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The map label for this gene is metA [H]

Identifier: 218709666

GI number: 218709666

Start: 1803533

End: 1804474

Strand: Direct

Name: metA [H]

Synonym: VS_1677

Alternate gene names: 218709666

Gene position: 1803533-1804474 (Clockwise)

Preceding gene: 218709663

Following gene: 218709667

Centisome position: 54.66

GC content: 44.37

Gene sequence:

>942_bases
TTGCCTATTCGCATTCCAGACCAATTGCCAGCATCTGATGTTCTTCGTGAAGAAAACATCTTTATTATGCCGTTATCAAG
AGCATCGACACAGGAAATTCGTCCACTTCGAGTCTTGATCCTCAACCTAATGCCAAAGAAGATTGAAACTGAAACTCAAT
TCTTGCGCCTACTATCCAACAGCCCATTGCAAGTCGATGTAGAGCTGTTGCGTATTGATGACCGACCAAGTAAAAACACG
CCGACAGAACACCTTGATAACTTCTACCGTCAATTTGAAATGGTCAAAGGGAGAAACTTTGATGGATTGATCATCACTGG
TGCGCCACTTGGCTTGGTTCAATTTGAAGACGTTATCTACTGGGATCATCTAAAAACCATCATGGAATGGGCAAACAAGC
ATGTTACCTCAACCTTGTATGTGTGTTGGGCTGCTCAAGCTGGCTTAAAGCTCTTGTATGATTTACCAAAGCGAACTCGT
AAAGATAAGCTTTCTGGGGTTTACAACCACGAGATACATAACCCGTACCACCCAATTTTACGTGGCTTCGACGATACCTT
CTTGGCACCGCACTCTCGCTATGCTGATTTCTCTCAGGAATACTTAGCCGAGCATACCGACCTTGATGTTCTTGCGACTT
CTGATGTAGCGGGCGTATACCTTGCGGCAACCAAAGATAAGCGAAACGTGTTTGTAACCGGTCACCCTGAATACGATGCT
CATACACTTCACAACGAATACATTCGTGATTTGGGTGAAGGCATGGAGCCTGTGATACCAATCAACTACTACCCGAACAA
CAATCCAGACAACAAGCCTGTAGCAAGTTGGCGTAGTCATGGACACTTATTGTTTTCAAACTGGCTAAACTACTGTGTTT
ACCAACAAACGCCTTACGATCTGGATCACTTCAGCGAAGACAACTTCACCAAGGACGACTAA

Upstream 100 bases:

>100_bases
AAATAATTTACAACTATCCATTTTGTATATCGACAAGCGTATCAAACTACTATAGATTTAGATGTATAGACGTCTACATA
TCTAGCTTAGGGAGAAAGCT

Downstream 100 bases:

>100_bases
GTTCTTTCTTCCGATTCACAAACACATTAAGCCGTCTTCCATAGGTTGTTGATAAAACACCAAATGGGACACGGCTTTTT
TATGGTGTTTGGGTCGCATT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPIRIPDQLPASDVLREENIFIMPLSRASTQEIRPLRVLILNLMPKKIETETQFLRLLSNSPLQVDVELLRIDDRPSKNT
PTEHLDNFYRQFEMVKGRNFDGLIITGAPLGLVQFEDVIYWDHLKTIMEWANKHVTSTLYVCWAAQAGLKLLYDLPKRTR
KDKLSGVYNHEIHNPYHPILRGFDDTFLAPHSRYADFSQEYLAEHTDLDVLATSDVAGVYLAATKDKRNVFVTGHPEYDA
HTLHNEYIRDLGEGMEPVIPINYYPNNNPDNKPVASWRSHGHLLFSNWLNYCVYQQTPYDLDHFSEDNFTKDD

Sequences:

>Translated_313_residues
MPIRIPDQLPASDVLREENIFIMPLSRASTQEIRPLRVLILNLMPKKIETETQFLRLLSNSPLQVDVELLRIDDRPSKNT
PTEHLDNFYRQFEMVKGRNFDGLIITGAPLGLVQFEDVIYWDHLKTIMEWANKHVTSTLYVCWAAQAGLKLLYDLPKRTR
KDKLSGVYNHEIHNPYHPILRGFDDTFLAPHSRYADFSQEYLAEHTDLDVLATSDVAGVYLAATKDKRNVFVTGHPEYDA
HTLHNEYIRDLGEGMEPVIPINYYPNNNPDNKPVASWRSHGHLLFSNWLNYCVYQQTPYDLDHFSEDNFTKDD
>Mature_312_residues
PIRIPDQLPASDVLREENIFIMPLSRASTQEIRPLRVLILNLMPKKIETETQFLRLLSNSPLQVDVELLRIDDRPSKNTP
TEHLDNFYRQFEMVKGRNFDGLIITGAPLGLVQFEDVIYWDHLKTIMEWANKHVTSTLYVCWAAQAGLKLLYDLPKRTRK
DKLSGVYNHEIHNPYHPILRGFDDTFLAPHSRYADFSQEYLAEHTDLDVLATSDVAGVYLAATKDKRNVFVTGHPEYDAH
TLHNEYIRDLGEGMEPVIPINYYPNNNPDNKPVASWRSHGHLLFSNWLNYCVYQQTPYDLDHFSEDNFTKDD

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family [H]

Homologues:

Organism=Escherichia coli, GI1790443, Length=305, Percent_Identity=65.2459016393443, Blast_Score=431, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005697
- ProDom:   PD037892 [H]

Pfam domain/function: PF04204 HTS [H]

EC number: =2.3.1.46 [H]

Molecular weight: Translated: 36371; Mature: 36240

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRIPDQLPASDVLREENIFIMPLSRASTQEIRPLRVLILNLMPKKIETETQFLRLLSN
CCCCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
SPLQVDVELLRIDDRPSKNTPTEHLDNFYRQFEMVKGRNFDGLIITGAPLGLVQFEDVIY
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHHH
WDHLKTIMEWANKHVTSTLYVCWAAQAGLKLLYDLPKRTRKDKLSGVYNHEIHNPYHPIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHH
RGFDDTFLAPHSRYADFSQEYLAEHTDLDVLATSDVAGVYLAATKDKRNVFVTGHPEYDA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCEEEEECCCCCCH
HTLHNEYIRDLGEGMEPVIPINYYPNNNPDNKPVASWRSHGHLLFSNWLNYCVYQQTPYD
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEHHHHHHHEEECCCCCC
LDHFSEDNFTKDD
HHHCCCCCCCCCC
>Mature Secondary Structure 
PIRIPDQLPASDVLREENIFIMPLSRASTQEIRPLRVLILNLMPKKIETETQFLRLLSN
CCCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
SPLQVDVELLRIDDRPSKNTPTEHLDNFYRQFEMVKGRNFDGLIITGAPLGLVQFEDVIY
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEHHHHHH
WDHLKTIMEWANKHVTSTLYVCWAAQAGLKLLYDLPKRTRKDKLSGVYNHEIHNPYHPIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHH
RGFDDTFLAPHSRYADFSQEYLAEHTDLDVLATSDVAGVYLAATKDKRNVFVTGHPEYDA
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCEEEEECCCCCCH
HTLHNEYIRDLGEGMEPVIPINYYPNNNPDNKPVASWRSHGHLLFSNWLNYCVYQQTPYD
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEHHHHHHHEEECCCCCC
LDHFSEDNFTKDD
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]