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The map label for this gene is cirA [H]

Identifier: 218709623

GI number: 218709623

Start: 1751109

End: 1753157

Strand: Reverse

Name: cirA [H]

Synonym: VS_1633

Alternate gene names: 218709623

Gene position: 1753157-1751109 (Counterclockwise)

Preceding gene: 218709624

Following gene: 218709620

Centisome position: 53.14

GC content: 45.1

Gene sequence:

>2049_bases
ATGTCTGAGAAATCTCTTTTGATTCGCAAGCCTCTTTTAGTTCGCAAACCTCTTATGATTCGTAAACCCCTTTCGGTCGC
AGTAGCTGTTATTTGCACCTCACTATCGGCTAACGTGTTAGCGCAAAAAGAAGCGCAAGCGACAGATGAGCAAATGGTTG
TTACGGCAACTCGTACTGAAATGGCTCTAAAACAAGCGCCAGCTTCAATGTCGGTTATCACCGCTCAAGACATCGAAGAC
AGCCCTGGAATCACTTTGGCTGACATCGTTGCAGAATCAACGAGTGTGGAATCTGATTTTGATAGCACACGTGCTGGCCG
TCAGATGATCTCTATTCGTGGTATGGATTCAGACTATACGCTTATCATGGTGAATGGCCGTCGCTTAAGCTCTGCAAGTG
CCATCATTCGTGGTAACGATTTCGATCTCTCGACTATTCCAGCTGAGTCAATCGAACGTGTTGAAATCATCCGCGGCCCA
ATGTCTGCACTTTACGGTTCAGATGGTATGGGTGGCACAATCAACATCATCACCAAAGCTCCAGAAAATGATTGGAGCTC
AACGATTAACATGGACACTTCATCTCCATTAGACGGAGATGGTGGGGAAGAATATTCTGTTGGTTTTACCACGTCCGGTG
CACTAATTGATGATGAGTTATTTGCGCGTTTTTCTTTAAATCAAACCTCGCGTGACGCATGGCAACCATATACAGGTAAT
GGTCGTGAGAATATTACCGCTCTAGAGGAACGCGACACTTTAAGTTTGCTTGCCAACCTGACATGGAATATGACAGACAA
TCAGACGATTGATTTGGACCTTGGCTATAGTGACGATAAACGTGATGGTTTAGCAGAACACGCTACAGGTTCGAACCTAG
TGGATAGTAATGTTGTACGTAACAGTCAAGCGATTACACACAGCGGTTTTTGGAACTGGGGTGACACACAAGTTCGTTAC
TCTCGTGAAAACGTGACAGACAACGATGCCGCTGATCTAGGTAACAATTACAGTAGCGATGTAGAAGAGCTAACTCAAAT
AGTAGAAGCGTCAGCAACGACTTATCTTGGTGATAGTCACACCGTAACTTTTGGTATGGACTACCAGTTGAGCGAATTAA
CCAACAAAGAAAACTTGATCAACGGTACATCAGAAGCGTATCAAGGTGCTTTGTTTGTTCAAGACCAGTGGTTGATGACT
GAACAACTCACCGCAACCATTGGTGGACGTTTAGATAAGCACGAATTGTACGGTGAAGAATTCAGCCCGCGTGTGTACTT
AGTTCACCAAACGACTAATGACCTCATCATCAAAGGTGGTGTAGGTAAGGCTTTCAAAGCACCTTCGCTGACTCAAAACC
AAGCCGACTACACAGTTAATAGCTGCAAAGGGAAGTGTGATTTGTATGGCAATGAAAACCTGAAGCCTGAAACGAGCTTG
AACTATGAAATTGCAGCAATATACAACCAACCACGTTGGAACGTTGAAGGTGCCTTGTTCCGCAACGAAATCAATGACCT
TATTGATCGCGATGAAACGTACTGCGAGAACGGCGGAGTGTTTGAATCGGGTAAAGGGTGCGCAGACACTTCTAGCTCTA
CTGGCTATGTGAAAGGGAAGCGTACTTATACCAATGTATCTGAGGCGGTGGTTCAAGGTGCCGAACTTACGGGTCAATTC
CAGATTACCGATGAGTGGGGCGTGTCTGGTAACTACACGTTCTTAGACACAGAAGATAAGTCAACGGGTGAAGAACTGCT
CGAGCGTTACAAGCATTCAGGCTTAGTTAAACTGAACTGGAGCCCAACTTTCGATCTGAATGCCTTTATTAGTGCGCGTT
ACCGTGGAGAGCGTAATATCGAAAGCGACTTAACGCAAGACGCATACACAACACTGAACATCGGTACGGTGTATAACGTT
AATGATTCTGTTCGAGTGCGTGCTGGTATCACTAACTTGACTGATGAAGCTGTATCACAAGAGCTAGAGAGTATGGGTTA
TGTTGAAGAGCCACGTACTTACTACGTAGGTATGACAGCGGACTTCTAA

Upstream 100 bases:

>100_bases
CATAATGAATTTTCAGCATGAAACTTTCGTTGATTGGAGTGATAACTGGTTGTTTAATGCAAACCATTATCATTACTAAT
TACATATAAGAATAAATATC

Downstream 100 bases:

>100_bases
TCAATCTGTGTTTGATTTGGTAGCAAGATACATATAAAAACGAAGAACCCACATTGGCTCGATACTCTATAAAGAGAACG
GCGAGTGTGGGTTGTTTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 681

Protein sequence:

>682_residues
MSEKSLLIRKPLLVRKPLMIRKPLSVAVAVICTSLSANVLAQKEAQATDEQMVVTATRTEMALKQAPASMSVITAQDIED
SPGITLADIVAESTSVESDFDSTRAGRQMISIRGMDSDYTLIMVNGRRLSSASAIIRGNDFDLSTIPAESIERVEIIRGP
MSALYGSDGMGGTINIITKAPENDWSSTINMDTSSPLDGDGGEEYSVGFTTSGALIDDELFARFSLNQTSRDAWQPYTGN
GRENITALEERDTLSLLANLTWNMTDNQTIDLDLGYSDDKRDGLAEHATGSNLVDSNVVRNSQAITHSGFWNWGDTQVRY
SRENVTDNDAADLGNNYSSDVEELTQIVEASATTYLGDSHTVTFGMDYQLSELTNKENLINGTSEAYQGALFVQDQWLMT
EQLTATIGGRLDKHELYGEEFSPRVYLVHQTTNDLIIKGGVGKAFKAPSLTQNQADYTVNSCKGKCDLYGNENLKPETSL
NYEIAAIYNQPRWNVEGALFRNEINDLIDRDETYCENGGVFESGKGCADTSSSTGYVKGKRTYTNVSEAVVQGAELTGQF
QITDEWGVSGNYTFLDTEDKSTGEELLERYKHSGLVKLNWSPTFDLNAFISARYRGERNIESDLTQDAYTTLNIGTVYNV
NDSVRVRAGITNLTDEAVSQELESMGYVEEPRTYYVGMTADF

Sequences:

>Translated_682_residues
MSEKSLLIRKPLLVRKPLMIRKPLSVAVAVICTSLSANVLAQKEAQATDEQMVVTATRTEMALKQAPASMSVITAQDIED
SPGITLADIVAESTSVESDFDSTRAGRQMISIRGMDSDYTLIMVNGRRLSSASAIIRGNDFDLSTIPAESIERVEIIRGP
MSALYGSDGMGGTINIITKAPENDWSSTINMDTSSPLDGDGGEEYSVGFTTSGALIDDELFARFSLNQTSRDAWQPYTGN
GRENITALEERDTLSLLANLTWNMTDNQTIDLDLGYSDDKRDGLAEHATGSNLVDSNVVRNSQAITHSGFWNWGDTQVRY
SRENVTDNDAADLGNNYSSDVEELTQIVEASATTYLGDSHTVTFGMDYQLSELTNKENLINGTSEAYQGALFVQDQWLMT
EQLTATIGGRLDKHELYGEEFSPRVYLVHQTTNDLIIKGGVGKAFKAPSLTQNQADYTVNSCKGKCDLYGNENLKPETSL
NYEIAAIYNQPRWNVEGALFRNEINDLIDRDETYCENGGVFESGKGCADTSSSTGYVKGKRTYTNVSEAVVQGAELTGQF
QITDEWGVSGNYTFLDTEDKSTGEELLERYKHSGLVKLNWSPTFDLNAFISARYRGERNIESDLTQDAYTTLNIGTVYNV
NDSVRVRAGITNLTDEAVSQELESMGYVEEPRTYYVGMTADF
>Mature_681_residues
SEKSLLIRKPLLVRKPLMIRKPLSVAVAVICTSLSANVLAQKEAQATDEQMVVTATRTEMALKQAPASMSVITAQDIEDS
PGITLADIVAESTSVESDFDSTRAGRQMISIRGMDSDYTLIMVNGRRLSSASAIIRGNDFDLSTIPAESIERVEIIRGPM
SALYGSDGMGGTINIITKAPENDWSSTINMDTSSPLDGDGGEEYSVGFTTSGALIDDELFARFSLNQTSRDAWQPYTGNG
RENITALEERDTLSLLANLTWNMTDNQTIDLDLGYSDDKRDGLAEHATGSNLVDSNVVRNSQAITHSGFWNWGDTQVRYS
RENVTDNDAADLGNNYSSDVEELTQIVEASATTYLGDSHTVTFGMDYQLSELTNKENLINGTSEAYQGALFVQDQWLMTE
QLTATIGGRLDKHELYGEEFSPRVYLVHQTTNDLIIKGGVGKAFKAPSLTQNQADYTVNSCKGKCDLYGNENLKPETSLN
YEIAAIYNQPRWNVEGALFRNEINDLIDRDETYCENGGVFESGKGCADTSSSTGYVKGKRTYTNVSEAVVQGAELTGQFQ
ITDEWGVSGNYTFLDTEDKSTGEELLERYKHSGLVKLNWSPTFDLNAFISARYRGERNIESDLTQDAYTTLNIGTVYNVN
DSVRVRAGITNLTDEAVSQELESMGYVEEPRTYYVGMTADF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=693, Percent_Identity=35.6421356421356, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1786798, Length=740, Percent_Identity=24.4594594594595, Blast_Score=165, Evalue=1e-41,
Organism=Escherichia coli, GI1790405, Length=663, Percent_Identity=24.132730015083, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 75075; Mature: 74943

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKSLLIRKPLLVRKPLMIRKPLSVAVAVICTSLSANVLAQKEAQATDEQMVVTATRTE
CCCCCEEEECCHHHCCCHHHCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEEHHHH
MALKQAPASMSVITAQDIEDSPGITLADIVAESTSVESDFDSTRAGRQMISIRGMDSDYT
HHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCEEEEEECCCCCEE
LIMVNGRRLSSASAIIRGNDFDLSTIPAESIERVEIIRGPMSALYGSDGMGGTINIITKA
EEEEECCEECCCEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEEEC
PENDWSSTINMDTSSPLDGDGGEEYSVGFTTSGALIDDELFARFSLNQTSRDAWQPYTGN
CCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCEECHHHHHEEECCCCCHHHCCCCCCC
GRENITALEERDTLSLLANLTWNMTDNQTIDLDLGYSDDKRDGLAEHATGSNLVDSNVVR
CCCCEEEEHHHHHHHHHHHCEECCCCCEEEEEEECCCCCCCCCCHHCCCCCCCCCHHHHC
NSQAITHSGFWNWGDTQVRYSRENVTDNDAADLGNNYSSDVEELTQIVEASATTYLGDSH
CCCEEEECCCCCCCCCEEEEECCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEECCCE
TVTFGMDYQLSELTNKENLINGTSEAYQGALFVQDQWLMTEQLTATIGGRLDKHELYGEE
EEEEECCEEHHHHCCHHHHCCCCHHHHCCEEEEECCHHHHHHHHHHHCCCCCHHHHCCCC
FSPRVYLVHQTTNDLIIKGGVGKAFKAPSLTQNQADYTVNSCKGKCDLYGNENLKPETSL
CCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCC
NYEIAAIYNQPRWNVEGALFRNEINDLIDRDETYCENGGVFESGKGCADTSSSTGYVKGK
CEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEECCCCCCCCCCCCCEEECC
RTYTNVSEAVVQGAELTGQFQITDEWGVSGNYTFLDTEDKSTGEELLERYKHSGLVKLNW
CCCCCHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEC
SPTFDLNAFISARYRGERNIESDLTQDAYTTLNIGTVYNVNDSVRVRAGITNLTDEAVSQ
CCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEEECEEEECCCCEEEEECCCCCHHHHHHH
ELESMGYVEEPRTYYVGMTADF
HHHHCCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
SEKSLLIRKPLLVRKPLMIRKPLSVAVAVICTSLSANVLAQKEAQATDEQMVVTATRTE
CCCCEEEECCHHHCCCHHHCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEEHHHH
MALKQAPASMSVITAQDIEDSPGITLADIVAESTSVESDFDSTRAGRQMISIRGMDSDYT
HHHHHCCCCEEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHCCEEEEEECCCCCEE
LIMVNGRRLSSASAIIRGNDFDLSTIPAESIERVEIIRGPMSALYGSDGMGGTINIITKA
EEEEECCEECCCEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCCEEEEEEEC
PENDWSSTINMDTSSPLDGDGGEEYSVGFTTSGALIDDELFARFSLNQTSRDAWQPYTGN
CCCCCCCEEECCCCCCCCCCCCCEEEEEEECCCCEECHHHHHEEECCCCCHHHCCCCCCC
GRENITALEERDTLSLLANLTWNMTDNQTIDLDLGYSDDKRDGLAEHATGSNLVDSNVVR
CCCCEEEEHHHHHHHHHHHCEECCCCCEEEEEEECCCCCCCCCCHHCCCCCCCCCHHHHC
NSQAITHSGFWNWGDTQVRYSRENVTDNDAADLGNNYSSDVEELTQIVEASATTYLGDSH
CCCEEEECCCCCCCCCEEEEECCCCCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEECCCE
TVTFGMDYQLSELTNKENLINGTSEAYQGALFVQDQWLMTEQLTATIGGRLDKHELYGEE
EEEEECCEEHHHHCCHHHHCCCCHHHHCCEEEEECCHHHHHHHHHHHCCCCCHHHHCCCC
FSPRVYLVHQTTNDLIIKGGVGKAFKAPSLTQNQADYTVNSCKGKCDLYGNENLKPETSL
CCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCCC
NYEIAAIYNQPRWNVEGALFRNEINDLIDRDETYCENGGVFESGKGCADTSSSTGYVKGK
CEEEEEEECCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCEEECCCCCCCCCCCCCEEECC
RTYTNVSEAVVQGAELTGQFQITDEWGVSGNYTFLDTEDKSTGEELLERYKHSGLVKLNW
CCCCCHHHHHHCCCCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEEC
SPTFDLNAFISARYRGERNIESDLTQDAYTTLNIGTVYNVNDSVRVRAGITNLTDEAVSQ
CCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEEECEEEECCCCEEEEECCCCCHHHHHHH
ELESMGYVEEPRTYYVGMTADF
HHHHCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]