Click here to switch to the map view.

The map label for this gene is fadR [H]

Identifier: 218709001

GI number: 218709001

Start: 1044319

End: 1045158

Strand: Direct

Name: fadR [H]

Synonym: VS_1007

Alternate gene names: 218709001

Gene position: 1044319-1045158 (Clockwise)

Preceding gene: 218708998

Following gene: 218709004

Centisome position: 31.65

GC content: 41.43

Gene sequence:

>840_bases
ATGGTCATTAAGGCAAAGAGCCCGGCAGGATTTGCAGAAAAGTATATCATTGAAAGTATTTGGAATGGCCGTTTCGCTCC
AGGTTCTATCTTGCCCGCAGAGCGTGAGCTTTCTGAGCTGATTGGTGTTACACGTACTACGCTTCGTGAAGTACTTCAGC
GTCTTGCTCGTGATGGTTGGTTGACAATCCAACACGGTAAGCCAACTAAAGTTAATCAGTTTATGGAAACGTCAGGTCTT
CATATCCTTGATACATTAATGACGTTGGACGTTGATAACGCAAGTAAAATGGTAGAAGACCTGCTTGCTGCTCGTACTAA
TATCAGCCCTATCTTTATGCGTTATGCATTCAAAGCAAATAAAGAGGCTTCAGAGCGTACGATTACTAACGTAATTGAAT
CTTGTGAATCTTTACTTGCGGCACCTACTTGGGATGAATTCTTAGAATCGTCGCCATATGCTGACAAGATCAAACAATCG
GTGAAAGAAGACGTAGAAAAAGATGAAGCGAAGCGTCAAACGATCTTAATTGCTAAAACTTTTAACTTCTACGATTACAT
GCTTTTCCAACGTTTAGCATTCCATTCAGGTAACCAAATTTATGGCCTGATCTTTAATGGTGTTCGTAAATTGTACGACC
GTGTTGGCAGCTACTACTTCTCTAACCCAGAAGCTCGTCGTTTAGCCATGGAGTTCTATAAAAACTTGTTTGTTATTTGT
GAAAGCGGTGAGCGTGAGAATTTACCACTTGTGATTCGTAACTACGGTATCGCAAGCGCACAGATTTGGAACGAGATGAA
GACAACGTTACCGACAAACTTTACTGAAGACGACAGCTAA

Upstream 100 bases:

>100_bases
TTTGAGTGAGTAAAATTTTTTGGGGGTATTTCCGCAGGGTGTTAACTAGTGGTATGATGAGTAAATTAGAACAAAATAAT
TAAATTGGATTGAAGTGTAG

Downstream 100 bases:

>100_bases
GTCTTTTCATAAAAGTATTGTTCGGTTGTTTTACTTATTGAGTAAACGACGTAAAGAAAACGAAAAAGCGGCGAGATAAT
CAAATTATCTCGCCGCTTTT

Product: fatty acid metabolism regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MVIKAKSPAGFAEKYIIESIWNGRFAPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGL
HILDTLMTLDVDNASKMVEDLLAARTNISPIFMRYAFKANKEASERTITNVIESCESLLAAPTWDEFLESSPYADKIKQS
VKEDVEKDEAKRQTILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGVRKLYDRVGSYYFSNPEARRLAMEFYKNLFVIC
ESGERENLPLVIRNYGIASAQIWNEMKTTLPTNFTEDDS

Sequences:

>Translated_279_residues
MVIKAKSPAGFAEKYIIESIWNGRFAPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGL
HILDTLMTLDVDNASKMVEDLLAARTNISPIFMRYAFKANKEASERTITNVIESCESLLAAPTWDEFLESSPYADKIKQS
VKEDVEKDEAKRQTILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGVRKLYDRVGSYYFSNPEARRLAMEFYKNLFVIC
ESGERENLPLVIRNYGIASAQIWNEMKTTLPTNFTEDDS
>Mature_279_residues
MVIKAKSPAGFAEKYIIESIWNGRFAPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNQFMETSGL
HILDTLMTLDVDNASKMVEDLLAARTNISPIFMRYAFKANKEASERTITNVIESCESLLAAPTWDEFLESSPYADKIKQS
VKEDVEKDEAKRQTILIAKTFNFYDYMLFQRLAFHSGNQIYGLIFNGVRKLYDRVGSYYFSNPEARRLAMEFYKNLFVIC
ESGERENLPLVIRNYGIASAQIWNEMKTTLPTNFTEDDS

Specific function: Multifunctional regulator of fatty acid metabolism [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787436, Length=274, Percent_Identity=50, Blast_Score=272, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07840 FadR_C; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 31957; Mature: 31957

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKAKSPAGFAEKYIIESIWNGRFAPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNQFMETSGLHILDTLMTLDVDNASKMVEDLLAARTNISPIFMRYAFKAN
EEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
KEASERTITNVIESCESLLAAPTWDEFLESSPYADKIKQSVKEDVEKDEAKRQTILIAKT
CCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEH
FNFYDYMLFQRLAFHSGNQIYGLIFNGVRKLYDRVGSYYFSNPEARRLAMEFYKNLFVIC
HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEE
ESGERENLPLVIRNYGIASAQIWNEMKTTLPTNFTEDDS
CCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MVIKAKSPAGFAEKYIIESIWNGRFAPGSILPAERELSELIGVTRTTLREVLQRLARDGW
CEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNQFMETSGLHILDTLMTLDVDNASKMVEDLLAARTNISPIFMRYAFKAN
EEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
KEASERTITNVIESCESLLAAPTWDEFLESSPYADKIKQSVKEDVEKDEAKRQTILIAKT
CCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEH
FNFYDYMLFQRLAFHSGNQIYGLIFNGVRKLYDRVGSYYFSNPEARRLAMEFYKNLFVIC
HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEE
ESGERENLPLVIRNYGIASAQIWNEMKTTLPTNFTEDDS
CCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]