Click here to switch to the map view.

The map label for this gene is sufC [H]

Identifier: 218709890

GI number: 218709890

Start: 2043795

End: 2044541

Strand: Direct

Name: sufC [H]

Synonym: VS_1903

Alternate gene names: 218709890

Gene position: 2043795-2044541 (Clockwise)

Preceding gene: 218709889

Following gene: 218709891

Centisome position: 61.95

GC content: 41.9

Gene sequence:

>747_bases
ATGTTAGAAATTAAAAATTTACATGTCAGCGTTGAAGAAAATACTATCCTAAAAGGTATTAACCTAACCGTTAAACCTGG
TGAAGTTCACGCAATTATGGGGCCTAATGGGTCAGGAAAAAGTACCCTATCCGCCACACTGGCAGGCAAGGATGATTACG
AGGTCGTCAGTGGTGAGATTGTTTTCAAAGGTCAAGATCTTACAGAGCTAGATCCAGAGGAAAGAGCCGGTGAAGGGGTA
TTTTTAGCCTTTCAGTACCCTGTCGAAATTCCAGGTGTCAGTAACAAACTCTTTCTAAATACAGCTCTCAACGAGGTTCG
TGAATATCGAGGCTTAGAACCGATCGATCGTTTTGACTTTGAAGATCTATTGGAAGAAAAAGCGCAATTGTTGAAGATGC
CGGCAAATTTACTCCAACGCTCTGTCAATGAGGGATTCTCTGGTGGAGAGAAAAAGCGCAATGACATTCTACAAATGGCG
GTGCTCTCACCTGATCTTTGTATACTAGACGAGACCGACTCCGGTCTAGATATTGATGCTCTTAAAGCCGTCTCTGAAGG
TGTAAACGCGCTACAGAATGAAAAACGAGCTTTCATTTTAGTCACGCACTATCAACGTATCCTCAATTACATCAAACCAG
ATTTCGTGCACGTGTTGTACCAAGGGAAAATTGTAAAATCTGGTGACCATACGTTAGCTCAAGAATTAGAAGAGAAAGGC
TATGGGTGGATCATTGATGAACAATAA

Upstream 100 bases:

>100_bases
AATGGTTTTTGTAAAGACGTATTTTCAGAATTACCACTCGAATTCGCTGTTGAAGCGCAGAAACTTCTATCAATCAGCCT
CGAGCATAGTGTGGGATAAA

Downstream 100 bases:

>100_bases
ACATTCATTGCTTGATTCATTTGAAACCCTTGTTCGACCGCATGAGTGGCAAAAAAAACAATGGTCTAAATTGCTTGGGA
TTGAGCTACCGTCCCCTCAA

Product: cysteine desulfurase ATPase component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLEIKNLHVSVEENTILKGINLTVKPGEVHAIMGPNGSGKSTLSATLAGKDDYEVVSGEIVFKGQDLTELDPEERAGEGV
FLAFQYPVEIPGVSNKLFLNTALNEVREYRGLEPIDRFDFEDLLEEKAQLLKMPANLLQRSVNEGFSGGEKKRNDILQMA
VLSPDLCILDETDSGLDIDALKAVSEGVNALQNEKRAFILVTHYQRILNYIKPDFVHVLYQGKIVKSGDHTLAQELEEKG
YGWIIDEQ

Sequences:

>Translated_248_residues
MLEIKNLHVSVEENTILKGINLTVKPGEVHAIMGPNGSGKSTLSATLAGKDDYEVVSGEIVFKGQDLTELDPEERAGEGV
FLAFQYPVEIPGVSNKLFLNTALNEVREYRGLEPIDRFDFEDLLEEKAQLLKMPANLLQRSVNEGFSGGEKKRNDILQMA
VLSPDLCILDETDSGLDIDALKAVSEGVNALQNEKRAFILVTHYQRILNYIKPDFVHVLYQGKIVKSGDHTLAQELEEKG
YGWIIDEQ
>Mature_248_residues
MLEIKNLHVSVEENTILKGINLTVKPGEVHAIMGPNGSGKSTLSATLAGKDDYEVVSGEIVFKGQDLTELDPEERAGEGV
FLAFQYPVEIPGVSNKLFLNTALNEVREYRGLEPIDRFDFEDLLEEKAQLLKMPANLLQRSVNEGFSGGEKKRNDILQMA
VLSPDLCILDETDSGLDIDALKAVSEGVNALQNEKRAFILVTHYQRILNYIKPDFVHVLYQGKIVKSGDHTLAQELEEKG
YGWIIDEQ

