Click here to switch to the map view.

The map label for this gene is sdhB [H]

Identifier: 218710212

GI number: 218710212

Start: 2413089

End: 2413808

Strand: Reverse

Name: sdhB [H]

Synonym: VS_2244

Alternate gene names: 218710212

Gene position: 2413808-2413089 (Counterclockwise)

Preceding gene: 218710213

Following gene: 218710211

Centisome position: 73.16

GC content: 44.31

Gene sequence:

>720_bases
ATGACCATGAAACTGAATTTCTCTTTATACCGTTACAACCCAGATGTGGACCAGAAACCTTACATGAAAGAGTACACCCT
AGAGGTGGAAGAAGGTTCTGACATGATGCTTTTGGACGCGCTTATTCTTTTGAAAGAGCAAGATCCAACGATTTCATTCC
GTCGCTCATGCCGTGAAGGTGTATGTGGTTCTGATGGTTTGAACATGAATGGTAAAAATGGATTGGCGTGTATCACGCCA
CTGTCTGCACTTTCTGGCCAAGATAAGATCGTAATTCGCCCACTTCCAGGTTTGCCTGTTGTGCGTGACTTAATCGTAGA
CATGACTCAGTTCTACGATAACTACGAAAAAGTTAAGCCGTTCTTAGTGTCTGATGGCAATGTGCCACCGGCTCGTGAAA
ACCTACAAAGCCCTGATGAGCGTGCTCATTTAGATGGTTTGTATGAATGTATTATGTGTGCATGTTGTACGACTTCATGC
CCATCATTCTGGTGGAATCCAGATAAGTTCATCGGACCAGCTGGCCTACTTGCAGCATACCGTTGGCTAATAGATAGCCG
AGATACGGCGACAGACGAACGTCTGTCCGATCTTGATGATGCATTTAGCGTTTTTCGTTGCCATGGCATAATGAATTGTG
TAAGTGTTTGTCCTAAGGGATTAAATCCGACGAAAGCGATTGGTCACATCAAGACCATGCTTGTGAATCGTTCGGTTTAA

Upstream 100 bases:

>100_bases
TTACAACCCTGAATCAGAAAGTATGACTAAGCGTGGCGTGAACATGGAACCTATCCATCGTGAAGCATTCCCGCCGAAAG
CACGTACGTACTAAGGAGAT

Downstream 100 bases:

>100_bases
GTTATATAAAAATTGCCGCCCTAGAAGTTTTGGGGCGGCCTTTTAATAGCTCGGCATAGACCGCAGCAAACGTGAAAACT
ACTGGTTAAGGGAAAATATG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MTMKLNFSLYRYNPDVDQKPYMKEYTLEVEEGSDMMLLDALILLKEQDPTISFRRSCREGVCGSDGLNMNGKNGLACITP
LSALSGQDKIVIRPLPGLPVVRDLIVDMTQFYDNYEKVKPFLVSDGNVPPARENLQSPDERAHLDGLYECIMCACCTTSC
PSFWWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSDLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLVNRSV

Sequences:

>Translated_239_residues
MTMKLNFSLYRYNPDVDQKPYMKEYTLEVEEGSDMMLLDALILLKEQDPTISFRRSCREGVCGSDGLNMNGKNGLACITP
LSALSGQDKIVIRPLPGLPVVRDLIVDMTQFYDNYEKVKPFLVSDGNVPPARENLQSPDERAHLDGLYECIMCACCTTSC
PSFWWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSDLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLVNRSV
>Mature_238_residues
TMKLNFSLYRYNPDVDQKPYMKEYTLEVEEGSDMMLLDALILLKEQDPTISFRRSCREGVCGSDGLNMNGKNGLACITPL
SALSGQDKIVIRPLPGLPVVRDLIVDMTQFYDNYEKVKPFLVSDGNVPPARENLQSPDERAHLDGLYECIMCACCTTSCP
SFWWNPDKFIGPAGLLAAYRWLIDSRDTATDERLSDLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLVNRSV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=235, Percent_Identity=51.4893617021277, Blast_Score=249, Evalue=1e-66,
Organism=Escherichia coli, GI1786943, Length=238, Percent_Identity=77.3109243697479, Blast_Score=395, Evalue=1e-112,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=37.117903930131, Blast_Score=154, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17533915, Length=233, Percent_Identity=49.3562231759657, Blast_Score=243, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6322987, Length=232, Percent_Identity=49.1379310344828, Blast_Score=242, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=52.3605150214592, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=51.2820512820513, Blast_Score=242, Evalue=1e-64,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26773; Mature: 26642

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
8.8 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKLNFSLYRYNPDVDQKPYMKEYTLEVEEGSDMMLLDALILLKEQDPTISFRRSCREG
CEEEEEEEEEEECCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCC
VCGSDGLNMNGKNGLACITPLSALSGQDKIVIRPLPGLPVVRDLIVDMTQFYDNYEKVKP
CCCCCCCCCCCCCCEEEECCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCHHHCCC
FLVSDGNVPPARENLQSPDERAHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAY
EEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHH
RWLIDSRDTATDERLSDLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLVNRSV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TMKLNFSLYRYNPDVDQKPYMKEYTLEVEEGSDMMLLDALILLKEQDPTISFRRSCREG
EEEEEEEEEEECCCCCCCCCHHHEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCC
VCGSDGLNMNGKNGLACITPLSALSGQDKIVIRPLPGLPVVRDLIVDMTQFYDNYEKVKP
CCCCCCCCCCCCCCEEEECCHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCHHHCCC
FLVSDGNVPPARENLQSPDERAHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAY
EEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHH
RWLIDSRDTATDERLSDLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLVNRSV
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]