Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 218710213

GI number: 218710213

Start: 2413930

End: 2415588

Strand: Reverse

Name: sdhA [H]

Synonym: VS_2246

Alternate gene names: 218710213

Gene position: 2415588-2413930 (Counterclockwise)

Preceding gene: 218710214

Following gene: 218710212

Centisome position: 73.22

GC content: 47.2

Gene sequence:

>1659_bases
GTGACTATTCCTGTTCGTGAGTTTGATGCTGTAGTAATTGGCGCTGGTGGTGCTGGTATGCGCGCCGCGCTACAAATTTC
TGAGCAAGGCCTATCTTGTGCGTTGCTTTCTAAAGTTTTCCCAACTCGTTCTCATACTGTATCTGCGCAAGGTGGTATCA
CCGTTGCTCTTGGTAATGCGCATGAAGATCACTGGGAACAACACATGTACGATACGGTAAAAGGTTCTGATTACATCGGC
GACCAAGATGCTATCGAATACATGTGTAAAAATGGTCCTGAGTCGGTTATCGAACTAGAAAAAATGGGTCTTCCATTTTC
TCGTTTTGATAACGGCAGTATTTACCAACGTCCGTTTGGTGGCCAATCTAAGAATTTTGGTGGTGAGCAAGCGGCTCGTA
CCGCAGCGGCAGCCGACCGTACTGGTCACGCACTGTTACACACGCTTTACCAACAAAACATTAAACACAAAACGACGGTT
TTCTCTGAGTGGTATGCACTGGATCTTGTTAAAAACGAAGATGGTGCAATCTTAGGTACTACCGCGCTTTGTATGGAGAC
GGGTGAGGTTTGCTACTTCAAAGCGAAGGCAACAATCCTTGCTACTGGTGGTGCTGGTCGTATTTACGCATCAACAACCA
ATGCTCACATTAACACTGGTGACGGTGTTGGCATGGCGATTCGTGCTGGCGTTCCAATGCAAGACATCGAAATGTGGCAG
TTCCACCCAACGGGTATCGCTGGCGCAGGTGTTTTGGTAACAGAAGGTTGTCGTGGTGAAGGTGGTTACCTTCTCAATAA
AGACGGCGAGCGCTTCATGGAACGTTATGCTCCGAATGCTAAAGATTTAGCAGGTCGTGATGTTGTAGCTCGTTCGATGA
TGGTTGAGATTCGTGAAGGTCGTGGTTGTGATGGTCCATGGGGTCCACACATCAAGCTGAAACTCGATCACCTAGGTAAA
GAGACGCTTGAATCTCGTCTACCGGGTGTATGTGAGCTTTCTCGTACGTTCGCTCACGTTGATCCTGTTAAAGAACCAAT
TCCTGTAATCCCAACGTGTCACTACATGATGGGTGGTGTTCCTACACAGGTTTCTGGTCAAGCAATTAAACAAACTGAAG
ACGGTACAGACGTTGAAATTCAAGGTCTATTCGCTTGTGGCGAAATCGCTTCAGTATCCGTACACGGTGCAAACCGTCTA
GGTGGCAACTCGCTACTTGATTTGGTTGTGTTCGGTCGTGCGACAGGTCTTCACCTTGGTGAGACTTTGAACAAACAAGC
TGAAGCAAAACCTGCATCTGAAGCTGACATTGAACGTTCACTAGAGCGCTACAATCGTTGGGAAAACAGTACTGACGGTG
AAGATCCTGCGGTAATTCGTAAAGACCTTCAGCAATGTATGCAGAACAACTTCTCTGTATTCCGTGAAGGTAAAGCGATG
GCTGACGGCTTAGAAGAGCTGAAAGTGATTCGTGAGCGTCTTAAAAATGCACACCTTTCAGACAAGTCGACTGAGTTCAA
CACGCAACGTATTGAGTGTTTAGAGCTTGAAAACTTGATGGAAACGGCATTCGCAACCGCGGTTGCAGCAAACTTCCGTA
CAGAGAGTCGTGGAGCGCATGCTCGTTTCGACTTCCCAGATCGTGATGATGAACGATGA

Upstream 100 bases:

>100_bases
CATCAAATGTGCAAAATTGCGCGTTGGTCTTCAAGTCGGTGTTGTTGCGGTTCTTCTAGGATATTTCTTCTCTGGTCTGT
TTATTTTGTGGGGTGCGTAA

Downstream 100 bases:

>100_bases
GCAATGGCTATGCCACTCACTTTACAACCCTGAATCAGAAAGTATGACTAAGCGTGGCGTGAACATGGAACCTATCCATC
GTGAAGCATTCCCGCCGAAA

Product: putative succinate dehydrogenase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MTIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDYIG
DQDAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTTV
FSEWYALDLVKNEDGAILGTTALCMETGEVCYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREGRGCDGPWGPHIKLKLDHLGK
ETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQTEDGTDVEIQGLFACGEIASVSVHGANRL
GGNSLLDLVVFGRATGLHLGETLNKQAEAKPASEADIERSLERYNRWENSTDGEDPAVIRKDLQQCMQNNFSVFREGKAM
ADGLEELKVIRERLKNAHLSDKSTEFNTQRIECLELENLMETAFATAVAANFRTESRGAHARFDFPDRDDER

Sequences:

>Translated_552_residues
MTIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDYIG
DQDAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTTV
FSEWYALDLVKNEDGAILGTTALCMETGEVCYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREGRGCDGPWGPHIKLKLDHLGK
ETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQTEDGTDVEIQGLFACGEIASVSVHGANRL
GGNSLLDLVVFGRATGLHLGETLNKQAEAKPASEADIERSLERYNRWENSTDGEDPAVIRKDLQQCMQNNFSVFREGKAM
ADGLEELKVIRERLKNAHLSDKSTEFNTQRIECLELENLMETAFATAVAANFRTESRGAHARFDFPDRDDER
>Mature_551_residues
TIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDYIGD
QDAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTTVF
SEWYALDLVKNEDGAILGTTALCMETGEVCYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREGRGCDGPWGPHIKLKLDHLGKE
TLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQTEDGTDVEIQGLFACGEIASVSVHGANRLG
GNSLLDLVVFGRATGLHLGETLNKQAEAKPASEADIERSLERYNRWENSTDGEDPAVIRKDLQQCMQNNFSVFREGKAMA
DGLEELKVIRERLKNAHLSDKSTEFNTQRIECLELENLMETAFATAVAANFRTESRGAHARFDFPDRDDER

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=546, Percent_Identity=54.2124542124542, Blast_Score=553, Evalue=1e-157,
Organism=Escherichia coli, GI1786942, Length=551, Percent_Identity=83.6660617059891, Blast_Score=919, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=535, Percent_Identity=41.1214953271028, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1788928, Length=565, Percent_Identity=30.4424778761062, Blast_Score=219, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17550100, Length=534, Percent_Identity=53.1835205992509, Blast_Score=539, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17505833, Length=529, Percent_Identity=52.7410207939509, Blast_Score=538, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322701, Length=547, Percent_Identity=54.4789762340037, Blast_Score=574, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6322416, Length=546, Percent_Identity=54.3956043956044, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI17137288, Length=545, Percent_Identity=54.4954128440367, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24655642, Length=545, Percent_Identity=54.4954128440367, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24655647, Length=545, Percent_Identity=54.4954128440367, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24663005, Length=551, Percent_Identity=49.7277676950998, Blast_Score=521, Evalue=1e-148,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 60144; Mature: 60013

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCCEEEEECCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDYIGDQDAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTTVFSEWYALDLVKNEDGAILGT
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCEEEEEEEECCCCCEEEH
TALCMETGEVCYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMWQ
HHHHHCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCCEEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCC
RGCDGPWGPHIKLKLDHLGKETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGV
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCC
PTQVSGQAIKQTEDGTDVEIQGLFACGEIASVSVHGANRLGGNSLLDLVVFGRATGLHLG
CCCCCCCHHHCCCCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHH
ETLNKQAEAKPASEADIERSLERYNRWENSTDGEDPAVIRKDLQQCMQNNFSVFREGKAM
HHHCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHH
ADGLEELKVIRERLKNAHLSDKSTEFNTQRIECLELENLMETAFATAVAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ARFDFPDRDDER
EECCCCCCCCCC
>Mature Secondary Structure 
TIPVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCEEEEECCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDYIGDQDAIEYMCKNGPESVIELEKMGLPFSRFDNGSIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCEEECCCC
GQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTTVFSEWYALDLVKNEDGAILGT
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCEEEEEEEECCCCCEEEH
TALCMETGEVCYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMWQ
HHHHHCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCCEEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHCC
RGCDGPWGPHIKLKLDHLGKETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGV
CCCCCCCCCEEEEEHHHCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCC
PTQVSGQAIKQTEDGTDVEIQGLFACGEIASVSVHGANRLGGNSLLDLVVFGRATGLHLG
CCCCCCCHHHCCCCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHH
ETLNKQAEAKPASEADIERSLERYNRWENSTDGEDPAVIRKDLQQCMQNNFSVFREGKAM
HHHCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHCCHHH
ADGLEELKVIRERLKNAHLSDKSTEFNTQRIECLELENLMETAFATAVAANFRTESRGAH
HHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ARFDFPDRDDER
EECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]