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The map label for this gene is folP [H]

Identifier: 218710450

GI number: 218710450

Start: 2660686

End: 2661516

Strand: Reverse

Name: folP [H]

Synonym: VS_2489

Alternate gene names: 218710450

Gene position: 2661516-2660686 (Counterclockwise)

Preceding gene: 218710451

Following gene: 218710449

Centisome position: 80.67

GC content: 44.65

Gene sequence:

>831_bases
ATGATATTAAAAGCACACAATAAAACGCTCGTTTTAGACCGCCCACATGTGATGGGTATCCTCAATGTTACGCCTGACTC
TTTCTCTGATGGCGGAAAATTCAATTCATTAGATAATGCTTTACTGCAAGCAGAGCGAATGATTCAGGCTGGCGTTAGCA
TTATTGATATTGGTGGTGAGTCGACTCGTCCGGGGGCTCCAGAGGTGTCCTTAGAGGAAGAGTTAGCTCGAGTTATCCCT
GCGATTAAAGCGATTCGCGCCAAGTTTGATGTGTGGATCTCGATTGATACCAGCAAAGCTGAGGTGATGCGTCAAGCTGT
TGAAGCGGGTGCTGACTTGATCAATGATGTGCGCGCACTGCAAGAGCCGGGCGCTTTAGAGGCTGCTGCTCAAGCTCAAG
TTCCAGTTTGTTTGATGCACATGAAAGGCCAGCCAAGAACCATGCAAGCTAACCCTAGCTATGACGATGTTTTCACTGAT
GTTGAAGACTTTTTAAAAGAAAGGGTTGAGGCTTGTAAGTCCGTAGGTATACCTAAAGAGCAACTTATTTTAGATCCTGG
CTTTGGCTTTGGTAAAACGATAGAGCATAATTACCACCTATTAGCACACCTTGAAAAATTTCATACGCTTGGCTTGCCAG
TCTTAGCGGGGATGTCGAGAAAATCGATGATCTTTAAACTGCTAGACAAAGTCCCAGCTGACTGCATGGTAGGAAGTGTT
ACTTGCGCCACCATTGCTGCGATGAAAGGTGCTCAAATTATTCGCGTTCACGATGTAGAAGATACATTGGAAGCGATGAA
GATAATCGAAGTGATGAATAACAATCACTAA

Upstream 100 bases:

>100_bases
AAGATTCTTAATTGCTAAGCTTTAAATTAAAACCCTGAGTACGCTCAGGGTTTTTCTATTTCTAGCCCAAGATATTTTTT
ACCTTTAAGACCCACCTTCC

Downstream 100 bases:

>100_bases
TCATAATTAAGGAAAATCAATATGTCTGAAAAAAGACGTTACTTCGGCACAGATGGTGTACGTGGAAAAGTGGGCCAGTA
CCCAATCACACCTGATTTTG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MILKAHNKTLVLDRPHVMGILNVTPDSFSDGGKFNSLDNALLQAERMIQAGVSIIDIGGESTRPGAPEVSLEEELARVIP
AIKAIRAKFDVWISIDTSKAEVMRQAVEAGADLINDVRALQEPGALEAAAQAQVPVCLMHMKGQPRTMQANPSYDDVFTD
VEDFLKERVEACKSVGIPKEQLILDPGFGFGKTIEHNYHLLAHLEKFHTLGLPVLAGMSRKSMIFKLLDKVPADCMVGSV
TCATIAAMKGAQIIRVHDVEDTLEAMKIIEVMNNNH

Sequences:

>Translated_276_residues
MILKAHNKTLVLDRPHVMGILNVTPDSFSDGGKFNSLDNALLQAERMIQAGVSIIDIGGESTRPGAPEVSLEEELARVIP
AIKAIRAKFDVWISIDTSKAEVMRQAVEAGADLINDVRALQEPGALEAAAQAQVPVCLMHMKGQPRTMQANPSYDDVFTD
VEDFLKERVEACKSVGIPKEQLILDPGFGFGKTIEHNYHLLAHLEKFHTLGLPVLAGMSRKSMIFKLLDKVPADCMVGSV
TCATIAAMKGAQIIRVHDVEDTLEAMKIIEVMNNNH
>Mature_276_residues
MILKAHNKTLVLDRPHVMGILNVTPDSFSDGGKFNSLDNALLQAERMIQAGVSIIDIGGESTRPGAPEVSLEEELARVIP
AIKAIRAKFDVWISIDTSKAEVMRQAVEAGADLINDVRALQEPGALEAAAQAQVPVCLMHMKGQPRTMQANPSYDDVFTD
VEDFLKERVEACKSVGIPKEQLILDPGFGFGKTIEHNYHLLAHLEKFHTLGLPVLAGMSRKSMIFKLLDKVPADCMVGSV
TCATIAAMKGAQIIRVHDVEDTLEAMKIIEVMNNNH

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=270, Percent_Identity=61.1111111111111, Blast_Score=353, Evalue=5e-99,
Organism=Saccharomyces cerevisiae, GI6324073, Length=313, Percent_Identity=29.7124600638978, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30132; Mature: 30132

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKAHNKTLVLDRPHVMGILNVTPDSFSDGGKFNSLDNALLQAERMIQAGVSIIDIGGE
CEEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCC
STRPGAPEVSLEEELARVIPAIKAIRAKFDVWISIDTSKAEVMRQAVEAGADLINDVRAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
QEPGALEAAAQAQVPVCLMHMKGQPRTMQANPSYDDVFTDVEDFLKERVEACKSVGIPKE
CCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
QLILDPGFGFGKTIEHNYHLLAHLEKFHTLGLPVLAGMSRKSMIFKLLDKVPADCMVGSV
HEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHH
TCATIAAMKGAQIIRVHDVEDTLEAMKIIEVMNNNH
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MILKAHNKTLVLDRPHVMGILNVTPDSFSDGGKFNSLDNALLQAERMIQAGVSIIDIGGE
CEEECCCCEEEEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCC
STRPGAPEVSLEEELARVIPAIKAIRAKFDVWISIDTSKAEVMRQAVEAGADLINDVRAL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
QEPGALEAAAQAQVPVCLMHMKGQPRTMQANPSYDDVFTDVEDFLKERVEACKSVGIPKE
CCCCCHHHHHHCCCCEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
QLILDPGFGFGKTIEHNYHLLAHLEKFHTLGLPVLAGMSRKSMIFKLLDKVPADCMVGSV
HEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHH
TCATIAAMKGAQIIRVHDVEDTLEAMKIIEVMNNNH
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]