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The map label for this gene is ubiB [H]

Identifier: 218710124

GI number: 218710124

Start: 2301742

End: 2303061

Strand: Direct

Name: ubiB [H]

Synonym: VS_2145

Alternate gene names: 218710124

Gene position: 2301742-2303061 (Clockwise)

Preceding gene: 218710122

Following gene: 218710125

Centisome position: 69.76

GC content: 47.35

Gene sequence:

>1320_bases
ATGTCGGCTAAAGAGAGAAACCTTCCCACTCATCGAATTTCTAGATTCAGTAAGTTTGCCTCGCTGGCAACAAGGGTCGC
GGGTAATGTGCTAACGGAAGGCACCAAGCAAATAGCACAAGGCAACAGGCCCAAAGCAAAAGACTTACTGCTAACGCCAC
AAAACATTGCTCGACTCACCGACCAACTGGCCCACCTGCGCGGTGCAGCAATGAAACTTGGGCAGATGCTATCAATGGAT
GCTGGCGATGTCTTAGAACCTGAATTAGCCGACATTCTTTCTCGCCTGCGCTCAGACGCAGATCCTCTGCCAACAAAGCA
GCTCAACCAAGTGTTAGAAAGCTCACTCGGCATCAACTGGAAAGCCGAATTCCTTTCCTTCAACTTTAAACCTATTGCCA
GCGCATCTATAGGCCAGGTTCACCAAGCCTATAGCGATGCGGGAGACAAACTCGCCGTCAAAGTCCAATACCCTGGCATT
CGAAAAAGCATCGACAGTGATGTGGACAACGTTGGTACATTGCTCAATATTGTTGGGTTGATACCAAAGTCAGTCGATTA
CAAAGGCTTGTTAGAAGAGGCGAAAAAACAACTACATGATGAAGCCGACTATGCTCGCGAGGCTGACTACGCAACTCGTT
ATCAAAATGCATTAAAAGAGCACTCTCACTTCGTCGTGCCTAAGATTCATGCGCAAATCTCATCAGAATCGGTGCTCGCC
ATGGACTTCATTGAGGGCATCTCGATAGAGCAAATTGAAGGTTATGATCAAAGTACTCGAGATTTTGTGATGCACAGCTT
GCTCGAACTCATGTTCATGGAATTGTTCGATTTTAAGATGGTGCAGACCGACCCCAACTTCGCCAATTACTTGTATGTAG
AACAAACACGACAGATTGGCTTATTGGATTTCGGTGCCACCCGTGAATACAGCGACCGCTTCAGTGATGGATATCGTTTG
GCCTTTACTTCTGTTGTTAATAAAGACGAATCAGGGCTCAATCAAGCACTCGAACAGATTGGATTCTTTAGCGAAGTCAT
ACTGCCCGATCAGCGCCAAGCCATTCTTAACTTAGTGACTATGGCGTGTGAGCCCATGCTTGTCGACGAAGATTACAACT
TCAAAGCCAGTGGTTTAGCACAAAGGCTTCGTGAAGCAGGAACCATACTCAGCATGGAGCAAGAGTATTGGCACACACCA
CCAGCCGATGCCCTATTCCTCCACCGAAAGATCGGAGGCATGTACCTGCTGGCATCTCGTCTTGGAGCCAAGGTAAACAT
CAGACGCTTGGTGGAACCCTATTTGCTAAGCAACAATTGA

Upstream 100 bases:

>100_bases
ATCAAAAAATCTAACGACGTTATCGAGATTTTTAACAAGCTAGGGTGAACAGTTATTTACTACGATTGGTATCAATCTTG
ATAACTAAGTGAGAACCTTT

Downstream 100 bases:

>100_bases
CACTTAAGCGATAGCTGATACTTAAGCGATTCTGGTCTTTAAAGTGATCATTTCAAGTCGCTGAACAGTAATAACAGTTA
CGCTAACTAAAATGAGTCGG

Product: putative ABC transporter

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSAKERNLPTHRISRFSKFASLATRVAGNVLTEGTKQIAQGNRPKAKDLLLTPQNIARLTDQLAHLRGAAMKLGQMLSMD
AGDVLEPELADILSRLRSDADPLPTKQLNQVLESSLGINWKAEFLSFNFKPIASASIGQVHQAYSDAGDKLAVKVQYPGI
RKSIDSDVDNVGTLLNIVGLIPKSVDYKGLLEEAKKQLHDEADYAREADYATRYQNALKEHSHFVVPKIHAQISSESVLA
MDFIEGISIEQIEGYDQSTRDFVMHSLLELMFMELFDFKMVQTDPNFANYLYVEQTRQIGLLDFGATREYSDRFSDGYRL
AFTSVVNKDESGLNQALEQIGFFSEVILPDQRQAILNLVTMACEPMLVDEDYNFKASGLAQRLREAGTILSMEQEYWHTP
PADALFLHRKIGGMYLLASRLGAKVNIRRLVEPYLLSNN

Sequences:

>Translated_439_residues
MSAKERNLPTHRISRFSKFASLATRVAGNVLTEGTKQIAQGNRPKAKDLLLTPQNIARLTDQLAHLRGAAMKLGQMLSMD
AGDVLEPELADILSRLRSDADPLPTKQLNQVLESSLGINWKAEFLSFNFKPIASASIGQVHQAYSDAGDKLAVKVQYPGI
RKSIDSDVDNVGTLLNIVGLIPKSVDYKGLLEEAKKQLHDEADYAREADYATRYQNALKEHSHFVVPKIHAQISSESVLA
MDFIEGISIEQIEGYDQSTRDFVMHSLLELMFMELFDFKMVQTDPNFANYLYVEQTRQIGLLDFGATREYSDRFSDGYRL
AFTSVVNKDESGLNQALEQIGFFSEVILPDQRQAILNLVTMACEPMLVDEDYNFKASGLAQRLREAGTILSMEQEYWHTP
PADALFLHRKIGGMYLLASRLGAKVNIRRLVEPYLLSNN
>Mature_438_residues
SAKERNLPTHRISRFSKFASLATRVAGNVLTEGTKQIAQGNRPKAKDLLLTPQNIARLTDQLAHLRGAAMKLGQMLSMDA
GDVLEPELADILSRLRSDADPLPTKQLNQVLESSLGINWKAEFLSFNFKPIASASIGQVHQAYSDAGDKLAVKVQYPGIR
KSIDSDVDNVGTLLNIVGLIPKSVDYKGLLEEAKKQLHDEADYAREADYATRYQNALKEHSHFVVPKIHAQISSESVLAM
DFIEGISIEQIEGYDQSTRDFVMHSLLELMFMELFDFKMVQTDPNFANYLYVEQTRQIGLLDFGATREYSDRFSDGYRLA
FTSVVNKDESGLNQALEQIGFFSEVILPDQRQAILNLVTMACEPMLVDEDYNFKASGLAQRLREAGTILSMEQEYWHTPP
ADALFLHRKIGGMYLLASRLGAKVNIRRLVEPYLLSNN

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=436, Percent_Identity=33.9449541284404, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI27363457, Length=437, Percent_Identity=33.6384439359268, Blast_Score=248, Evalue=9e-66,
Organism=Homo sapiens, GI217416386, Length=430, Percent_Identity=31.1627906976744, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI40254938, Length=294, Percent_Identity=29.2517006802721, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI41393593, Length=228, Percent_Identity=28.5087719298246, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI217035081, Length=227, Percent_Identity=28.6343612334802, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI2367309, Length=255, Percent_Identity=27.0588235294118, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32565180, Length=434, Percent_Identity=32.258064516129, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17559152, Length=285, Percent_Identity=27.0175438596491, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=431, Percent_Identity=36.4269141531323, Blast_Score=302, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6323282, Length=289, Percent_Identity=23.8754325259516, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859849, Length=426, Percent_Identity=32.8638497652582, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI22024280, Length=282, Percent_Identity=29.7872340425532, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24662575, Length=312, Percent_Identity=26.6025641025641, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49242; Mature: 49111

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKERNLPTHRISRFSKFASLATRVAGNVLTEGTKQIAQGNRPKAKDLLLTPQNIARLT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHH
DQLAHLRGAAMKLGQMLSMDAGDVLEPELADILSRLRSDADPLPTKQLNQVLESSLGINW
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCE
KAEFLSFNFKPIASASIGQVHQAYSDAGDKLAVKVQYPGIRKSIDSDVDNVGTLLNIVGL
EEHHHEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHHHHH
IPKSVDYKGLLEEAKKQLHDEADYAREADYATRYQNALKEHSHFVVPKIHAQISSESVLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHCCCCCCHH
MDFIEGISIEQIEGYDQSTRDFVMHSLLELMFMELFDFKMVQTDPNFANYLYVEQTRQIG
HHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHEEEEECCCCCC
LLDFGATREYSDRFSDGYRLAFTSVVNKDESGLNQALEQIGFFSEVILPDQRQAILNLVT
EEECCCCCHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MACEPMLVDEDYNFKASGLAQRLREAGTILSMEQEYWHTPPADALFLHRKIGGMYLLASR
HHCCCEEECCCCCCCHHHHHHHHHHHCCEEEECHHHCCCCCHHHHHHHHHHCHHHHHHHH
LGAKVNIRRLVEPYLLSNN
HCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SAKERNLPTHRISRFSKFASLATRVAGNVLTEGTKQIAQGNRPKAKDLLLTPQNIARLT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHH
DQLAHLRGAAMKLGQMLSMDAGDVLEPELADILSRLRSDADPLPTKQLNQVLESSLGINW
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCE
KAEFLSFNFKPIASASIGQVHQAYSDAGDKLAVKVQYPGIRKSIDSDVDNVGTLLNIVGL
EEHHHEECCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHHHHH
IPKSVDYKGLLEEAKKQLHDEADYAREADYATRYQNALKEHSHFVVPKIHAQISSESVLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHCCCCCCHH
MDFIEGISIEQIEGYDQSTRDFVMHSLLELMFMELFDFKMVQTDPNFANYLYVEQTRQIG
HHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHEEEEECCCCCC
LLDFGATREYSDRFSDGYRLAFTSVVNKDESGLNQALEQIGFFSEVILPDQRQAILNLVT
EEECCCCCHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
MACEPMLVDEDYNFKASGLAQRLREAGTILSMEQEYWHTPPADALFLHRKIGGMYLLASR
HHCCCEEECCCCCCCHHHHHHHHHHHCCEEEECHHHCCCCCHHHHHHHHHHCHHHHHHHH
LGAKVNIRRLVEPYLLSNN
HCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]