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The map label for this gene is fabF [H]

Identifier: 218709020

GI number: 218709020

Start: 1066497

End: 1067741

Strand: Direct

Name: fabF [H]

Synonym: VS_1026

Alternate gene names: 218709020

Gene position: 1066497-1067741 (Clockwise)

Preceding gene: 218709019

Following gene: 218709021

Centisome position: 32.32

GC content: 48.11

Gene sequence:

>1245_bases
GTGTCCAAGCGTCGTGTAGTTGTCACTGGCATGGGTATGTTGTCGCCGGTAGGCAACACTGTAGAATCTTCTTGGAAAGC
CCTGCTAGCTGGTCAAAGTGGTATCGTTAATATCGATCATTTTGACGCAACCAATTTCTCAACTCGTTTTGCAGGTCTAG
TTAAAGACTTTAACTGCGAAGAGTATATGACTAAAAAAGATGCTCGTAAGATGGACTTGTTCATCCAGTACGGCGTCGCA
GCAGGTATTCAAGCTTTAGATGATTCAGCCCTAACTATTACTGAAGAAAACGCTCCTCGTGTAGGCGTTGCTATCGGTTC
TGGTATTGGTGGTCTTGGTTTGATCGAAGCCGGTCACAAGGCTCTAACTGAAAAAGGCCCTCGTAAAATCAGCCCGTTCT
TCGTACCGTCGACGATCGTGAATATGATTGCGGGTCACATGTCTATCATGCGTGGCCTACGCGGTCCAAACATCGCGATC
TCTACAGCATGTACGACTGGCCTACATAACATTGGCCACGCGGCTCGTATGATTGCATACGGCGATGCTGACGCAATGCT
AGCGGGTGGTGCTGAAAAAGCATCGACACCACTAGGTATGGGCGGTTTTGGTGCGGCTAAAGCACTGTCTACTCGTAACG
ATGAGCCTCAAAAAGCTTCTCGTCCATGGGACAAAGGCCGTGACGGCTTCGTTCTTGGTGACGGTGCAGGCATGATGGTT
CTTGAAGAGTATGAACATGCTAAAGCTCGTGGCGCTAAGATTTACTGTGAGCTAGTTGGCTTCGGTATGTCGGGTGACGC
TTACCACATGACATCTCCAAGTGAAGATGGTTCTGGTGGCGCACTAGCAATGGAAGCGGCTATGCGTGATGCTGGCATTA
CTGGTGAACAAATCGGTTATGTTAACGCACACGGTACTTCGACTCCTGCAGGTGACGTAGCGGAAGTGAAGGGCATCAAG
CGTGCTCTTGGCGAAGCAGGCAGCAAGCAGGTCTTGGTTTCTTCTACGAAATCAATGACTGGCCACCTTCTAGGTGCTGC
GGGTTCTGCTGAAGCGATCATCACTGCGATGTCTCTAATTGATCAAATTGTTCCACCAACAATCAATTTAGATGATCCTG
AAGAAGGCTTAGATATTGACTTAGTACCTCACACTGCGCGTAAAGTTAGCGGTATGGAATATGCTGCATGTAACTCATTC
GGTTTCGGTGGTACTAACGGCTGTTTGATCTTCAAAAAGATTTAA

Upstream 100 bases:

>100_bases
TCAGTAATAATCTCTCCCAGGCGGTCACCTCGACCGCCTGTGTTTTATCTAACTCATCTATCCTCATCTTAAATCACCTC
AATCCCCGGAGTGTAATATC

Downstream 100 bases:

>100_bases
TCATCTTATATAAGAGTCAAACATCGTAGATAGTCATAATTAGAACTGTTTTTAAACGGCTCGATGCTTTAGCATTGAGC
CGTTTCTTTTTATGGGGAAA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSKRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIDHFDATNFSTRFAGLVKDFNCEEYMTKKDARKMDLFIQYGVA
AGIQALDDSALTITEENAPRVGVAIGSGIGGLGLIEAGHKALTEKGPRKISPFFVPSTIVNMIAGHMSIMRGLRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTPLGMGGFGAAKALSTRNDEPQKASRPWDKGRDGFVLGDGAGMMV
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGITGEQIGYVNAHGTSTPAGDVAEVKGIK
RALGEAGSKQVLVSSTKSMTGHLLGAAGSAEAIITAMSLIDQIVPPTINLDDPEEGLDIDLVPHTARKVSGMEYAACNSF
GFGGTNGCLIFKKI

Sequences:

>Translated_414_residues
MSKRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIDHFDATNFSTRFAGLVKDFNCEEYMTKKDARKMDLFIQYGVA
AGIQALDDSALTITEENAPRVGVAIGSGIGGLGLIEAGHKALTEKGPRKISPFFVPSTIVNMIAGHMSIMRGLRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTPLGMGGFGAAKALSTRNDEPQKASRPWDKGRDGFVLGDGAGMMV
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGITGEQIGYVNAHGTSTPAGDVAEVKGIK
RALGEAGSKQVLVSSTKSMTGHLLGAAGSAEAIITAMSLIDQIVPPTINLDDPEEGLDIDLVPHTARKVSGMEYAACNSF
GFGGTNGCLIFKKI
>Mature_413_residues
SKRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIDHFDATNFSTRFAGLVKDFNCEEYMTKKDARKMDLFIQYGVAA
GIQALDDSALTITEENAPRVGVAIGSGIGGLGLIEAGHKALTEKGPRKISPFFVPSTIVNMIAGHMSIMRGLRGPNIAIS
TACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTPLGMGGFGAAKALSTRNDEPQKASRPWDKGRDGFVLGDGAGMMVL
EEYEHAKARGAKIYCELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGITGEQIGYVNAHGTSTPAGDVAEVKGIKR
ALGEAGSKQVLVSSTKSMTGHLLGAAGSAEAIITAMSLIDQIVPPTINLDDPEEGLDIDLVPHTARKVSGMEYAACNSFG
FGGTNGCLIFKKI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=415, Percent_Identity=44.8192771084337, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI223972627, Length=151, Percent_Identity=48.3443708609272, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI41872631, Length=421, Percent_Identity=25.41567695962, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=76.5700483091787, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=37.4701670644391, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=38.4057971014493, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=43.984962406015, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI212642053, Length=426, Percent_Identity=23.2394366197183, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=410, Percent_Identity=24.6341463414634, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=37.5565610859729, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=45.0704225352113, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24581345, Length=375, Percent_Identity=22.4, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19920632, Length=428, Percent_Identity=22.4299065420561, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221330659, Length=428, Percent_Identity=22.4299065420561, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43008; Mature: 42876

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIDHFDATNFSTRFAGLVKDFNCE
CCCCEEEEECCCHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCHH
EYMTKKDARKMDLFIQYGVAAGIQALDDSALTITEENAPRVGVAIGSGIGGLGLIEAGHK
HHHHHHHHHHHHHEEEHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHH
ALTEKGPRKISPFFVPSTIVNMIAGHMSIMRGLRGPNIAISTACTTGLHNIGHAARMIAY
HHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEEEEE
GDADAMLAGGAEKASTPLGMGGFGAAKALSTRNDEPQKASRPWDKGRDGFVLGDGAGMMV
CCCCCEEECCCHHCCCCCCCCCCCHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGITGEQIGY
EHHHHHHHHCCCEEEEEEEEECCCCCEEECCCCCCCCCCCEEEHHHHHHHCCCCCCCEEE
VNAHGTSTPAGDVAEVKGIKRALGEAGSKQVLVSSTKSMTGHLLGAAGSAEAIITAMSLI
EECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHEEECCCCHHHHHHHHHHH
DQIVPPTINLDDPEEGLDIDLVPHTARKVSGMEYAACNSFGFGGTNGCLIFKKI
HHHCCCCCCCCCCCCCCEEEECCCHHHHHCCCEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SKRRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIDHFDATNFSTRFAGLVKDFNCE
CCCEEEEECCCHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCHH
EYMTKKDARKMDLFIQYGVAAGIQALDDSALTITEENAPRVGVAIGSGIGGLGLIEAGHK
HHHHHHHHHHHHHEEEHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHH
ALTEKGPRKISPFFVPSTIVNMIAGHMSIMRGLRGPNIAISTACTTGLHNIGHAARMIAY
HHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEEEEE
GDADAMLAGGAEKASTPLGMGGFGAAKALSTRNDEPQKASRPWDKGRDGFVLGDGAGMMV
CCCCCEEECCCHHCCCCCCCCCCCHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGITGEQIGY
EHHHHHHHHCCCEEEEEEEEECCCCCEEECCCCCCCCCCCEEEHHHHHHHCCCCCCCEEE
VNAHGTSTPAGDVAEVKGIKRALGEAGSKQVLVSSTKSMTGHLLGAAGSAEAIITAMSLI
EECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHEEECCCCHHHHHHHHHHH
DQIVPPTINLDDPEEGLDIDLVPHTARKVSGMEYAACNSFGFGGTNGCLIFKKI
HHHCCCCCCCCCCCCCCEEEECCCHHHHHCCCEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]