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The map label for this gene is fhuB [H]

Identifier: 218710093

GI number: 218710093

Start: 2269683

End: 2271680

Strand: Direct

Name: fhuB [H]

Synonym: VS_2114

Alternate gene names: 218710093

Gene position: 2269683-2271680 (Clockwise)

Preceding gene: 218710092

Following gene: 218710094

Centisome position: 68.79

GC content: 49.25

Gene sequence:

>1998_bases
ATGGCTACCGCAAAGATCGAAAAAACCGTCACCGGGCGATTCAGTATCAAGGCAGCGGCACTACCTGTCGCTGCTGTTTT
GTTGATCAGCTCGCTACTGCAAATTACCGCTCCTTACTCGCAAGGGGTTGGCTTGATTTGGGATACGCTGTTTCACTTTG
ATTCTTCAAATTATCAGCATCTGATTACTCACCTCACCTATTTACCTAGGCTTACCGTCGCTCTCATTTGTGGTTTTGCA
CTGGCAGTCGCTGGGTGTGTGATGCAATTTGTACTGCGTAACCCCATTGCCTCACCTACCACATTGGGTGTTGCTGCGGG
CGCAGAACTCGGCATGGTATTAGGGATCCTTTTAATTCCTGCTAACCTAGCTATCCCAGGGTTTATTCCCGCTTTCATTG
GGGGCTGCCTTGCAACAGGCTTAGTTTTTACCTTAAGTTCTGCACGAGGCTTTTCACCATTACACATGGTGTTAGCCGGT
ATGGTGGTCAGCCTATTTTTAGGCTCACTCAACACCATGTTGCTCATGCTGCATGAACAACGGCTTACCAGTATTTTTGT
TTGGGGTGCAGGTGTACTGAATCAGAATGATTGGTCGAGCGTGCAGGTTCTCATACCTTTAGTCTCGATCCCGACGCTGT
TATTACTGGTTTTACAGCGTCCATTATCAGCGCTGCAATTTGGCGATAATGTCGCCACTTCGCTTGGTGTAAACATCAAA
CAAATCAAATTGCTTTGCTTATCGTTGGCGATCTTTATTACTGCAGCCGTAGTCAGTGAAGTAGGCTTAATCGGATTCGT
TGGCATTGTGGCTCCTGCTATCGCTAGGCTTATCGGTGTAAGAGCACTCGCGAAACAGATTCTGGTCAGCGGGTTGGTAG
GCAGCTTCATTCTATTGATTGTGGATTTAGTGATTCAGCCCTTCTCTGGCTTCGGTGGCGAACTGCTCCCTACCGGCGCA
ATGACGGCGCTACTGGGTGCTCCTTTCTTATTGTGGTTACTGCAACGTACCAAGCTGCAGTCCGATCTCAAAAACCGCAG
TGAAACCATTGAGCACTACAAATTCGTCAGTACGCGTAAAGTACTTGCCGCGATGTCAGTACTATTGATGGCAATGTGTG
TTCTTACCCTTACAGTAGGTAAAAACCAGTTCGGCTGGAATGTTGAACTCAACCCATCGCTATTCGATCTACGTCTACCG
CGTGTATTAGTCGCGCTATTGGCAGGGATCGGGCTTGCGTTTGCAGGCACGATTATTCAACGCATCTCAAACAACCCAAT
GGCGAGCCCCGAAGTATTGGGGATCAGCTCAGGGGCTGCTCTGGCGTTAGTGCTCGGCACACTATTTGGCACAGCAGTCG
GCCGAGAAGAGCAAATGCTGCTTGGTACACTCGGCGCAACTTCAGTGACTGCCGTGGTTTGGTTAATGGGAAGAAAACAC
AATTTCGCCCCAACGCAAACCTTGTTAACAGGCATCGCGCTAAGTGCAGGGCTCGACGCTCTACTGCGCATCACAATGAG
CTCGGGTAATGAGAATGCAACCGCGCTCCTCACTTGGCTTTCAGGATCGACTTATTTAGTCGCTAATCAAGATGTCATTT
TGCTCGCCGTTGGGGTTACCATCATCAGTGCAGTGGCGCTGTCTTTGAATCGCTGGATAGAGCTGATTAACTTAGGCGAC
GTCACCACAAGCAGCCTAGGTATGAACACAACCGCTGTTCGATTGGCTTTGCTTTTGCTAGTCGCGGCACTAACAACTCT
GTGCACCATCGTCATTGGGCCATTAAGTTTCATTGGATTATTGGCGCCGCACATGGCGCGTTCGCTTCACCAATATCGCG
CGATTCCTCAAATGCTCACTGCAGCATTATTAGGCGCTATCATCATGGTGGCTGCCGACTGGATTGGTCGTACGCTATGG
TTCCCTTGGCAGTTCCCTGCAGGTCTATTAGCCTCTCTGATTGGTGGCGGCTACTTCCTCTATCTAATGAGAAAATAA

Upstream 100 bases:

>100_bases
CAGACTCCGTTTACGAACTTCCTACCATCTGGACCTTCGGTGGGCTAATCGCCGCTCAAAGGTTTAGTGACCACATTACC
GAACTGCTTATCCAAAAATA

Downstream 100 bases:

>100_bases
GCACACACGAGAAGTCACTTTCTCCGCCTTAAGCCCCGTTTGAAGCCTCTATTTGAGTCGAGGCTTTAAGCGGGCTCTCT
TCTTACCCACTCATCACCGC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MATAKIEKTVTGRFSIKAAALPVAAVLLISSLLQITAPYSQGVGLIWDTLFHFDSSNYQHLITHLTYLPRLTVALICGFA
LAVAGCVMQFVLRNPIASPTTLGVAAGAELGMVLGILLIPANLAIPGFIPAFIGGCLATGLVFTLSSARGFSPLHMVLAG
MVVSLFLGSLNTMLLMLHEQRLTSIFVWGAGVLNQNDWSSVQVLIPLVSIPTLLLLVLQRPLSALQFGDNVATSLGVNIK
QIKLLCLSLAIFITAAVVSEVGLIGFVGIVAPAIARLIGVRALAKQILVSGLVGSFILLIVDLVIQPFSGFGGELLPTGA
MTALLGAPFLLWLLQRTKLQSDLKNRSETIEHYKFVSTRKVLAAMSVLLMAMCVLTLTVGKNQFGWNVELNPSLFDLRLP
RVLVALLAGIGLAFAGTIIQRISNNPMASPEVLGISSGAALALVLGTLFGTAVGREEQMLLGTLGATSVTAVVWLMGRKH
NFAPTQTLLTGIALSAGLDALLRITMSSGNENATALLTWLSGSTYLVANQDVILLAVGVTIISAVALSLNRWIELINLGD
VTTSSLGMNTTAVRLALLLLVAALTTLCTIVIGPLSFIGLLAPHMARSLHQYRAIPQMLTAALLGAIIMVAADWIGRTLW
FPWQFPAGLLASLIGGGYFLYLMRK

Sequences:

>Translated_665_residues
MATAKIEKTVTGRFSIKAAALPVAAVLLISSLLQITAPYSQGVGLIWDTLFHFDSSNYQHLITHLTYLPRLTVALICGFA
LAVAGCVMQFVLRNPIASPTTLGVAAGAELGMVLGILLIPANLAIPGFIPAFIGGCLATGLVFTLSSARGFSPLHMVLAG
MVVSLFLGSLNTMLLMLHEQRLTSIFVWGAGVLNQNDWSSVQVLIPLVSIPTLLLLVLQRPLSALQFGDNVATSLGVNIK
QIKLLCLSLAIFITAAVVSEVGLIGFVGIVAPAIARLIGVRALAKQILVSGLVGSFILLIVDLVIQPFSGFGGELLPTGA
MTALLGAPFLLWLLQRTKLQSDLKNRSETIEHYKFVSTRKVLAAMSVLLMAMCVLTLTVGKNQFGWNVELNPSLFDLRLP
RVLVALLAGIGLAFAGTIIQRISNNPMASPEVLGISSGAALALVLGTLFGTAVGREEQMLLGTLGATSVTAVVWLMGRKH
NFAPTQTLLTGIALSAGLDALLRITMSSGNENATALLTWLSGSTYLVANQDVILLAVGVTIISAVALSLNRWIELINLGD
VTTSSLGMNTTAVRLALLLLVAALTTLCTIVIGPLSFIGLLAPHMARSLHQYRAIPQMLTAALLGAIIMVAADWIGRTLW
FPWQFPAGLLASLIGGGYFLYLMRK
>Mature_664_residues
ATAKIEKTVTGRFSIKAAALPVAAVLLISSLLQITAPYSQGVGLIWDTLFHFDSSNYQHLITHLTYLPRLTVALICGFAL
AVAGCVMQFVLRNPIASPTTLGVAAGAELGMVLGILLIPANLAIPGFIPAFIGGCLATGLVFTLSSARGFSPLHMVLAGM
VVSLFLGSLNTMLLMLHEQRLTSIFVWGAGVLNQNDWSSVQVLIPLVSIPTLLLLVLQRPLSALQFGDNVATSLGVNIKQ
IKLLCLSLAIFITAAVVSEVGLIGFVGIVAPAIARLIGVRALAKQILVSGLVGSFILLIVDLVIQPFSGFGGELLPTGAM
TALLGAPFLLWLLQRTKLQSDLKNRSETIEHYKFVSTRKVLAAMSVLLMAMCVLTLTVGKNQFGWNVELNPSLFDLRLPR
VLVALLAGIGLAFAGTIIQRISNNPMASPEVLGISSGAALALVLGTLFGTAVGREEQMLLGTLGATSVTAVVWLMGRKHN
FAPTQTLLTGIALSAGLDALLRITMSSGNENATALLTWLSGSTYLVANQDVILLAVGVTIISAVALSLNRWIELINLGDV
TTSSLGMNTTAVRLALLLLVAALTTLCTIVIGPLSFIGLLAPHMARSLHQYRAIPQMLTAALLGAIIMVAADWIGRTLWF
PWQFPAGLLASLIGGGYFLYLMRK

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=640, Percent_Identity=40.625, Blast_Score=351, Evalue=8e-98,
Organism=Escherichia coli, GI1790741, Length=277, Percent_Identity=39.7111913357401, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1790740, Length=324, Percent_Identity=33.641975308642, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1786804, Length=227, Percent_Identity=31.7180616740088, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786805, Length=279, Percent_Identity=32.258064516129, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788004, Length=269, Percent_Identity=30.1115241635688, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70338; Mature: 70207

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00146 BETA_LACTAMASE_A ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATAKIEKTVTGRFSIKAAALPVAAVLLISSLLQITAPYSQGVGLIWDTLFHFDSSNYQH
CCCCHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCCCHHH
LITHLTYLPRLTVALICGFALAVAGCVMQFVLRNPIASPTTLGVAAGAELGMVLGILLIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHH
ANLAIPGFIPAFIGGCLATGLVFTLSSARGFSPLHMVLAGMVVSLFLGSLNTMLLMLHEQ
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLTSIFVWGAGVLNQNDWSSVQVLIPLVSIPTLLLLVLQRPLSALQFGDNVATSLGVNIK
HHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
QIKLLCLSLAIFITAAVVSEVGLIGFVGIVAPAIARLIGVRALAKQILVSGLVGSFILLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLVIQPFSGFGGELLPTGAMTALLGAPFLLWLLQRTKLQSDLKNRSETIEHYKFVSTRK
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAAMSVLLMAMCVLTLTVGKNQFGWNVELNPSLFDLRLPRVLVALLAGIGLAFAGTIIQ
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RISNNPMASPEVLGISSGAALALVLGTLFGTAVGREEQMLLGTLGATSVTAVVWLMGRKH
HHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCC
NFAPTQTLLTGIALSAGLDALLRITMSSGNENATALLTWLSGSTYLVANQDVILLAVGVT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCCEEEHHHHHH
IISAVALSLNRWIELINLGDVTTSSLGMNTTAVRLALLLLVAALTTLCTIVIGPLSFIGL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPHMARSLHQYRAIPQMLTAALLGAIIMVAADWIGRTLWFPWQFPAGLLASLIGGGYFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEE
YLMRK
EEEEC
>Mature Secondary Structure 
ATAKIEKTVTGRFSIKAAALPVAAVLLISSLLQITAPYSQGVGLIWDTLFHFDSSNYQH
CCCHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCCCHHH
LITHLTYLPRLTVALICGFALAVAGCVMQFVLRNPIASPTTLGVAAGAELGMVLGILLIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHHHHH
ANLAIPGFIPAFIGGCLATGLVFTLSSARGFSPLHMVLAGMVVSLFLGSLNTMLLMLHEQ
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLTSIFVWGAGVLNQNDWSSVQVLIPLVSIPTLLLLVLQRPLSALQFGDNVATSLGVNIK
HHHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
QIKLLCLSLAIFITAAVVSEVGLIGFVGIVAPAIARLIGVRALAKQILVSGLVGSFILLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLVIQPFSGFGGELLPTGAMTALLGAPFLLWLLQRTKLQSDLKNRSETIEHYKFVSTRK
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLAAMSVLLMAMCVLTLTVGKNQFGWNVELNPSLFDLRLPRVLVALLAGIGLAFAGTIIQ
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RISNNPMASPEVLGISSGAALALVLGTLFGTAVGREEQMLLGTLGATSVTAVVWLMGRKH
HHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCCCC
NFAPTQTLLTGIALSAGLDALLRITMSSGNENATALLTWLSGSTYLVANQDVILLAVGVT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCCEEEHHHHHH
IISAVALSLNRWIELINLGDVTTSSLGMNTTAVRLALLLLVAALTTLCTIVIGPLSFIGL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPHMARSLHQYRAIPQMLTAALLGAIIMVAADWIGRTLWFPWQFPAGLLASLIGGGYFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEE
YLMRK
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]