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The map label for this gene is dsbC [C]

Identifier: 218710097

GI number: 218710097

Start: 2277191

End: 2277916

Strand: Reverse

Name: dsbC [C]

Synonym: VS_2118

Alternate gene names: 218710097

Gene position: 2277916-2277191 (Counterclockwise)

Preceding gene: 218710098

Following gene: 218710096

Centisome position: 69.04

GC content: 38.71

Gene sequence:

>726_bases
ATGAAATTCATTACAAGAAGCATCATCACACTATTGGTTACTCTGGCTTTCTCACCCGTCACTTTCGCAATGACAAAACA
AGAAAAAATTGCCGAGATAACGCAAATGCTAGAAACGAACGAAGGTATTATCGATTCAGTTCACGACAGTCTAGCTGCTT
ACATAGATCAACAAAGTAGCTTTGATAAAACGTTAGTTGAGAGTCATGACTTTATTTATAACAACCCACATCACCCTTGG
TATGGTTCCGAACATCCAAAACTGACGATCGTAAATATGACTGATTTTAGTTGCCCGTGGTGTAAAAAATTAGACCCTGT
TCTTCGAAAAATAGCGGATGAGTTCCCTAATGACATCAAGGTGATAAATATTTATATCCCTCTAAAGGAGAGAGATTCGC
CATTGAACTCAGCAACTTTTGGACTCAATGTCTGGAACAATGACAAAGAAAAATACAAAGCAGTTGAAGAGATGTTGATC
AGTAAGCCTGGTATTCACAACGTTCGTTCGATAATGAAAGTAGCGAAGAAGAACAAAGCCACCGATTATGTTTCTTCAGA
CAGTGAAATAGCGATTGAAGTTGCTGAAAACTATAACTTATTTACGAGGCTGGGTGTTCGGGGTACACCAGCGATGCTAA
TTGATGGAACATTGCTCCCCGGCTACTTGCCATACGAAAAACTATATCCAATAGTAAAGGCTAAGCTAGAAGAGAAAAGT
AAATAG

Upstream 100 bases:

>100_bases
GTTATTAATGATGGAAAAGTAACAAGTGTTACTTCAGGAATTACTACGCCAATAGGTATCGCAGCCCGACTTTGGTTAGC
TAAGTATTAATGGGAAAAAT

Downstream 100 bases:

>100_bases
AATAAATTTACGATAACTTAATTATTATCTTTGATGGATAAAAAGCCCTATTGATTAGGGCTTTCTATCATTTAAATATT
AATTGTAAAAGTAGATTACA

Product: putative outer membrane protein

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: Outer Membrane Protein; Suppressor For Copper-Sensitivity C; Secreted Protein Suppressor For Copper-Sensitivity ScsC; Secreted Protein Suppressor For Copper-Sensitivity C; Metal Resistance Protein; DsbA Oxidoreductase; DSBA-Like Thioredoxin Domain-Containing Protein; 27kDa Outer Membrane Protein; ThiolDisulfide Interchange Protein DsbA; Protein-Disulfide Isomerase; Copper-Sensitivity Suppressor C Protein; Copper Sensitivity Protein ScsC; Secreted Copper-Sensitivity Suppressor C; Lipoprotein

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKFITRSIITLLVTLAFSPVTFAMTKQEKIAEITQMLETNEGIIDSVHDSLAAYIDQQSSFDKTLVESHDFIYNNPHHPW
YGSEHPKLTIVNMTDFSCPWCKKLDPVLRKIADEFPNDIKVINIYIPLKERDSPLNSATFGLNVWNNDKEKYKAVEEMLI
SKPGIHNVRSIMKVAKKNKATDYVSSDSEIAIEVAENYNLFTRLGVRGTPAMLIDGTLLPGYLPYEKLYPIVKAKLEEKS
K

Sequences:

>Translated_241_residues
MKFITRSIITLLVTLAFSPVTFAMTKQEKIAEITQMLETNEGIIDSVHDSLAAYIDQQSSFDKTLVESHDFIYNNPHHPW
YGSEHPKLTIVNMTDFSCPWCKKLDPVLRKIADEFPNDIKVINIYIPLKERDSPLNSATFGLNVWNNDKEKYKAVEEMLI
SKPGIHNVRSIMKVAKKNKATDYVSSDSEIAIEVAENYNLFTRLGVRGTPAMLIDGTLLPGYLPYEKLYPIVKAKLEEKS
K
>Mature_241_residues
MKFITRSIITLLVTLAFSPVTFAMTKQEKIAEITQMLETNEGIIDSVHDSLAAYIDQQSSFDKTLVESHDFIYNNPHHPW
YGSEHPKLTIVNMTDFSCPWCKKLDPVLRKIADEFPNDIKVINIYIPLKERDSPLNSATFGLNVWNNDKEKYKAVEEMLI
SKPGIHNVRSIMKVAKKNKATDYVSSDSEIAIEVAENYNLFTRLGVRGTPAMLIDGTLLPGYLPYEKLYPIVKAKLEEKS
K

Specific function: Required For Disulfide Bond Formation In Some Periplasmic Proteins. Acts By Transferring Its Disulfide Bond To Other Proteins And Is Reduced In The Process. Dsbc Is Reoxidized By A Yet Uncharacterized Protein. Also Acts As A Disulfide Isomerase. [C]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 27443; Mature: 27443

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFITRSIITLLVTLAFSPVTFAMTKQEKIAEITQMLETNEGIIDSVHDSLAAYIDQQSS
CCHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
FDKTLVESHDFIYNNPHHPWYGSEHPKLTIVNMTDFSCPWCKKLDPVLRKIADEFPNDIK
HHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEE
VINIYIPLKERDSPLNSATFGLNVWNNDKEKYKAVEEMLISKPGIHNVRSIMKVAKKNKA
EEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
TDYVSSDSEIAIEVAENYNLFTRLGVRGTPAMLIDGTLLPGYLPYEKLYPIVKAKLEEKS
CHHCCCCCEEEEEEECCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure
MKFITRSIITLLVTLAFSPVTFAMTKQEKIAEITQMLETNEGIIDSVHDSLAAYIDQQSS
CCHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCH
FDKTLVESHDFIYNNPHHPWYGSEHPKLTIVNMTDFSCPWCKKLDPVLRKIADEFPNDIK
HHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEE
VINIYIPLKERDSPLNSATFGLNVWNNDKEKYKAVEEMLISKPGIHNVRSIMKVAKKNKA
EEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
TDYVSSDSEIAIEVAENYNLFTRLGVRGTPAMLIDGTLLPGYLPYEKLYPIVKAKLEEKS
CHHCCCCCEEEEEEECCCCEEEECCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA