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The map label for this gene is norM [H]

Identifier: 218709508

GI number: 218709508

Start: 1650895

End: 1652265

Strand: Direct

Name: norM [H]

Synonym: VS_1517

Alternate gene names: 218709508

Gene position: 1650895-1652265 (Clockwise)

Preceding gene: 218709506

Following gene: 218709510

Centisome position: 50.04

GC content: 44.49

Gene sequence:

>1371_bases
GTGCATCGTTACAAAGAAGAATCCTCGAATCTAATCAAACTTGCGACCCCAGTATTGATCGCATCTGTTGCACAAACTGG
AATGGGTTTTGTCGATACCGTAATGGCCGGTGGTGTAAGTGCTATCGATATGGCGGCGGTTTCGATTGCAGCAAGTATCT
GGCTACCATCAATCTTATTTGGTGTGGGTCTGTTGATGGCGTTGGTTCCTGTCGTTGCACAACTTCATGGTTCTGGTAGA
CAAGTAAAAATTCCATTTGAGATTCAACAAGGTGCGTTTTTAGCGCTTGTCATCTCCCTTCCAATCATTGGCGTACTTTT
TCAGACACAACTGATATTGGAGTGGATGGACATAGAACAACTCATGGCAGAAAAAACCATCGGTTATATGAATGCGGTGA
TGTTTGCTGTCCCTGCATTTTTGTTGTTCCAAACATTGAGAAGCTTTACAGATGGTATGTCTTTAACTAAGCCTGCAATG
GTGATTGGTTTTATTGGCTTGCTATTAAACATCCCGCTTAACTGGATGTTCGTATACGGAAAGCTTGGCGCTCCCGCTCT
AGGTGGTGTCGGCTGTGGAGTTGCAACGGCTATCGTATATTGGGTGATGTTTGCTCTGCTGTTCGCTTACGTTTTAACAT
CAAAGCGTTTGGCTAAAATCAATATCTTCGGTACGTTCCACAAACCTCAGCTCAAAGCACAAATTCGTTTGTTTAAACTA
GGCTTTCCAGTTGCCGCTGCTATCTTCTTTGAGGTGACGCTATTCGCTGTTGTTTCTCTGTTGGTTGCCCCTCTTGGGTC
TTTGGTTGTCGCCGCACACCAGGTTGCAATTAACTTCTCGTCACTGATATTTATGATACCAATGAGTATCGGTGCCGCCG
TGAGTATTCGTGTTGGTCATAAGTTGGGTGAAAACAACACTGAAGGAGCGAAAATCGCGACACACGTGGGAATCATTGTT
GGTTTAGTCACAGCCCTAATGACAGCTACATTGACGGTACTATTCAGAGAGCAAGTTTCGTTACTGTACACAGAGAATAC
GGCGGTAATTACTGTTGCAATGCAATTACTATTGTTCGCTGCAGTTTATCAATGTACTGACGCAATCCAAGTTATCGCTG
CAGGGGCTTTGCGTGGATACAAAGACATGCGTTCGATCTTCAACATTACTTTCGTTGCTTACTGGTTGCTTGGTCTTCCT
ATTGGCTACATTTTAGGAATGAAAGATTGGATTGTTGAGCCTATGGGCGCGCACGGTTTCTGGGTTGGGTTCATTGTTGG
TCTAACGTCTGCAGCTATTATGCTAGGTATGCGTCTGCACTGGATGCACAAACAAGACGACGATGTGCAGTTAGAATTTA
GCTCTCGCTGA

Upstream 100 bases:

>100_bases
TGATTCGTCCAGTGGAAGCTTAAGATCATTGTCTCTGATTCCTTCAGAATGTCCTTTCCTACACTATTATTCTAATTTTC
CCTCTTATTTGGAGTTGTTT

Downstream 100 bases:

>100_bases
GTTCTAACTCACTCAACCGGTATCCCTGATATTGAATACGAAAAAGAGCTCTGATATTCAGAGCTCTTTTTCGTTTACTG
TGTGTGTATGACTATATTGT

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MHRYKEESSNLIKLATPVLIASVAQTGMGFVDTVMAGGVSAIDMAAVSIAASIWLPSILFGVGLLMALVPVVAQLHGSGR
QVKIPFEIQQGAFLALVISLPIIGVLFQTQLILEWMDIEQLMAEKTIGYMNAVMFAVPAFLLFQTLRSFTDGMSLTKPAM
VIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWVMFALLFAYVLTSKRLAKINIFGTFHKPQLKAQIRLFKL
GFPVAAAIFFEVTLFAVVSLLVAPLGSLVVAAHQVAINFSSLIFMIPMSIGAAVSIRVGHKLGENNTEGAKIATHVGIIV
GLVTALMTATLTVLFREQVSLLYTENTAVITVAMQLLLFAAVYQCTDAIQVIAAGALRGYKDMRSIFNITFVAYWLLGLP
IGYILGMKDWIVEPMGAHGFWVGFIVGLTSAAIMLGMRLHWMHKQDDDVQLEFSSR

Sequences:

>Translated_456_residues
MHRYKEESSNLIKLATPVLIASVAQTGMGFVDTVMAGGVSAIDMAAVSIAASIWLPSILFGVGLLMALVPVVAQLHGSGR
QVKIPFEIQQGAFLALVISLPIIGVLFQTQLILEWMDIEQLMAEKTIGYMNAVMFAVPAFLLFQTLRSFTDGMSLTKPAM
VIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWVMFALLFAYVLTSKRLAKINIFGTFHKPQLKAQIRLFKL
GFPVAAAIFFEVTLFAVVSLLVAPLGSLVVAAHQVAINFSSLIFMIPMSIGAAVSIRVGHKLGENNTEGAKIATHVGIIV
GLVTALMTATLTVLFREQVSLLYTENTAVITVAMQLLLFAAVYQCTDAIQVIAAGALRGYKDMRSIFNITFVAYWLLGLP
IGYILGMKDWIVEPMGAHGFWVGFIVGLTSAAIMLGMRLHWMHKQDDDVQLEFSSR
>Mature_456_residues
MHRYKEESSNLIKLATPVLIASVAQTGMGFVDTVMAGGVSAIDMAAVSIAASIWLPSILFGVGLLMALVPVVAQLHGSGR
QVKIPFEIQQGAFLALVISLPIIGVLFQTQLILEWMDIEQLMAEKTIGYMNAVMFAVPAFLLFQTLRSFTDGMSLTKPAM
VIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWVMFALLFAYVLTSKRLAKINIFGTFHKPQLKAQIRLFKL
GFPVAAAIFFEVTLFAVVSLLVAPLGSLVVAAHQVAINFSSLIFMIPMSIGAAVSIRVGHKLGENNTEGAKIATHVGIIV
GLVTALMTATLTVLFREQVSLLYTENTAVITVAMQLLLFAAVYQCTDAIQVIAAGALRGYKDMRSIFNITFVAYWLLGLP
IGYILGMKDWIVEPMGAHGFWVGFIVGLTSAAIMLGMRLHWMHKQDDDVQLEFSSR

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=442, Percent_Identity=23.5294117647059, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI153792564, Length=442, Percent_Identity=24.2081447963801, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI38261960, Length=478, Percent_Identity=23.0125523012552, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI48994890, Length=457, Percent_Identity=53.8293216630197, Blast_Score=487, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6320545, Length=436, Percent_Identity=22.2477064220184, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6321821, Length=379, Percent_Identity=24.0105540897098, Blast_Score=103, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49369; Mature: 49369

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRYKEESSNLIKLATPVLIASVAQTGMGFVDTVMAGGVSAIDMAAVSIAASIWLPSILF
CCCCHHHCCCEEHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GVGLLMALVPVVAQLHGSGRQVKIPFEIQQGAFLALVISLPIIGVLFQTQLILEWMDIEQ
HHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMAEKTIGYMNAVMFAVPAFLLFQTLRSFTDGMSLTKPAMVIGFIGLLLNIPLNWMFVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
KLGAPALGGVGCGVATAIVYWVMFALLFAYVLTSKRLAKINIFGTFHKPQLKAQIRLFKL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHEEE
GFPVAAAIFFEVTLFAVVSLLVAPLGSLVVAAHQVAINFSSLIFMIPMSIGAAVSIRVGH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KLGENNTEGAKIATHVGIIVGLVTALMTATLTVLFREQVSLLYTENTAVITVAMQLLLFA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHH
AVYQCTDAIQVIAAGALRGYKDMRSIFNITFVAYWLLGLPIGYILGMKDWIVEPMGAHGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHH
WVGFIVGLTSAAIMLGMRLHWMHKQDDDVQLEFSSR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
>Mature Secondary Structure
MHRYKEESSNLIKLATPVLIASVAQTGMGFVDTVMAGGVSAIDMAAVSIAASIWLPSILF
CCCCHHHCCCEEHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GVGLLMALVPVVAQLHGSGRQVKIPFEIQQGAFLALVISLPIIGVLFQTQLILEWMDIEQ
HHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMAEKTIGYMNAVMFAVPAFLLFQTLRSFTDGMSLTKPAMVIGFIGLLLNIPLNWMFVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
KLGAPALGGVGCGVATAIVYWVMFALLFAYVLTSKRLAKINIFGTFHKPQLKAQIRLFKL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHEEE
GFPVAAAIFFEVTLFAVVSLLVAPLGSLVVAAHQVAINFSSLIFMIPMSIGAAVSIRVGH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
KLGENNTEGAKIATHVGIIVGLVTALMTATLTVLFREQVSLLYTENTAVITVAMQLLLFA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHH
AVYQCTDAIQVIAAGALRGYKDMRSIFNITFVAYWLLGLPIGYILGMKDWIVEPMGAHGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHH
WVGFIVGLTSAAIMLGMRLHWMHKQDDDVQLEFSSR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA