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The map label for this gene is hutU

Identifier: 218709210

GI number: 218709210

Start: 1292736

End: 1294430

Strand: Reverse

Name: hutU

Synonym: VS_1217

Alternate gene names: 218709210

Gene position: 1294430-1292736 (Counterclockwise)

Preceding gene: 218709211

Following gene: 218709209

Centisome position: 39.23

GC content: 49.38

Gene sequence:

>1695_bases
ATGACGGAACACCACAACAGTGACCCTCGTCTCGATACGACTCGCGAAATTCGCGCACCTCATGGCACCACTTTGCGCGC
TAAATCTTGGTTAACAGAAGCACCACTTCGTATGCTGATGAACAACCTGGACCCTGATGTGGCAGAACATCCACATGCAC
TGGTTGTGTATGGTGGTATCGGTCGCGCTGCGCGTGATTGGAAATGTTATGACAAGATTGTTGAAGTATTAGAGCGTTTA
GAAGACGACCAAACGTTGCTTGTTCAATCAGGTAAGCCTGTGGGCGTGTTCCCGACTCATAAAAACGCGCCTCGCGTACT
GATCGCGAATTCTAACCTTGTTCCACACTGGGCTAACTGGGAGCACTTCAACGAGCTCGATAAAGAAGGCTTGATGATGT
ACGGCCAAATGACTGCTGGTAGCTGGATTTACATTGGCTCACAAGGCATCGTTCAAGGCACTTATGAAACGTTTGTTGCT
ATCGCGAAGAAGCATTTCCAAGGCGAAGCAAACGGCAAGTGGGTTCTAACGGGTGGTCTTGGCGGTATGGGTGGTGCTCA
ACCTCTCGCAGCGACAATGGCTGGCTTCTCAATGATCGCGGTTGAATGTGATGAATCACGAATCGACTACCGCTTGCGTA
CTGGCTATGTCGACAGAAAAGCCACCAGCATCGATGAAGCGATGGCAATGATTAAAGAATCAGACACGCCAATCTCTGTT
GGCTTATTAGGCAACGCTGCTGATGTATTCCCAGAGTTAGTTGAACGTAATATCACGCCTGATGTAGTGACCGATCAAAC
CTCTGCCCACGATCCGCTGAACGGATACTTGCCGCAAGGTTGGACGATGGAGAAAGCAGCACAAGAACGAACCATTGATG
AAGCTAAAGTAGTGAAAGCCGCTAAGCAGTCCATGGCCATTCAAGTACAAGCTATGCTAGATCTTCAGTACCGCGGCGCA
GCGACCGTGGATTACGGTAATAACATTCGCCAAATGGCACTGGAAGAAGGTGTGGAAAACGCATTTGATTTCCCAGGCTT
CGTTCCTGCTTATATACGACCTTTATTTTGCGAAGGCGTTGGACCGTTCCGTTGGGCGGCACTGTCTGGTGACCCAGAAG
ACATCTACAAAACAGACCAAAAAGTAAAAGAACTGATTCCAGATAACCCACATCTACACAACTGGTTAGATATGGCGCGT
GAACGCATTCAGTTCCAAGGCCTGCCAGCGCGTATTTGTTGGGTCGGCTTGAAAGACCGTGAACGCTTAGGCCAAGCATT
CAATGAAATGGTGAAAAATGGCGAACTAAAAGCACCAGTTGTTATTGGTCGTGACCACCTAGATTCAGGTTCAGTAGCAA
GCCCGAACCGCGAAACAGAAGGTATGATGGATGGCTCAGATGCGGTGTCTGATTGGCCTCTTTTGAATGCCCTTCTGAAC
ACAGCTGGTGGCGCAACTTGGGTTTCTCTGCACCATGGCGGCGGCGTTGGCATGGGCTTCTCGCAACACTCAGGCATGGT
GATTTGTTGTGACGGCAGTGAAGATGCTTCGCAGCGTATTTCTCGCGTACTTCACAATGACCCAGCAACCGGCGTTATGC
GTCATGCTGATGCAGGTTACGATATTGCCAAGCAGTGTGCCAAAGAGCAGAAGCTTGATTTACCTATGCTAAACGAAGAA
CTTCGTCGCCTTTAA

Upstream 100 bases:

>100_bases
AATGGCCAGCGACTAATCCAGCTATACCGATAACTACAACTACAACTACAACTACAACTACAACTACAACGATATAACGT
GAAACAGAAGGAATTCCAAA

Downstream 100 bases:

>100_bases
TGTCTGGAGAGAACATGTTGAATTTATTACTTAAGCCAGGACTACTAGGCCTATCTGAACTTCGTAAGATTAGTCGTAGC
CCTGTGAACTTATCACTCGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MTEHHNSDPRLDTTREIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARDWKCYDKIVEVLERL
EDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKEGLMMYGQMTAGSWIYIGSQGIVQGTYETFVA
IAKKHFQGEANGKWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDRKATSIDEAMAMIKESDTPISV
GLLGNAADVFPELVERNITPDVVTDQTSAHDPLNGYLPQGWTMEKAAQERTIDEAKVVKAAKQSMAIQVQAMLDLQYRGA
ATVDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGVGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMAR
ERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGSEDASQRISRVLHNDPATGVMRHADAGYDIAKQCAKEQKLDLPMLNEE
LRRL

Sequences:

>Translated_564_residues
MTEHHNSDPRLDTTREIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARDWKCYDKIVEVLERL
EDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKEGLMMYGQMTAGSWIYIGSQGIVQGTYETFVA
IAKKHFQGEANGKWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDRKATSIDEAMAMIKESDTPISV
GLLGNAADVFPELVERNITPDVVTDQTSAHDPLNGYLPQGWTMEKAAQERTIDEAKVVKAAKQSMAIQVQAMLDLQYRGA
ATVDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGVGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMAR
ERIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGSEDASQRISRVLHNDPATGVMRHADAGYDIAKQCAKEQKLDLPMLNEE
LRRL
>Mature_563_residues
TEHHNSDPRLDTTREIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGIGRAARDWKCYDKIVEVLERLE
DDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANWEHFNELDKEGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAI
AKKHFQGEANGKWVLTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDRKATSIDEAMAMIKESDTPISVG
LLGNAADVFPELVERNITPDVVTDQTSAHDPLNGYLPQGWTMEKAAQERTIDEAKVVKAAKQSMAIQVQAMLDLQYRGAA
TVDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGVGPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARE
RIQFQGLPARICWVGLKDRERLGQAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLNT
AGGATWVSLHHGGGVGMGFSQHSGMVICCDGSEDASQRISRVLHNDPATGVMRHADAGYDIAKQCAKEQKLDLPMLNEEL
RRL

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=588, Percent_Identity=33.5034013605442, Blast_Score=295, Evalue=1e-79,
Organism=Homo sapiens, GI260306182, Length=218, Percent_Identity=37.1559633027523, Blast_Score=157, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71997891, Length=581, Percent_Identity=34.4234079173838, Blast_Score=318, Evalue=6e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_VIBSL (B7VMU2)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416831.1
- ProteinModelPortal:   B7VMU2
- GeneID:   7160802
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_1217
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 62183; Mature: 62052

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 413-413

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHHNSDPRLDTTREIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGI
CCCCCCCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCC
GRAARDWKCYDKIVEVLERLEDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANW
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCC
EHFNELDKEGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAIAKKHFQGEANGKWVLTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDRKATSIDEAMAMIKESDTPISV
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEE
GLLGNAADVFPELVERNITPDVVTDQTSAHDPLNGYLPQGWTMEKAAQERTIDEAKVVKA
EECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKQSMAIQVQAMLDLQYRGAATVDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGV
HHHHHEEEEEEEEEEEECCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
GPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDR
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCH
ERLGQAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGSEDASQRISRVLHNDPATGVMRHADAGY
CCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCCCH
DIAKQCAKEQKLDLPMLNEELRRL
HHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TEHHNSDPRLDTTREIRAPHGTTLRAKSWLTEAPLRMLMNNLDPDVAEHPHALVVYGGI
CCCCCCCCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCC
GRAARDWKCYDKIVEVLERLEDDQTLLVQSGKPVGVFPTHKNAPRVLIANSNLVPHWANW
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCC
EHFNELDKEGLMMYGQMTAGSWIYIGSQGIVQGTYETFVAIAKKHFQGEANGKWVLTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDYRLRTGYVDRKATSIDEAMAMIKESDTPISV
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEE
GLLGNAADVFPELVERNITPDVVTDQTSAHDPLNGYLPQGWTMEKAAQERTIDEAKVVKA
EECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AKQSMAIQVQAMLDLQYRGAATVDYGNNIRQMALEEGVENAFDFPGFVPAYIRPLFCEGV
HHHHHEEEEEEEEEEEECCCEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
GPFRWAALSGDPEDIYKTDQKVKELIPDNPHLHNWLDMARERIQFQGLPARICWVGLKDR
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCH
ERLGQAFNEMVKNGELKAPVVIGRDHLDSGSVASPNRETEGMMDGSDAVSDWPLLNALLN
HHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TAGGATWVSLHHGGGVGMGFSQHSGMVICCDGSEDASQRISRVLHNDPATGVMRHADAGY
CCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHCCCCH
DIAKQCAKEQKLDLPMLNEELRRL
HHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA