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The map label for this gene is cueR [H]

Identifier: 218710250

GI number: 218710250

Start: 2452305

End: 2452712

Strand: Reverse

Name: cueR [H]

Synonym: VS_2283

Alternate gene names: 218710250

Gene position: 2452712-2452305 (Counterclockwise)

Preceding gene: 218710251

Following gene: 218710244

Centisome position: 74.34

GC content: 41.18

Gene sequence:

>408_bases
TTGAGTAATATTATGAACATAAGCGAAGTTGCAAGCCTCACGCAGTTATCACCTAAGTCTATTCGTTTGTATGAAGACAA
AGGGGTGATATCTGCCCCGTTACGTTCTGAAAATGGTTATCGGTCTTATGGTGAGAAGCAGATTAAAGAGCTCGGAATCG
TAGCGAAAGCGAGAAGCGCTGGTTTTTCGCTTGATGAGTGTCGTGCGCTTGTTGAATTAGCCGACAACCCATGTCGCGAA
AGTGCCGATGTTAAAGCAAAAGCGTTAAGTAAATTGGAAGAAGTGAATAAAAAAATTGAAGACTTACTGATCATTCAGAA
GACATTGAAAGAGTGGGTTGAACAATGCCCTGGTGACTCAAATAGCCATTGCCCAATTATCGATTCACTTGTAGAGAAAA
AGCCATAA

Upstream 100 bases:

>100_bases
GAACATTATATTGCTTCAATGTTTTTGTTTCGGTAGTTAGCATTCCTAGATGTTTGAATAATAGTCTTAGGTTTCTAAAT
AGTTTTTATGCGATATTTAC

Downstream 100 bases:

>100_bases
GTTGGTTACTTATGGCTTTGACGGAGGGTTTTCTTGATTATTGTTTAGTAGGGCTTATCGTGAGAACAATGCCATCGACA
GCAGTAATCACGACTTCCTC

Product: HTH-type transcriptional regulator CueR

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MSNIMNISEVASLTQLSPKSIRLYEDKGVISAPLRSENGYRSYGEKQIKELGIVAKARSAGFSLDECRALVELADNPCRE
SADVKAKALSKLEEVNKKIEDLLIIQKTLKEWVEQCPGDSNSHCPIIDSLVEKKP

Sequences:

>Translated_135_residues
MSNIMNISEVASLTQLSPKSIRLYEDKGVISAPLRSENGYRSYGEKQIKELGIVAKARSAGFSLDECRALVELADNPCRE
SADVKAKALSKLEEVNKKIEDLLIIQKTLKEWVEQCPGDSNSHCPIIDSLVEKKP
>Mature_134_residues
SNIMNISEVASLTQLSPKSIRLYEDKGVISAPLRSENGYRSYGEKQIKELGIVAKARSAGFSLDECRALVELADNPCRES
ADVKAKALSKLEEVNKKIEDLLIIQKTLKEWVEQCPGDSNSHCPIIDSLVEKKP

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=126, Percent_Identity=46.031746031746, Blast_Score=128, Evalue=1e-31,
Organism=Escherichia coli, GI1789687, Length=133, Percent_Identity=30.8270676691729, Blast_Score=77, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14961; Mature: 14830

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIMNISEVASLTQLSPKSIRLYEDKGVISAPLRSENGYRSYGEKQIKELGIVAKARSA
CCCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GFSLDECRALVELADNPCRESADVKAKALSKLEEVNKKIEDLLIIQKTLKEWVEQCPGDS
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NSHCPIIDSLVEKKP
CCCCCHHHHHHCCCC
>Mature Secondary Structure 
SNIMNISEVASLTQLSPKSIRLYEDKGVISAPLRSENGYRSYGEKQIKELGIVAKARSA
CCCCCHHHHHHHHHCCCCCEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GFSLDECRALVELADNPCRESADVKAKALSKLEEVNKKIEDLLIIQKTLKEWVEQCPGDS
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NSHCPIIDSLVEKKP
CCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA