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The map label for this gene is zraR [H]

Identifier: 218710120

GI number: 218710120

Start: 2297347

End: 2298690

Strand: Direct

Name: zraR [H]

Synonym: VS_2141

Alternate gene names: 218710120

Gene position: 2297347-2298690 (Clockwise)

Preceding gene: 218710115

Following gene: 218710122

Centisome position: 69.63

GC content: 44.2

Gene sequence:

>1344_bases
ATGCCATCAAAAAGAGTATCGCCTGAGCCAATAACTCGTTCTGTGATTTTGTTATGCAACACCGCATGCCTGCACCATAG
TCAGTGGGTAGGAGAGCTGCGTCTCCATAACTGGGAAGCTCAAGTTGCAGAAACGACCGAACAGGCCATTCACTTACTTG
ATAGACGCGGCGAAAGCTACGCACCAATTGTCGTTTCTTGTCTAACATCATCCTCAATCGACAAACAGTGTGAGCAAATA
TCAGCGTTAAAGGTTCACTCTCCAAGTTTAAAAGCAATCGCTATCTGCAACCAACCACCAAGCCGCAACTTATCGCTCAT
TAAGCAAACCTTTTGGGATTATTACCACCTACCTATTGATACAGAATGGCTTTGTCGAAATTTAGGGCATGCGTATGGCA
TGGTCGACACCAAGCAAACTAAACCTAAGCCTGCCTCGTGCCATGAATGTCAATTGGTAGGGCAATCCAGAACCATCCAA
CAACTTAAAAAGAAGATAGCCAAGATCGCTAACAACGATTTTCCAGTGCTGATTCAAGGGGAAACCGGAACTGGAAAAAG
CCTATGTGCGCGTTTAATACATGAGGCCTCAGCCCGCAGTCAAAAACCTTTCATCGCTGTAAATTGTGGCGCAATTCCAC
AATCCCTGATTCACTCAGAGTTATTTGGCTTTGAAAAAGGCTCGTTCACGGGTGCAAACAAACGCTACGTCGGACACGTG
GAAAGAGCGAATGGTGGCACGCTATTTTTGGATGAGATCGGCGACCTTGAACTGTCGCTGCAAACCTACTTACTCCACTT
TCTAGAAAATAACTTGATAGAGCGACTCGGCAGTAACAACCAACTGCCCGTAGATTGCCGTGTGATTTTCGCCACCAACG
TCAATATCGAACAAGCCGTTGCTGCGGGTAAATTTCGAAAGGATCTCTTTCATCGCATCAATGTACTTCCATTAGACCTA
GTACCACTCAATGATCACAAAGAAGACATTGAAGATTTGGTTCGATTTGAACTGAAGCACAATTACGCATCCAAAACCAA
ACTGCCTAGTGACACCCTTGAGCAAATGAAACAGTACCATTGGCCGGGCAATGTCAGAGAATTATTTAACTGCATAAAAA
GAGCGATTGTTCTTTCTAACTCAAGCGCCCTCTCTACTCGTCATATGGGGATTCAATTAAAAGACGCGTCGCCCGATACT
GAGAGTGACACTCGACTTTCTTCAAAAAATGTTCGTCGAGTGATTCAGCAACACCACTACAATATTTCCCAATCTGCTAA
AGCGTTGTCTATTTCTCGGACAACCTTGTACAAGCTGATCAAAAAACATCAGATAGTAATTTAA

Upstream 100 bases:

>100_bases
TGTGTGCTCGAATTAATTGAATTTTGCTTCTAAGCTTATGGATATTTAGGGGGCTTACTAAAGGTTTCATCATGGAGTCG
AAACATGAAGAGTGAGCACA

Downstream 100 bases:

>100_bases
GTCGCCTAGCTAGCTAAATAACTAATAAAGCAGCCTAACGAATTAGGCTGCTTTGGAGTTTAGTTGTACTCAATTAATGA
AAGTACTTATGGCTCAGGTA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MPSKRVSPEPITRSVILLCNTACLHHSQWVGELRLHNWEAQVAETTEQAIHLLDRRGESYAPIVVSCLTSSSIDKQCEQI
SALKVHSPSLKAIAICNQPPSRNLSLIKQTFWDYYHLPIDTEWLCRNLGHAYGMVDTKQTKPKPASCHECQLVGQSRTIQ
QLKKKIAKIANNDFPVLIQGETGTGKSLCARLIHEASARSQKPFIAVNCGAIPQSLIHSELFGFEKGSFTGANKRYVGHV
ERANGGTLFLDEIGDLELSLQTYLLHFLENNLIERLGSNNQLPVDCRVIFATNVNIEQAVAAGKFRKDLFHRINVLPLDL
VPLNDHKEDIEDLVRFELKHNYASKTKLPSDTLEQMKQYHWPGNVRELFNCIKRAIVLSNSSALSTRHMGIQLKDASPDT
ESDTRLSSKNVRRVIQQHHYNISQSAKALSISRTTLYKLIKKHQIVI

Sequences:

>Translated_447_residues
MPSKRVSPEPITRSVILLCNTACLHHSQWVGELRLHNWEAQVAETTEQAIHLLDRRGESYAPIVVSCLTSSSIDKQCEQI
SALKVHSPSLKAIAICNQPPSRNLSLIKQTFWDYYHLPIDTEWLCRNLGHAYGMVDTKQTKPKPASCHECQLVGQSRTIQ
QLKKKIAKIANNDFPVLIQGETGTGKSLCARLIHEASARSQKPFIAVNCGAIPQSLIHSELFGFEKGSFTGANKRYVGHV
ERANGGTLFLDEIGDLELSLQTYLLHFLENNLIERLGSNNQLPVDCRVIFATNVNIEQAVAAGKFRKDLFHRINVLPLDL
VPLNDHKEDIEDLVRFELKHNYASKTKLPSDTLEQMKQYHWPGNVRELFNCIKRAIVLSNSSALSTRHMGIQLKDASPDT
ESDTRLSSKNVRRVIQQHHYNISQSAKALSISRTTLYKLIKKHQIVI
>Mature_446_residues
PSKRVSPEPITRSVILLCNTACLHHSQWVGELRLHNWEAQVAETTEQAIHLLDRRGESYAPIVVSCLTSSSIDKQCEQIS
ALKVHSPSLKAIAICNQPPSRNLSLIKQTFWDYYHLPIDTEWLCRNLGHAYGMVDTKQTKPKPASCHECQLVGQSRTIQQ
LKKKIAKIANNDFPVLIQGETGTGKSLCARLIHEASARSQKPFIAVNCGAIPQSLIHSELFGFEKGSFTGANKRYVGHVE
RANGGTLFLDEIGDLELSLQTYLLHFLENNLIERLGSNNQLPVDCRVIFATNVNIEQAVAAGKFRKDLFHRINVLPLDLV
PLNDHKEDIEDLVRFELKHNYASKTKLPSDTLEQMKQYHWPGNVRELFNCIKRAIVLSNSSALSTRHMGIQLKDASPDTE
SDTRLSSKNVRRVIQQHHYNISQSAKALSISRTTLYKLIKKHQIVI

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=341, Percent_Identity=36.3636363636364, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082117, Length=261, Percent_Identity=45.2107279693487, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=39.0243902439024, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI87082152, Length=320, Percent_Identity=37.8125, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788905, Length=425, Percent_Identity=31.0588235294118, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788550, Length=295, Percent_Identity=41.0169491525424, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1789087, Length=307, Percent_Identity=37.1335504885993, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786524, Length=310, Percent_Identity=39.3548387096774, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1790299, Length=362, Percent_Identity=34.8066298342541, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI87081872, Length=327, Percent_Identity=33.6391437308869, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=35.5769230769231, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87081858, Length=289, Percent_Identity=29.4117647058824, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789828, Length=242, Percent_Identity=35.1239669421488, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50387; Mature: 50256

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKRVSPEPITRSVILLCNTACLHHSQWVGELRLHNWEAQVAETTEQAIHLLDRRGESY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
APIVVSCLTSSSIDKQCEQISALKVHSPSLKAIAICNQPPSRNLSLIKQTFWDYYHLPID
CHHHHHHHHCCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHHEEECCCC
TEWLCRNLGHAYGMVDTKQTKPKPASCHECQLVGQSRTIQQLKKKIAKIANNDFPVLIQG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEECCCHHHHHHHHHHHHHHHCCCCCEEEEC
ETGTGKSLCARLIHEASARSQKPFIAVNCGAIPQSLIHSELFGFEKGSFTGANKRYVGHV
CCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEE
ERANGGTLFLDEIGDLELSLQTYLLHFLENNLIERLGSNNQLPVDCRVIFATNVNIEQAV
EECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHH
AAGKFRKDLFHRINVLPLDLVPLNDHKEDIEDLVRFELKHNYASKTKLPSDTLEQMKQYH
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHC
WPGNVRELFNCIKRAIVLSNSSALSTRHMGIQLKDASPDTESDTRLSSKNVRRVIQQHHY
CCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
NISQSAKALSISRTTLYKLIKKHQIVI
CHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PSKRVSPEPITRSVILLCNTACLHHSQWVGELRLHNWEAQVAETTEQAIHLLDRRGESY
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
APIVVSCLTSSSIDKQCEQISALKVHSPSLKAIAICNQPPSRNLSLIKQTFWDYYHLPID
CHHHHHHHHCCHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHHEEECCCC
TEWLCRNLGHAYGMVDTKQTKPKPASCHECQLVGQSRTIQQLKKKIAKIANNDFPVLIQG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHEECCCHHHHHHHHHHHHHHHCCCCCEEEEC
ETGTGKSLCARLIHEASARSQKPFIAVNCGAIPQSLIHSELFGFEKGSFTGANKRYVGHV
CCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEE
ERANGGTLFLDEIGDLELSLQTYLLHFLENNLIERLGSNNQLPVDCRVIFATNVNIEQAV
EECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCHHHHH
AAGKFRKDLFHRINVLPLDLVPLNDHKEDIEDLVRFELKHNYASKTKLPSDTLEQMKQYH
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHC
WPGNVRELFNCIKRAIVLSNSSALSTRHMGIQLKDASPDTESDTRLSSKNVRRVIQQHHY
CCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
NISQSAKALSISRTTLYKLIKKHQIVI
CHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]