Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 218709023

GI number: 218709023

Start: 1069747

End: 1070379

Strand: Direct

Name: tmk [H]

Synonym: VS_1029

Alternate gene names: 218709023

Gene position: 1069747-1070379 (Clockwise)

Preceding gene: 218709022

Following gene: 218709024

Centisome position: 32.42

GC content: 47.39

Gene sequence:

>633_bases
ATGAATCAGTCGAAATTTATCGTGGTTGAAGGCCTTGAAGGTGCTGGCAAAAGTACAGCAATCAATGCCATCGTTGAGAC
ATTGAAAACAGCTGGTGTCGCTGACATCGTTAATACTCGTGAACCCGGTGGTACCGTGCTTGCCGAGAAGATGCGCTCGT
TGGTCAAAGAAGAACACGAGGGCGAGAAGCTTCAAGACATGACTGAGTTGCTGCTGATGTACGCAGCGCGTGTTCAATTA
GTAGAAAACGTCATCAAGCCTGCACTAGACAGTGGTAAATGGGTGTTGGGTGATCGCCATGATATGTCTTCTCAAGCATA
CCAAGGTGGTGGTCGTCAGATCGCTCGTAGCACTATGGAATCACTGAAAGCAACCACGCTAGGCGGCTTTAAGCCAGATT
TAACACTATATTTGGACCTAGACCCTAGAGTCGGGCTTGAACGCGCTAGAGGTCGTGGTGAGCTTGATAGAATTGAAAAG
ATGGACATCTCATTTTTCGATCGCACGCGTGAGCGTTACTTAGAAATTGCAGGGCAAGACGATTCTGTACTCGTGATTAA
TGCGCAGCAAGAAATTGAGCAAGTAGCCGCTGATATTAAAGTCGCGCTCAGTGCTTGGCTCAATAAACAGTAG

Upstream 100 bases:

>100_bases
GGAACCGGCGGTCACGTATTTTCAAAGAGTTTGACTGAGCATAACCGTGCAGTACGAGCTTACTTAAAGCAATTAAGAAA
AAACAAATAAAGAAAGAATT

Downstream 100 bases:

>100_bases
GTAGTCATGGCTGAAGTTTATTCTTGGCTCACACCGGTATGGAGTGAGTGGAAAAAAAGTCTCGATGCAGAACGTTTTCC
TAACTCTGTGATCGTTAATG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNQSKFIVVEGLEGAGKSTAINAIVETLKTAGVADIVNTREPGGTVLAEKMRSLVKEEHEGEKLQDMTELLLMYAARVQL
VENVIKPALDSGKWVLGDRHDMSSQAYQGGGRQIARSTMESLKATTLGGFKPDLTLYLDLDPRVGLERARGRGELDRIEK
MDISFFDRTRERYLEIAGQDDSVLVINAQQEIEQVAADIKVALSAWLNKQ

Sequences:

>Translated_210_residues
MNQSKFIVVEGLEGAGKSTAINAIVETLKTAGVADIVNTREPGGTVLAEKMRSLVKEEHEGEKLQDMTELLLMYAARVQL
VENVIKPALDSGKWVLGDRHDMSSQAYQGGGRQIARSTMESLKATTLGGFKPDLTLYLDLDPRVGLERARGRGELDRIEK
MDISFFDRTRERYLEIAGQDDSVLVINAQQEIEQVAADIKVALSAWLNKQ
>Mature_210_residues
MNQSKFIVVEGLEGAGKSTAINAIVETLKTAGVADIVNTREPGGTVLAEKMRSLVKEEHEGEKLQDMTELLLMYAARVQL
VENVIKPALDSGKWVLGDRHDMSSQAYQGGGRQIARSTMESLKATTLGGFKPDLTLYLDLDPRVGLERARGRGELDRIEK
MDISFFDRTRERYLEIAGQDDSVLVINAQQEIEQVAADIKVALSAWLNKQ

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=57.8947368421053, Blast_Score=246, Evalue=8e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23219; Mature: 23219

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSKFIVVEGLEGAGKSTAINAIVETLKTAGVADIVNTREPGGTVLAEKMRSLVKEEHE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHC
GEKLQDMTELLLMYAARVQLVENVIKPALDSGKWVLGDRHDMSSQAYQGGGRQIARSTME
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCHHHHHHHHHH
SLKATTLGGFKPDLTLYLDLDPRVGLERARGRGELDRIEKMDISFFDRTRERYLEIAGQD
HHHHHHCCCCCCCEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
DSVLVINAQQEIEQVAADIKVALSAWLNKQ
CCEEEEECHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNQSKFIVVEGLEGAGKSTAINAIVETLKTAGVADIVNTREPGGTVLAEKMRSLVKEEHE
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHHHHC
GEKLQDMTELLLMYAARVQLVENVIKPALDSGKWVLGDRHDMSSQAYQGGGRQIARSTME
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCHHHHHHHHHH
SLKATTLGGFKPDLTLYLDLDPRVGLERARGRGELDRIEKMDISFFDRTRERYLEIAGQD
HHHHHHCCCCCCCEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
DSVLVINAQQEIEQVAADIKVALSAWLNKQ
CCEEEEECHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA