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The map label for this gene is sbcD [H]

Identifier: 218709616

GI number: 218709616

Start: 1743960

End: 1745213

Strand: Reverse

Name: sbcD [H]

Synonym: VS_1626

Alternate gene names: 218709616

Gene position: 1745213-1743960 (Counterclockwise)

Preceding gene: 218709617

Following gene: 218709615

Centisome position: 52.9

GC content: 45.85

Gene sequence:

>1254_bases
ATGAAGATTCTTCACACGTCCGATTGGCACCTTGGCCAAAACTTCTACAATAAAAGCCGTAAGAATGAACATGAACGGTT
TTTACAATGGTTACTTGAGCAAGTTACTGAGCACAACATCGACGCGATCATTGTTGCTGGCGATATTTTTGATACCAGCA
CACCGCCGAGTTACGCTCGTGAGATGTATAACAAGTTTGTGGTCGACTCGAGCAAGATCGGCTGCCAATTGGTGTTGTTA
GGTGGAAATCACGATTCGGTGTCTGTGCTTAAAGAGACACAACAGCTGCTCAAATACATGGGCGCCGATGTGATTCCTAA
TACCAATGAAGATCATGCGACTCAGGTTGTCGAACTAAAAGGCAAGAACGGCGATGTAGAAGCGCTGGTTTGTGCCATTC
CCTTTATTCGCCCTCGCGATGTGTTGACCAGCCAGGCGGGTGTTACTGGTGTAGAGCGTCAGAAGCAACTCGGCGATGCA
ATCAAACAGCACTACCAAAGTGTTTATGATGCCGCTTTAGAAAAACGTGCGACGTTTGAAAACAGCGAGCACATGCCGAT
TATCGCTACTGGTCATTTAACAGCGATGGGTGTTCAACAATCGGATTCTGTGCGTGATATCTATGTCGGTAACCTTGATG
GTTTCGCCGCTGATGGTTTCCCAGATGCCGATTATATTGCACTTGGTCATATCCACCGCCCACAAGTTGTGGCAAAACGT
GAATACATTCGTTACTGCGGTTCACCAATCCCATTAAGCTTTGACGAACTTAAATCTCAAAAGCAGGTATGTGTGGTTGA
ATTTGTTGAGGGCGTGCGAACCATTTGTCAATTGCCCGTTCCTACATTCCAACCTCTAGCTGAAATCAAAGGCGACTTGA
GCGAGATCGAATCTCAGCTGAACCAATACATAGGTTTAGATAGCGAACAAAGCGTGTGGTTATCGATAGAAGTGCAAGCG
CAAGATTACTTGTCGGATCTACAAGAGCGCATGCGCTCATTAACTGACGGTTTGAATGTGGAAGTACTTCAACTGCGCCG
CGCAAGAGAGCGTCGTAATCAAGCATTAGAGCAAGAGTCGGCAGAGACCTTATCTGAACTGAGCCCGATGGACGTGTTTA
GCAAGCGTATTGCCTTAGAAGAGTTTGAAACCGATTCTGAAAAAGCACGTTTAGAGCGAATGACGGTGAAGTTTAAACAA
GTGATGGTTGAAGTGTCTGAAAGCGCTCAAACACCAAACAAAGTAGAAGAGTAA

Upstream 100 bases:

>100_bases
GGTTTTCACAAGCTTATAAACGGTAAATAATGCTAACTCATTTGGTAGTTGATCGGTATTTTGGTAAATTAAAGCTATTA
CCGACTTCCAGTGAGCAGCA

Downstream 100 bases:

>100_bases
CCAGTATGAAGATTTTAAGCCTAGAATTTGAAAACCTGAACTCTTTGAAAGGGCGTTGGAAGCTCGATTTTACCCAATCA
CCGTTTGCAGAAAATGGTCT

Product: exonuclease subunit SbcD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MKILHTSDWHLGQNFYNKSRKNEHERFLQWLLEQVTEHNIDAIIVAGDIFDTSTPPSYAREMYNKFVVDSSKIGCQLVLL
GGNHDSVSVLKETQQLLKYMGADVIPNTNEDHATQVVELKGKNGDVEALVCAIPFIRPRDVLTSQAGVTGVERQKQLGDA
IKQHYQSVYDAALEKRATFENSEHMPIIATGHLTAMGVQQSDSVRDIYVGNLDGFAADGFPDADYIALGHIHRPQVVAKR
EYIRYCGSPIPLSFDELKSQKQVCVVEFVEGVRTICQLPVPTFQPLAEIKGDLSEIESQLNQYIGLDSEQSVWLSIEVQA
QDYLSDLQERMRSLTDGLNVEVLQLRRARERRNQALEQESAETLSELSPMDVFSKRIALEEFETDSEKARLERMTVKFKQ
VMVEVSESAQTPNKVEE

Sequences:

>Translated_417_residues
MKILHTSDWHLGQNFYNKSRKNEHERFLQWLLEQVTEHNIDAIIVAGDIFDTSTPPSYAREMYNKFVVDSSKIGCQLVLL
GGNHDSVSVLKETQQLLKYMGADVIPNTNEDHATQVVELKGKNGDVEALVCAIPFIRPRDVLTSQAGVTGVERQKQLGDA
IKQHYQSVYDAALEKRATFENSEHMPIIATGHLTAMGVQQSDSVRDIYVGNLDGFAADGFPDADYIALGHIHRPQVVAKR
EYIRYCGSPIPLSFDELKSQKQVCVVEFVEGVRTICQLPVPTFQPLAEIKGDLSEIESQLNQYIGLDSEQSVWLSIEVQA
QDYLSDLQERMRSLTDGLNVEVLQLRRARERRNQALEQESAETLSELSPMDVFSKRIALEEFETDSEKARLERMTVKFKQ
VMVEVSESAQTPNKVEE
>Mature_417_residues
MKILHTSDWHLGQNFYNKSRKNEHERFLQWLLEQVTEHNIDAIIVAGDIFDTSTPPSYAREMYNKFVVDSSKIGCQLVLL
GGNHDSVSVLKETQQLLKYMGADVIPNTNEDHATQVVELKGKNGDVEALVCAIPFIRPRDVLTSQAGVTGVERQKQLGDA
IKQHYQSVYDAALEKRATFENSEHMPIIATGHLTAMGVQQSDSVRDIYVGNLDGFAADGFPDADYIALGHIHRPQVVAKR
EYIRYCGSPIPLSFDELKSQKQVCVVEFVEGVRTICQLPVPTFQPLAEIKGDLSEIESQLNQYIGLDSEQSVWLSIEVQA
QDYLSDLQERMRSLTDGLNVEVLQLRRARERRNQALEQESAETLSELSPMDVFSKRIALEEFETDSEKARLERMTVKFKQ
VMVEVSESAQTPNKVEE

Specific function: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sbcD family [H]

Homologues:

Organism=Escherichia coli, GI1786598, Length=395, Percent_Identity=51.1392405063291, Blast_Score=422, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR004593 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 47118; Mature: 47118

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILHTSDWHLGQNFYNKSRKNEHERFLQWLLEQVTEHNIDAIIVAGDIFDTSTPPSYAR
CCCEECCCCHHCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
EMYNKFVVDSSKIGCQLVLLGGNHDSVSVLKETQQLLKYMGADVIPNTNEDHATQVVELK
HHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEEE
GKNGDVEALVCAIPFIRPRDVLTSQAGVTGVERQKQLGDAIKQHYQSVYDAALEKRATFE
CCCCCCEEHEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSEHMPIIATGHLTAMGVQQSDSVRDIYVGNLDGFAADGFPDADYIALGHIHRPQVVAKR
CCCCCCEEEECCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHH
EYIRYCGSPIPLSFDELKSQKQVCVVEFVEGVRTICQLPVPTFQPLAEIKGDLSEIESQL
HHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHH
NQYIGLDSEQSVWLSIEVQAQDYLSDLQERMRSLTDGLNVEVLQLRRARERRNQALEQES
HHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AETLSELSPMDVFSKRIALEEFETDSEKARLERMTVKFKQVMVEVSESAQTPNKVEE
HHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKILHTSDWHLGQNFYNKSRKNEHERFLQWLLEQVTEHNIDAIIVAGDIFDTSTPPSYAR
CCCEECCCCHHCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
EMYNKFVVDSSKIGCQLVLLGGNHDSVSVLKETQQLLKYMGADVIPNTNEDHATQVVELK
HHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEEEEEE
GKNGDVEALVCAIPFIRPRDVLTSQAGVTGVERQKQLGDAIKQHYQSVYDAALEKRATFE
CCCCCCEEHEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSEHMPIIATGHLTAMGVQQSDSVRDIYVGNLDGFAADGFPDADYIALGHIHRPQVVAKR
CCCCCCEEEECCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHH
EYIRYCGSPIPLSFDELKSQKQVCVVEFVEGVRTICQLPVPTFQPLAEIKGDLSEIESQL
HHHHHCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHH
NQYIGLDSEQSVWLSIEVQAQDYLSDLQERMRSLTDGLNVEVLQLRRARERRNQALEQES
HHHHCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AETLSELSPMDVFSKRIALEEFETDSEKARLERMTVKFKQVMVEVSESAQTPNKVEE
HHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]