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The map label for this gene is pepD [H]

Identifier: 218710385

GI number: 218710385

Start: 2591273

End: 2592745

Strand: Direct

Name: pepD [H]

Synonym: VS_2422

Alternate gene names: 218710385

Gene position: 2591273-2592745 (Clockwise)

Preceding gene: 218710369

Following gene: 218710387

Centisome position: 78.54

GC content: 47.05

Gene sequence:

>1473_bases
GTGTCTGAATTCCATTCTGAGATCAGTAAATTGTCCCCTGCCCCTATTTGGCAGTTTTTCGATAAAATTTGTTCAATCCC
GCACCCTTCGAAACATGAAGAAGAACTTGCTCAATACATTATTGCTTGGGCAACAGAGCAAGGCCTAGATGTACGTCGTG
ACCCAACGGGTAACGTATTCATCAAAAAGCCTGCAACGGCGGGTATGGAAAACAAAAAAGGTGTCGTGCTACAAGCTCAC
ATCGATATGGTTCCACAAAAGAACGAAGACACAGTTCATGACTTCGCTAAAGATCCAATCCAACCATACATTGATGGTGA
GTGGGTTACAGCGAAAGGCACAACGCTTGGTGCTGATAACGGCATGGGCATGGCTTCTTGCCTAGCGGTTCTGGCTTCAA
ACGAAATCCAGCACGGTCCTATCGAAGTTCTACTTACCGTAGATGAAGAAGCAGGCATGACTGGTGCTTTCGGTCTTGAA
GCGGGTTGGTTAGAAGGCGATATCCTTCTTAACACCGATTCTGAGCAAGAAGGCGAAGTGTACATGGGTTGTGCTGGCGG
TATCGACGGCGCAATGACATTTGAAATTGCACGTAACGCGATTCCGGCTGACTTCGTAACACGTAAGCTAACGCTAAAAG
GCCTAAAAGGCGGTCACTCTGGTTGCGACATCCACACAGGTCGTGCAAACGCAAACAAACTGCTTGCTCGTTTCCTAGCG
GGTCACGCAAAAGAGCTAGACCTTCGCATCGTCGAATTCAAAGGTGGTAGCCTTCGTAACGCTATTCCTCGTGAAGGTTT
CGTAACGGTTGCTGTTCCTGCTGAAAACCAAGAGAAACTGGCTTCGCTATACAACTACTACACAGAGCTGCTTTCAACAG
AGCTAGGTAAAGTAGAAGACAGCATCGTGACTTTCAACGAAGAAGCTTCTGTAGAAATGGGCGCACTTGCGTCAGCAGAC
CAAGCTCGCTTTATCGCGGCACTTAACGCATGTCCAAACGGCGTGATTCGTATGAGTGACGAGATTGAAGGTGTTGTTGA
AACATCTCTAAACGTAGGTGTTATCACAACAGAAGAGAACTCAATCACAGTGCTTTGCCTGATCCGTTCTCTTATCGATT
CAGGTCGTAGCCAAGTAGAAAGCATGCTTCACTCTGTTGCTGAACTAGCAGGCGCTAACATCGCGTTCTCTGGTGCTTAC
CCAGGTTGGAAGCCAGATGCAGATTCAGAAATCATGCACATCTTCCGCGACATGTACGAAGGTATCTACGGTCACAAACC
AAACATCATGGTTATCCACGCTGGTCTTGAGTGTGGTCTATTCAAAGAACCTTACCCGAACATGGATATGGTTTCTTTCG
GCCCAACCATCAAGTTCCCTCACTCTCCTGATGAGAAAGTGAAGATCGATACGGTTGAGCTATTCTGGAATCAAATGGTT
GCACTGCTTGCAGCTATCCCAGAAAAAGCATAA

Upstream 100 bases:

>100_bases
CTGTTGCCATCAAAACAGACCCATATTTTAGATTTTTGTTCTAGTTTTTTGCCATTACAAAACCTAAATATATGGTTATC
AAATAAAAAAGGAGTCATCC

Downstream 100 bases:

>100_bases
TTCGATAAGCTATGTATCTTCAATAAATGGTGTTTCCTATAAACAGAGCTCTTCACTAAATAGCACTTTTCAGTAAACAC
CGTTTATAGACACAAAATAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MSEFHSEISKLSPAPIWQFFDKICSIPHPSKHEEELAQYIIAWATEQGLDVRRDPTGNVFIKKPATAGMENKKGVVLQAH
IDMVPQKNEDTVHDFAKDPIQPYIDGEWVTAKGTTLGADNGMGMASCLAVLASNEIQHGPIEVLLTVDEEAGMTGAFGLE
AGWLEGDILLNTDSEQEGEVYMGCAGGIDGAMTFEIARNAIPADFVTRKLTLKGLKGGHSGCDIHTGRANANKLLARFLA
GHAKELDLRIVEFKGGSLRNAIPREGFVTVAVPAENQEKLASLYNYYTELLSTELGKVEDSIVTFNEEASVEMGALASAD
QARFIAALNACPNGVIRMSDEIEGVVETSLNVGVITTEENSITVLCLIRSLIDSGRSQVESMLHSVAELAGANIAFSGAY
PGWKPDADSEIMHIFRDMYEGIYGHKPNIMVIHAGLECGLFKEPYPNMDMVSFGPTIKFPHSPDEKVKIDTVELFWNQMV
ALLAAIPEKA

Sequences:

>Translated_490_residues
MSEFHSEISKLSPAPIWQFFDKICSIPHPSKHEEELAQYIIAWATEQGLDVRRDPTGNVFIKKPATAGMENKKGVVLQAH
IDMVPQKNEDTVHDFAKDPIQPYIDGEWVTAKGTTLGADNGMGMASCLAVLASNEIQHGPIEVLLTVDEEAGMTGAFGLE
AGWLEGDILLNTDSEQEGEVYMGCAGGIDGAMTFEIARNAIPADFVTRKLTLKGLKGGHSGCDIHTGRANANKLLARFLA
GHAKELDLRIVEFKGGSLRNAIPREGFVTVAVPAENQEKLASLYNYYTELLSTELGKVEDSIVTFNEEASVEMGALASAD
QARFIAALNACPNGVIRMSDEIEGVVETSLNVGVITTEENSITVLCLIRSLIDSGRSQVESMLHSVAELAGANIAFSGAY
PGWKPDADSEIMHIFRDMYEGIYGHKPNIMVIHAGLECGLFKEPYPNMDMVSFGPTIKFPHSPDEKVKIDTVELFWNQMV
ALLAAIPEKA
>Mature_489_residues
SEFHSEISKLSPAPIWQFFDKICSIPHPSKHEEELAQYIIAWATEQGLDVRRDPTGNVFIKKPATAGMENKKGVVLQAHI
DMVPQKNEDTVHDFAKDPIQPYIDGEWVTAKGTTLGADNGMGMASCLAVLASNEIQHGPIEVLLTVDEEAGMTGAFGLEA
GWLEGDILLNTDSEQEGEVYMGCAGGIDGAMTFEIARNAIPADFVTRKLTLKGLKGGHSGCDIHTGRANANKLLARFLAG
HAKELDLRIVEFKGGSLRNAIPREGFVTVAVPAENQEKLASLYNYYTELLSTELGKVEDSIVTFNEEASVEMGALASADQ
ARFIAALNACPNGVIRMSDEIEGVVETSLNVGVITTEENSITVLCLIRSLIDSGRSQVESMLHSVAELAGANIAFSGAYP
GWKPDADSEIMHIFRDMYEGIYGHKPNIMVIHAGLECGLFKEPYPNMDMVSFGPTIKFPHSPDEKVKIDTVELFWNQMVA
LLAAIPEKA

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=484, Percent_Identity=62.8099173553719, Blast_Score=648, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53241; Mature: 53110

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFHSEISKLSPAPIWQFFDKICSIPHPSKHEEELAQYIIAWATEQGLDVRRDPTGNVF
CCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
IKKPATAGMENKKGVVLQAHIDMVPQKNEDTVHDFAKDPIQPYIDGEWVTAKGTTLGADN
EECCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCEECCCC
GMGMASCLAVLASNEIQHGPIEVLLTVDEEAGMTGAFGLEAGWLEGDILLNTDSEQEGEV
CCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCE
YMGCAGGIDGAMTFEIARNAIPADFVTRKLTLKGLKGGHSGCDIHTGRANANKLLARFLA
EEEECCCCCCCEEHHHHHCCCCHHHHHHHHEEECCCCCCCCCEEECCCCCHHHHHHHHHC
GHAKELDLRIVEFKGGSLRNAIPREGFVTVAVPAENQEKLASLYNYYTELLSTELGKVED
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
SIVTFNEEASVEMGALASADQARFIAALNACPNGVIRMSDEIEGVVETSLNVGVITTEEN
CEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCEEEEEECCC
SITVLCLIRSLIDSGRSQVESMLHSVAELAGANIAFSGAYPGWKPDADSEIMHIFRDMYE
CEEHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
GIYGHKPNIMVIHAGLECGLFKEPYPNMDMVSFGPTIKFPHSPDEKVKIDTVELFWNQMV
HHCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEEHHHHHHHHHHH
ALLAAIPEKA
HHHHHCCCCC
>Mature Secondary Structure 
SEFHSEISKLSPAPIWQFFDKICSIPHPSKHEEELAQYIIAWATEQGLDVRRDPTGNVF
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
IKKPATAGMENKKGVVLQAHIDMVPQKNEDTVHDFAKDPIQPYIDGEWVTAKGTTLGADN
EECCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCCEECCCC
GMGMASCLAVLASNEIQHGPIEVLLTVDEEAGMTGAFGLEAGWLEGDILLNTDSEQEGEV
CCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCE
YMGCAGGIDGAMTFEIARNAIPADFVTRKLTLKGLKGGHSGCDIHTGRANANKLLARFLA
EEEECCCCCCCEEHHHHHCCCCHHHHHHHHEEECCCCCCCCCEEECCCCCHHHHHHHHHC
GHAKELDLRIVEFKGGSLRNAIPREGFVTVAVPAENQEKLASLYNYYTELLSTELGKVED
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCC
SIVTFNEEASVEMGALASADQARFIAALNACPNGVIRMSDEIEGVVETSLNVGVITTEEN
CEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHCCCCEEEEEECCC
SITVLCLIRSLIDSGRSQVESMLHSVAELAGANIAFSGAYPGWKPDADSEIMHIFRDMYE
CEEHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
GIYGHKPNIMVIHAGLECGLFKEPYPNMDMVSFGPTIKFPHSPDEKVKIDTVELFWNQMV
HHCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEEHHHHHHHHHHH
ALLAAIPEKA
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]