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The map label for this gene is folM [H]

Identifier: 218709739

GI number: 218709739

Start: 1872581

End: 1873297

Strand: Direct

Name: folM [H]

Synonym: VS_1751

Alternate gene names: 218709739

Gene position: 1872581-1873297 (Clockwise)

Preceding gene: 218709738

Following gene: 218709743

Centisome position: 56.76

GC content: 46.44

Gene sequence:

>717_bases
ATGAGTGAAACAATCCTGATAACCGGCGTGGGAAAGCGACTCGGATTCGCACTGGCGCAGCAACTTTTAGCGGATGGATA
CAATGTGGTTGGCACTTACCGCAACGACTATCCTCAATTGCAACTGTTGCGCGACAGTGGAGCCGACTTGCAGCAAGTAG
ACTTTTATCAACAAAGCAGCCTAGAGGGCTTTCTTGATTATGTTGGTCAAGAATATAAGACACTCAGAGCCGTCATACAC
AACGCTTCGGACTGGAAACCTGAGAGCAAGAAAGATCCCAGTGACAATGCATCCCAAATCATGCACCAGATGATGACGAT
TCACGCTACCGTGCCTTATCTGTTCAATTTAACACTCAAAGACCAACTGATGTCTGGCGATGAAACTTCAGACATCATCC
ACATCAGTGATTACGTTGCGGAAAAAGGCAGTAAAAAACACATCGCTTACGCGGCCAGTAAAGCTGCGCTCAACAACCTA
ACGCTGTCGTTTTCAGCGATGCTGGCTCCCAAGGTCAAAGTAAATACCCTCTCTCCAGCCATGATTAAGTTTAATGAACA
TGACGATGAGGCATACAAAACCAAAGCGCTGAAGAAAGCTCTGATTCCCACAGAAGCGGGCTTTGAGGAAATAATCGATG
GCATCAAGTTTGTGTTGGCCAGTCACTACATGACAGGAAGAACCTTACACCTAGATGGCGGCAGACATTTGAAGTAA

Upstream 100 bases:

>100_bases
TTAAATCCAGAGGCGTCATGGATGCAAACTCTGAAACCTCAACGACTGCACTCGGTGGCATTTTCAAAACTAACCCTCAA
ACCAGAGCTGAGTTTTTACG

Downstream 100 bases:

>100_bases
TGCGCTTACATTGTCTGCTACCTAAAACGGCTGCTATATAGCGAATGCGGTTAACTAGGAACCGCTATAAGCTAGAAATT
CTTATAACCTAGAAACTGCT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: DHFR [H]

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSETILITGVGKRLGFALAQQLLADGYNVVGTYRNDYPQLQLLRDSGADLQQVDFYQQSSLEGFLDYVGQEYKTLRAVIH
NASDWKPESKKDPSDNASQIMHQMMTIHATVPYLFNLTLKDQLMSGDETSDIIHISDYVAEKGSKKHIAYAASKAALNNL
TLSFSAMLAPKVKVNTLSPAMIKFNEHDDEAYKTKALKKALIPTEAGFEEIIDGIKFVLASHYMTGRTLHLDGGRHLK

Sequences:

>Translated_238_residues
MSETILITGVGKRLGFALAQQLLADGYNVVGTYRNDYPQLQLLRDSGADLQQVDFYQQSSLEGFLDYVGQEYKTLRAVIH
NASDWKPESKKDPSDNASQIMHQMMTIHATVPYLFNLTLKDQLMSGDETSDIIHISDYVAEKGSKKHIAYAASKAALNNL
TLSFSAMLAPKVKVNTLSPAMIKFNEHDDEAYKTKALKKALIPTEAGFEEIIDGIKFVLASHYMTGRTLHLDGGRHLK
>Mature_237_residues
SETILITGVGKRLGFALAQQLLADGYNVVGTYRNDYPQLQLLRDSGADLQQVDFYQQSSLEGFLDYVGQEYKTLRAVIHN
ASDWKPESKKDPSDNASQIMHQMMTIHATVPYLFNLTLKDQLMSGDETSDIIHISDYVAEKGSKKHIAYAASKAALNNLT
LSFSAMLAPKVKVNTLSPAMIKFNEHDDEAYKTKALKKALIPTEAGFEEIIDGIKFVLASHYMTGRTLHLDGGRHLK

Specific function: Catalyzes the reduction of dihydrofolate to tetrahydrofolate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787891, Length=235, Percent_Identity=46.8085106382979, Blast_Score=215, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.5.1.3 [H]

Molecular weight: Translated: 26500; Mature: 26368

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETILITGVGKRLGFALAQQLLADGYNVVGTYRNDYPQLQLLRDSGADLQQVDFYQQSS
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHH
LEGFLDYVGQEYKTLRAVIHNASDWKPESKKDPSDNASQIMHQMMTIHATVPYLFNLTLK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEHH
DQLMSGDETSDIIHISDYVAEKGSKKHIAYAASKAALNNLTLSFSAMLAPKVKVNTLSPA
HHHCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHEEEEHHHHCCCEEEECCCCE
MIKFNEHDDEAYKTKALKKALIPTEAGFEEIIDGIKFVLASHYMTGRTLHLDGGRHLK
EEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
SETILITGVGKRLGFALAQQLLADGYNVVGTYRNDYPQLQLLRDSGADLQQVDFYQQSS
CCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHH
LEGFLDYVGQEYKTLRAVIHNASDWKPESKKDPSDNASQIMHQMMTIHATVPYLFNLTLK
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEHH
DQLMSGDETSDIIHISDYVAEKGSKKHIAYAASKAALNNLTLSFSAMLAPKVKVNTLSPA
HHHCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHEEEEHHHHCCCEEEECCCCE
MIKFNEHDDEAYKTKALKKALIPTEAGFEEIIDGIKFVLASHYMTGRTLHLDGGRHLK
EEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA