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The map label for this gene is echA8 [H]

Identifier: 218710115

GI number: 218710115

Start: 2292936

End: 2293748

Strand: Direct

Name: echA8 [H]

Synonym: VS_2136

Alternate gene names: 218710115

Gene position: 2292936-2293748 (Clockwise)

Preceding gene: 218710110

Following gene: 218710120

Centisome position: 69.5

GC content: 45.51

Gene sequence:

>813_bases
ATGACACTACTATCTGTGACTAACCAAAATGGCATCGCAACGGTATCAATCAACAACCCACCAGTGAACGTGCTGACTTT
CGACTTGATCAACGAGATCAATGCCTTTGTGCTTTCATTGAAAGATGATCGTGAGACTAAGGTTGTAGTCTTTAAATCAT
TACATGAGAGCTTCTTTCTGGCTCACTTAGATCTTAATGTGATCAATGGTACGCAAGGTGGACAAGCGGGTTCGATTGAA
TTCAATCACATGATTGAGAACATCAAATCAATGAAGCAAGTGTCTGTTGCAGTGGTTGATGGTGTGGCTCGTGGGGGCGG
TAATGAATTTGTGATGGCGTGTGACCTAGCTTATGGCACTGAAAACTCAGCGTTCGCACAACCAGAAATTCATGTAAACA
TCCCAACGGGTGGCCAAGGCGCAGTGCAATTTGCAAGACGCATGGGTAAAAACAAAGCGCTGCAAGCATTGTTACTCGGC
AACGATTTTACTCCTCAACAAGCAGAGAGCCGTAACATCATCACGCAGTTCGTACCGAAGGCCGACCTAGACGACTTCTT
AGCAACAACGTTAGGTGTGATCAGCCAGTTAGAAGTACGTGACATCGTGATGTACAAAGAGATCATCGCGGCTTCAATCA
AAGACGAACAAGCGGGCGCAGAGCTAGAGCTTCGTTACTTCTTAGAGCGTGCAAAAGAGCAAAAAACAGCGGCAATCATT
GGCGCGTTTCTAAAACATGGCGGACAAACAGAGCGTGAAGCTAAAGATATGCCAGGTATCTTCGCCGATACTGCAGCTGA
GCTATCTAAATAA

Upstream 100 bases:

>100_bases
TAAGTGCCAATATGAGTATTTTTCTCATCTTATTACAAATCTATAGTAGCTGCACATAACGGAGACAACATTCAGTCCCG
GCCTAATAGAGGAACACCCC

Downstream 100 bases:

>100_bases
TCAGCCATGTAATCATCATACAAAAAACGGTCACCTGAGGGTGGCCGTTTCTGTGCTTAATTAATCACGAGCTTACAACC
TAAGACTCAACCTTAATAAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTLLSVTNQNGIATVSINNPPVNVLTFDLINEINAFVLSLKDDRETKVVVFKSLHESFFLAHLDLNVINGTQGGQAGSIE
FNHMIENIKSMKQVSVAVVDGVARGGGNEFVMACDLAYGTENSAFAQPEIHVNIPTGGQGAVQFARRMGKNKALQALLLG
NDFTPQQAESRNIITQFVPKADLDDFLATTLGVISQLEVRDIVMYKEIIAASIKDEQAGAELELRYFLERAKEQKTAAII
GAFLKHGGQTEREAKDMPGIFADTAAELSK

Sequences:

>Translated_270_residues
MTLLSVTNQNGIATVSINNPPVNVLTFDLINEINAFVLSLKDDRETKVVVFKSLHESFFLAHLDLNVINGTQGGQAGSIE
FNHMIENIKSMKQVSVAVVDGVARGGGNEFVMACDLAYGTENSAFAQPEIHVNIPTGGQGAVQFARRMGKNKALQALLLG
NDFTPQQAESRNIITQFVPKADLDDFLATTLGVISQLEVRDIVMYKEIIAASIKDEQAGAELELRYFLERAKEQKTAAII
GAFLKHGGQTEREAKDMPGIFADTAAELSK
>Mature_269_residues
TLLSVTNQNGIATVSINNPPVNVLTFDLINEINAFVLSLKDDRETKVVVFKSLHESFFLAHLDLNVINGTQGGQAGSIEF
NHMIENIKSMKQVSVAVVDGVARGGGNEFVMACDLAYGTENSAFAQPEIHVNIPTGGQGAVQFARRMGKNKALQALLLGN
DFTPQQAESRNIITQFVPKADLDDFLATTLGVISQLEVRDIVMYKEIIAASIKDEQAGAELELRYFLERAKEQKTAAIIG
AFLKHGGQTEREAKDMPGIFADTAAELSK

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=171, Percent_Identity=27.4853801169591, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI31542718, Length=185, Percent_Identity=25.4054054054054, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1787659, Length=184, Percent_Identity=27.1739130434783, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788682, Length=181, Percent_Identity=24.8618784530387, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788597, Length=181, Percent_Identity=28.1767955801105, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI221142681, Length=184, Percent_Identity=24.4565217391304, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=175, Percent_Identity=29.7142857142857, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=177, Percent_Identity=26.5536723163842, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129971, Length=174, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653477, Length=174, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922422, Length=186, Percent_Identity=26.8817204301075, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29326; Mature: 29195

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLSVTNQNGIATVSINNPPVNVLTFDLINEINAFVLSLKDDRETKVVVFKSLHESFFL
CEEEEEECCCCEEEEEECCCCCEEEEHHHHHHHHHEEEEECCCCCCEEEEHHHHHHHHEE
AHLDLNVINGTQGGQAGSIEFNHMIENIKSMKQVSVAVVDGVARGGGNEFVMACDLAYGT
EEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
ENSAFAQPEIHVNIPTGGQGAVQFARRMGKNKALQALLLGNDFTPQQAESRNIITQFVPK
CCCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCHHHHHCCC
ADLDDFLATTLGVISQLEVRDIVMYKEIIAASIKDEQAGAELELRYFLERAKEQKTAAII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GAFLKHGGQTEREAKDMPGIFADTAAELSK
HHHHHCCCCCCHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TLLSVTNQNGIATVSINNPPVNVLTFDLINEINAFVLSLKDDRETKVVVFKSLHESFFL
EEEEEECCCCEEEEEECCCCCEEEEHHHHHHHHHEEEEECCCCCCEEEEHHHHHHHHEE
AHLDLNVINGTQGGQAGSIEFNHMIENIKSMKQVSVAVVDGVARGGGNEFVMACDLAYGT
EEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
ENSAFAQPEIHVNIPTGGQGAVQFARRMGKNKALQALLLGNDFTPQQAESRNIITQFVPK
CCCCCCCCEEEEECCCCCHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCHHHHHCCC
ADLDDFLATTLGVISQLEVRDIVMYKEIIAASIKDEQAGAELELRYFLERAKEQKTAAII
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GAFLKHGGQTEREAKDMPGIFADTAAELSK
HHHHHCCCCCCHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]