Click here to switch to the map view.

The map label for this gene is fur [H]

Identifier: 218710225

GI number: 218710225

Start: 2424938

End: 2425387

Strand: Direct

Name: fur [H]

Synonym: VS_2258

Alternate gene names: 218710225

Gene position: 2424938-2425387 (Clockwise)

Preceding gene: 218710223

Following gene: 218710228

Centisome position: 73.5

GC content: 40.67

Gene sequence:

>450_bases
ATGTCAGACAATAATCAAGCGCTAAAAGATGCTGGTCTTAAAGTGACCCTCCCACGGCTCAAAATTTTAGAAGTATTACA
ACAACCAGATTGCCAACATATTAGTGCTGAAGATTTATATAAAAAGCTGATCGACTTAGGTGAAGAGATTGGTCTTGCGA
CCGTTTATCGCGTACTAAACCAATTCGATGATGCAGGCATTGTAACTCGTCACCACTTTGAAGGTGGTAAGTCTGTATTC
GAACTTTCAACACAGCATCACCACGATCACCTAGTATGTTTAGACTGCGGTGAAGTTATCGAGTTCTCTGATGATCTTAT
CGAAGAAAGACAAAAAGAAATCGCTCAACGCTACAATGTACAGCTAACTAACCACAGTTTGTATCTGTATGGTAAAAGCA
TCACTGGGGATTGCAAAGGCAACCCAGACGCACATAAAGCGAAGAAGTAA

Upstream 100 bases:

>100_bases
AACCCTTTGAAGTTCGTGGTTTATTGTTATGCCTGACTAAACTATAATGGTATTAATATTGAATTCTGTTAATTGCTGCA
GATCATCAACAGGAAAGTAT

Downstream 100 bases:

>100_bases
CACAGAACGCTGGCTTAGGCCGGCGTTTTTTATTTGGGCTGATATTGTATTAAGAATCACAGTAGCTTGGCCCACAATTT
GGTTATTTCTCAGATACAAA

Product: ferric uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MSDNNQALKDAGLKVTLPRLKILEVLQQPDCQHISAEDLYKKLIDLGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVF
ELSTQHHHDHLVCLDCGEVIEFSDDLIEERQKEIAQRYNVQLTNHSLYLYGKSITGDCKGNPDAHKAKK

Sequences:

>Translated_149_residues
MSDNNQALKDAGLKVTLPRLKILEVLQQPDCQHISAEDLYKKLIDLGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVF
ELSTQHHHDHLVCLDCGEVIEFSDDLIEERQKEIAQRYNVQLTNHSLYLYGKSITGDCKGNPDAHKAKK
>Mature_148_residues
SDNNQALKDAGLKVTLPRLKILEVLQQPDCQHISAEDLYKKLIDLGEEIGLATVYRVLNQFDDAGIVTRHHFEGGKSVFE
LSTQHHHDHLVCLDCGEVIEFSDDLIEERQKEIAQRYNVQLTNHSLYLYGKSITGDCKGNPDAHKAKK

Specific function: Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=148, Percent_Identity=77.027027027027, Blast_Score=242, Evalue=9e-66,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 16868; Mature: 16737

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNNQALKDAGLKVTLPRLKILEVLQQPDCQHISAEDLYKKLIDLGEEIGLATVYRVLN
CCCCCCHHHHCCCEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHCCHHHHHHHHH
QFDDAGIVTRHHFEGGKSVFELSTQHHHDHLVCLDCGEVIEFSDDLIEERQKEIAQRYNV
HCCCCCCEEEEECCCCCCEEHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCE
QLTNHSLYLYGKSITGDCKGNPDAHKAKK
EECCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDNNQALKDAGLKVTLPRLKILEVLQQPDCQHISAEDLYKKLIDLGEEIGLATVYRVLN
CCCCCHHHHCCCEEECHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHCCHHHHHHHHH
QFDDAGIVTRHHFEGGKSVFELSTQHHHDHLVCLDCGEVIEFSDDLIEERQKEIAQRYNV
HCCCCCCEEEEECCCCCCEEHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCE
QLTNHSLYLYGKSITGDCKGNPDAHKAKK
EECCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1372314 [H]