Click here to switch to the map view.

The map label for this gene is fadE [H]

Identifier: 218710288

GI number: 218710288

Start: 2489053

End: 2491518

Strand: Direct

Name: fadE [H]

Synonym: VS_2322

Alternate gene names: 218710288

Gene position: 2489053-2491518 (Clockwise)

Preceding gene: 218710285

Following gene: 218710291

Centisome position: 75.44

GC content: 47.49

Gene sequence:

>2466_bases
ATGAACATATTGCTCTCCCTACTCGGCATGACAGCCATCTTAGGCGTCTGTCTTTACCATAGAGTTAGTCTGGTCCGTGC
GTTAATTGTGTTAACTGGCGCAATGGTCGCATTAACCCTGTTTGGCAGCGTGGCAGTCACTGGCTGGCTTTGTTATCTAT
TGGCCATTGCAATCTTTGCTGTACCAGCAATTCGCCAGACCCTGATTAGCCAAAAAGCACTTTCTTTGTTTAAGAAGGTT
CTACCAGCAATGTCTCAGACGGAAAAAGAGGCATTAGAAGCAGGCACTGTATGGTGGGAAGCAGAGCTGTTCAAAGGCAA
GCCTGAGTGGAAGAAGCTTCAAAACATTGCGGATCCAAAACTTTCTGAGGCGGAACAAGCGTTTTTAGATGGCCCAGTCA
ATACAGTGTGTGAAATGGTCAACGATTATCAAGTGACACATGAACTTGCCGATTTGCCACCAGAAGTTTGGCAGTACCTG
AAAGACCATAAATTCTTCGCCATGATCATCAAGAAAAAATACGGCGGTTTAGAATTCTCAGCTTACGCTCAGTCTTTAGT
TCTACAGAAACTAACGGGTGTTTCGAGCGTATTATCCTCAACCGTTGGCGTACCTAACTCACTAGGTCCTGGTGAGCTAT
TGCAGCACTACGGTACAGAAGATCAAAGAAACCATTACCTGCCACGCCTAGCTGAAGGTAAAGAGATCCCTTGTTTCGCA
CTGACCAGTCCAGAAGCCGGCTCAGATGCTGGCTCAATCCCAGATTACGGCGTGGTGTGTAAAGGTCAATGGCAAGGCGA
AGAAGTATTGGGCATGCGCCTAACTTGGAACAAACGTTACATCACTCTAGCGCCTGTCGCGACCGTTTTAGGCTTAGCCT
TTAAACTGAGAGACCCAGAAGGTCTGCTTGGTGACAAACAAGATCTTGGCATCACCTGTGCTCTTATCCCTACCGATTTA
AAAGGCGTAGAGATTGGTAACCGCCACTTCCCACTCAACGTGCCTTTCCAAAATGGTCCGACTCAAGGTGATGACATCTT
CGTGCCTATCGATTTCATCATCGGCGGCCAGAAAATGGCAGGACAAGGCTGGCGTATGTTGGTTGAATGTCTGTCGGTTG
GTCGTGGTATCACACTGCCTTCAAACTCAACCGGTGGTATTAAATCTGCAGCATTAGCAACTGGTGCTTACGCTCGTATT
CGTCGTCAATTCAAACAACCCATTGGTAGCATGGAAGGGGTTGAAGAGCCACTGGCACGTCTAGCAGGTAACGCCTATGT
AATGGATGCAGCAAGTAACCTGACGGTTGCGGGTATCGATCTTGGTGAAAAGCCTTCGGTTATCTCAGCAATCGTGAAGT
ACCACTGTACTCACCGTGGCCAACGCAGCATCATCGATGCGATGGATATCGTCGGCGGTAAAGGCATTTGCTTAGGCCCA
TCGAACTTCCTCGCTCGTGGTTATCAAGGCTCACCAATTGCAATTACGGTTGAAGGCGCAAACATCCTGACTCGTTCAAT
GATCATCTATGGTCAAGGCGCGATTCGCTGCCACCCTTATGTTCTGAACGAAATGGAAGCGGCTTATTCGGAAAGCAGCG
ATGCACTTGATAAGTTTGATTCAGCATTAGCAGGACACGTTAGCTTTACTATGAGTAACCTAGTCCGCAGCTTGTGGTTT
GGTTTAACCGACGGTCGTGGTTCAGATGCTCCAACACCATCCAATAAAACGAATAAGCAGACACAGCGTTACTACCAACA
GCTGAACCGCTACAGTGCTAACCTAGCGCTACTGTCTGATATTTCAATGGCTGTATTAGGCGGTTCACTGAAACGCAGAG
AGCGCCTGTCAGCAAGACTGGGGGATATCCTGAGTCAACTCTACCTAGGTTCAGCAACACTTAAGCGCTTTGAAAGCGAA
GGTAGCCATGCTGAAGATCTCCCATTAGTCCATTGGGGTATGCAAGACAGCTTGCGTCAAACTGAAGTCGCGATTGATGA
GTTCTTGGCGAACTTCCCTAACCCTGTGATTGGTCGACTACTTCGCGTTGTGTTAATGCCATTTGGCCGTATCCGTCGTG
CACCAAACGACAAGTTGGATAGCCAAGTCGCGCACATCCTACAAACACCTAGTGAAACACGCTCTCGTATCGGCCGTGGC
CAATACTTGGAAGCAACGGAATACAACCCTGTAGGCAAGATTGAAAAAGCGCTAGAGGTGATTCTTCAAGCTGAACCTCT
GTTCGATAAGGTTTGTAAAGAAACACATCAAAAACGTGCTTTCTTACGACTCGACCTTGTCGCTCAGTTGGGACTTGAGA
AAGGTATTTTAACGCAAGAAGAAGCAAATCTTCTGATTAGCGCTGAGGAACACAGACTGTACACAATTAACGTTAATGAT
TTCTCACCAGAGGAGCTTGCAGCAAAGACTCAGTACCCAGACCAATCGATTGATAACGTCGCTTAA

Upstream 100 bases:

>100_bases
TGGAGTTTTACAAATATTTAATATTTTGTTTACACTTGACTGGTTAGACCTCTTACCTAAACTTAATAACAATAAGTGAT
CTCTGAAAAGGAAATCGATC

Downstream 100 bases:

>100_bases
GGTCAGAGACAGAAACAAAAACGGGACTCCTATGAGTCCCGTTTTTTTATTCATCACTTCATTGTCACAAATTTTAATGC
TTGCTCTATCGAGGCTTGTT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 821; Mature: 821

Protein sequence:

>821_residues
MNILLSLLGMTAILGVCLYHRVSLVRALIVLTGAMVALTLFGSVAVTGWLCYLLAIAIFAVPAIRQTLISQKALSLFKKV
LPAMSQTEKEALEAGTVWWEAELFKGKPEWKKLQNIADPKLSEAEQAFLDGPVNTVCEMVNDYQVTHELADLPPEVWQYL
KDHKFFAMIIKKKYGGLEFSAYAQSLVLQKLTGVSSVLSSTVGVPNSLGPGELLQHYGTEDQRNHYLPRLAEGKEIPCFA
LTSPEAGSDAGSIPDYGVVCKGQWQGEEVLGMRLTWNKRYITLAPVATVLGLAFKLRDPEGLLGDKQDLGITCALIPTDL
KGVEIGNRHFPLNVPFQNGPTQGDDIFVPIDFIIGGQKMAGQGWRMLVECLSVGRGITLPSNSTGGIKSAALATGAYARI
RRQFKQPIGSMEGVEEPLARLAGNAYVMDAASNLTVAGIDLGEKPSVISAIVKYHCTHRGQRSIIDAMDIVGGKGICLGP
SNFLARGYQGSPIAITVEGANILTRSMIIYGQGAIRCHPYVLNEMEAAYSESSDALDKFDSALAGHVSFTMSNLVRSLWF
GLTDGRGSDAPTPSNKTNKQTQRYYQQLNRYSANLALLSDISMAVLGGSLKRRERLSARLGDILSQLYLGSATLKRFESE
GSHAEDLPLVHWGMQDSLRQTEVAIDEFLANFPNPVIGRLLRVVLMPFGRIRRAPNDKLDSQVAHILQTPSETRSRIGRG
QYLEATEYNPVGKIEKALEVILQAEPLFDKVCKETHQKRAFLRLDLVAQLGLEKGILTQEEANLLISAEEHRLYTINVND
FSPEELAAKTQYPDQSIDNVA

Sequences:

>Translated_821_residues
MNILLSLLGMTAILGVCLYHRVSLVRALIVLTGAMVALTLFGSVAVTGWLCYLLAIAIFAVPAIRQTLISQKALSLFKKV
LPAMSQTEKEALEAGTVWWEAELFKGKPEWKKLQNIADPKLSEAEQAFLDGPVNTVCEMVNDYQVTHELADLPPEVWQYL
KDHKFFAMIIKKKYGGLEFSAYAQSLVLQKLTGVSSVLSSTVGVPNSLGPGELLQHYGTEDQRNHYLPRLAEGKEIPCFA
LTSPEAGSDAGSIPDYGVVCKGQWQGEEVLGMRLTWNKRYITLAPVATVLGLAFKLRDPEGLLGDKQDLGITCALIPTDL
KGVEIGNRHFPLNVPFQNGPTQGDDIFVPIDFIIGGQKMAGQGWRMLVECLSVGRGITLPSNSTGGIKSAALATGAYARI
RRQFKQPIGSMEGVEEPLARLAGNAYVMDAASNLTVAGIDLGEKPSVISAIVKYHCTHRGQRSIIDAMDIVGGKGICLGP
SNFLARGYQGSPIAITVEGANILTRSMIIYGQGAIRCHPYVLNEMEAAYSESSDALDKFDSALAGHVSFTMSNLVRSLWF
GLTDGRGSDAPTPSNKTNKQTQRYYQQLNRYSANLALLSDISMAVLGGSLKRRERLSARLGDILSQLYLGSATLKRFESE
GSHAEDLPLVHWGMQDSLRQTEVAIDEFLANFPNPVIGRLLRVVLMPFGRIRRAPNDKLDSQVAHILQTPSETRSRIGRG
QYLEATEYNPVGKIEKALEVILQAEPLFDKVCKETHQKRAFLRLDLVAQLGLEKGILTQEEANLLISAEEHRLYTINVND
FSPEELAAKTQYPDQSIDNVA
>Mature_821_residues
MNILLSLLGMTAILGVCLYHRVSLVRALIVLTGAMVALTLFGSVAVTGWLCYLLAIAIFAVPAIRQTLISQKALSLFKKV
LPAMSQTEKEALEAGTVWWEAELFKGKPEWKKLQNIADPKLSEAEQAFLDGPVNTVCEMVNDYQVTHELADLPPEVWQYL
KDHKFFAMIIKKKYGGLEFSAYAQSLVLQKLTGVSSVLSSTVGVPNSLGPGELLQHYGTEDQRNHYLPRLAEGKEIPCFA
LTSPEAGSDAGSIPDYGVVCKGQWQGEEVLGMRLTWNKRYITLAPVATVLGLAFKLRDPEGLLGDKQDLGITCALIPTDL
KGVEIGNRHFPLNVPFQNGPTQGDDIFVPIDFIIGGQKMAGQGWRMLVECLSVGRGITLPSNSTGGIKSAALATGAYARI
RRQFKQPIGSMEGVEEPLARLAGNAYVMDAASNLTVAGIDLGEKPSVISAIVKYHCTHRGQRSIIDAMDIVGGKGICLGP
SNFLARGYQGSPIAITVEGANILTRSMIIYGQGAIRCHPYVLNEMEAAYSESSDALDKFDSALAGHVSFTMSNLVRSLWF
GLTDGRGSDAPTPSNKTNKQTQRYYQQLNRYSANLALLSDISMAVLGGSLKRRERLSARLGDILSQLYLGSATLKRFESE
GSHAEDLPLVHWGMQDSLRQTEVAIDEFLANFPNPVIGRLLRVVLMPFGRIRRAPNDKLDSQVAHILQTPSETRSRIGRG
QYLEATEYNPVGKIEKALEVILQAEPLFDKVCKETHQKRAFLRLDLVAQLGLEKGILTQEEANLLISAEEHRLYTINVND
FSPEELAAKTQYPDQSIDNVA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=550, Percent_Identity=26.9090909090909, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI4557235, Length=413, Percent_Identity=25.6658595641646, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=26.0053619302949, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI7656849, Length=274, Percent_Identity=24.0875912408759, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI87081702, Length=809, Percent_Identity=67.3671199011125, Blast_Score=1125, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538396, Length=320, Percent_Identity=23.75, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=383, Percent_Identity=23.7597911227154, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=274, Percent_Identity=24.8175182481752, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71985192, Length=326, Percent_Identity=23.0061349693252, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508101, Length=252, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534353, Length=119, Percent_Identity=36.1344537815126, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281363737, Length=350, Percent_Identity=26.5714285714286, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646207, Length=368, Percent_Identity=24.1847826086957, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24666513, Length=328, Percent_Identity=25.9146341463415, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 89891; Mature: 89891

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLSLLGMTAILGVCLYHRVSLVRALIVLTGAMVALTLFGSVAVTGWLCYLLAIAIFA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPAIRQTLISQKALSLFKKVLPAMSQTEKEALEAGTVWWEAELFKGKPEWKKLQNIADPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHCCCCHHHHHHHCCCCC
LSEAEQAFLDGPVNTVCEMVNDYQVTHELADLPPEVWQYLKDHKFFAMIIKKKYGGLEFS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCCHH
AYAQSLVLQKLTGVSSVLSSTVGVPNSLGPGELLQHYGTEDQRNHYLPRLAEGKEIPCFA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTSPEAGSDAGSIPDYGVVCKGQWQGEEVLGMRLTWNKRYITLAPVATVLGLAFKLRDPE
ECCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHHCCCCC
GLLGDKQDLGITCALIPTDLKGVEIGNRHFPLNVPFQNGPTQGDDIFVPIDFIIGGQKMA
CCCCCCCCCCEEEEEECCCCCCEEECCEECCEECCCCCCCCCCCEEEEEEEEEECCCHHC
GQGWRMLVECLSVGRGITLPSNSTGGIKSAALATGAYARIRRQFKQPIGSMEGVEEPLAR
CCHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHH
LAGNAYVMDAASNLTVAGIDLGEKPSVISAIVKYHCTHRGQRSIIDAMDIVGGKGICLGP
HCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECC
SNFLARGYQGSPIAITVEGANILTRSMIIYGQGAIRCHPYVLNEMEAAYSESSDALDKFD
HHHHHCCCCCCCEEEEECCCHHHHHHEEEECCCCEEECHHHHHHHHHHHCCCHHHHHHHH
SALAGHVSFTMSNLVRSLWFGLTDGRGSDAPTPSNKTNKQTQRYYQQLNRYSANLALLSD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
ISMAVLGGSLKRRERLSARLGDILSQLYLGSATLKRFESEGSHAEDLPLVHWGMQDSLRQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHH
TEVAIDEFLANFPNPVIGRLLRVVLMPFGRIRRAPNDKLDSQVAHILQTPSETRSRIGRG
HHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHCCCC
QYLEATEYNPVGKIEKALEVILQAEPLFDKVCKETHQKRAFLRLDLVAQLGLEKGILTQE
CEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCC
EANLLISAEEHRLYTINVNDFSPEELAAKTQYPDQSIDNVA
CCCEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNILLSLLGMTAILGVCLYHRVSLVRALIVLTGAMVALTLFGSVAVTGWLCYLLAIAIFA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPAIRQTLISQKALSLFKKVLPAMSQTEKEALEAGTVWWEAELFKGKPEWKKLQNIADPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHCCCCHHHHHHHCCCCC
LSEAEQAFLDGPVNTVCEMVNDYQVTHELADLPPEVWQYLKDHKFFAMIIKKKYGGLEFS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCCHH
AYAQSLVLQKLTGVSSVLSSTVGVPNSLGPGELLQHYGTEDQRNHYLPRLAEGKEIPCFA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
LTSPEAGSDAGSIPDYGVVCKGQWQGEEVLGMRLTWNKRYITLAPVATVLGLAFKLRDPE
ECCCCCCCCCCCCCCCCEEECCCCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHHCCCCC
GLLGDKQDLGITCALIPTDLKGVEIGNRHFPLNVPFQNGPTQGDDIFVPIDFIIGGQKMA
CCCCCCCCCCEEEEEECCCCCCEEECCEECCEECCCCCCCCCCCEEEEEEEEEECCCHHC
GQGWRMLVECLSVGRGITLPSNSTGGIKSAALATGAYARIRRQFKQPIGSMEGVEEPLAR
CCHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHCCHHHHHHH
LAGNAYVMDAASNLTVAGIDLGEKPSVISAIVKYHCTHRGQRSIIDAMDIVGGKGICLGP
HCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECC
SNFLARGYQGSPIAITVEGANILTRSMIIYGQGAIRCHPYVLNEMEAAYSESSDALDKFD
HHHHHCCCCCCCEEEEECCCHHHHHHEEEECCCCEEECHHHHHHHHHHHCCCHHHHHHHH
SALAGHVSFTMSNLVRSLWFGLTDGRGSDAPTPSNKTNKQTQRYYQQLNRYSANLALLSD
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHH
ISMAVLGGSLKRRERLSARLGDILSQLYLGSATLKRFESEGSHAEDLPLVHWGMQDSLRQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHH
TEVAIDEFLANFPNPVIGRLLRVVLMPFGRIRRAPNDKLDSQVAHILQTPSETRSRIGRG
HHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHCCCC
QYLEATEYNPVGKIEKALEVILQAEPLFDKVCKETHQKRAFLRLDLVAQLGLEKGILTQE
CEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCC
EANLLISAEEHRLYTINVNDFSPEELAAKTQYPDQSIDNVA
CCCEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]