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The map label for this gene is lolC [H]

Identifier: 218710047

GI number: 218710047

Start: 2217970

End: 2219190

Strand: Reverse

Name: lolC [H]

Synonym: VS_2067

Alternate gene names: 218710047

Gene position: 2219190-2217970 (Counterclockwise)

Preceding gene: 218710052

Following gene: 218710046

Centisome position: 67.26

GC content: 45.86

Gene sequence:

>1221_bases
ATGGTTCAAAGTATGTTTCATCCTATTTCATTGTTTGTTGGCCTGCGTTATTTGAAAGGCCGTTCAGGTGATCGCTTTAG
CCGTTTTGTTTCTTATATGTCGACAGCCGGAATTACCATTGGTGTGCTGTCTCTGGTTACTGTTTTGTCGGTAATGAATG
GATTCGAAGCGCAGTTAAAAGACCGAATTCTTGGTGTCCTTCCTCAAGCCGTCGTTTACGAGCAAGGAGGCACAACGTCA
CTTTCTGCTCAAGCACCTAGCTTTGCGGAGCAAATGTCGCTCAATGGCCACGTAGAACCTATTGTTCGCAGTGAAGCGGT
GATCCAAAGTCCTGCTCAGTTATCTGCGGGCTTGTTAATTGGTATTGAGCCAAATTCCGATGACCCTCTTCAGAATCATT
TAATTGCTGGCAGACTGTCTTCACTCAAGGCTGGTCAGTATCAGCTTTTCCTTGGTCATACATTAGCAAGAAACTTGAAA
GTGTCTATGGGCGACAAAGTTCGCTTAATGGTGACCAGTGCCAGCCAATACACGCCGTTAGGACGTATTCCAAGCCAGCG
AAATTTTACCGTAGCTGGGATTTTTAACACGGGTTCGGATATCGATGCTCAATTGATGGTGACAGATATCAACGATGCTG
GGCGTTTGATGCGCTATAAATCAGACACCATTTCAGGCTGGCGACTGTTTTTTGATGACCCATTTGAAGTGGCAGAACTA
TCAAACCAACCGCTACCGGAAGGTTGGGTGTGGAGCGATTGGCGAGACCAACGTGGCGAGCTATTCCAAGCCGTTCGAAT
GGAAAAAAACATGATGGGTTTGATGCTTGGGCTGATCATTGGTGTTGCTGCGTTTAACATTATTTCTGCGCTTATTATGG
TGGTGATGGAGAAACAGTCCGAAGTCGCCATCTTAAAAACCCAAGGTATGCGTGATGGTCAAGTCATGGGGATCTTTATG
GTTCAAGGTGCAAGTAGTGGTGTGATCGGCGCATTATCTGGTGGCATCCTGGGCGTGATTTTAGCTTCGAACCTCAATAC
TATTTTAGAGGCGATGGGTGTTGCTCTGTTTTCATTTGGTGGACAGTTGCCAATTTTAATTAACCCAATTCAAATCGCCG
TTGTTGTGGTTCTGGCTATTGCACTTAGCTTGATTGCCACTGTCTTCCCTTCTTATCGTGCATCGTCTGTGAAACCTGCT
GAGGCCCTTCGTTATGAGTAA

Upstream 100 bases:

>100_bases
TTTTTCAAGCCTAACTAATTGAGTTAATTCACTCTATATTTTCAATTAACCCCTACACAGTAACGGCAATACCCGTTACA
TTAACCCGCATCTCCTTTAG

Downstream 100 bases:

>100_bases
TTTTCTTCAATGTAATGATATCCGTAAAACGTACCGTGAAGGCTCGTTAGATACTGAGGTTCTCAAGGGCGTCAGCTTCG
AAATAGAAAAGGGTGAGCTA

Product: lipoprotein-releasing system transmembrane protein LolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVQSMFHPISLFVGLRYLKGRSGDRFSRFVSYMSTAGITIGVLSLVTVLSVMNGFEAQLKDRILGVLPQAVVYEQGGTTS
LSAQAPSFAEQMSLNGHVEPIVRSEAVIQSPAQLSAGLLIGIEPNSDDPLQNHLIAGRLSSLKAGQYQLFLGHTLARNLK
VSMGDKVRLMVTSASQYTPLGRIPSQRNFTVAGIFNTGSDIDAQLMVTDINDAGRLMRYKSDTISGWRLFFDDPFEVAEL
SNQPLPEGWVWSDWRDQRGELFQAVRMEKNMMGLMLGLIIGVAAFNIISALIMVVMEKQSEVAILKTQGMRDGQVMGIFM
VQGASSGVIGALSGGILGVILASNLNTILEAMGVALFSFGGQLPILINPIQIAVVVVLAIALSLIATVFPSYRASSVKPA
EALRYE

Sequences:

>Translated_406_residues
MVQSMFHPISLFVGLRYLKGRSGDRFSRFVSYMSTAGITIGVLSLVTVLSVMNGFEAQLKDRILGVLPQAVVYEQGGTTS
LSAQAPSFAEQMSLNGHVEPIVRSEAVIQSPAQLSAGLLIGIEPNSDDPLQNHLIAGRLSSLKAGQYQLFLGHTLARNLK
VSMGDKVRLMVTSASQYTPLGRIPSQRNFTVAGIFNTGSDIDAQLMVTDINDAGRLMRYKSDTISGWRLFFDDPFEVAEL
SNQPLPEGWVWSDWRDQRGELFQAVRMEKNMMGLMLGLIIGVAAFNIISALIMVVMEKQSEVAILKTQGMRDGQVMGIFM
VQGASSGVIGALSGGILGVILASNLNTILEAMGVALFSFGGQLPILINPIQIAVVVVLAIALSLIATVFPSYRASSVKPA
EALRYE
>Mature_406_residues
MVQSMFHPISLFVGLRYLKGRSGDRFSRFVSYMSTAGITIGVLSLVTVLSVMNGFEAQLKDRILGVLPQAVVYEQGGTTS
LSAQAPSFAEQMSLNGHVEPIVRSEAVIQSPAQLSAGLLIGIEPNSDDPLQNHLIAGRLSSLKAGQYQLFLGHTLARNLK
VSMGDKVRLMVTSASQYTPLGRIPSQRNFTVAGIFNTGSDIDAQLMVTDINDAGRLMRYKSDTISGWRLFFDDPFEVAEL
SNQPLPEGWVWSDWRDQRGELFQAVRMEKNMMGLMLGLIIGVAAFNIISALIMVVMEKQSEVAILKTQGMRDGQVMGIFM
VQGASSGVIGALSGGILGVILASNLNTILEAMGVALFSFGGQLPILINPIQIAVVVVLAIALSLIATVFPSYRASSVKPA
EALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=402, Percent_Identity=52.2388059701493, Blast_Score=415, Evalue=1e-117,
Organism=Escherichia coli, GI1787362, Length=413, Percent_Identity=30.2663438256659, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43861; Mature: 43861

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQSMFHPISLFVGLRYLKGRSGDRFSRFVSYMSTAGITIGVLSLVTVLSVMNGFEAQLK
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHH
DRILGVLPQAVVYEQGGTTSLSAQAPSFAEQMSLNGHVEPIVRSEAVIQSPAQLSAGLLI
HHHHHHCCHHHEEECCCCCEECCCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCEEE
GIEPNSDDPLQNHLIAGRLSSLKAGQYQLFLGHTLARNLKVSMGDKVRLMVTSASQYTPL
EECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCEEECCCEEEEEEECCCCCCCC
GRIPSQRNFTVAGIFNTGSDIDAQLMVTDINDAGRLMRYKSDTISGWRLFFDDPFEVAEL
CCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCHHEEECCCCCCCEEEEECCCHHHHHC
SNQPLPEGWVWSDWRDQRGELFQAVRMEKNMMGLMLGLIIGVAAFNIISALIMVVMEKQS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVAILKTQGMRDGQVMGIFMVQGASSGVIGALSGGILGVILASNLNTILEAMGVALFSFG
CEEEEEECCCCCCCEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GQLPILINPIQIAVVVVLAIALSLIATVFPSYRASSVKPAEALRYE
CCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MVQSMFHPISLFVGLRYLKGRSGDRFSRFVSYMSTAGITIGVLSLVTVLSVMNGFEAQLK
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHH
DRILGVLPQAVVYEQGGTTSLSAQAPSFAEQMSLNGHVEPIVRSEAVIQSPAQLSAGLLI
HHHHHHCCHHHEEECCCCCEECCCCCHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCCEEE
GIEPNSDDPLQNHLIAGRLSSLKAGQYQLFLGHTLARNLKVSMGDKVRLMVTSASQYTPL
EECCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCEEECCCEEEEEEECCCCCCCC
GRIPSQRNFTVAGIFNTGSDIDAQLMVTDINDAGRLMRYKSDTISGWRLFFDDPFEVAEL
CCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCHHEEECCCCCCCEEEEECCCHHHHHC
SNQPLPEGWVWSDWRDQRGELFQAVRMEKNMMGLMLGLIIGVAAFNIISALIMVVMEKQS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EVAILKTQGMRDGQVMGIFMVQGASSGVIGALSGGILGVILASNLNTILEAMGVALFSFG
CEEEEEECCCCCCCEEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GQLPILINPIQIAVVVVLAIALSLIATVFPSYRASSVKPAEALRYE
CCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]