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The map label for this gene is grxA [H]

Identifier: 218709824

GI number: 218709824

Start: 1978147

End: 1978410

Strand: Direct

Name: grxA [H]

Synonym: VS_1836

Alternate gene names: 218709824

Gene position: 1978147-1978410 (Clockwise)

Preceding gene: 218709822

Following gene: 218709825

Centisome position: 59.96

GC content: 44.7

Gene sequence:

>264_bases
ATGTTTGTAGTTATTTTTGGTCGCCCTGCTTGTCCATTCTGTGTTCGCGCAAAAGAGCATGCTGAAACTCTTAAAGCTAA
ACGCGATGACTTCAACTACCGTTACGTTGACATCCACGCTGAAGGCATCAGCAAAGCTGACCTAGAGAAGACCGTTGGTA
AACCTGTAGACACAGTGCCACAAATCTTCATCGACCAAGATCACATTGGCGGCTGCACAGAATTTGAAGCATACGCAAAA
GAAAACCTAGGTCTTTTCGACTAA

Upstream 100 bases:

>100_bases
TGAGGCATAGTTGGTTTTAAGAAATTTTGAGTGGCATTCATAATAGAATAGTTAACATAAATGAGTTAACGAGCCTCATC
CCGTATTTAGGAGAAATTAA

Downstream 100 bases:

>100_bases
GCTGGGATTTCTCAAACGAAAATCGAGGCTAACGCCTTAAACAGCTAATAAATAAGATAGTTAGACTGTATGATTGATAT
AAAGCCCGCTCATTGCAGCG

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: NA

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MFVVIFGRPACPFCVRAKEHAETLKAKRDDFNYRYVDIHAEGISKADLEKTVGKPVDTVPQIFIDQDHIGGCTEFEAYAK
ENLGLFD

Sequences:

>Translated_87_residues
MFVVIFGRPACPFCVRAKEHAETLKAKRDDFNYRYVDIHAEGISKADLEKTVGKPVDTVPQIFIDQDHIGGCTEFEAYAK
ENLGLFD
>Mature_87_residues
MFVVIFGRPACPFCVRAKEHAETLKAKRDDFNYRYVDIHAEGISKADLEKTVGKPVDTVPQIFIDQDHIGGCTEFEAYAK
ENLGLFD

Specific function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins [H]

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=83, Percent_Identity=66.2650602409639, Blast_Score=122, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9837; Mature: 9837

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVVIFGRPACPFCVRAKEHAETLKAKRDDFNYRYVDIHAEGISKADLEKTVGKPVDTVP
CEEEEECCCCCCCEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCC
QIFIDQDHIGGCTEFEAYAKENLGLFD
EEEECCCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MFVVIFGRPACPFCVRAKEHAETLKAKRDDFNYRYVDIHAEGISKADLEKTVGKPVDTVP
CEEEEECCCCCCCEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCC
QIFIDQDHIGGCTEFEAYAKENLGLFD
EEEECCCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]