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The map label for this gene is dxs

Identifier: 218710369

GI number: 218710369

Start: 2575428

End: 2577311

Strand: Direct

Name: dxs

Synonym: VS_2406

Alternate gene names: 218710369

Gene position: 2575428-2577311 (Clockwise)

Preceding gene: 218710368

Following gene: 218710385

Centisome position: 78.06

GC content: 47.88

Gene sequence:

>1884_bases
ATGACTCTTGATATATCAAAGTACCCAACTCTTGCTTTGGCTGATAAGCCAGAGGATTTGCGTCTACTTCCAAAAGAGAC
GCTTACACAGCTTTGTGATGAATTACGTACCTATCTTCTTAACTCAGTGAGCCAGTCAAGTGGTCACTTAGCATCAGGCT
TAGGTACAGTAGAGCTAACCGTAGCTCTTCACTATGTGTACAACACGCCTTTTGACCAGTTGGTTTGGGATGTTGGCCAC
CAAGCCTACCCACATAAAATTCTTACTGGTCGTCGCGACCGTTTATCGACTATCCGTCAAAAAGATGGACTGCACCCATT
CCCATGGCGTGAAGAGAGCGAATACGACACGCTTTCTGTTGGTCACTCTTCAACTTCGATCAGTGCTGCACTTGGTATGG
CTATCAGTGCGAAGAAAGAAGGCAAGAACCGTAAAGTCGTCAGTGTGATTGGTGATGGCGCGATTACCGCAGGTATGGCA
TTTGAAGCCATGAACCACGCGGGCGATATTCACAATGACATGCTGGTTATCCTGAACGATAACGAGATGTCGATCTCTGA
AAACGTCGGTGCTCTGAACAACCATCTAGCTCAAGTTCTTTCTGGCAGTCTTTACACGTCTATTCGTGAGGGTGGCAAGA
AAGTGCTATCGGGCGTTCCGCCGATTAAAGAGCTCGTTCGTCGTACAGAAGAACATCTAAAAGGCATGGTTGTCCCTGGC
ACCATGTTTGAAGAGTTAGGCTTTAACTACATTGGTCCGGTTGACGGTCACGATGTGAATGAGCTGATTAAAACGTTGAA
GAACATGAGAGACCTTAAAGGCCCTCAGTTCCTGCATATCATGACCAAGAAAGGCAAAGGCTACGAGCCTGCTGAGAAAG
ACCCAATTGGTTATCACGGCGTACCTAAATTCGATCCTGCACACTCAAGTCTGCCTAAGAGCACCAGCTCTAAACCAACT
TTCTCTAAGATTTTTGGCGACTTCCTGTGTGATATGGCCGCGCAAGATCCTAAGCTAATGGCGATCACGCCAGCAATGCG
TGAAGGTTCTGGCATGGTGCGTTTCTCTAAAGAGTACCCAAAGCAATACTTCGATGTAGCGATTGCTGAGCAACACGCCG
TGACACTAGCAACTGGTATGGCGATTGCGGGTGATAAGCCGATTGTGGCTATCTACTCGACGTTCTTACAACGTGGCTAC
GATCAACTGATCCACGATGTCGCCATCATGGATCTACCGGTTATGTTCGCTATTGACCGTGCAGGTCTTGTTGGCGCCGA
TGGTCAAACACACCAAGGTGCGTTCGACTTAAGCTTTATGCGCTGTATTCCAAACATGGTGATCATGGCACCAAGCGACG
AAAACGAATGTCGCCAAATGCTATACACTGGCCACCAGCACACAGGGCCAAGTGCCGTTCGTTATCCTCGTGGTAATGGT
ATGGGCACCGAGATTCAAAGTGAGTTTACCGCACTTGAGATTGGTAAAGGTCGTATCGTTCGCGAAAGCAAAAAAGCAAA
AGATGGCTCGAAAGTCGCTATCCTAAGCTTCGGTACTTTCCTTGAGAGTGCACTTCAAACGGCTGACGCTATCGATGCGA
CAGTGGCAGACATGCGCTTTGTGAAGCCCCTCGATGAAGCTCTGATCAAACAACTTGCTGCTGACCACGATGTACTTGTG
ACAATCGAAGAAAACGCGATTGCAGGTGGTGCGGGCGCAGGTGTGATTGAATTCTTGATGCAAGAAAAGCTGCTGATGCC
AGTACTGAACCTTGGCCTCCCAGACAAGTTTATTGCTCAAGGAACACAGGATGAGCTGCATGAAGAGCTTGGCTTAGATG
CTAAAGGCATAGAGAAGTCGATCTCTGACTATCTTGCTAAATAG

Upstream 100 bases:

>100_bases
TCAAGCTTTGGCTGCAATCCCATACAATACCCAGTTACTCGAAGAGTTCGCCCGATACGTCATCGAGCGCAAGAACTAAG
ACAATAAGCGCGCATTACCT

Downstream 100 bases:

>100_bases
CCTTAACACGTAAGCTCGTAAGCAATAAAAGCAAAAAAGGTTGGCCCTAGGGTCAACCTTTTTAGTATCCGAGACTTAGC
TTAATGTGCTTGCAACTAAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MTLDISKYPTLALADKPEDLRLLPKETLTQLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYNTPFDQLVWDVGH
QAYPHKILTGRRDRLSTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAALGMAISAKKEGKNRKVVSVIGDGAITAGMA
FEAMNHAGDIHNDMLVILNDNEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPG
TMFEELGFNYIGPVDGHDVNELIKTLKNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGYHGVPKFDPAHSSLPKSTSSKPT
FSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPKQYFDVAIAEQHAVTLATGMAIAGDKPIVAIYSTFLQRGY
DQLIHDVAIMDLPVMFAIDRAGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGHQHTGPSAVRYPRGNG
MGTEIQSEFTALEIGKGRIVRESKKAKDGSKVAILSFGTFLESALQTADAIDATVADMRFVKPLDEALIKQLAADHDVLV
TIEENAIAGGAGAGVIEFLMQEKLLMPVLNLGLPDKFIAQGTQDELHEELGLDAKGIEKSISDYLAK

Sequences:

>Translated_627_residues
MTLDISKYPTLALADKPEDLRLLPKETLTQLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYNTPFDQLVWDVGH
QAYPHKILTGRRDRLSTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAALGMAISAKKEGKNRKVVSVIGDGAITAGMA
FEAMNHAGDIHNDMLVILNDNEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPG
TMFEELGFNYIGPVDGHDVNELIKTLKNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGYHGVPKFDPAHSSLPKSTSSKPT
FSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPKQYFDVAIAEQHAVTLATGMAIAGDKPIVAIYSTFLQRGY
DQLIHDVAIMDLPVMFAIDRAGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGHQHTGPSAVRYPRGNG
MGTEIQSEFTALEIGKGRIVRESKKAKDGSKVAILSFGTFLESALQTADAIDATVADMRFVKPLDEALIKQLAADHDVLV
TIEENAIAGGAGAGVIEFLMQEKLLMPVLNLGLPDKFIAQGTQDELHEELGLDAKGIEKSISDYLAK
>Mature_626_residues
TLDISKYPTLALADKPEDLRLLPKETLTQLCDELRTYLLNSVSQSSGHLASGLGTVELTVALHYVYNTPFDQLVWDVGHQ
AYPHKILTGRRDRLSTIRQKDGLHPFPWREESEYDTLSVGHSSTSISAALGMAISAKKEGKNRKVVSVIGDGAITAGMAF
EAMNHAGDIHNDMLVILNDNEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPGT
MFEELGFNYIGPVDGHDVNELIKTLKNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGYHGVPKFDPAHSSLPKSTSSKPTF
SKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYPKQYFDVAIAEQHAVTLATGMAIAGDKPIVAIYSTFLQRGYD
QLIHDVAIMDLPVMFAIDRAGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGHQHTGPSAVRYPRGNGM
GTEIQSEFTALEIGKGRIVRESKKAKDGSKVAILSFGTFLESALQTADAIDATVADMRFVKPLDEALIKQLAADHDVLVT
IEENAIAGGAGAGVIEFLMQEKLLMPVLNLGLPDKFIAQGTQDELHEELGLDAKGIEKSISDYLAK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=677, Percent_Identity=22.8951255539143, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4507521, Length=677, Percent_Identity=22.8951255539143, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI133778974, Length=672, Percent_Identity=23.3630952380952, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI225637463, Length=551, Percent_Identity=22.6860254083485, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI225637461, Length=551, Percent_Identity=22.6860254083485, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI225637459, Length=551, Percent_Identity=22.6860254083485, Blast_Score=76, Evalue=8e-14,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=74.8006379585327, Blast_Score=983, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=571, Percent_Identity=24.1681260945709, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24666278, Length=622, Percent_Identity=24.1157556270096, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551847, Length=671, Percent_Identity=23.9940387481371, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI45550715, Length=671, Percent_Identity=23.9940387481371, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24645119, Length=573, Percent_Identity=24.2582897033159, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_VIBSL (B7VJA1)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002417990.1
- GeneID:   7161943
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2406
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68441; Mature: 68310

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDISKYPTLALADKPEDLRLLPKETLTQLCDELRTYLLNSVSQSSGHLASGLGTVELT
CCCCCCCCCCEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEE
VALHYVYNTPFDQLVWDVGHQAYPHKILTGRRDRLSTIRQKDGLHPFPWREESEYDTLSV
EEEEHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSSTSISAALGMAISAKKEGKNRKVVSVIGDGAITAGMAFEAMNHAGDIHNDMLVILND
CCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TMFEELGFNYIGPVDGHDVNELIKTLKNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGYHG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPAHSSLPKSTSSKPTFSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCCEEECHHCC
KQYFDVAIAEQHAVTLATGMAIAGDKPIVAIYSTFLQRGYDQLIHDVAIMDLPVMFAIDR
HHHHHHHHHHHHHEEHHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECC
AGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGHQHTGPSAVRYPRGNG
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
MGTEIQSEFTALEIGKGRIVRESKKAKDGSKVAILSFGTFLESALQTADAIDATVADMRF
CCCHHHHHHHEEECCCCCEEECHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
VKPLDEALIKQLAADHDVLVTIEENAIAGGAGAGVIEFLMQEKLLMPVLNLGLPDKFIAQ
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GTQDELHEELGLDAKGIEKSISDYLAK
CCHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLDISKYPTLALADKPEDLRLLPKETLTQLCDELRTYLLNSVSQSSGHLASGLGTVELT
CCCCCCCCCEEECCCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEE
VALHYVYNTPFDQLVWDVGHQAYPHKILTGRRDRLSTIRQKDGLHPFPWREESEYDTLSV
EEEEHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSSTSISAALGMAISAKKEGKNRKVVSVIGDGAITAGMAFEAMNHAGDIHNDMLVILND
CCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQVLSGSLYTSIREGGKKVLSGVPPIKELVRRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TMFEELGFNYIGPVDGHDVNELIKTLKNMRDLKGPQFLHIMTKKGKGYEPAEKDPIGYHG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPAHSSLPKSTSSKPTFSKIFGDFLCDMAAQDPKLMAITPAMREGSGMVRFSKEYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHCCCCCEEECHHCC
KQYFDVAIAEQHAVTLATGMAIAGDKPIVAIYSTFLQRGYDQLIHDVAIMDLPVMFAIDR
HHHHHHHHHHHHHEEHHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEECC
AGLVGADGQTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGHQHTGPSAVRYPRGNG
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
MGTEIQSEFTALEIGKGRIVRESKKAKDGSKVAILSFGTFLESALQTADAIDATVADMRF
CCCHHHHHHHEEECCCCCEEECHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
VKPLDEALIKQLAADHDVLVTIEENAIAGGAGAGVIEFLMQEKLLMPVLNLGLPDKFIAQ
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GTQDELHEELGLDAKGIEKSISDYLAK
CCHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA