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The map label for this gene is aslA [H]

Identifier: 218709629

GI number: 218709629

Start: 1759810

End: 1761357

Strand: Direct

Name: aslA [H]

Synonym: VS_1639

Alternate gene names: 218709629

Gene position: 1759810-1761357 (Clockwise)

Preceding gene: 218709622

Following gene: 218709632

Centisome position: 53.34

GC content: 46.38

Gene sequence:

>1548_bases
TTGACTAAATTAACCAAAACCGTGTTAGCAATGAGCGCACTCAGCGTTGCTCAAGGCGTCGCTGCGGCAGACCAACCGAA
CATTCTTGCTATCTGGGCAGATGATCTTGGTTACTACAACACTAGCGCATACAACCGTGGAATGATGGGCTACGAAACGC
CGAACATCGATCGTATTGCTAATGAGGGTGCTATTTTTACGGATATGTACGCACAACAATCTTGTACGGCTGGCCGTGCT
TCGTTCGTGACGGGTCAACACCCATTCCGTACCGGCCTACTTACTATCGGTATGCCAGGTTCTTCGCATGGTATTCCTGA
CTGGGCTCCTACCATTGGTGATGCTCTTAAAGAAGAAGGTTACGCGACGGCACAATTCGGTAAAAATCACTTAGGCGATC
AAGACAAACACCTTCCTACAAACCATGGTTTTGATGAGTTCTTTGGTAACCTTTACCACTTAAACGCGGAAGAAGAGCCT
GAAACCTACTTTTATCCTAAAGACCCAGAATTCAGAAAGAACTACGGGCCTCGTGGCGTTATTAAAGCAACCTCTGATGG
CAAAATCGAAGATACGGGTCCACTGACTCGCGCTCGTATGGAAAACATCGATGAGGACTTTACCGAAGCGGCTATCACGT
TCATGGAGAAATCTGTAAAAGAAGATAAGCCGTTCTTTATCTGGTACAACTCGACTCGTATGCACGTTTGGACTCGTCTG
AACGAACATTACAGCGGCATTTCTGGTCAAGGCATCTATGCAGATGGTATGGCTCAATTAGACGACAACGTTGGCGCACT
ACTAGATACTCTTGAACGCTTAGAGGTTGCTGACAACACTATTGTTATCCTTTCTACTGATAACGGTGCAGAGAAGTTCA
CATGGCCTGACGGCGGTACATCTCCTTTCCACGGTGAAAAAGGCACAACTTACGAAGGCGGCATGCGTGTTCCACAAATC
GTGAAATGGCCTGGTGTAATCGAACCTGGCTCTGCGGTTAACGCGCTAATGTCTCAAGAAGACTGGTTACCGACACTAGC
TGCTGCTGCCGGTAATGACTCTATCGTTGAAGACCTTAAAGAAGGTGTTTCTCTAAATAATACAGATTGGCGTGTTCACT
TAGATGGCTCGAACTTTATGCCATATTTTGAAGGAGAGGCTGAAAAGTCACCCCGTGAAACTATCTTCTACTTCTCTGCA
AACGGTGACTTCAATGCGCTTCGTTGGAACGATTGGAAAGCAAGCTTCGCTATGATGGAAGGCACAATGCAATCGGCTAT
CCGTCAAGCTCCTGCTTGGGCTTCAATTACAAACCTACGTATGGACCCGTTTGAAACCGCAGCGAAAGAATCTGGCATGT
ACACTCGTTGGATGGTAGACAACATGTGGTTATTCGTACCAATGTCTCAAGAAGTGATTAAGTTCATGGGCTCTCTAAAC
GATTACCCAATGCAACAAGGCCAAGGCTTCAGTGCCGCAGAGATCAATTACAACACGCTAAAAATGCAAAAGCTGATTCA
GCAGATGCAAGCACAAAACGCGAAATAG

Upstream 100 bases:

>100_bases
TCCTCTAAGTAACTAGAATTCATACCCAGTAGTCCTCTGAGTTAATACAAAATTGGTATTTTCTTTCTAAACAAATAGAA
ACTAAAGAAAGGACATTACC

Downstream 100 bases:

>100_bases
CGGAGCAAGGGTTAAACAGCGAAGCAACAGCTAGATAACCTGGCTACCGACCATTAAAGATAACTGACTAATTAAAGCCC
CATTGGGGCTTTTTTTGTGA

Product: arylsulfatase A

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTKLTKTVLAMSALSVAQGVAAADQPNILAIWADDLGYYNTSAYNRGMMGYETPNIDRIANEGAIFTDMYAQQSCTAGRA
SFVTGQHPFRTGLLTIGMPGSSHGIPDWAPTIGDALKEEGYATAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEP
ETYFYPKDPEFRKNYGPRGVIKATSDGKIEDTGPLTRARMENIDEDFTEAAITFMEKSVKEDKPFFIWYNSTRMHVWTRL
NEHYSGISGQGIYADGMAQLDDNVGALLDTLERLEVADNTIVILSTDNGAEKFTWPDGGTSPFHGEKGTTYEGGMRVPQI
VKWPGVIEPGSAVNALMSQEDWLPTLAAAAGNDSIVEDLKEGVSLNNTDWRVHLDGSNFMPYFEGEAEKSPRETIFYFSA
NGDFNALRWNDWKASFAMMEGTMQSAIRQAPAWASITNLRMDPFETAAKESGMYTRWMVDNMWLFVPMSQEVIKFMGSLN
DYPMQQGQGFSAAEINYNTLKMQKLIQQMQAQNAK

Sequences:

>Translated_515_residues
MTKLTKTVLAMSALSVAQGVAAADQPNILAIWADDLGYYNTSAYNRGMMGYETPNIDRIANEGAIFTDMYAQQSCTAGRA
SFVTGQHPFRTGLLTIGMPGSSHGIPDWAPTIGDALKEEGYATAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEP
ETYFYPKDPEFRKNYGPRGVIKATSDGKIEDTGPLTRARMENIDEDFTEAAITFMEKSVKEDKPFFIWYNSTRMHVWTRL
NEHYSGISGQGIYADGMAQLDDNVGALLDTLERLEVADNTIVILSTDNGAEKFTWPDGGTSPFHGEKGTTYEGGMRVPQI
VKWPGVIEPGSAVNALMSQEDWLPTLAAAAGNDSIVEDLKEGVSLNNTDWRVHLDGSNFMPYFEGEAEKSPRETIFYFSA
NGDFNALRWNDWKASFAMMEGTMQSAIRQAPAWASITNLRMDPFETAAKESGMYTRWMVDNMWLFVPMSQEVIKFMGSLN
DYPMQQGQGFSAAEINYNTLKMQKLIQQMQAQNAK
>Mature_514_residues
TKLTKTVLAMSALSVAQGVAAADQPNILAIWADDLGYYNTSAYNRGMMGYETPNIDRIANEGAIFTDMYAQQSCTAGRAS
FVTGQHPFRTGLLTIGMPGSSHGIPDWAPTIGDALKEEGYATAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEPE
TYFYPKDPEFRKNYGPRGVIKATSDGKIEDTGPLTRARMENIDEDFTEAAITFMEKSVKEDKPFFIWYNSTRMHVWTRLN
EHYSGISGQGIYADGMAQLDDNVGALLDTLERLEVADNTIVILSTDNGAEKFTWPDGGTSPFHGEKGTTYEGGMRVPQIV
KWPGVIEPGSAVNALMSQEDWLPTLAAAAGNDSIVEDLKEGVSLNNTDWRVHLDGSNFMPYFEGEAEKSPRETIFYFSAN
GDFNALRWNDWKASFAMMEGTMQSAIRQAPAWASITNLRMDPFETAAKESGMYTRWMVDNMWLFVPMSQEVIKFMGSLND
YPMQQGQGFSAAEINYNTLKMQKLIQQMQAQNAK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=424, Percent_Identity=33.2547169811321, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI146229329, Length=424, Percent_Identity=33.2547169811321, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI6005990, Length=424, Percent_Identity=33.2547169811321, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI146229324, Length=424, Percent_Identity=33.2547169811321, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4503899, Length=384, Percent_Identity=32.5520833333333, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI58743319, Length=467, Percent_Identity=29.1220556745182, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI45430057, Length=354, Percent_Identity=29.0960451977401, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI146229327, Length=350, Percent_Identity=31.1428571428571, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI109389362, Length=418, Percent_Identity=28.4688995215311, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI38569407, Length=342, Percent_Identity=29.8245614035088, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI38569405, Length=340, Percent_Identity=29.7058823529412, Blast_Score=116, Evalue=7e-26,
Organism=Homo sapiens, GI59797060, Length=410, Percent_Identity=26.0975609756098, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI53831991, Length=228, Percent_Identity=29.3859649122807, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI157266309, Length=146, Percent_Identity=41.0958904109589, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI71852586, Length=153, Percent_Identity=37.9084967320261, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71852584, Length=153, Percent_Identity=37.9084967320261, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI31742482, Length=251, Percent_Identity=24.7011952191235, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1790233, Length=487, Percent_Identity=29.7741273100616, Blast_Score=195, Evalue=7e-51,
Organism=Escherichia coli, GI87081924, Length=439, Percent_Identity=23.6902050113895, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI115533416, Length=353, Percent_Identity=27.7620396600567, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI115533418, Length=339, Percent_Identity=27.1386430678466, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17559078, Length=278, Percent_Identity=28.4172661870504, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281366397, Length=402, Percent_Identity=29.1044776119403, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281366395, Length=402, Percent_Identity=29.1044776119403, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24666163, Length=402, Percent_Identity=29.1044776119403, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24666109, Length=418, Percent_Identity=27.9904306220096, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24666175, Length=408, Percent_Identity=28.921568627451, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI281363223, Length=144, Percent_Identity=31.9444444444444, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57394; Mature: 57263

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLTKTVLAMSALSVAQGVAAADQPNILAIWADDLGYYNTSAYNRGMMGYETPNIDRIA
CCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCHHHHH
NEGAIFTDMYAQQSCTAGRASFVTGQHPFRTGLLTIGMPGSSHGIPDWAPTIGDALKEEG
CCCCEEEHHHHHHCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
YATAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEPETYFYPKDPEFRKNYGPRGV
CEEHHHCHHHCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCEECCCCCCHHHCCCCCCE
IKATSDGKIEDTGPLTRARMENIDEDFTEAAITFMEKSVKEDKPFFIWYNSTRMHVWTRL
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEH
NEHYSGISGQGIYADGMAQLDDNVGALLDTLERLEVADNTIVILSTDNGAEKFTWPDGGT
HHHHCCCCCCCEEECCHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCC
SPFHGEKGTTYEGGMRVPQIVKWPGVIEPGSAVNALMSQEDWLPTLAAAAGNDSIVEDLK
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCHHHHHHHH
EGVSLNNTDWRVHLDGSNFMPYFEGEAEKSPRETIFYFSANGDFNALRWNDWKASFAMME
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCHHHHHHHHH
GTMQSAIRQAPAWASITNLRMDPFETAAKESGMYTRWMVDNMWLFVPMSQEVIKFMGSLN
HHHHHHHHHCCCCHHHHCCCCCHHHHHHHHCCCEEEEEECCEEEEEECHHHHHHHHHCCC
DYPMQQGQGFSAAEINYNTLKMQKLIQQMQAQNAK
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKLTKTVLAMSALSVAQGVAAADQPNILAIWADDLGYYNTSAYNRGMMGYETPNIDRIA
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHCCCCCCCCCCCHHHHH
NEGAIFTDMYAQQSCTAGRASFVTGQHPFRTGLLTIGMPGSSHGIPDWAPTIGDALKEEG
CCCCEEEHHHHHHCCCCCCCEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
YATAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEPETYFYPKDPEFRKNYGPRGV
CEEHHHCHHHCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCEECCCCCCHHHCCCCCCE
IKATSDGKIEDTGPLTRARMENIDEDFTEAAITFMEKSVKEDKPFFIWYNSTRMHVWTRL
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEEEH
NEHYSGISGQGIYADGMAQLDDNVGALLDTLERLEVADNTIVILSTDNGAEKFTWPDGGT
HHHHCCCCCCCEEECCHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCC
SPFHGEKGTTYEGGMRVPQIVKWPGVIEPGSAVNALMSQEDWLPTLAAAAGNDSIVEDLK
CCCCCCCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHCCCCCCHHHHHHCCCHHHHHHHH
EGVSLNNTDWRVHLDGSNFMPYFEGEAEKSPRETIFYFSANGDFNALRWNDWKASFAMME
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCHHHHHHHHH
GTMQSAIRQAPAWASITNLRMDPFETAAKESGMYTRWMVDNMWLFVPMSQEVIKFMGSLN
HHHHHHHHHCCCCHHHHCCCCCHHHHHHHHCCCEEEEEECCEEEEEECHHHHHHHHHCCC
DYPMQQGQGFSAAEINYNTLKMQKLIQQMQAQNAK
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]