Click here to switch to the map view.

The map label for this gene is msrAB [H]

Identifier: 218709252

GI number: 218709252

Start: 1355965

End: 1356648

Strand: Reverse

Name: msrAB [H]

Synonym: VS_1259

Alternate gene names: 218709252

Gene position: 1356648-1355965 (Counterclockwise)

Preceding gene: 218709256

Following gene: 218709251

Centisome position: 41.12

GC content: 44.3

Gene sequence:

>684_bases
TTGTTCAGTCGCACAGGTTTACAATGCCTAAACGCTTGTTTTTATTTGCGCACTCATTTTTATAGACGCTTTTTTATACG
TACGGGTATCATCATATTGATTCACGCATCGAACAGACATAAGCAAACATCGACAAACACAGAGAGCTCAAAGAGAAGTA
TGGAACAAATTTATTTAGCTGGCGGTTGCTTGTGGGGCGTACAAGAATTTATTAAGTACGTTCCTGGCGTTATCAGCACA
GAAGCAGGTCGTGCCAATGGAAGCGCCCAGCTAACAGAAAACGGGACGACACAATGCGATAGCACGCAATGCAATGGCAC
ACAAAGCGATTACGATGGCTACGCAGAGTGCGTACAAATAGAGTTTGATCCAAGTATCACGTCTGTAATGATTTTGATGA
AACACTTGTTTGAGATTATCGACCCTTACAGCGTCAATAAACAAGGTGTCGATGTCGGAGAAAAATACCGCACAGGCGTT
TACAGTACTAACGCAGAACACTTAACCGAAGCTAAGCACTATATTGCCTCTCGTGACGACGCCGACCGTATCGCACTTGA
GATATTGCCGTTAACTCACTATGTCGCGAGTGATGATATCCACCAGCATCACCTAAGCCACTTCCCTGAAGATCACCACT
TGTGCCATATCCCTTGGGATCTGCTGCATAAGTACAAATCCTAG

Upstream 100 bases:

>100_bases
GATCAAACATGTTTAGAGTAACGCTCACTTGATGTTGAGATTCGGGTTGATGACAAAGCAATACTGACTTATATAACCAC
AAATCATATTAAACTTATGT

Downstream 100 bases:

>100_bases
ACTTAAACGTTACGCCTTGAGCCTTGAGCCTTGAGCCTTGAGCCTTGAGCCTTGAGCCTAGAGCCTAGAGCCTAGAGCCT
AGAGCCTAGAAACAGAACAC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MFSRTGLQCLNACFYLRTHFYRRFFIRTGIIILIHASNRHKQTSTNTESSKRSMEQIYLAGGCLWGVQEFIKYVPGVIST
EAGRANGSAQLTENGTTQCDSTQCNGTQSDYDGYAECVQIEFDPSITSVMILMKHLFEIIDPYSVNKQGVDVGEKYRTGV
YSTNAEHLTEAKHYIASRDDADRIALEILPLTHYVASDDIHQHHLSHFPEDHHLCHIPWDLLHKYKS

Sequences:

>Translated_227_residues
MFSRTGLQCLNACFYLRTHFYRRFFIRTGIIILIHASNRHKQTSTNTESSKRSMEQIYLAGGCLWGVQEFIKYVPGVIST
EAGRANGSAQLTENGTTQCDSTQCNGTQSDYDGYAECVQIEFDPSITSVMILMKHLFEIIDPYSVNKQGVDVGEKYRTGV
YSTNAEHLTEAKHYIASRDDADRIALEILPLTHYVASDDIHQHHLSHFPEDHHLCHIPWDLLHKYKS
>Mature_227_residues
MFSRTGLQCLNACFYLRTHFYRRFFIRTGIIILIHASNRHKQTSTNTESSKRSMEQIYLAGGCLWGVQEFIKYVPGVIST
EAGRANGSAQLTENGTTQCDSTQCNGTQSDYDGYAECVQIEFDPSITSVMILMKHLFEIIDPYSVNKQGVDVGEKYRTGV
YSTNAEHLTEAKHYIASRDDADRIALEILPLTHYVASDDIHQHHLSHFPEDHHLCHIPWDLLHKYKS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Escherichia coli, GI1790665, Length=186, Percent_Identity=31.7204301075269, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=27.8481012658228, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 25889; Mature: 25889

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRTGLQCLNACFYLRTHFYRRFFIRTGIIILIHASNRHKQTSTNTESSKRSMEQIYLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
GGCLWGVQEFIKYVPGVISTEAGRANGSAQLTENGTTQCDSTQCNGTQSDYDGYAECVQI
CHHHHHHHHHHHHCCCCEECCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEE
EFDPSITSVMILMKHLFEIIDPYSVNKQGVDVGEKYRTGVYSTNAEHLTEAKHYIASRDD
EECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCC
ADRIALEILPLTHYVASDDIHQHHLSHFPEDHHLCHIPWDLLHKYKS
HHHHHHHEEHHHHHHHCCHHHHHHHHHCCCCCCEEECCHHHHHHCCC
>Mature Secondary Structure
MFSRTGLQCLNACFYLRTHFYRRFFIRTGIIILIHASNRHKQTSTNTESSKRSMEQIYLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
GGCLWGVQEFIKYVPGVISTEAGRANGSAQLTENGTTQCDSTQCNGTQSDYDGYAECVQI
CHHHHHHHHHHHHCCCCEECCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEEEE
EFDPSITSVMILMKHLFEIIDPYSVNKQGVDVGEKYRTGVYSTNAEHLTEAKHYIASRDD
EECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCC
ADRIALEILPLTHYVASDDIHQHHLSHFPEDHHLCHIPWDLLHKYKS
HHHHHHHEEHHHHHHHCCHHHHHHHHHCCCCCCEEECCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA