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The map label for this gene is fabD [H]

Identifier: 218709017

GI number: 218709017

Start: 1064320

End: 1065243

Strand: Direct

Name: fabD [H]

Synonym: VS_1023

Alternate gene names: 218709017

Gene position: 1064320-1065243 (Clockwise)

Preceding gene: 218709016

Following gene: 218709018

Centisome position: 32.26

GC content: 47.4

Gene sequence:

>924_bases
ATGAGCAAATTTGCTATCGTATTCCCAGGCCAAGGCTCTCAAGCTATCGGTATGCTTGCTGACCTAGGCGAACAGTATGA
TGTTGTTAAAAAGACATTTGCTGAAGCTTCAGAAGCACTTGGTTACGATCTATGGGCATTGGTTCAAGATGGTCCAGTAG
AAAATCTAAATGAAACTTTCCGTACTCAACCGGCTCTACTAACAGCGTCTGTTGCAATCTGGCGTGTATGGCAAGAGCTT
GGTCTAGAGCAACCTGCAAACCTAGCCGGCCACAGCCTAGGCGAATACTCTGCACTAGTGTGTGCGGGTGTTATCGACTT
TAAAGAAGCGATCAAGCTAGTTGAGCTACGTGGTCAACTGATGCAAGAAGCGGTTCCTGCGGGCGTTGGTGCAATGTACG
CAATCATCGGTCTAGATGATGAAGCGATTGCTAAAGCGTGTGAAGAAGCGGCACAAGACGAAGTTGTGTCTCCAGTTAAC
TTCAATTCACCTGGCCAAGTTGTTATCGCGGGTAACAAAGCAGCAGTAGAGCGCGCTGGTGCACTATGTAAAGAAGCGGG
CGCTAAACGTGCACTTCCTTTACCAGTATCTGTGCCGTCTCACTGTGCCCTTATGAAGCCTGCAGCAGACAAGCTAGCAG
TTGCTCTAGAAGCTCTAGAGTTCAACACGCCGGCACTGCCTGTTATCAATAACGTTGATGTTATTGCTGAAACAGACCCG
GCAAAAATCAAAAGCGCACTTGTTCGCCAGCTGTACAGCCCAGTTCGTTGGACTGAAGGTGTACAAGCTATGAATGAGCA
AGGCGTAGAGAAGCTACTAGAATTAGGCCCAGGTAAAGTTCTTACCGGTCTAACAAAACGAATCGTAAAAACTATGACAG
CTGCTGCAGTTAATGACACTGCATCACTAGAAGCTGCTAAGTAA

Upstream 100 bases:

>100_bases
CTGCGTTAGTTAAATTCTAACCCCAAGCGATAATCAACAAACAAGGCACATAACTTATGTGCCTTATTCAATTTTTTGCT
TTGCTTAAAGGAAAATTACT

Downstream 100 bases:

>100_bases
ATAAACACTTAATAGAGAAGTTATGATGAATTTAGAAGGCAAAGTTGCACTAGTTACAGGCGCAAGCCGTGGTATCGGTC
GTGCAATCGCTGAACTTTTA

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSKFAIVFPGQGSQAIGMLADLGEQYDVVKKTFAEASEALGYDLWALVQDGPVENLNETFRTQPALLTASVAIWRVWQEL
GLEQPANLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQEAVPAGVGAMYAIIGLDDEAIAKACEEAAQDEVVSPVN
FNSPGQVVIAGNKAAVERAGALCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALEALEFNTPALPVINNVDVIAETDP
AKIKSALVRQLYSPVRWTEGVQAMNEQGVEKLLELGPGKVLTGLTKRIVKTMTAAAVNDTASLEAAK

Sequences:

>Translated_307_residues
MSKFAIVFPGQGSQAIGMLADLGEQYDVVKKTFAEASEALGYDLWALVQDGPVENLNETFRTQPALLTASVAIWRVWQEL
GLEQPANLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQEAVPAGVGAMYAIIGLDDEAIAKACEEAAQDEVVSPVN
FNSPGQVVIAGNKAAVERAGALCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALEALEFNTPALPVINNVDVIAETDP
AKIKSALVRQLYSPVRWTEGVQAMNEQGVEKLLELGPGKVLTGLTKRIVKTMTAAAVNDTASLEAAK
>Mature_306_residues
SKFAIVFPGQGSQAIGMLADLGEQYDVVKKTFAEASEALGYDLWALVQDGPVENLNETFRTQPALLTASVAIWRVWQELG
LEQPANLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQEAVPAGVGAMYAIIGLDDEAIAKACEEAAQDEVVSPVNF
NSPGQVVIAGNKAAVERAGALCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALEALEFNTPALPVINNVDVIAETDPA
KIKSALVRQLYSPVRWTEGVQAMNEQGVEKLLELGPGKVLTGLTKRIVKTMTAAAVNDTASLEAAK

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=296, Percent_Identity=34.4594594594595, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI27477045, Length=107, Percent_Identity=42.0560747663551, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1787334, Length=306, Percent_Identity=71.5686274509804, Blast_Score=426, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71984332, Length=294, Percent_Identity=29.9319727891156, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=299, Percent_Identity=29.7658862876254, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24665753, Length=301, Percent_Identity=33.2225913621262, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32402; Mature: 32270

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFAIVFPGQGSQAIGMLADLGEQYDVVKKTFAEASEALGYDLWALVQDGPVENLNETF
CCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHH
RTQPALLTASVAIWRVWQELGLEQPANLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQL
HCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQEAVPAGVGAMYAIIGLDDEAIAKACEEAAQDEVVSPVNFNSPGQVVIAGNKAAVERAG
HHHHHCCCHHHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHH
ALCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALEALEFNTPALPVINNVDVIAETDP
HHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCH
AKIKSALVRQLYSPVRWTEGVQAMNEQGVEKLLELGPGKVLTGLTKRIVKTMTAAAVNDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
ASLEAAK
CCCCCCC
>Mature Secondary Structure 
SKFAIVFPGQGSQAIGMLADLGEQYDVVKKTFAEASEALGYDLWALVQDGPVENLNETF
CCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHH
RTQPALLTASVAIWRVWQELGLEQPANLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQL
HCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MQEAVPAGVGAMYAIIGLDDEAIAKACEEAAQDEVVSPVNFNSPGQVVIAGNKAAVERAG
HHHHHCCCHHHHHHEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHH
ALCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALEALEFNTPALPVINNVDVIAETDP
HHHHHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCH
AKIKSALVRQLYSPVRWTEGVQAMNEQGVEKLLELGPGKVLTGLTKRIVKTMTAAAVNDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
ASLEAAK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]