAGAAATTTGGTGGGACGTCGGTGGGTTCAATTGAACGAATCCATCATGTAGCAGAAAA
AATCATTGAAGCGAAAAATGAAGGGAACCAGATCCTGGTTGTCGTTTCTGCTATGTCAGGTGAAACAAATCGGTTAGTTA
ACTTAGCTTCACAAGTTGATAGCGTACCAAACGCTAGAGAGTTGGATGTGCTGTTAACGGCCGGAGAACAAGTTTCCATG
GCTTTGTTGGCGATGACGTTGCACAAGTTGGGTTATGAAGCGACATCGATGACTGGCTATCAAGCCAAAATACACACCGA
TTCTAATCATAATAATGCGACGATTGAGCGTATTGATACCGCTCCTATTAAAGCGCTGTTAGATGATGACCAGATTGTCA
TTGTTGCAGGTTTTCAAGGCGTTAATGCAAAAGGTGATATCACAACCTTAGGGCGAGGTGGTTCAGACACCACGGCCGTT
GCGTTGGCAGGCGCCCTTCAAGCGAAAGAGTGTCAGATATATACCGATGTTGATGGCGTATATTCCTGCGACCCTAGAGT
GGTTAAGCAATCTAAGAAATTAGATACCTTAGACTTTCCCTCTATGGAAGAAATGGCTCGCAGAGGCGCTAAGGTTTTAC
ACCTTCCATGTGTTCAACATGCGTGGCGACACAATGTACCATTGAGAGTGCTTTCGAGCTTTGAAGAAGGCGAGGGAACT
CTTATCGCGGGTAATGACTGTTTGAATGATATTGCTGGGATAGCCATTCAAAGAGATATGGTTCGCGTCGAGTGTTTGAA
TCAAGATTTACCGTCTCTCATGTCGCATTGCCATTTATTAGGGATTGAAGTCTGTAGTGTGATCGAGGAAGCAGAACGGG
CAGCACTCATTATCAAACCGGACATAAGTGCTAAATTAAAACTAGTTTTTGACGAGAAAATCCGTAATAGTGAACAGGTT
AGTTTGTTAACTGTGGTAGGAAGCCGAACACAAGAAATTGTGGTCAGTTCACATGGATTGTTGTCTGAAGGCGAAATTGA
TGTACAGCATCACTTATTGCAACAGCAGTCTTTAACTTTGGTGATATCACCAACGCAAGTCGATATGGCTGCTAACATAT
TACACAATGCATACATCGTAGCGCGTGAAACACAGGGTTATCCTAAAAAAGAAGTGCATTTTGGTTAA

Upstream 100 bases:

>100_bases
ACGTTAGACTCCTTGGTTAATTTTTTATTGCTTCGCCATGACGCGGAGTATGTGTTTTTTTTGTCATATATAGACATTGG
TCTTGGGAAGGTGAGGAAGG

Downstream 100 bases:

>100_bases
ATAAACTCAATCGATAGTTTACGAAAATATAACTTTTGTTGGATAATGCTCGCGTAGCTAGATAAATTTAGAGATTACTC
AAGGAGCAAAGAATGCTAAT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKMPLIVQKFGGTSVGSIERIHHVAEKIIEAKNEGNQILVVVSAMSGETNRLVNLASQVDSVPNARELDVLLTAGEQVSM
ALLAMTLHKLGYEATSMTGYQAKIHTDSNHNNATIERIDTAPIKALLDDDQIVIVAGFQGVNAKGDITTLGRGGSDTTAV
ALAGALQAKECQIYTDVDGVYSCDPRVVKQSKKLDTLDFPSMEEMARRGAKVLHLPCVQHAWRHNVPLRVLSSFEEGEGT
LIAGNDCLNDIAGIAIQRDMVRVECLNQDLPSLMSHCHLLGIEVCSVIEEAERAALIIKPDISAKLKLVFDEKIRNSEQV
SLLTVVGSRTQEIVVSSHGLLSEGEIDVQHHLLQQQSLTLVISPTQVDMAANILHNAYIVARETQGYPKKEVHFG

Sequences:

>Translated_395_residues
MKMPLIVQKFGGTSVGSIERIHHVAEKIIEAKNEGNQILVVVSAMSGETNRLVNLASQVDSVPNARELDVLLTAGEQVSM
ALLAMTLHKLGYEATSMTGYQAKIHTDSNHNNATIERIDTAPIKALLDDDQIVIVAGFQGVNAKGDITTLGRGGSDTTAV
ALAGALQAKECQIYTDVDGVYSCDPRVVKQSKKLDTLDFPSMEEMARRGAKVLHLPCVQHAWRHNVPLRVLSSFEEGEGT
LIAGNDCLNDIAGIAIQRDMVRVECLNQDLPSLMSHCHLLGIEVCSVIEEAERAALIIKPDISAKLKLVFDEKIRNSEQV
SLLTVVGSRTQEIVVSSHGLLSEGEIDVQHHLLQQQSLTLVISPTQVDMAANILHNAYIVARETQGYPKKEVHFG
>Mature_395_residues
MKMPLIVQKFGGTSVGSIERIHHVAEKIIEAKNEGNQILVVVSAMSGETNRLVNLASQVDSVPNARELDVLLTAGEQVSM
ALLAMTLHKLGYEATSMTGYQAKIHTDSNHNNATIERIDTAPIKALLDDDQIVIVAGFQGVNAKGDITTLGRGGSDTTAV
ALAGALQAKECQIYTDVDGVYSCDPRVVKQSKKLDTLDFPSMEEMARRGAKVLHLPCVQHAWRHNVPLRVLSSFEEGEGT
LIAGNDCLNDIAGIAIQRDMVRVECLNQDLPSLMSHCHLLGIEVCSVIEEAERAALIIKPDISAKLKLVFDEKIRNSEQV
SLLTVVGSRTQEIVVSSHGLLSEGEIDVQHHLLQQQSLTLVISPTQVDMAANILHNAYIVARETQGYPKKEVHFG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=182, Percent_Identity=33.5164835164835, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790455, Length=133, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790376, Length=285, Percent_Identity=24.9122807017544, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=311, Percent_Identity=24.4372990353698, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 42946; Mature: 42946

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMPLIVQKFGGTSVGSIERIHHVAEKIIEAKNEGNQILVVVSAMSGETNRLVNLASQVD
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHC
SVPNARELDVLLTAGEQVSMALLAMTLHKLGYEATSMTGYQAKIHTDSNHNNATIERIDT
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCHHCCCCEEEEEEECCCCCCCEEEEECC
APIKALLDDDQIVIVAGFQGVNAKGDITTLGRGGSDTTAVALAGALQAKECQIYTDVDGV
CHHHHEECCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCC
YSCDPRVVKQSKKLDTLDFPSMEEMARRGAKVLHLPCVQHAWRHNVPLRVLSSFEEGEGT
CCCCHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHCCCCCCCC
LIAGNDCLNDIAGIAIQRDMVRVECLNQDLPSLMSHCHLLGIEVCSVIEEAERAALIIKP
EEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
DISAKLKLVFDEKIRNSEQVSLLTVVGSRTQEIVVSSHGLLSEGEIDVQHHLLQQQSLTL
CCCCEEEEEEEHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEEE
VISPTQVDMAANILHNAYIVARETQGYPKKEVHFG
EECCCHHHHHHHHHHCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKMPLIVQKFGGTSVGSIERIHHVAEKIIEAKNEGNQILVVVSAMSGETNRLVNLASQVD
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHC
SVPNARELDVLLTAGEQVSMALLAMTLHKLGYEATSMTGYQAKIHTDSNHNNATIERIDT
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCHHCCCCEEEEEEECCCCCCCEEEEECC
APIKALLDDDQIVIVAGFQGVNAKGDITTLGRGGSDTTAVALAGALQAKECQIYTDVDGV
CHHHHEECCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEECCCCC
YSCDPRVVKQSKKLDTLDFPSMEEMARRGAKVLHLPCVQHAWRHNVPLRVLSSFEEGEGT
CCCCHHHHHHCCCCCCCCCCCHHHHHHCCCEEEEEHHHHHHHHCCCCHHHHHCCCCCCCC
LIAGNDCLNDIAGIAIQRDMVRVECLNQDLPSLMSHCHLLGIEVCSVIEEAERAALIIKP
EEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
DISAKLKLVFDEKIRNSEQVSLLTVVGSRTQEIVVSSHGLLSEGEIDVQHHLLQQQSLTL
CCCCEEEEEEEHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHCCCEEE
VISPTQVDMAANILHNAYIVARETQGYPKKEVHFG
EECCCHHHHHHHHHHCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]