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The map label for this gene is hpt [H]

Identifier: 218710499

GI number: 218710499

Start: 2728367

End: 2728897

Strand: Reverse

Name: hpt [H]

Synonym: VS_2538

Alternate gene names: 218710499

Gene position: 2728897-2728367 (Counterclockwise)

Preceding gene: 218710501

Following gene: 218710497

Centisome position: 82.71

GC content: 42.37

Gene sequence:

>531_bases
ATGAAGCATACAGTTGAAGTCATGATCTCTGAGCAAGAAGTTCAGGATCGAGTGAACGAACTAGGCAAGCAGATCACGGA
GCACTACCAAGGTAGCGAAGATCTAGTTTTAGTTGGCTTATTGCGCGGATCTTTTGTCTTTATGGCGGATCTTGCTCGTG
CTATCGATTTAACTCACCAAGTGGATTTCATGACTGCGTCTAGCTACGGCAACGGCATGGAAAGCTCACGTGATGTTCGT
ATTTTGAAAGACCTTGATGATGACATCCAAGGTAAAGATGTTCTACTTGTAGAAGACATTATCGATACTGGTAACACGCT
GACTAAAGTAAAAGAAATTCTGAGCCTGCGTGGTCCTAAATCTATCGAAATTTGTACGTTATTAGACAAGCCTTCTCGTC
GTGAAGTCATTGTAGACACAAAGTGGATTGGTTTTGAAATCCCAGATGAATTCGTTGTTGGTGTGGGTATCGACTACGCA
CAAAAATATCGTCACCTACCGTACATCGGTAAAGTTGTACCTCAAGAGTAA

Upstream 100 bases:

>100_bases
GTGGGTATTTGAGCAGTGCTAGACTTACGCACAAAATTGAGCGACACAACTGACGAAAGTGTCAACATTCGTCGCAATCA
CCAAATAAAATGAGAGCAGT

Downstream 100 bases:

>100_bases
TAACGACTCTGTTGAACACAAACAAAAAAGGCTCGCAAAACGCGAGCCTTTTTTATATCTATTCTTTCTTATATCTATTG
GTTAGACGTTAAGAATTAAC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKHTVEVMISEQEVQDRVNELGKQITEHYQGSEDLVLVGLLRGSFVFMADLARAIDLTHQVDFMTASSYGNGMESSRDVR
ILKDLDDDIQGKDVLLVEDIIDTGNTLTKVKEILSLRGPKSIEICTLLDKPSRREVIVDTKWIGFEIPDEFVVGVGIDYA
QKYRHLPYIGKVVPQE

Sequences:

>Translated_176_residues
MKHTVEVMISEQEVQDRVNELGKQITEHYQGSEDLVLVGLLRGSFVFMADLARAIDLTHQVDFMTASSYGNGMESSRDVR
ILKDLDDDIQGKDVLLVEDIIDTGNTLTKVKEILSLRGPKSIEICTLLDKPSRREVIVDTKWIGFEIPDEFVVGVGIDYA
QKYRHLPYIGKVVPQE
>Mature_176_residues
MKHTVEVMISEQEVQDRVNELGKQITEHYQGSEDLVLVGLLRGSFVFMADLARAIDLTHQVDFMTASSYGNGMESSRDVR
ILKDLDDDIQGKDVLLVEDIIDTGNTLTKVKEILSLRGPKSIEICTLLDKPSRREVIVDTKWIGFEIPDEFVVGVGIDYA
QKYRHLPYIGKVVPQE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=176, Percent_Identity=33.5227272727273, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=31.2138728323699, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI87081689, Length=174, Percent_Identity=74.1379310344828, Blast_Score=270, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17510817, Length=176, Percent_Identity=36.3636363636364, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19879; Mature: 19879

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTVEVMISEQEVQDRVNELGKQITEHYQGSEDLVLVGLLRGSFVFMADLARAIDLTHQ
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHH
VDFMTASSYGNGMESSRDVRILKDLDDDIQGKDVLLVEDIIDTGNTLTKVKEILSLRGPK
HHEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCC
SIEICTLLDKPSRREVIVDTKWIGFEIPDEFVVGVGIDYAQKYRHLPYIGKVVPQE
CEEEEEECCCCCCCEEEEEEEEECEECCCCEEEECCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKHTVEVMISEQEVQDRVNELGKQITEHYQGSEDLVLVGLLRGSFVFMADLARAIDLTHQ
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHH
VDFMTASSYGNGMESSRDVRILKDLDDDIQGKDVLLVEDIIDTGNTLTKVKEILSLRGPK
HHEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCC
SIEICTLLDKPSRREVIVDTKWIGFEIPDEFVVGVGIDYAQKYRHLPYIGKVVPQE
CEEEEEECCCCCCCEEEEEEEEECEECCCCEEEECCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]