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The map label for this gene is ppiB [H]

Identifier: 218710071

GI number: 218710071

Start: 2245656

End: 2246150

Strand: Direct

Name: ppiB [H]

Synonym: VS_2092

Alternate gene names: 218710071

Gene position: 2245656-2246150 (Clockwise)

Preceding gene: 218710070

Following gene: 218710072

Centisome position: 68.06

GC content: 47.07

Gene sequence:

>495_bases
ATGATTATTCTGACCACTAACTTTGGCGACATCGAAATTGAACTTAACCTTGAGAAAGCGCCAGTAAGTTCAAAAAACTT
CCTTAAATACTGCCAAGAAGGCTTCTATGAAGGCACCACATTTCACCGTGTGATTGAGGGTTTCATGATTCAAGGTGGTG
GACACACTATCGACATGACAGAGAAGCCAACACACGCACCTATCGTCAATGAAGCAAATCGTGGACTAAAGAACGTGATT
GGCTCAGTGGCAATGGCTCGTACAGACGCACCACACTCAGCAACGGCGCAGTTCTTTATCAACCTTGACGACAATGATTT
CCTTGACCATACCGCGACCAGCAACGCAGGTTGGGGTTACGCAGTGTTTGGCAAAGTATCGGCAGGCATGGACGTGGTCA
ACAAGATTGCGCTTGCACCAACCACTACTCGCTGGGGACACGAAGATGTACCTTGCGAAGATATTGTGATTACCAAGGTC
ACGATTCGCGATTAA

Upstream 100 bases:

>100_bases
TCACTGGCATCCGTCGTTATTTCTCATATACTGCACCCTATTACGTCATCCACTACTCTGTAGTACTCAAAATATTAGTA
CTCGAACATTGGGCACCTTT

Downstream 100 bases:

>100_bases
TTCAAAATTAGCAGTCAATTCGCTTTTTTATCAAATAACGAAGCAATGTTGGTGCTAATTGCATCGGTATTAGTTACGAT
GACAATAGTTGTAATGTCAT

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIILTTNFGDIEIELNLEKAPVSSKNFLKYCQEGFYEGTTFHRVIEGFMIQGGGHTIDMTEKPTHAPIVNEANRGLKNVI
GSVAMARTDAPHSATAQFFINLDDNDFLDHTATSNAGWGYAVFGKVSAGMDVVNKIALAPTTTRWGHEDVPCEDIVITKV
TIRD

Sequences:

>Translated_164_residues
MIILTTNFGDIEIELNLEKAPVSSKNFLKYCQEGFYEGTTFHRVIEGFMIQGGGHTIDMTEKPTHAPIVNEANRGLKNVI
GSVAMARTDAPHSATAQFFINLDDNDFLDHTATSNAGWGYAVFGKVSAGMDVVNKIALAPTTTRWGHEDVPCEDIVITKV
TIRD
>Mature_164_residues
MIILTTNFGDIEIELNLEKAPVSSKNFLKYCQEGFYEGTTFHRVIEGFMIQGGGHTIDMTEKPTHAPIVNEANRGLKNVI
GSVAMARTDAPHSATAQFFINLDDNDFLDHTATSNAGWGYAVFGKVSAGMDVVNKIALAPTTTRWGHEDVPCEDIVITKV
TIRD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=33.1325301204819, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI64276486, Length=141, Percent_Identity=37.5886524822695, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=31.7073170731707, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=31.7073170731707, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=31.7073170731707, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI24308049, Length=171, Percent_Identity=30.4093567251462, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI303305009, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=57.9268292682927, Blast_Score=190, Evalue=4e-50,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=52.7950310559006, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17506311, Length=164, Percent_Identity=34.1463414634146, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=34.0136054421769, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=147, Percent_Identity=34.0136054421769, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=129, Percent_Identity=34.8837209302326, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=29.3413173652695, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=176, Percent_Identity=31.8181818181818, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=28.8235294117647, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=29.0909090909091, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357249, Length=140, Percent_Identity=32.1428571428571, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17974; Mature: 17974

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILTTNFGDIEIELNLEKAPVSSKNFLKYCQEGFYEGTTFHRVIEGFMIQGGGHTIDMT
CEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHEEECCCCCEEECC
EKPTHAPIVNEANRGLKNVIGSVAMARTDAPHSATAQFFINLDDNDFLDHTATSNAGWGY
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVSAGMDVVNKIALAPTTTRWGHEDVPCEDIVITKVTIRD
EEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MIILTTNFGDIEIELNLEKAPVSSKNFLKYCQEGFYEGTTFHRVIEGFMIQGGGHTIDMT
CEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHEEECCCCCEEECC
EKPTHAPIVNEANRGLKNVIGSVAMARTDAPHSATAQFFINLDDNDFLDHTATSNAGWGY
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVSAGMDVVNKIALAPTTTRWGHEDVPCEDIVITKVTIRD
EEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]