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The map label for this gene is hutH [H]

Identifier: 218709209

GI number: 218709209

Start: 1291189

End: 1292736

Strand: Reverse

Name: hutH [H]

Synonym: VS_1216

Alternate gene names: 218709209

Gene position: 1292736-1291189 (Counterclockwise)

Preceding gene: 218709210

Following gene: 218709208

Centisome position: 39.18

GC content: 47.8

Gene sequence:

>1548_bases
ATGTCTGGAGAGAACATGTTGAATTTATTACTTAAGCCAGGACTACTAGGCCTATCTGAACTTCGTAAGATTAGTCGTAG
CCCTGTGAACTTATCACTCGACCCGGCTGCGATTCCTGATATTGAAGCGAGCATGCAGGTTGTCGAGCAAGTAATTGCTG
AAGATCGCACTGTGTATGGCATCAACACAGGTTTTGGCTTGTTAGCAAATACCAAAATTGCGCCTGAAGATCTCGAAGTT
CTACAGAAAAGTATCGTACTTTCTCACGCAGCGGGCATTGGCAAGTTTATGTCTGATGAAACCGTGCGTTTGATGATGGT
ATTGAAGATTAACAGCTTGTCTCGCGGTTACTCGGGTATCCGCCTCAAGGTGATTAATGCTCTTATCGATCTAGTGAACG
CGCAGGTTTACCCATGTGTTCCACAAAAAGGATCAGTAGGTGCCTCTGGAGATCTTGCTCCCCTAGCCCACATGAGTACC
GTTCTGTTAGGTGAAGGCCAAGCACGTCACAACGGCAAGATCATCACTGGCTTAGAAGCAATGCAGATCGCAGGCTTGGA
GCCTATAACACTAGCACCTAAAGAAGGTCTGGCGCTGTTAAACGGTACTCAGGCATCAACTGCATTTGCATTAGAAGGTT
TGTTTGCAGCAGAAGACTTATTCGCGTCTGCAACCGTGTGTGGTGCAATGTCTGTAGAAGCCGCGCTAGGTAGCCGTCGT
CCGTTTGACCCTCGTATACACCGCGTTCGTGGTCATCGTGGCCAAATGGATGCAGCACTTGCTTACCGCCATATGCTTGA
TCAAAAGAGTGAAATTGGCGAATCACACACTTGCTGTGAAAAGGTTCAAGACCCTTACTCACTGCGTTGCCAACCTCAAG
TGATGGGTGCTTGTTTGCAGCAGATTCGTAACTCAGCAGAGACTTTAACGATTGAAGCGAATGCCGTATCCGACAACCCG
CTTGTTTTCGCTGACGATGGCGACATCATTTCAGGTGGTAACTTCCACGCAGAGCCCGTCGCAATGGCAGCCGATAACCT
TGCACTAGCGATAGCTGAAATCGGTAGCTTGTCAGAACGTAGAATGGCGCTGCTGATTGATAGCGCACTAAGCAAACTTC
CACCTTTCTTGGTCGATAACGGCGGCGTGAACTCTGGCTTTATGATTGCTCAGGTTACCTCTGCAGCATTGGCAAGTGAG
AACAAAACCTTGGCTCATCCGGCGTCAATAGACAGCCTACCTACTTCTGCCAACCAAGAAGACCACGTATCAATGGCCAC
CTTTGCCGCGCGTAGGCTTAGATACATGGCTGAAAACACCCGTGGGATATTGGCAGTAGAATATTTAGCAGCAGCACAAG
GACTCGACTTCCGAGCGCCTAATCTATCTTCTCCTCGTGTGGAAGAAGCGAAGCAGATTCTGCGTGAGAAAGTGAGCTTC
TACGATAAAGACAGATATTTTGCTCCAGATATTGAACAAGCTAACCTGTTACTCAAGTTATCCGTTCATAACCACCTAAT
GCCAGAAGGAACACTGTCAAGTTTTTAG

Upstream 100 bases:

>100_bases
TTATGCGTCATGCTGATGCAGGTTACGATATTGCCAAGCAGTGTGCCAAAGAGCAGAAGCTTGATTTACCTATGCTAAAC
GAAGAACTTCGTCGCCTTTA

Downstream 100 bases:

>100_bases
TACTTTCCGTATACTGGGCTGTACTCTCGTTACAGCCCACTTGTCCATAAAAAATGAATACACTTATTGATAGGAGTGAT
ACTATCCGAAAAATCATCAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSGENMLNLLLKPGLLGLSELRKISRSPVNLSLDPAAIPDIEASMQVVEQVIAEDRTVYGINTGFGLLANTKIAPEDLEV
LQKSIVLSHAAGIGKFMSDETVRLMMVLKINSLSRGYSGIRLKVINALIDLVNAQVYPCVPQKGSVGASGDLAPLAHMST
VLLGEGQARHNGKIITGLEAMQIAGLEPITLAPKEGLALLNGTQASTAFALEGLFAAEDLFASATVCGAMSVEAALGSRR
PFDPRIHRVRGHRGQMDAALAYRHMLDQKSEIGESHTCCEKVQDPYSLRCQPQVMGACLQQIRNSAETLTIEANAVSDNP
LVFADDGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASE
NKTLAHPASIDSLPTSANQEDHVSMATFAARRLRYMAENTRGILAVEYLAAAQGLDFRAPNLSSPRVEEAKQILREKVSF
YDKDRYFAPDIEQANLLLKLSVHNHLMPEGTLSSF

Sequences:

>Translated_515_residues
MSGENMLNLLLKPGLLGLSELRKISRSPVNLSLDPAAIPDIEASMQVVEQVIAEDRTVYGINTGFGLLANTKIAPEDLEV
LQKSIVLSHAAGIGKFMSDETVRLMMVLKINSLSRGYSGIRLKVINALIDLVNAQVYPCVPQKGSVGASGDLAPLAHMST
VLLGEGQARHNGKIITGLEAMQIAGLEPITLAPKEGLALLNGTQASTAFALEGLFAAEDLFASATVCGAMSVEAALGSRR
PFDPRIHRVRGHRGQMDAALAYRHMLDQKSEIGESHTCCEKVQDPYSLRCQPQVMGACLQQIRNSAETLTIEANAVSDNP
LVFADDGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASE
NKTLAHPASIDSLPTSANQEDHVSMATFAARRLRYMAENTRGILAVEYLAAAQGLDFRAPNLSSPRVEEAKQILREKVSF
YDKDRYFAPDIEQANLLLKLSVHNHLMPEGTLSSF
>Mature_514_residues
SGENMLNLLLKPGLLGLSELRKISRSPVNLSLDPAAIPDIEASMQVVEQVIAEDRTVYGINTGFGLLANTKIAPEDLEVL
QKSIVLSHAAGIGKFMSDETVRLMMVLKINSLSRGYSGIRLKVINALIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTV
LLGEGQARHNGKIITGLEAMQIAGLEPITLAPKEGLALLNGTQASTAFALEGLFAAEDLFASATVCGAMSVEAALGSRRP
FDPRIHRVRGHRGQMDAALAYRHMLDQKSEIGESHTCCEKVQDPYSLRCQPQVMGACLQQIRNSAETLTIEANAVSDNPL
VFADDGDIISGGNFHAEPVAMAADNLALAIAEIGSLSERRMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASEN
KTLAHPASIDSLPTSANQEDHVSMATFAARRLRYMAENTRGILAVEYLAAAQGLDFRAPNLSSPRVEEAKQILREKVSFY
DKDRYFAPDIEQANLLLKLSVHNHLMPEGTLSSF

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=487, Percent_Identity=44.35318275154, Blast_Score=417, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=459, Percent_Identity=45.0980392156863, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 55164; Mature: 55033

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGENMLNLLLKPGLLGLSELRKISRSPVNLSLDPAAIPDIEASMQVVEQVIAEDRTVYG
CCCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEEE
INTGFGLLANTKIAPEDLEVLQKSIVLSHAAGIGKFMSDETVRLMMVLKINSLSRGYSGI
ECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHCCCCCCH
RLKVINALIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTVLLGEGQARHNGKIITGLEA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCEEEECCHH
MQIAGLEPITLAPKEGLALLNGTQASTAFALEGLFAAEDLFASATVCGAMSVEAALGSRR
HHHCCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PFDPRIHRVRGHRGQMDAALAYRHMLDQKSEIGESHTCCEKVQDPYSLRCQPQVMGACLQ
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
QIRNSAETLTIEANAVSDNPLVFADDGDIISGGNFHAEPVAMAADNLALAIAEIGSLSER
HHHCCCCEEEEEEEECCCCCEEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHCCCCHH
RMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASENKTLAHPASIDSLPTSANQE
HHHHHHHHHHHHCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
DHVSMATFAARRLRYMAENTRGILAVEYLAAAQGLDFRAPNLSSPRVEEAKQILREKVSF
HHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YDKDRYFAPDIEQANLLLKLSVHNHLMPEGTLSSF
HCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SGENMLNLLLKPGLLGLSELRKISRSPVNLSLDPAAIPDIEASMQVVEQVIAEDRTVYG
CCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEEE
INTGFGLLANTKIAPEDLEVLQKSIVLSHAAGIGKFMSDETVRLMMVLKINSLSRGYSGI
ECCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEHHHCCCCCCH
RLKVINALIDLVNAQVYPCVPQKGSVGASGDLAPLAHMSTVLLGEGQARHNGKIITGLEA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCEEEECCHH
MQIAGLEPITLAPKEGLALLNGTQASTAFALEGLFAAEDLFASATVCGAMSVEAALGSRR
HHHCCCCCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PFDPRIHRVRGHRGQMDAALAYRHMLDQKSEIGESHTCCEKVQDPYSLRCQPQVMGACLQ
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHH
QIRNSAETLTIEANAVSDNPLVFADDGDIISGGNFHAEPVAMAADNLALAIAEIGSLSER
HHHCCCCEEEEEEEECCCCCEEEECCCCEECCCCCCCCCHHHHHCCHHHHHHHHCCCCHH
RMALLIDSALSKLPPFLVDNGGVNSGFMIAQVTSAALASENKTLAHPASIDSLPTSANQE
HHHHHHHHHHHHCCCEEEECCCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
DHVSMATFAARRLRYMAENTRGILAVEYLAAAQGLDFRAPNLSSPRVEEAKQILREKVSF
HHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
YDKDRYFAPDIEQANLLLKLSVHNHLMPEGTLSSF
HCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA