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The map label for this gene is ptrB [H]

Identifier: 218709054

GI number: 218709054

Start: 1112441

End: 1114606

Strand: Reverse

Name: ptrB [H]

Synonym: VS_1060

Alternate gene names: 218709054

Gene position: 1114606-1112441 (Counterclockwise)

Preceding gene: 218709055

Following gene: 218709053

Centisome position: 33.78

GC content: 46.08

Gene sequence:

>2166_bases
ATGCGTTTCGCTTTAACCACATTAGCCGTATCGGCCGCACTTGTCGCCGGATGCAGTAATCAAGGAATAACAACCATGGA
CCACAACTCTCCATCGCAACTCATCGCACATCAAACCCAAGCTCCCGTAGCTAAGAAAGTCCCTCATGCAATGACGATTC
ATGGTGATACCCGAATCGATGATTATTACTGGATGCGTGATGATGAGCGCCAAGACCCAGAGATCTTGCAGCATCTTGAG
CAAGAAAACCAGTACGCAGAGGCCGTGCTGAAACACACTGAAGCATCACAAGAACAGTTATTTGAAGAGATCAAAGGCCG
AATCGCAAAAGACGACCATTCGGTTCCAGTTCGCAAAGGCAGCTACTACTACTCGAATGAAGTCACAGGTGACAACGAAT
ACCCAGTTCACTTGCGTGAAAATGACTTTTTAGGTACAGACAAGCAAGTCATCTTAGATGTTAACGAACTAGCAAAAGAC
CATGAATTTTTCAGTATTGGTGGCTTAACGATCAGCCCAAGCGAAAACTTGTTGGCCTATGGCGAAGACACGCTGAGCCG
CCGTATTTACACCATCAAGATTAAAGACCTCACGACAGGTGAATACCTAACAGATGAAATTGAAGGGGCTTCGAGCGCGA
TTGCATGGCAAAACGACAACCAAGCCTTTTACTACATCAAAAAAGATCCACAAACATTACTTGGTTATCAAGTTTACCGC
CATGTGTTAGGCACACCTCAAACAAGCGATGAGCTAATCTACGAAGAAGCCGATAGCGCTTATTACACCTCTTTAAGTAA
AAGCAAAGATGGTGAACAGGTCTACATTTGGCACTCGAGTACAGAAACCAGCGGTGTTTCAGTCATAGATGCCAACAACC
CAAACGCTAAAGCTGAAGCTTTCTACCCACGAGAAACGGGTATCGAGTACAGCATCGCTAAGCTAGGTGATTGGTACTAC
ATCTACACCAACTACCAAGCGGTCAACTTCCGTTTAATGAAAGTCACAGCCGAAAAGATGCATGACCGCTCTAAATGGGT
CGATGTCATTCCTGCTGACGATAACACTCAGCTTGTTGACTTCGAGTTGTTTGATGACCATCTGGTTTATGAGCAACGTG
CGAATGGCTTGTCTACCGTGAAAGTTCGTCAACTCTCCACGAGCAAAGAGTTCCCACTCGAATTTAACGACACTGCTTTT
GCTGCTTACCTAACAAGTAACTATGAATTAGATAACTCAAAAGTTCGCGTCTATTACAGCAGCTTAACCACGCCTGGTAC
TTACTATGATTTCGACCTAAGTTCAGGAGAATCCGAAGTCATGAAACAAACACCTGTATTGGGTGATTTCGAAGCGGATA
ACTACCAATCAGAGCGAATTATGGTAACGGCTCGCGATGGTAAGCAAGTACCTGTGTCTTTGGTTTATCGCAAAGACTTA
TTCAAGAAGGACGGCACTAACTCAATCTACCAATACGGCTATGGCTCTTACGGCCACACGATCGAACCAACCTTTGGCTC
GGCTCGTCTCAGCTTACTTGATCGCGGATTCGTTTATGCTATCGCACATATTCGAGGTTCCGAGATGCTTGGGCGCCCTT
GGTATGAGGACGGCAAAAAGCTGACCAAGCAAAACACGTTCAACGACTTTATCGATGTGACCAAAGGGCTGGTTGAAGAA
GGCTACGGCGCACAAGATAAAGTGTTCGCCGTTGGTGGTTCTGCTGGCGGTCTATTGATGGGCGCAATCATCAACCAAGC
ACCAGAACTGTACCGTGGCATCGGAGCACATGTTCCGTTTGTGGACGTTGTCACAACCATGCTTGACGAATCGATTCCTC
TTACCACCAACGAGTATGACGAATGGGGCAACCCGAACGAGCAAACCTATTACAATTACATGCTAGGTTACTCACCATAT
GACAATGTGAAGGCTCAAAGCTACCCGAACATGTTGGTAACAACAGGCCTGCATGACTCACAAGTACAATACTTTGAACC
CATGAAGTGGGTGGCGAAGCTGCGTGAGATGAAAACAGACAACAACGTGCTGCTGTTCAAAACCGATATGGAAGCTGGTC
ACGGTGGCGCTTCCGGTCGATTTAAGCGATTAAAAGAAGACGCACTTGAATACGCGTTCTTTTTAGACTTGCTAAAGACT
CAGTAG

Upstream 100 bases:

>100_bases
ACCAATCCAGAATCCAATTATAAATAACATCACTGGAAGAAAACTAACCACTAAAGGATGCTGGCATTAAAACGAGTAAG
GTACACAATAGGATATACAG

Downstream 100 bases:

>100_bases
ATTCTGCGTAAAAGTGAGTATTCACACCATTTTGTCGCCATTTAGGGGCGACAAAATGGCGACAGAAATTATTAAGCATG
CTTAAATACGATTAATCATG

Product: protease II

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 721; Mature: 721

Protein sequence:

>721_residues
MRFALTTLAVSAALVAGCSNQGITTMDHNSPSQLIAHQTQAPVAKKVPHAMTIHGDTRIDDYYWMRDDERQDPEILQHLE
QENQYAEAVLKHTEASQEQLFEEIKGRIAKDDHSVPVRKGSYYYSNEVTGDNEYPVHLRENDFLGTDKQVILDVNELAKD
HEFFSIGGLTISPSENLLAYGEDTLSRRIYTIKIKDLTTGEYLTDEIEGASSAIAWQNDNQAFYYIKKDPQTLLGYQVYR
HVLGTPQTSDELIYEEADSAYYTSLSKSKDGEQVYIWHSSTETSGVSVIDANNPNAKAEAFYPRETGIEYSIAKLGDWYY
IYTNYQAVNFRLMKVTAEKMHDRSKWVDVIPADDNTQLVDFELFDDHLVYEQRANGLSTVKVRQLSTSKEFPLEFNDTAF
AAYLTSNYELDNSKVRVYYSSLTTPGTYYDFDLSSGESEVMKQTPVLGDFEADNYQSERIMVTARDGKQVPVSLVYRKDL
FKKDGTNSIYQYGYGSYGHTIEPTFGSARLSLLDRGFVYAIAHIRGSEMLGRPWYEDGKKLTKQNTFNDFIDVTKGLVEE
GYGAQDKVFAVGGSAGGLLMGAIINQAPELYRGIGAHVPFVDVVTTMLDESIPLTTNEYDEWGNPNEQTYYNYMLGYSPY
DNVKAQSYPNMLVTTGLHDSQVQYFEPMKWVAKLREMKTDNNVLLFKTDMEAGHGGASGRFKRLKEDALEYAFFLDLLKT
Q

Sequences:

>Translated_721_residues
MRFALTTLAVSAALVAGCSNQGITTMDHNSPSQLIAHQTQAPVAKKVPHAMTIHGDTRIDDYYWMRDDERQDPEILQHLE
QENQYAEAVLKHTEASQEQLFEEIKGRIAKDDHSVPVRKGSYYYSNEVTGDNEYPVHLRENDFLGTDKQVILDVNELAKD
HEFFSIGGLTISPSENLLAYGEDTLSRRIYTIKIKDLTTGEYLTDEIEGASSAIAWQNDNQAFYYIKKDPQTLLGYQVYR
HVLGTPQTSDELIYEEADSAYYTSLSKSKDGEQVYIWHSSTETSGVSVIDANNPNAKAEAFYPRETGIEYSIAKLGDWYY
IYTNYQAVNFRLMKVTAEKMHDRSKWVDVIPADDNTQLVDFELFDDHLVYEQRANGLSTVKVRQLSTSKEFPLEFNDTAF
AAYLTSNYELDNSKVRVYYSSLTTPGTYYDFDLSSGESEVMKQTPVLGDFEADNYQSERIMVTARDGKQVPVSLVYRKDL
FKKDGTNSIYQYGYGSYGHTIEPTFGSARLSLLDRGFVYAIAHIRGSEMLGRPWYEDGKKLTKQNTFNDFIDVTKGLVEE
GYGAQDKVFAVGGSAGGLLMGAIINQAPELYRGIGAHVPFVDVVTTMLDESIPLTTNEYDEWGNPNEQTYYNYMLGYSPY
DNVKAQSYPNMLVTTGLHDSQVQYFEPMKWVAKLREMKTDNNVLLFKTDMEAGHGGASGRFKRLKEDALEYAFFLDLLKT
Q
>Mature_721_residues
MRFALTTLAVSAALVAGCSNQGITTMDHNSPSQLIAHQTQAPVAKKVPHAMTIHGDTRIDDYYWMRDDERQDPEILQHLE
QENQYAEAVLKHTEASQEQLFEEIKGRIAKDDHSVPVRKGSYYYSNEVTGDNEYPVHLRENDFLGTDKQVILDVNELAKD
HEFFSIGGLTISPSENLLAYGEDTLSRRIYTIKIKDLTTGEYLTDEIEGASSAIAWQNDNQAFYYIKKDPQTLLGYQVYR
HVLGTPQTSDELIYEEADSAYYTSLSKSKDGEQVYIWHSSTETSGVSVIDANNPNAKAEAFYPRETGIEYSIAKLGDWYY
IYTNYQAVNFRLMKVTAEKMHDRSKWVDVIPADDNTQLVDFELFDDHLVYEQRANGLSTVKVRQLSTSKEFPLEFNDTAF
AAYLTSNYELDNSKVRVYYSSLTTPGTYYDFDLSSGESEVMKQTPVLGDFEADNYQSERIMVTARDGKQVPVSLVYRKDL
FKKDGTNSIYQYGYGSYGHTIEPTFGSARLSLLDRGFVYAIAHIRGSEMLGRPWYEDGKKLTKQNTFNDFIDVTKGLVEE
GYGAQDKVFAVGGSAGGLLMGAIINQAPELYRGIGAHVPFVDVVTTMLDESIPLTTNEYDEWGNPNEQTYYNYMLGYSPY
DNVKAQSYPNMLVTTGLHDSQVQYFEPMKWVAKLREMKTDNNVLLFKTDMEAGHGGASGRFKRLKEDALEYAFFLDLLKT
Q

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=724, Percent_Identity=26.9337016574586, Blast_Score=193, Evalue=6e-49,
Organism=Homo sapiens, GI284172420, Length=542, Percent_Identity=28.4132841328413, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI284172413, Length=542, Percent_Identity=28.4132841328413, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI70778815, Length=542, Percent_Identity=28.4132841328413, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI284172438, Length=542, Percent_Identity=28.4132841328413, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI284172431, Length=542, Percent_Identity=28.4132841328413, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI108860686, Length=291, Percent_Identity=30.9278350515464, Blast_Score=137, Evalue=5e-32,
Organism=Homo sapiens, GI108860692, Length=218, Percent_Identity=35.3211009174312, Blast_Score=130, Evalue=4e-30,
Organism=Escherichia coli, GI1788150, Length=678, Percent_Identity=48.5250737463127, Blast_Score=666, Evalue=0.0,
Organism=Drosophila melanogaster, GI221510989, Length=700, Percent_Identity=26.2857142857143, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24583414, Length=734, Percent_Identity=25.6130790190736, Blast_Score=188, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 81776; Mature: 81776

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFALTTLAVSAALVAGCSNQGITTMDHNSPSQLIAHQTQAPVAKKVPHAMTIHGDTRID
CCEEHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCHHHHCCCEEEECCCCEEC
DYYWMRDDERQDPEILQHLEQENQYAEAVLKHTEASQEQLFEEIKGRIAKDDHSVPVRKG
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEECC
SYYYSNEVTGDNEYPVHLRENDFLGTDKQVILDVNELAKDHEFFSIGGLTISPSENLLAY
CEEECCCCCCCCCCCEEEECCCCCCCCCEEEEEHHHHHCCCCEEEECCEEECCCCCEEEE
GEDTLSRRIYTIKIKDLTTGEYLTDEIEGASSAIAWQNDNQAFYYIKKDPQTLLGYQVYR
CCHHHHCEEEEEEEEECCCCCHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
HVLGTPQTSDELIYEEADSAYYTSLSKSKDGEQVYIWHSSTETSGVSVIDANNPNAKAEA
HHHCCCCCCCHHHHCCCCCHHEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCEE
FYPRETGIEYSIAKLGDWYYIYTNYQAVNFRLMKVTAEKMHDRSKWVDVIPADDNTQLVD
ECCCCCCCEEEEEECCCEEEEEEEEEEEEEEEEEEEHHHHHCCCCCEEEEECCCCCEEEE
FELFDDHLVYEQRANGLSTVKVRQLSTSKEFPLEFNDTAFAAYLTSNYELDNSKVRVYYS
EEECCCHHHHHHHCCCCCEEEEEEECCCCCCCEEECCCEEEEEEECCEEECCCEEEEEEE
SLTTPGTYYDFDLSSGESEVMKQTPVLGDFEADNYQSERIMVTARDGKQVPVSLVYRKDL
CCCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHH
FKKDGTNSIYQYGYGSYGHTIEPTFGSARLSLLDRGFVYAIAHIRGSEMLGRPWYEDGKK
HHCCCCCCCEECCCCCCCCEECCCCCCHHHHHHHCCEEEEEEEECCCHHCCCCCHHHHHH
LTKQNTFNDFIDVTKGLVEEGYGAQDKVFAVGGSAGGLLMGAIINQAPELYRGIGAHVPF
HHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHCCCCCCH
VDVVTTMLDESIPLTTNEYDEWGNPNEQTYYNYMLGYSPYDNVKAQSYPNMLVTTGLHDS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCC
QVQYFEPMKWVAKLREMKTDNNVLLFKTDMEAGHGGASGRFKRLKEDALEYAFFLDLLKT
CHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
Q
C
>Mature Secondary Structure
MRFALTTLAVSAALVAGCSNQGITTMDHNSPSQLIAHQTQAPVAKKVPHAMTIHGDTRID
CCEEHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHCCCHHHHCCCEEEECCCCEEC
DYYWMRDDERQDPEILQHLEQENQYAEAVLKHTEASQEQLFEEIKGRIAKDDHSVPVRKG
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEECC
SYYYSNEVTGDNEYPVHLRENDFLGTDKQVILDVNELAKDHEFFSIGGLTISPSENLLAY
CEEECCCCCCCCCCCEEEECCCCCCCCCEEEEEHHHHHCCCCEEEECCEEECCCCCEEEE
GEDTLSRRIYTIKIKDLTTGEYLTDEIEGASSAIAWQNDNQAFYYIKKDPQTLLGYQVYR
CCHHHHCEEEEEEEEECCCCCHHHHHHCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
HVLGTPQTSDELIYEEADSAYYTSLSKSKDGEQVYIWHSSTETSGVSVIDANNPNAKAEA
HHHCCCCCCCHHHHCCCCCHHEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCEE
FYPRETGIEYSIAKLGDWYYIYTNYQAVNFRLMKVTAEKMHDRSKWVDVIPADDNTQLVD
ECCCCCCCEEEEEECCCEEEEEEEEEEEEEEEEEEEHHHHHCCCCCEEEEECCCCCEEEE
FELFDDHLVYEQRANGLSTVKVRQLSTSKEFPLEFNDTAFAAYLTSNYELDNSKVRVYYS
EEECCCHHHHHHHCCCCCEEEEEEECCCCCCCEEECCCEEEEEEECCEEECCCEEEEEEE
SLTTPGTYYDFDLSSGESEVMKQTPVLGDFEADNYQSERIMVTARDGKQVPVSLVYRKDL
CCCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHH
FKKDGTNSIYQYGYGSYGHTIEPTFGSARLSLLDRGFVYAIAHIRGSEMLGRPWYEDGKK
HHCCCCCCCEECCCCCCCCEECCCCCCHHHHHHHCCEEEEEEEECCCHHCCCCCHHHHHH
LTKQNTFNDFIDVTKGLVEEGYGAQDKVFAVGGSAGGLLMGAIINQAPELYRGIGAHVPF
HHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCHHHHHHCCCCCCH
VDVVTTMLDESIPLTTNEYDEWGNPNEQTYYNYMLGYSPYDNVKAQSYPNMLVTTGLHDS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCC
QVQYFEPMKWVAKLREMKTDNNVLLFKTDMEAGHGGASGRFKRLKEDALEYAFFLDLLKT
CHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]