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The map label for this gene is copA [H]

Identifier: 218709455

GI number: 218709455

Start: 1596350

End: 1598722

Strand: Direct

Name: copA [H]

Synonym: VS_1464

Alternate gene names: 218709455

Gene position: 1596350-1598722 (Clockwise)

Preceding gene: 218709454

Following gene: 218709456

Centisome position: 48.38

GC content: 46.14

Gene sequence:

>2373_bases
ATGTGTGAATCCTGTTATCACTGCGGTGAAGATGTACCAGCGGAAACGGATTTTAAAGTGGAAATTTTAGGATCGGTTCG
TCCGATGTGTTGTCCGGGTTGCGAAACCGTAGCCCAGACAATCATAGATAGCGGTTTGGTCTCTTATTACCAATACCGTA
CTGCTCCGGCTGAAAAAGCCGATCTGGTGCCAGAGCAACTTCTGGCTCTCAGTCACTATGACAATGAAGATGTTCAACTT
GAGTTCGTCCGTAACTCCGAAAACATCTCTGAGGTGACATTGTCACTAGATGGTGTCTCTTGTGCGGCTTGTGCTTGGCT
TATTGAGAAGCAAGTTTCTTCAAAGCTTGGCGTTGTGAGTATTCGTGTTAATACCACGACTAACCGTGCCCTGCTTAGTT
GGGACAACACTCAGGCCAAACTGAGCGAGTTGCTATCCGCGATTCATAGGTTGGGCTACAAAGCCGCACCATTCGAGGCT
GACCAACAAGAAGCTGCTTATCATCGTTCGATGAAAAACTACCTTTATCGTCTTGGTGTCGCGGGTTTAGCGACCATGCA
AGTTATGATGCTAGCGGTGGCGCTTTATCTCGAAGTTTTTGGCAGCCTTGAGCCGGAATTCAAAAGCTACTTTCGTTGGG
TGAGTTTGATCTTCGCAACGCCTGTACTGCTCTACTCTGCATTACCGTTCTATATTAACGCTTGGCGTAGTATTAAAGGC
CGAACCTTGGGCATGGATGTTCCTGTGTCGATCGCTCTATTGTTTGCCTATGTTGCGAGTTTAGTGGCAACGGTGACAGA
GCAAGGCGAAGTGTTCTTTGAATCTATCTCGATGTTCACCTTCTTCTTGTTGCTTGGTCGTTTCCTTGAGATGCGCGCGC
GTCGTAAAGCAGCAGCCGCGAGTGGTAATCTGCTTAAGTTGGTTCCTGCGATGGCGACAACTTTAGACGGTGAGCAAGTT
CCGGTAAAAACCTTGAAGGTTGGCGATCAGATTCGGGTTCTACCCGGTGAGCATATCCCTGCGGATGGTAAAGTACTGTC
TGGTAGAGTTCATATTGATGAATCGATGCTGACTGGCGAATCGATTCATGTGGTTAAGAATGAAGGCGATACCGTCTTTG
CTGGTACATTGAATGGTGATGAATCGTTTGAATTGGAAGTGATGACGTCTAAAGCGGATTCCGTGATTTCCAATATCGTT
CGCCTTCAGGATGAAGCGCAACTGTCTAAGCCTCGCATCGCAGAGATTGCCGATGTGGTTGCTCGATACTTTGTTGCTGT
GATTCTGGTTATCTCGTTCGGCACTTGGTTTTACTGGCACCAAACACGTCCAGAAGATGCTTTCTGGATTATGCTCTCGG
TACTTGTTGCGACATGTCCTTGTGCTCTATCGCTTGCAACACCGACAGCCATCACCTGCTCAACTTCTCGTATGGGTAAT
TTCGGTATCTTGCTGCGCAAAGGCCATGTGTTTGAAACTTTGTGCAAAGTGAATCACTTGATCATAGATAAAACAGGCAC
GTTGACCGAGGGTGATATTCGTATCAGCCAAGTTGAAACCTTCGCAGAACTTGATAAAGACACCTGTTTGAAAGTAGCGG
CGAGCCTAGAGCAACATGCTAACCACCCTATCGCGAAAGCGTTCAAGACTCATCTTTCTGATGATATCGAAGTAGAGTCT
GTCAATAACGTAATTGGCTCTGGTATCACTGGTGAGTGGAATGGACAAGAAGTCGCTATCGGCAGCAGTGAATTCATTCT
TGGTGATGCACAAACATCGGAAAGCAATGGTATTTACTTGTCGATGTCTGGTCGACATATCGCAACATTCACTTATGAAG
ACCCTATTCGTAAAGAAAGTATTGAGTTCATTAAGCAATTCAAAGAAGCGGGAATCAAAACCACGCTGCTGACTGGCGAT
TCCTTGATTAACGCGAAACATGTTGCGGCAGAGATTGGTATTACTGACATTGTTGCTAACGCGAAGCCAGAAGATAAACT
GGCTTATTTAAACTCTAGAGACGCTAGTGACATCACCATGATGGTTGGTGACGGTATTAACGATGCGCCGATTCTTGCAG
GTGCACACCTTTCGGTTGCTATGGGCGGCGGTACCGACGTGGCGAAAGCCTCAGCGGATATGGTGTTATTGGGTGACAAA
CTCGATAGATTACTTAAATCACGAACATTAGCGCTTAAAACGCGTAAGATAATCCGTGAAAATTTAGCGTGGTCGTTGGG
GTATAACTTACTTATTCTTCCATTGGCCGTAGCGGGTTTGGTTGCTCCATACATTGCCGTTGTTGGCATGTCTGCTAGCT
CTATTATTGTTGTGTCTAACTCGTTAAGGCTCTTAAAAGAGCAAGGTAAATAA

Upstream 100 bases:

>100_bases
CATGGTTTATTGAGCTTTCTCCGCATGATTCTGAATGGTTAGTGCAAGGTCGCATGAACTTCCCTATTGATACTCCTACT
CAACTAACGAATTAAAGCTT

Downstream 100 bases:

>100_bases
TGGAAAGTTTATACATACTTATTCCAATTGCGATCGTACTTGTGTGCATCGCTGTCGGTATCTTTCTGTGGGCCGTTAAG
AGTGAGCAGTTTGAAGACCT

Product: putative cation transport ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 790; Mature: 790

Protein sequence:

>790_residues
MCESCYHCGEDVPAETDFKVEILGSVRPMCCPGCETVAQTIIDSGLVSYYQYRTAPAEKADLVPEQLLALSHYDNEDVQL
EFVRNSENISEVTLSLDGVSCAACAWLIEKQVSSKLGVVSIRVNTTTNRALLSWDNTQAKLSELLSAIHRLGYKAAPFEA
DQQEAAYHRSMKNYLYRLGVAGLATMQVMMLAVALYLEVFGSLEPEFKSYFRWVSLIFATPVLLYSALPFYINAWRSIKG
RTLGMDVPVSIALLFAYVASLVATVTEQGEVFFESISMFTFFLLLGRFLEMRARRKAAAASGNLLKLVPAMATTLDGEQV
PVKTLKVGDQIRVLPGEHIPADGKVLSGRVHIDESMLTGESIHVVKNEGDTVFAGTLNGDESFELEVMTSKADSVISNIV
RLQDEAQLSKPRIAEIADVVARYFVAVILVISFGTWFYWHQTRPEDAFWIMLSVLVATCPCALSLATPTAITCSTSRMGN
FGILLRKGHVFETLCKVNHLIIDKTGTLTEGDIRISQVETFAELDKDTCLKVAASLEQHANHPIAKAFKTHLSDDIEVES
VNNVIGSGITGEWNGQEVAIGSSEFILGDAQTSESNGIYLSMSGRHIATFTYEDPIRKESIEFIKQFKEAGIKTTLLTGD
SLINAKHVAAEIGITDIVANAKPEDKLAYLNSRDASDITMMVGDGINDAPILAGAHLSVAMGGGTDVAKASADMVLLGDK
LDRLLKSRTLALKTRKIIRENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSASSIIVVSNSLRLLKEQGK

Sequences:

>Translated_790_residues
MCESCYHCGEDVPAETDFKVEILGSVRPMCCPGCETVAQTIIDSGLVSYYQYRTAPAEKADLVPEQLLALSHYDNEDVQL
EFVRNSENISEVTLSLDGVSCAACAWLIEKQVSSKLGVVSIRVNTTTNRALLSWDNTQAKLSELLSAIHRLGYKAAPFEA
DQQEAAYHRSMKNYLYRLGVAGLATMQVMMLAVALYLEVFGSLEPEFKSYFRWVSLIFATPVLLYSALPFYINAWRSIKG
RTLGMDVPVSIALLFAYVASLVATVTEQGEVFFESISMFTFFLLLGRFLEMRARRKAAAASGNLLKLVPAMATTLDGEQV
PVKTLKVGDQIRVLPGEHIPADGKVLSGRVHIDESMLTGESIHVVKNEGDTVFAGTLNGDESFELEVMTSKADSVISNIV
RLQDEAQLSKPRIAEIADVVARYFVAVILVISFGTWFYWHQTRPEDAFWIMLSVLVATCPCALSLATPTAITCSTSRMGN
FGILLRKGHVFETLCKVNHLIIDKTGTLTEGDIRISQVETFAELDKDTCLKVAASLEQHANHPIAKAFKTHLSDDIEVES
VNNVIGSGITGEWNGQEVAIGSSEFILGDAQTSESNGIYLSMSGRHIATFTYEDPIRKESIEFIKQFKEAGIKTTLLTGD
SLINAKHVAAEIGITDIVANAKPEDKLAYLNSRDASDITMMVGDGINDAPILAGAHLSVAMGGGTDVAKASADMVLLGDK
LDRLLKSRTLALKTRKIIRENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSASSIIVVSNSLRLLKEQGK
>Mature_790_residues
MCESCYHCGEDVPAETDFKVEILGSVRPMCCPGCETVAQTIIDSGLVSYYQYRTAPAEKADLVPEQLLALSHYDNEDVQL
EFVRNSENISEVTLSLDGVSCAACAWLIEKQVSSKLGVVSIRVNTTTNRALLSWDNTQAKLSELLSAIHRLGYKAAPFEA
DQQEAAYHRSMKNYLYRLGVAGLATMQVMMLAVALYLEVFGSLEPEFKSYFRWVSLIFATPVLLYSALPFYINAWRSIKG
RTLGMDVPVSIALLFAYVASLVATVTEQGEVFFESISMFTFFLLLGRFLEMRARRKAAAASGNLLKLVPAMATTLDGEQV
PVKTLKVGDQIRVLPGEHIPADGKVLSGRVHIDESMLTGESIHVVKNEGDTVFAGTLNGDESFELEVMTSKADSVISNIV
RLQDEAQLSKPRIAEIADVVARYFVAVILVISFGTWFYWHQTRPEDAFWIMLSVLVATCPCALSLATPTAITCSTSRMGN
FGILLRKGHVFETLCKVNHLIIDKTGTLTEGDIRISQVETFAELDKDTCLKVAASLEQHANHPIAKAFKTHLSDDIEVES
VNNVIGSGITGEWNGQEVAIGSSEFILGDAQTSESNGIYLSMSGRHIATFTYEDPIRKESIEFIKQFKEAGIKTTLLTGD
SLINAKHVAAEIGITDIVANAKPEDKLAYLNSRDASDITMMVGDGINDAPILAGAHLSVAMGGGTDVAKASADMVLLGDK
LDRLLKSRTLALKTRKIIRENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSASSIIVVSNSLRLLKEQGK

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=784, Percent_Identity=28.4438775510204, Blast_Score=292, Evalue=8e-79,
Organism=Homo sapiens, GI115529486, Length=816, Percent_Identity=28.0637254901961, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI55743073, Length=506, Percent_Identity=29.4466403162055, Blast_Score=206, Evalue=9e-53,
Organism=Homo sapiens, GI27886529, Length=190, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI310128958, Length=192, Percent_Identity=29.6875, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI10835220, Length=190, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI209413709, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI24638454, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI4502285, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786691, Length=853, Percent_Identity=29.89449003517, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI1789879, Length=732, Percent_Identity=30.7377049180328, Blast_Score=273, Evalue=4e-74,
Organism=Escherichia coli, GI1786914, Length=456, Percent_Identity=27.8508771929825, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17556548, Length=797, Percent_Identity=27.7289836888331, Blast_Score=254, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6320475, Length=735, Percent_Identity=28.7074829931973, Blast_Score=280, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6319772, Length=601, Percent_Identity=29.450915141431, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321271, Length=177, Percent_Identity=32.2033898305085, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221329854, Length=607, Percent_Identity=29.4892915980231, Blast_Score=206, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86140; Mature: 86140

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCESCYHCGEDVPAETDFKVEILGSVRPMCCPGCETVAQTIIDSGLVSYYQYRTAPAEKA
CCCCHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
DLVPEQLLALSHYDNEDVQLEFVRNSENISEVTLSLDGVSCAACAWLIEKQVSSKLGVVS
HCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
IRVNTTTNRALLSWDNTQAKLSELLSAIHRLGYKAAPFEADQQEAAYHRSMKNYLYRLGV
EEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGLATMQVMMLAVALYLEVFGSLEPEFKSYFRWVSLIFATPVLLYSALPFYINAWRSIKG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RTLGMDVPVSIALLFAYVASLVATVTEQGEVFFESISMFTFFLLLGRFLEMRARRKAAAA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLLKLVPAMATTLDGEQVPVKTLKVGDQIRVLPGEHIPADGKVLSGRVHIDESMLTGE
CCCHHHHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCCCCCCEEEEEEEECHHHCCCC
SIHVVKNEGDTVFAGTLNGDESFELEVMTSKADSVISNIVRLQDEAQLSKPRIAEIADVV
EEEEEECCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ARYFVAVILVISFGTWFYWHQTRPEDAFWIMLSVLVATCPCALSLATPTAITCSTSRMGN
HHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCC
FGILLRKGHVFETLCKVNHLIIDKTGTLTEGDIRISQVETFAELDKDTCLKVAASLEQHA
CEEEEECCHHHHHHHHHCCEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHC
NHPIAKAFKTHLSDDIEVESVNNVIGSGITGEWNGQEVAIGSSEFILGDAQTSESNGIYL
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEE
SMSGRHIATFTYEDPIRKESIEFIKQFKEAGIKTTLLTGDSLINAKHVAAEIGITDIVAN
EECCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCHHHHHCC
AKPEDKLAYLNSRDASDITMMVGDGINDAPILAGAHLSVAMGGGTDVAKASADMVLLGDK
CCCCCCEEEECCCCCCCEEEEECCCCCCCCEEECCEEEEEECCCCCHHHCCCCEEEECHH
LDRLLKSRTLALKTRKIIRENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSASSIIVVSN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
SLRLLKEQGK
CHHHHHHCCC
>Mature Secondary Structure
MCESCYHCGEDVPAETDFKVEILGSVRPMCCPGCETVAQTIIDSGLVSYYQYRTAPAEKA
CCCCHHHCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
DLVPEQLLALSHYDNEDVQLEFVRNSENISEVTLSLDGVSCAACAWLIEKQVSSKLGVVS
HCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCEEE
IRVNTTTNRALLSWDNTQAKLSELLSAIHRLGYKAAPFEADQQEAAYHRSMKNYLYRLGV
EEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGLATMQVMMLAVALYLEVFGSLEPEFKSYFRWVSLIFATPVLLYSALPFYINAWRSIKG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RTLGMDVPVSIALLFAYVASLVATVTEQGEVFFESISMFTFFLLLGRFLEMRARRKAAAA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLLKLVPAMATTLDGEQVPVKTLKVGDQIRVLPGEHIPADGKVLSGRVHIDESMLTGE
CCCHHHHHHHHHHHCCCCCCCCCEEECCCEEEECCCCCCCCCCCEEEEEEEECHHHCCCC
SIHVVKNEGDTVFAGTLNGDESFELEVMTSKADSVISNIVRLQDEAQLSKPRIAEIADVV
EEEEEECCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ARYFVAVILVISFGTWFYWHQTRPEDAFWIMLSVLVATCPCALSLATPTAITCSTSRMGN
HHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCC
FGILLRKGHVFETLCKVNHLIIDKTGTLTEGDIRISQVETFAELDKDTCLKVAASLEQHA
CEEEEECCHHHHHHHHHCCEEEECCCCCCCCCEEHHHHHHHHHCCHHHHHHHHHHHHHHC
NHPIAKAFKTHLSDDIEVESVNNVIGSGITGEWNGQEVAIGSSEFILGDAQTSESNGIYL
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCEEE
SMSGRHIATFTYEDPIRKESIEFIKQFKEAGIKTTLLTGDSLINAKHVAAEIGITDIVAN
EECCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCHHHHHCC
AKPEDKLAYLNSRDASDITMMVGDGINDAPILAGAHLSVAMGGGTDVAKASADMVLLGDK
CCCCCCEEEECCCCCCCEEEEECCCCCCCCEEECCEEEEEECCCCCHHHCCCCEEEECHH
LDRLLKSRTLALKTRKIIRENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSASSIIVVSN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
SLRLLKEQGK
CHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA