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The map label for this gene is ndh [H]

Identifier: 218710052

GI number: 218710052

Start: 2225067

End: 2226356

Strand: Reverse

Name: ndh [H]

Synonym: VS_2072

Alternate gene names: 218710052

Gene position: 2226356-2225067 (Counterclockwise)

Preceding gene: 218710053

Following gene: 218710047

Centisome position: 67.48

GC content: 47.6

Gene sequence:

>1290_bases
GTGACAAAAATTATCGTAGTAGGCGGCGGTGCTGGTGGTTTAGAACTAGCAACTAAGCTAGGCCGCACTTTAGGTCGTAA
GAAACGTGCCCAGATTACTCTGGTAGACCGTAAAGCAAGCCACCTATGGAAACCATTGCTTCATGAAGTAGCTACTGGCT
CATTGGATGAAGGTGTTGATGCGCTAAGCTACCGCGCACACGCAAAAAACCATTGCTTTGATTTCCAAATGGGCAGCCTG
AACGATATCGATCGTGAACGTAAAGTGATTGCGTTGAGCGAGTTGACTGATGAGCACGGTGAGCTGCTGATGCCAGGCCG
TGAACTTGAATACGACATTCTTGTGATGGCGTTAGGTTCAACGTCAAACGACTTCAATACCCCAGGTGTTCGTGACAACT
GTATTTTCCTTGATAGCCCAGAGCAAGCACACCGTTTCCGTACAGAAATGAACAACCAGTTCTTAAAGCTGCACGCTAAG
AATGGTCAAGGTACAGTAGACATCGCGATTGTTGGTGCGGGTGCTACTGGTGTTGAGCTGTCTGCTGAGCTTCACAACGC
TGTGAAAGAGCTTCGTACATACGGTTTTGGCGACCTAGATTCAAGCAAGCTGAACGTTAACCTTGTTGAAGCGGGTGAGC
GTATTCTTCCAGCTCTACCTCCTCGTATTTCCAGCGCAGCACATTCTGAGCTAACTAAGCTTGGCGTCAACGTGCGTACA
ACGACAATGGTTACACAAGCTGACGCTGACGGTCTAACGACCAAAGATGGTGAGAAGATCCCAGCACAGATCATGGTATG
GGCTGCTGGTATTAAAGCGCCAGATTTCATGAAAGATATCGGTGGTCTTGAGACGAACCGTATCAACCAGTTGGTTGTCA
AAAACACGCTGCAAACTACGCTTGATGACAACATCTTTGCTATCGGTGATTTGGCGCAATGTACACAAGCGGATGGTTCG
TTTGTTCCACCACGTGCGCAAGCGGCTCACCAAATGGCAAGCTGCGCATTTAGCAACATCATAGCTAAGCTGAACGGCCG
TGACCTGAAAGACTACATCTACAAAGATAAAGGCTCACTGGTTTCACTAAGCCGTTTCTCTACAGTAGGTAGCTTGATGG
GTAACCTGACTAAAGGTTCGATGATGGTTGAGGGACGTATTGCTCGTGTGGTTTACATCTCTTTGTACCGAATGCACCAG
ATGGCACTTCACGGCTTAATCAAAACATCACTGATGATGTTGGTGGGTCGTATTAACCGTGTCCTTCGTCCAAACCTAAA
GCTTCACTAA

Upstream 100 bases:

>100_bases
AGCCACAGCCTTTGGAATAAGGCCGAGTAGATACATAGAATTTATCGGTTGGAGTAATCGAGCCGAACCCCATTTATTCA
TTTTGTAGAGGATTGTCATT

Downstream 100 bases:

>100_bases
TCAGGTAAGCCTTCTAAGGTCATTACGCTGATAATAAAAAAGAGCTCTTCGGAGCTCTTTTTTGATCGTGTCGAGTACGT
GTTATTTCGGATTGTTACTC

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTKIIVVGGGAGGLELATKLGRTLGRKKRAQITLVDRKASHLWKPLLHEVATGSLDEGVDALSYRAHAKNHCFDFQMGSL
NDIDRERKVIALSELTDEHGELLMPGRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAK
NGQGTVDIAIVGAGATGVELSAELHNAVKELRTYGFGDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
TTMVTQADADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRINQLVVKNTLQTTLDDNIFAIGDLAQCTQADGS
FVPPRAQAAHQMASCAFSNIIAKLNGRDLKDYIYKDKGSLVSLSRFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQ
MALHGLIKTSLMMLVGRINRVLRPNLKLH

Sequences:

>Translated_429_residues
MTKIIVVGGGAGGLELATKLGRTLGRKKRAQITLVDRKASHLWKPLLHEVATGSLDEGVDALSYRAHAKNHCFDFQMGSL
NDIDRERKVIALSELTDEHGELLMPGRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAK
NGQGTVDIAIVGAGATGVELSAELHNAVKELRTYGFGDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
TTMVTQADADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRINQLVVKNTLQTTLDDNIFAIGDLAQCTQADGS
FVPPRAQAAHQMASCAFSNIIAKLNGRDLKDYIYKDKGSLVSLSRFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQ
MALHGLIKTSLMMLVGRINRVLRPNLKLH
>Mature_428_residues
TKIIVVGGGAGGLELATKLGRTLGRKKRAQITLVDRKASHLWKPLLHEVATGSLDEGVDALSYRAHAKNHCFDFQMGSLN
DIDRERKVIALSELTDEHGELLMPGRELEYDILVMALGSTSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAKN
GQGTVDIAIVGAGATGVELSAELHNAVKELRTYGFGDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRTT
TMVTQADADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRINQLVVKNTLQTTLDDNIFAIGDLAQCTQADGSF
VPPRAQAAHQMASCAFSNIIAKLNGRDLKDYIYKDKGSLVSLSRFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQM
ALHGLIKTSLMMLVGRINRVLRPNLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=430, Percent_Identity=74.4186046511628, Blast_Score=641, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323794, Length=349, Percent_Identity=30.3724928366762, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323515, Length=445, Percent_Identity=25.6179775280899, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320118, Length=348, Percent_Identity=27.2988505747126, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 46785; Mature: 46653

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIIVVGGGAGGLELATKLGRTLGRKKRAQITLVDRKASHLWKPLLHEVATGSLDEGVD
CEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHCHH
ALSYRAHAKNHCFDFQMGSLNDIDRERKVIALSELTDEHGELLMPGRELEYDILVMALGS
HHHHHHHHCCCCEEECCCCCCCCCHHHHEEEEHHHCCCCCCEECCCCCCCEEEEEEEECC
TSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAKNGQGTVDIAIVGAGATGVEL
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEECCCCCCEE
SAELHNAVKELRTYGFGDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHCCCEEE
TTMVTQADADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRINQLVVKNTLQTT
EEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
LDDNIFAIGDLAQCTQADGSFVPPRAQAAHQMASCAFSNIIAKLNGRDLKDYIYKDKGSL
HCCCEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCE
VSLSRFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQMALHGLIKTSLMMLVGRINR
EEHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPNLKLH
HHCCCCCCC
>Mature Secondary Structure 
TKIIVVGGGAGGLELATKLGRTLGRKKRAQITLVDRKASHLWKPLLHEVATGSLDEGVD
EEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHCHH
ALSYRAHAKNHCFDFQMGSLNDIDRERKVIALSELTDEHGELLMPGRELEYDILVMALGS
HHHHHHHHCCCCEEECCCCCCCCCHHHHEEEEHHHCCCCCCEECCCCCCCEEEEEEEECC
TSNDFNTPGVRDNCIFLDSPEQAHRFRTEMNNQFLKLHAKNGQGTVDIAIVGAGATGVEL
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCEEEEEEECCCCCEEEEEEEECCCCCCEE
SAELHNAVKELRTYGFGDLDSSKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHCCCEEE
TTMVTQADADGLTTKDGEKIPAQIMVWAAGIKAPDFMKDIGGLETNRINQLVVKNTLQTT
EEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
LDDNIFAIGDLAQCTQADGSFVPPRAQAAHQMASCAFSNIIAKLNGRDLKDYIYKDKGSL
HCCCEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCE
VSLSRFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQMALHGLIKTSLMMLVGRINR
EEHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPNLKLH
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]