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The map label for this gene is bioC [H]

Identifier: 218710018

GI number: 218710018

Start: 2183735

End: 2184538

Strand: Reverse

Name: bioC [H]

Synonym: VS_2038

Alternate gene names: 218710018

Gene position: 2184538-2183735 (Counterclockwise)

Preceding gene: 218710019

Following gene: 218710017

Centisome position: 66.21

GC content: 45.02

Gene sequence:

>804_bases
ATGTCACAAGAAGCAGTAGTGCATAATTACGTAAGCCAAGATAAGAGTGCGATTGCTGAAGCCTTCGGCAAAGCAGCTGC
AACCTATGACAAACACGCTGAGTTTCAGCGCGATGTAGGCCACCGACTATTGGATAAGCTACCGAGTGACCTCTCTGGGT
TAAAGGTGCTCGATCTAGGTTGTGGTACAGGGTATTTCTCTGAACAGTTAGTTAAGCGAGGTGCTGCAGTGGTATGTGCT
GACCTTTCCAATGGAATGTTGGACGAAGCAAAACAGCGCTGTGGTATATCAGTCTCTTCATATCAACAAGCCGACGCCGA
ACAATTACCGTTTGAAGACGGGCACTTTGACATCGTTTTCTCTAGCCTTGCGTTGCAATGGTGTGACGACTTGTCGTCAC
CTTTGAGAGAGATGAAGCGTGTTACAGCGGTTGGTGGACGTGTTATTTTCTCAACTTTGCTTGATGGATCACTGTTTGAA
CTGAAAAAGTCGTGGTCAAAAATTGACGCACATCAACACGTTAACCATTTTATTACAATCAATCAGGTAAAAATTGCGTT
AGCGCAATCTAGCTGTACTGCTCATCAACTAGACTTGCCCACCATCACCGTTTGGTACGACACTGCGTTTGAACTGATGC
GCGACCTTAAAGGTATCGGCGCTAATCACGTAAGTGGTCGCTCACAAGGTTTAACAAGCCGCCGCATGTTGCAGTTTGTT
GAACGGGAATATCGAGAGTTTAAAAACCATCAAGGTTTCTTGCCAGCAACATATCAAGTTTGTTTAGGGGTTATTCAATT
ATGA

Upstream 100 bases:

>100_bases
GTTAACTGACTCGTTGCTTCAAGCAATAGAGCGAAGCAACGACTCTGGAAGCAAACCAAGCATAGAATCAAGCTTTGAAT
TAAAGAAAGAGGCTCAGTAA

Downstream 100 bases:

>100_bases
TTGATGCATTATTCATTGCAGGTACGGATACCGAAGTGGGAAAAACTGTGGTTTCAAAAGCGATTCTTCAAGCTTTGGCC
GCACAAGATTTATCAACAAT

Product: biotin synthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSQEAVVHNYVSQDKSAIAEAFGKAAATYDKHAEFQRDVGHRLLDKLPSDLSGLKVLDLGCGTGYFSEQLVKRGAAVVCA
DLSNGMLDEAKQRCGISVSSYQQADAEQLPFEDGHFDIVFSSLALQWCDDLSSPLREMKRVTAVGGRVIFSTLLDGSLFE
LKKSWSKIDAHQHVNHFITINQVKIALAQSSCTAHQLDLPTITVWYDTAFELMRDLKGIGANHVSGRSQGLTSRRMLQFV
EREYREFKNHQGFLPATYQVCLGVIQL

Sequences:

>Translated_267_residues
MSQEAVVHNYVSQDKSAIAEAFGKAAATYDKHAEFQRDVGHRLLDKLPSDLSGLKVLDLGCGTGYFSEQLVKRGAAVVCA
DLSNGMLDEAKQRCGISVSSYQQADAEQLPFEDGHFDIVFSSLALQWCDDLSSPLREMKRVTAVGGRVIFSTLLDGSLFE
LKKSWSKIDAHQHVNHFITINQVKIALAQSSCTAHQLDLPTITVWYDTAFELMRDLKGIGANHVSGRSQGLTSRRMLQFV
EREYREFKNHQGFLPATYQVCLGVIQL
>Mature_266_residues
SQEAVVHNYVSQDKSAIAEAFGKAAATYDKHAEFQRDVGHRLLDKLPSDLSGLKVLDLGCGTGYFSEQLVKRGAAVVCAD
LSNGMLDEAKQRCGISVSSYQQADAEQLPFEDGHFDIVFSSLALQWCDDLSSPLREMKRVTAVGGRVIFSTLLDGSLFEL
KKSWSKIDAHQHVNHFITINQVKIALAQSSCTAHQLDLPTITVWYDTAFELMRDLKGIGANHVSGRSQGLTSRRMLQFVE
REYREFKNHQGFLPATYQVCLGVIQL

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=237, Percent_Identity=29.957805907173, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786994, Length=238, Percent_Identity=38.655462184874, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI48994983, Length=170, Percent_Identity=31.1764705882353, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17535003, Length=237, Percent_Identity=26.1603375527426, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922210, Length=261, Percent_Identity=27.5862068965517, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 29673; Mature: 29542

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEAVVHNYVSQDKSAIAEAFGKAAATYDKHAEFQRDVGHRLLDKLPSDLSGLKVLDLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
CGTGYFSEQLVKRGAAVVCADLSNGMLDEAKQRCGISVSSYQQADAEQLPFEDGHFDIVF
CCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHCCHHHCCCCCCCHHHHH
SSLALQWCDDLSSPLREMKRVTAVGGRVIFSTLLDGSLFELKKSWSKIDAHQHVNHFITI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEE
NQVKIALAQSSCTAHQLDLPTITVWYDTAFELMRDLKGIGANHVSGRSQGLTSRRMLQFV
HHHEEEEHHCCCCCEECCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
EREYREFKNHQGFLPATYQVCLGVIQL
HHHHHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQEAVVHNYVSQDKSAIAEAFGKAAATYDKHAEFQRDVGHRLLDKLPSDLSGLKVLDLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
CGTGYFSEQLVKRGAAVVCADLSNGMLDEAKQRCGISVSSYQQADAEQLPFEDGHFDIVF
CCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHCCHHHCCCCCCCHHHHH
SSLALQWCDDLSSPLREMKRVTAVGGRVIFSTLLDGSLFELKKSWSKIDAHQHVNHFITI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEE
NQVKIALAQSSCTAHQLDLPTITVWYDTAFELMRDLKGIGANHVSGRSQGLTSRRMLQFV
HHHEEEEHHCCCCCEECCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
EREYREFKNHQGFLPATYQVCLGVIQL
HHHHHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]