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The map label for this gene is fhuD [H]

Identifier: 218710092

GI number: 218710092

Start: 2268790

End: 2269683

Strand: Direct

Name: fhuD [H]

Synonym: VS_2113

Alternate gene names: 218710092

Gene position: 2268790-2269683 (Clockwise)

Preceding gene: 218710091

Following gene: 218710093

Centisome position: 68.77

GC content: 45.86

Gene sequence:

>894_bases
ATGCTGTTCACAGTATTAGCTTTCAACGCCCTTGCTCTAGAGAGCGTTCACGCACTAGAAATCAAACATGAAATGGGCAG
TGTCTCTTTCGATGCTACACCTAAAAAAGTGGTGGCTTTAGATTGGGCACTCACCGAAACCGTATTAAGCCTAGGCGTTG
AGTTGCAAGGTGTGGCAGACGCACAAGGTTATCAGCAATGGGTGGTAAAACCTGCGTTAAATGCAGACGTGACAGATGTG
GGATCTCGAAGAGAACCAAACCTAGAGCTACTAACAGAACTCAAACCTGACGTCATTTTAATCAGTGAGCATATGGCGGC
GGCCTACCACCAGCTCAATAAAATCGCACCTGTCTTGGTTTACAGTGTCTACAGCAAAAAGAAACAACCACTTGAATCCG
CAACTTCGGTTACCCTCTCTTTAGGCAAGCTATTTAACAAAGCACAACGCGCTCAACAAGTGATTGATGAGACAAACAAG
AGATTAAGCGATAACGGTGAAAAAATACGTGCCGCAGGCAACTCAGACAAACCACTGATTTTTGCACGCTTTATTAACGA
CAAAACCTTACGCATTCATAGCCAAGGTTCATTAGCGCAAGCCACCATAAGCAGCATGGGTCTTAAAAACGACTGGCAAG
AGCAGACAAACCTCTGGGGTTTTACCACTACAGGTACTGAAAGGCTCGCTGAACACCAACAGACGAATGTGATGATCTTT
GGCCCGCTAACGGAAGAAGAGCATAAGAAACTGACTCAATCCCCTCTTTGGCAAGCGATGGCGTTTACGCGTACAGACTC
CGTTTACGAACTTCCTACCATCTGGACCTTCGGTGGGCTAATCGCCGCTCAAAGGTTTAGTGACCACATTACCGAACTGC
TTATCCAAAAATAA

Upstream 100 bases:

>100_bases
ACGGAATGGAGCTTGCGCTCTTTAAACACCCTGAGACAGGGCAACCTATCAGCTACATCCCTTAAATCAAAAGGAACCTG
TTGTGAAAAAGTTCATCACC

Downstream 100 bases:

>100_bases
TGGCTACCGCAAAGATCGAAAAAACCGTCACCGGGCGATTCAGTATCAAGGCAGCGGCACTACCTGTCGCTGCTGTTTTG
TTGATCAGCTCGCTACTGCA

Product: hydroxamate-dependent iron ABC transporter periplasmic protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MLFTVLAFNALALESVHALEIKHEMGSVSFDATPKKVVALDWALTETVLSLGVELQGVADAQGYQQWVVKPALNADVTDV
GSRREPNLELLTELKPDVILISEHMAAAYHQLNKIAPVLVYSVYSKKKQPLESATSVTLSLGKLFNKAQRAQQVIDETNK
RLSDNGEKIRAAGNSDKPLIFARFINDKTLRIHSQGSLAQATISSMGLKNDWQEQTNLWGFTTTGTERLAEHQQTNVMIF
GPLTEEEHKKLTQSPLWQAMAFTRTDSVYELPTIWTFGGLIAAQRFSDHITELLIQK

Sequences:

>Translated_297_residues
MLFTVLAFNALALESVHALEIKHEMGSVSFDATPKKVVALDWALTETVLSLGVELQGVADAQGYQQWVVKPALNADVTDV
GSRREPNLELLTELKPDVILISEHMAAAYHQLNKIAPVLVYSVYSKKKQPLESATSVTLSLGKLFNKAQRAQQVIDETNK
RLSDNGEKIRAAGNSDKPLIFARFINDKTLRIHSQGSLAQATISSMGLKNDWQEQTNLWGFTTTGTERLAEHQQTNVMIF
GPLTEEEHKKLTQSPLWQAMAFTRTDSVYELPTIWTFGGLIAAQRFSDHITELLIQK
>Mature_297_residues
MLFTVLAFNALALESVHALEIKHEMGSVSFDATPKKVVALDWALTETVLSLGVELQGVADAQGYQQWVVKPALNADVTDV
GSRREPNLELLTELKPDVILISEHMAAAYHQLNKIAPVLVYSVYSKKKQPLESATSVTLSLGKLFNKAQRAQQVIDETNK
RLSDNGEKIRAAGNSDKPLIFARFINDKTLRIHSQGSLAQATISSMGLKNDWQEQTNLWGFTTTGTERLAEHQQTNVMIF
GPLTEEEHKKLTQSPLWQAMAFTRTDSVYELPTIWTFGGLIAAQRFSDHITELLIQK

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=253, Percent_Identity=33.201581027668, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082411, Length=301, Percent_Identity=22.9235880398671, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 33073; Mature: 33073

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFTVLAFNALALESVHALEIKHEMGSVSFDATPKKVVALDWALTETVLSLGVELQGVAD
CEEEEEHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHHHHHHHHCCCEEECCC
AQGYQQWVVKPALNADVTDVGSRREPNLELLTELKPDVILISEHMAAAYHQLNKIAPVLV
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHH
YSVYSKKKQPLESATSVTLSLGKLFNKAQRAQQVIDETNKRLSDNGEKIRAAGNSDKPLI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
FARFINDKTLRIHSQGSLAQATISSMGLKNDWQEQTNLWGFTTTGTERLAEHQQTNVMIF
EEEECCCCEEEEECCCCHHHHHHHHCCCCCCHHHHCCCCEEECCCHHHHHHHHHCCEEEE
GPLTEEEHKKLTQSPLWQAMAFTRTDSVYELPTIWTFGGLIAAQRFSDHITELLIQK
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLFTVLAFNALALESVHALEIKHEMGSVSFDATPKKVVALDWALTETVLSLGVELQGVAD
CEEEEEHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHHHHHHHHCCCEEECCC
AQGYQQWVVKPALNADVTDVGSRREPNLELLTELKPDVILISEHMAAAYHQLNKIAPVLV
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHH
YSVYSKKKQPLESATSVTLSLGKLFNKAQRAQQVIDETNKRLSDNGEKIRAAGNSDKPLI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEE
FARFINDKTLRIHSQGSLAQATISSMGLKNDWQEQTNLWGFTTTGTERLAEHQQTNVMIF
EEEECCCCEEEEECCCCHHHHHHHHCCCCCCHHHHCCCCEEECCCHHHHHHHHHCCEEEE
GPLTEEEHKKLTQSPLWQAMAFTRTDSVYELPTIWTFGGLIAAQRFSDHITELLIQK
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]