Specific function: Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May f

COG id: COG0396

COG function: function code O; ABC-type transport system involved in Fe-S cluster assembly, ATPase component

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI156105685, Length=239, Percent_Identity=28.0334728033473, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI42741659, Length=250, Percent_Identity=27.6, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI27262624, Length=189, Percent_Identity=31.2169312169312, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI27262626, Length=189, Percent_Identity=31.2169312169312, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787972, Length=248, Percent_Identity=74.1935483870968, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1786654, Length=244, Percent_Identity=26.2295081967213, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1786698, Length=214, Percent_Identity=29.9065420560748, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788761, Length=229, Percent_Identity=29.2576419213974, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081709, Length=230, Percent_Identity=24.7826086956522, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786703, Length=215, Percent_Identity=33.4883720930233, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789672, Length=204, Percent_Identity=26.4705882352941, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787500, Length=222, Percent_Identity=28.8288288288288, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789963, Length=225, Percent_Identity=28.4444444444444, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787143, Length=234, Percent_Identity=27.3504273504274, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=234, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558664, Length=223, Percent_Identity=28.6995515695067, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71996809, Length=236, Percent_Identity=26.271186440678, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17567269, Length=239, Percent_Identity=28.8702928870293, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193211017, Length=236, Percent_Identity=25.8474576271186, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI193211015, Length=236, Percent_Identity=25.8474576271186, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115533592, Length=234, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI193209708, Length=235, Percent_Identity=28.936170212766, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI212646699, Length=252, Percent_Identity=26.5873015873016, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71984940, Length=221, Percent_Identity=27.6018099547511, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567265, Length=220, Percent_Identity=29.0909090909091, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=236, Percent_Identity=28.3898305084746, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17565938, Length=217, Percent_Identity=26.7281105990783, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319856, Length=243, Percent_Identity=30.0411522633745, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323217, Length=257, Percent_Identity=27.6264591439689, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24641565, Length=223, Percent_Identity=26.0089686098655, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI85726357, Length=244, Percent_Identity=27.4590163934426, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR010230 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 27601; Mature: 27601

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEIKNLHVSVEENTILKGINLTVKPGEVHAIMGPNGSGKSTLSATLAGKDDYEVVSGEI
CCEEEEEEEEECCCEEEECCEEEEECCEEEEEECCCCCCCCEEEEEECCCCCCEEEECEE
VFKGQDLTELDPEERAGEGVFLAFQYPVEIPGVSNKLFLNTALNEVREYRGLEPIDRFDF
EEECCCCCCCCCHHHCCCEEEEEEECCEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCCH
EDLLEEKAQLLKMPANLLQRSVNEGFSGGEKKRNDILQMAVLSPDLCILDETDSGLDIDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
LKAVSEGVNALQNEKRAFILVTHYQRILNYIKPDFVHVLYQGKIVKSGDHTLAQELEEKG
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCHHHEEEEEECEEEECCCHHHHHHHHHCC
YGWIIDEQ
CCEEEECC
>Mature Secondary Structure
MLEIKNLHVSVEENTILKGINLTVKPGEVHAIMGPNGSGKSTLSATLAGKDDYEVVSGEI
CCEEEEEEEEECCCEEEECCEEEEECCEEEEEECCCCCCCCEEEEEECCCCCCEEEECEE
VFKGQDLTELDPEERAGEGVFLAFQYPVEIPGVSNKLFLNTALNEVREYRGLEPIDRFDF
EEECCCCCCCCCHHHCCCEEEEEEECCEECCCCCCEEEHHHHHHHHHHHCCCCCCCCCCH
EDLLEEKAQLLKMPANLLQRSVNEGFSGGEKKRNDILQMAVLSPDLCILDETDSGLDIDA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHH
LKAVSEGVNALQNEKRAFILVTHYQRILNYIKPDFVHVLYQGKIVKSGDHTLAQELEEKG
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCHHHEEEEEECEEEECCCHHHHHHHHHCC
YGWIIDEQ
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 10322040 [H]