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The map label for this gene is ahpC [H]

Identifier: 218710105

GI number: 218710105

Start: 2285847

End: 2286404

Strand: Direct

Name: ahpC [H]

Synonym: VS_2126

Alternate gene names: 218710105

Gene position: 2285847-2286404 (Clockwise)

Preceding gene: 218710102

Following gene: 218710106

Centisome position: 69.28

GC content: 46.77

Gene sequence:

>558_bases
ATGATCAACACAGAAATCAAACCATTCAACGCAACAGCATTCAAAAACGGCGAATTCGTAGAAATCACTGAGCAAGACGT
TAAAGGCAAGTGGGCTGTATTCTTCTTCTACCCAGCAGACTTCACGTTTGTATGTCCAACTGAGCTAGTTGACCTACAAG
ACAAATACGCAGAGCTTCAATCTCGCGGCGTAGAAGTTTTCTCCGTATCAACTGACACGCACTTCTCTCACAAAGCATGG
CACGATACTTCTGACAAAATCGGCACTATCGAATACTTCATGGTCGGCGACCAAACAGGCAACATCACAAACAACTTCAA
CGTTATGCGTGAAGGTCAAGGCCTTGCAGACCGTGCAACGTTCCTAATCGACCCTGAAGGCGTTATCCAAGCAATGGAAA
TCACAGCTGAAGGCATCGGCCGTGACGCTGAAGACCTACTACGCAAGGTTAAAGCAGCACAATACGTAGCCGCTAACCCA
GGTGAAGTTTGCCCAGCTAAATGGAAAGAAGGCGAAGAGACTCTAGCGCCATCTCTAGACCTAGTAGGCAAGATTTAA

Upstream 100 bases:

>100_bases
ATAGAAATGTCCGATTTCACTAATTTCCGGTGCGAATGCAATATAGCTCCATCGACGCGGGATAGCGTTAAACACTACAA
ATTAGAAAGAGAGTCGAATC

Downstream 100 bases:

>100_bases
TCTAAGCCTAGCTAAACAAGAATAGCCAAGAAAGAACGAGTAAAACAGACCAGTTAAACGGTTCTACAGGCGCGCTTCGG
CCCCCCTCCTAAAGGGCAGT

Product: alkyl hydroperoxide reductase subunit C

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; Peroxiredoxin; SCRP-23; Sulfate starvation-induced protein 8; SSI8; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MINTEIKPFNATAFKNGEFVEITEQDVKGKWAVFFFYPADFTFVCPTELVDLQDKYAELQSRGVEVFSVSTDTHFSHKAW
HDTSDKIGTIEYFMVGDQTGNITNNFNVMREGQGLADRATFLIDPEGVIQAMEITAEGIGRDAEDLLRKVKAAQYVAANP
GEVCPAKWKEGEETLAPSLDLVGKI

Sequences:

>Translated_185_residues
MINTEIKPFNATAFKNGEFVEITEQDVKGKWAVFFFYPADFTFVCPTELVDLQDKYAELQSRGVEVFSVSTDTHFSHKAW
HDTSDKIGTIEYFMVGDQTGNITNNFNVMREGQGLADRATFLIDPEGVIQAMEITAEGIGRDAEDLLRKVKAAQYVAANP
GEVCPAKWKEGEETLAPSLDLVGKI
>Mature_185_residues
MINTEIKPFNATAFKNGEFVEITEQDVKGKWAVFFFYPADFTFVCPTELVDLQDKYAELQSRGVEVFSVSTDTHFSHKAW
HDTSDKIGTIEYFMVGDQTGNITNNFNVMREGQGLADRATFLIDPEGVIQAMEITAEGIGRDAEDLLRKVKAAQYVAANP
GEVCPAKWKEGEETLAPSLDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=46.8208092485549, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=46.8208092485549, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI32189392, Length=175, Percent_Identity=39.4285714285714, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI5453549, Length=180, Percent_Identity=40, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI4505591, Length=175, Percent_Identity=38.2857142857143, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI32455266, Length=175, Percent_Identity=38.2857142857143, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI32455264, Length=175, Percent_Identity=38.2857142857143, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI33188454, Length=78, Percent_Identity=46.1538461538462, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1786822, Length=185, Percent_Identity=72.972972972973, Blast_Score=300, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=41.2429378531073, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI193204376, Length=174, Percent_Identity=38.5057471264368, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32565831, Length=174, Percent_Identity=38.5057471264368, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25153706, Length=164, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=33.1491712707182, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323613, Length=175, Percent_Identity=34.2857142857143, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319407, Length=158, Percent_Identity=27.2151898734177, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17738015, Length=177, Percent_Identity=37.2881355932203, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24656348, Length=181, Percent_Identity=37.5690607734807, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17864676, Length=181, Percent_Identity=37.5690607734807, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21357347, Length=177, Percent_Identity=37.2881355932203, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI17157991, Length=170, Percent_Identity=38.8235294117647, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24641739, Length=170, Percent_Identity=38.8235294117647, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=29.746835443038, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20593; Mature: 20593

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINTEIKPFNATAFKNGEFVEITEQDVKGKWAVFFFYPADFTFVCPTELVDLQDKYAELQ
CCCCCCCCCCCEEECCCCEEEEECCCCCCEEEEEEEECCCEEEECCHHHHHHHHHHHHHH
SRGVEVFSVSTDTHFSHKAWHDTSDKIGTIEYFMVGDQTGNITNNFNVMREGQGLADRAT
HCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCCEE
FLIDPEGVIQAMEITAEGIGRDAEDLLRKVKAAQYVAANPGEVCPAKWKEGEETLAPSLD
EEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHCCCCH
LVGKI
HHCCC
>Mature Secondary Structure
MINTEIKPFNATAFKNGEFVEITEQDVKGKWAVFFFYPADFTFVCPTELVDLQDKYAELQ
CCCCCCCCCCCEEECCCCEEEEECCCCCCEEEEEEEECCCEEEECCHHHHHHHHHHHHHH
SRGVEVFSVSTDTHFSHKAWHDTSDKIGTIEYFMVGDQTGNITNNFNVMREGQGLADRAT
HCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCCCEE
FLIDPEGVIQAMEITAEGIGRDAEDLLRKVKAAQYVAANPGEVCPAKWKEGEETLAPSLD
EEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHCCCCH
LVGKI
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]