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The map label for this gene is sucD [H]

Identifier: 218710208

GI number: 218710208

Start: 2406700

End: 2407572

Strand: Reverse

Name: sucD [H]

Synonym: VS_2240

Alternate gene names: 218710208

Gene position: 2407572-2406700 (Counterclockwise)

Preceding gene: 218710209

Following gene: 218710205

Centisome position: 72.97

GC content: 45.7

Gene sequence:

>873_bases
ATGTCTGTATTAATTAACAAAGACACTAAAGTAATCTGTCAGGGTTTCACTGGCGGTCAAGGTACATTCCACTCAGACCA
AGCTATCGCATACGGTACGCAAATGGTTGGTGGTGTTTCACCTGGTAAAGGTGGTCAAACTCACCTAGGCCTTCCAGTAT
TCAACACAGTACGTGAAGCAGTAGAAGTGACTGGCGCAACAGCAACAGTTATCTACGTACCAGCACCTTTCTGTAAAGAT
GCAATCCTAGAAGCGATTGATGCAGGTATCGAACTGATCGTAACGATCACTGAAGGTATCCCTACTACAGACATGATCGA
CGTTAAAGTGAAGCTAGAAGAAACTGGCGTTCGCATGATCGGTCCTAACTGTCCAGGTCTTATCACTCCAGACGAGTGTA
AGATTGGTATCATGCCTGGCCATATCCACAAGAAGGGTAAAGTAGGTATCGTATCTCGTTCAGGAACTTTGACGTACGAA
GCAGTTAAGCAAACAACAGATGAAGGCTTTGGTCAGTCTACATGTGTTGGTATCGGTGGTGACCCTATTCCAGGTTCAAA
CTTCATTGATATCCTAAAACTTTTCCAAGAAGACCCAGAGACTGAAGCAATCGTAATGATTGGTGAGATCGGTGGTACTG
CGGAAGAAGAAGCAGCTGAGTTCATCAAAGCAAACGTAACTAAGCCAGTTGTATCTTACATCGCTGGTGTTACTGCTCCT
CCGGGTAAACGTATGGGCCACGCAGGCGCAATCATCTCTGGCGGTAAAGGTACTGCTGAAGATAAATTCGCAGCACTGGA
AGCAGCAGGCGTTAAGACTGTTAAGTCTCTTGCTGACATCGGTAAAGGCCTACGTGAAATCACGGGTTGGTAA

Upstream 100 bases:

>100_bases
TAGGTCGTGAAGTACTTGCTAATTCTGATGTTGATATCATTGCTGCTGTATCTCTAACAGATGCTGCTCAGAAAGTTGTT
GCTGCTGCGGAGGCTAAATA

Downstream 100 bases:

>100_bases
TCAGCAGGCTTTTATCGATGAGATAGAAGTTAACTGAATGATATTAAAAAGGCTTGGTCACTGACCAAGCCTTTTTTATG
TTCTCGGGATACGGGATACG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSVLINKDTKVICQGFTGGQGTFHSDQAIAYGTQMVGGVSPGKGGQTHLGLPVFNTVREAVEVTGATATVIYVPAPFCKD
AILEAIDAGIELIVTITEGIPTTDMIDVKVKLEETGVRMIGPNCPGLITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKANVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW

Sequences:

>Translated_290_residues
MSVLINKDTKVICQGFTGGQGTFHSDQAIAYGTQMVGGVSPGKGGQTHLGLPVFNTVREAVEVTGATATVIYVPAPFCKD
AILEAIDAGIELIVTITEGIPTTDMIDVKVKLEETGVRMIGPNCPGLITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKANVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW
>Mature_289_residues
SVLINKDTKVICQGFTGGQGTFHSDQAIAYGTQMVGGVSPGKGGQTHLGLPVFNTVREAVEVTGATATVIYVPAPFCKDA
ILEAIDAGIELIVTITEGIPTTDMIDVKVKLEETGVRMIGPNCPGLITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEA
VKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKANVTKPVVSYIAGVTAPP
GKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=284, Percent_Identity=67.2535211267606, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI38569421, Length=314, Percent_Identity=30.8917197452229, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI38569423, Length=314, Percent_Identity=30.8917197452229, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786949, Length=287, Percent_Identity=84.3205574912892, Blast_Score=493, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17550194, Length=288, Percent_Identity=63.8888888888889, Blast_Score=346, Evalue=9e-96,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=63.7931034482759, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17557344, Length=308, Percent_Identity=29.5454545454545, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=308, Percent_Identity=28.8961038961039, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=53.4246575342466, Blast_Score=285, Evalue=8e-78,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=60.6896551724138, Blast_Score=343, Evalue=6e-95,
Organism=Drosophila melanogaster, GI28574296, Length=288, Percent_Identity=62.5, Blast_Score=329, Evalue=1e-90,
Organism=Drosophila melanogaster, GI281363477, Length=259, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363475, Length=259, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281363473, Length=259, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30024; Mature: 29893

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLINKDTKVICQGFTGGQGTFHSDQAIAYGTQMVGGVSPGKGGQTHLGLPVFNTVREA
CEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
VEVTGATATVIYVPAPFCKDAILEAIDAGIELIVTITEGIPTTDMIDVKVKLEETGVRMI
HHHCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEEEEECCCEEEE
GPNCPGLITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKANVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVLINKDTKVICQGFTGGQGTFHSDQAIAYGTQMVGGVSPGKGGQTHLGLPVFNTVREA
EEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
VEVTGATATVIYVPAPFCKDAILEAIDAGIELIVTITEGIPTTDMIDVKVKLEETGVRMI
HHHCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEEEEECCCEEEE
GPNCPGLITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKANVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]