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The map label for this gene is sbcB [H]

Identifier: 218709702

GI number: 218709702

Start: 1840269

End: 1841693

Strand: Direct

Name: sbcB [H]

Synonym: VS_1713

Alternate gene names: 218709702

Gene position: 1840269-1841693 (Clockwise)

Preceding gene: 218709701

Following gene: 218709703

Centisome position: 55.78

GC content: 47.16

Gene sequence:

>1425_bases
ATGAGTTCAGATAATCAGCCGACCTACTTCTTTTTCGATTACGAAACGTGGGGCGTTAGCCCAGCAAAAGACCGTCCGAG
TCAGTTTGCGGGTGTTCGTACCGACCAAGATTTCAATGTTATTGGAGAGCCTCTGGTTATCTATTGCCAACCTCCTGCTG
ATTACCTCCCTGCGCCTGAAGCTGCGTTGATCACCCGTATCACACCACAGAAAGCGGCTTCACAAGGTCTCCCTGAGCCA
GAGTTTATCGCTAAGATCCATGCTGAGTTGGCGAGACCAAACACCACAAGCCTTGGCTACAACAGTATCCGATTCGATGA
TGAAGTAACGCGTTACACCTGTTACCGAAATTTCATTGACCCATATGCGTGGAGCTGGCAGAACGGCAACTCACGTTGGG
ATCTATTAGATGTAATGCGCGCTGTTCACGCACTGCGCCCTGAAGGCATTGTTTGGCCAGAGAACGAAGAAGGTTATCCA
AGTTTCAAACTGGAACACCTATCTGTGGCAAACGGCATTGAACACGAGAACGCGCACGATGCGATGGCCGATGTTATTGC
GACCATCGAGTTAGCAAAGAAGCTTAAAGCTGCACAACCTAAGATGTTCGATTACCTTTACAACATGCGTCATAAGCGTA
AGCTAAATGACCTAGTTGATATCGTAAACATGACACCATTGATGCACGTTTCGGGCATGTTTGGCCGTGACTGCAACTAC
ACAAGCTGGATTGTGCCTATGGCTTGGCACCCAACTAATCAAAATGCGGTTATCGTGGTTGATTTAGCTAAAGATCCAAG
CCCACTACTAGAACTGGACGCTGATGAACTCAGAGACAGACTCTACACCAAACGCAGTGAACTGAGTGAAGACGAGCTAC
CCGTACCCATCAAATTGGTTCAACTGAACAAGTGCCCTATTCTTGCTCCAGCCAAAACGCTGACGGCTGAAAATGCCGAA
ACCATCGGTATCGATCGCCAACAATGCTTGAAGAACTTGGCACTGCTGCGCGAACATCCAGAGATCCGCGAAAAACTCAT
TGGCCTGTACTCTCAAGAGCGCGAGTACGAAAAGAGTGATGATGTTGATACCCACCTTTACGACGGTTTCTTTTCACCTG
CTGATAAAACAGCGATGAACATCATTCGTGAAACTGACCCGAACAACTTGGCAGCTTTGGATATCACCTTCAGTGACGAA
CGTATTAAACCGTTACTGTTCCGTTACCGTGCACGTAACTTCCCATGGACGCTCGACGAAGCTGAGCAATTGAAATGGGC
AAACCATTGTCGTGAGTTTTATGAATGCCGTTTAGAAGAGTACATGCTCAACCTTGAAAACCTCGCGCACGAACATGAAA
GTGACGAGAAGAAAATGGCTATCTTGAAGGCGGTTTATCAATACGTAGAAAAGTTAGCTAGTTAA

Upstream 100 bases:

>100_bases
TTGTGATCTGGGTTGCACGCGTACCGCATACTATCAGATACTGAACAAAACTAACCTTCAGCCACAGTAAACGTTCTGCG
CTTGCTGTTCAGGAATTTCA

Downstream 100 bases:

>100_bases
TTCCATTATCAAGAGACGTAACACTTTGAAAGAAAGATTGATCCAACTGGTTTACTGCTTAATCTCCTTCACCTTAATCA
TAGGTGCACTTACAGTAGGT

Product: exonuclease I

Products: NA

Alternate protein names: Exonuclease I; DNA deoxyribophosphodiesterase; dRPase [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSSDNQPTYFFFDYETWGVSPAKDRPSQFAGVRTDQDFNVIGEPLVIYCQPPADYLPAPEAALITRITPQKAASQGLPEP
EFIAKIHAELARPNTTSLGYNSIRFDDEVTRYTCYRNFIDPYAWSWQNGNSRWDLLDVMRAVHALRPEGIVWPENEEGYP
SFKLEHLSVANGIEHENAHDAMADVIATIELAKKLKAAQPKMFDYLYNMRHKRKLNDLVDIVNMTPLMHVSGMFGRDCNY
TSWIVPMAWHPTNQNAVIVVDLAKDPSPLLELDADELRDRLYTKRSELSEDELPVPIKLVQLNKCPILAPAKTLTAENAE
TIGIDRQQCLKNLALLREHPEIREKLIGLYSQEREYEKSDDVDTHLYDGFFSPADKTAMNIIRETDPNNLAALDITFSDE
RIKPLLFRYRARNFPWTLDEAEQLKWANHCREFYECRLEEYMLNLENLAHEHESDEKKMAILKAVYQYVEKLAS

Sequences:

>Translated_474_residues
MSSDNQPTYFFFDYETWGVSPAKDRPSQFAGVRTDQDFNVIGEPLVIYCQPPADYLPAPEAALITRITPQKAASQGLPEP
EFIAKIHAELARPNTTSLGYNSIRFDDEVTRYTCYRNFIDPYAWSWQNGNSRWDLLDVMRAVHALRPEGIVWPENEEGYP
SFKLEHLSVANGIEHENAHDAMADVIATIELAKKLKAAQPKMFDYLYNMRHKRKLNDLVDIVNMTPLMHVSGMFGRDCNY
TSWIVPMAWHPTNQNAVIVVDLAKDPSPLLELDADELRDRLYTKRSELSEDELPVPIKLVQLNKCPILAPAKTLTAENAE
TIGIDRQQCLKNLALLREHPEIREKLIGLYSQEREYEKSDDVDTHLYDGFFSPADKTAMNIIRETDPNNLAALDITFSDE
RIKPLLFRYRARNFPWTLDEAEQLKWANHCREFYECRLEEYMLNLENLAHEHESDEKKMAILKAVYQYVEKLAS
>Mature_473_residues
SSDNQPTYFFFDYETWGVSPAKDRPSQFAGVRTDQDFNVIGEPLVIYCQPPADYLPAPEAALITRITPQKAASQGLPEPE
FIAKIHAELARPNTTSLGYNSIRFDDEVTRYTCYRNFIDPYAWSWQNGNSRWDLLDVMRAVHALRPEGIVWPENEEGYPS
FKLEHLSVANGIEHENAHDAMADVIATIELAKKLKAAQPKMFDYLYNMRHKRKLNDLVDIVNMTPLMHVSGMFGRDCNYT
SWIVPMAWHPTNQNAVIVVDLAKDPSPLLELDADELRDRLYTKRSELSEDELPVPIKLVQLNKCPILAPAKTLTAENAET
IGIDRQQCLKNLALLREHPEIREKLIGLYSQEREYEKSDDVDTHLYDGFFSPADKTAMNIIRETDPNNLAALDITFSDER
IKPLLFRYRARNFPWTLDEAEQLKWANHCREFYECRLEEYMLNLENLAHEHESDEKKMAILKAVYQYVEKLAS

Specific function: Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase [H]

COG id: COG2925

COG function: function code L; Exonuclease I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788321, Length=468, Percent_Identity=58.974358974359, Blast_Score=579, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013620
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF08411 Exonuc_X-T_C [H]

EC number: =3.1.11.1 [H]

Molecular weight: Translated: 54708; Mature: 54577

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDNQPTYFFFDYETWGVSPAKDRPSQFAGVRTDQDFNVIGEPLVIYCQPPADYLPAPE
CCCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
AALITRITPQKAASQGLPEPEFIAKIHAELARPNTTSLGYNSIRFDDEVTRYTCYRNFID
HHHEEECCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCC
PYAWSWQNGNSRWDLLDVMRAVHALRPEGIVWPENEEGYPSFKLEHLSVANGIEHENAHD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCCHHH
AMADVIATIELAKKLKAAQPKMFDYLYNMRHKRKLNDLVDIVNMTPLMHVSGMFGRDCNY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCC
TSWIVPMAWHPTNQNAVIVVDLAKDPSPLLELDADELRDRLYTKRSELSEDELPVPIKLV
CEEEEEEEECCCCCCEEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
QLNKCPILAPAKTLTAENAETIGIDRQQCLKNLALLREHPEIREKLIGLYSQEREYEKSD
EECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DVDTHLYDGFFSPADKTAMNIIRETDPNNLAALDITFSDERIKPLLFRYRARNFPWTLDE
CCCHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCH
AEQLKWANHCREFYECRLEEYMLNLENLAHEHESDEKKMAILKAVYQYVEKLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSDNQPTYFFFDYETWGVSPAKDRPSQFAGVRTDQDFNVIGEPLVIYCQPPADYLPAPE
CCCCCCEEEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
AALITRITPQKAASQGLPEPEFIAKIHAELARPNTTSLGYNSIRFDDEVTRYTCYRNFID
HHHEEECCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCC
PYAWSWQNGNSRWDLLDVMRAVHALRPEGIVWPENEEGYPSFKLEHLSVANGIEHENAHD
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHHHHHCCCCCCCHHH
AMADVIATIELAKKLKAAQPKMFDYLYNMRHKRKLNDLVDIVNMTPLMHVSGMFGRDCNY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCC
TSWIVPMAWHPTNQNAVIVVDLAKDPSPLLELDADELRDRLYTKRSELSEDELPVPIKLV
CEEEEEEEECCCCCCEEEEEECCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
QLNKCPILAPAKTLTAENAETIGIDRQQCLKNLALLREHPEIREKLIGLYSQEREYEKSD
EECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DVDTHLYDGFFSPADKTAMNIIRETDPNNLAALDITFSDERIKPLLFRYRARNFPWTLDE
CCCHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCH
AEQLKWANHCREFYECRLEEYMLNLENLAHEHESDEKKMAILKAVYQYVEKLAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3539937; 9097040; 9278503; 1329027 [H]