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The map label for this gene is aaeR [H]

Identifier: 218708908

GI number: 218708908

Start: 937868

End: 938755

Strand: Reverse

Name: aaeR [H]

Synonym: VS_0909

Alternate gene names: 218708908

Gene position: 938755-937868 (Counterclockwise)

Preceding gene: 218708911

Following gene: 218708896

Centisome position: 28.45

GC content: 45.16

Gene sequence:

>888_bases
GTGTCTGGATTTATGAAATTAGATGATTTAAACCTCTTTCGACTTGTCGTTGAAAATGGGAGCTACACCGCAACATCACG
CAAGACTATGATTCCGGTTGCGACCATTACACGACGCATCCAAGCCTTAGAAGATTCACTAAACCTAAGACTTCTCAATA
GACACGCGCGTAAACTCTCTTTAACAGAGGCAGGCGAACGTTTCTTCAACGAATGCTCTCCGTTACTGCAACGTCTATCT
TCTACTGCAGAAGAACTGACTGACGTTTGTAAAGGGGCTTCCGGTAAGATTCGCATTACGGCACCCTCAAACCTGACCAA
GCGCATGATGATGCCGATGTTCAGTGAATTCATGACTCAATATCCTGATATTAATATTGAGCTGATGATGAACAACCAAG
CCGATCAGCTTGATCCAACCGAGTGGGACGTAATTTTCAGAGTAGGTCCACAACGTGATTCAAGCCTAATCGCTCGAAAA
ATCAGTGAAGTAAAAGATATTCTTATCGCAAGTCCTGACTACTTAGCGAAGAACCCGGCACCAAGTCATGCAGAAGAGCT
CGCGAATCATTCGCTACTTAAAGGCTATCCGCTGATTAAGTGGCAGCTGAGTAATTCGAATGAAGAGACGGTGGTGAATA
GCGAGAAAGGCCGTTTCAACGCGAATGCGCTCAATGTCGTGAGACAAGCATGTTCAGAAGGCCTCGGTATCACCCTAATG
CCCGACGTTATGATCCGCGAATACATTGAAGATGGCAGCTTAGTGCAAGTCTTAGAGGACTGGAGCGCTAACCCTCGTGA
TATCTACATGCTTTACAACCACAAAGACCACCTGCCAGAGAAGGTTAGATTGTTTATCGATTTTGTGATCGCATACCACA
TTCACTAA

Upstream 100 bases:

>100_bases
GTGACAAGGGTTGGAATACTGGTAAATAGTGCAACGAATTGACGTAACGCAAACATTGATCTCACTATTACGTATAAATT
AGATGAGATTGTAAACAAAT

Downstream 100 bases:

>100_bases
GATTCAATCCCCTTCCCCGCAAACAAAAAAACCAGAGTCGATGCTCTGGTTTTTTATTACTCATGTTTATGAGTACGCTA
AGCGCCTTCGTTATGTAACT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSGFMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDSLNLRLLNRHARKLSLTEAGERFFNECSPLLQRLS
STAEELTDVCKGASGKIRITAPSNLTKRMMMPMFSEFMTQYPDINIELMMNNQADQLDPTEWDVIFRVGPQRDSSLIARK
ISEVKDILIASPDYLAKNPAPSHAEELANHSLLKGYPLIKWQLSNSNEETVVNSEKGRFNANALNVVRQACSEGLGITLM
PDVMIREYIEDGSLVQVLEDWSANPRDIYMLYNHKDHLPEKVRLFIDFVIAYHIH

Sequences:

>Translated_295_residues
MSGFMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDSLNLRLLNRHARKLSLTEAGERFFNECSPLLQRLS
STAEELTDVCKGASGKIRITAPSNLTKRMMMPMFSEFMTQYPDINIELMMNNQADQLDPTEWDVIFRVGPQRDSSLIARK
ISEVKDILIASPDYLAKNPAPSHAEELANHSLLKGYPLIKWQLSNSNEETVVNSEKGRFNANALNVVRQACSEGLGITLM
PDVMIREYIEDGSLVQVLEDWSANPRDIYMLYNHKDHLPEKVRLFIDFVIAYHIH
>Mature_294_residues
SGFMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDSLNLRLLNRHARKLSLTEAGERFFNECSPLLQRLSS
TAEELTDVCKGASGKIRITAPSNLTKRMMMPMFSEFMTQYPDINIELMMNNQADQLDPTEWDVIFRVGPQRDSSLIARKI
SEVKDILIASPDYLAKNPAPSHAEELANHSLLKGYPLIKWQLSNSNEETVVNSEKGRFNANALNVVRQACSEGLGITLMP
DVMIREYIEDGSLVQVLEDWSANPRDIYMLYNHKDHLPEKVRLFIDFVIAYHIH

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=298, Percent_Identity=28.5234899328859, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI87081978, Length=296, Percent_Identity=28.7162162162162, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=29.5138888888889, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789440, Length=288, Percent_Identity=28.8194444444444, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1787589, Length=288, Percent_Identity=26.0416666666667, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI145693193, Length=289, Percent_Identity=26.643598615917, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1787128, Length=291, Percent_Identity=27.1477663230241, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789173, Length=287, Percent_Identity=24.390243902439, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788481, Length=303, Percent_Identity=22.4422442244224, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI157672245, Length=144, Percent_Identity=29.8611111111111, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790011, Length=298, Percent_Identity=22.4832214765101, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=125, Percent_Identity=26.4, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790783, Length=260, Percent_Identity=25, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33604; Mature: 33473

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDSLNLRLLNRHARKLS
CCCCCCCCCCCEEEEEEECCCEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTEAGERFFNECSPLLQRLSSTAEELTDVCKGASGKIRITAPSNLTKRMMMPMFSEFMTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
YPDINIELMMNNQADQLDPTEWDVIFRVGPQRDSSLIARKISEVKDILIASPDYLAKNPA
CCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCC
PSHAEELANHSLLKGYPLIKWQLSNSNEETVVNSEKGRFNANALNVVRQACSEGLGITLM
CHHHHHHHCCHHHCCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEC
PDVMIREYIEDGSLVQVLEDWSANPRDIYMLYNHKDHLPEKVRLFIDFVIAYHIH
HHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGFMKLDDLNLFRLVVENGSYTATSRKTMIPVATITRRIQALEDSLNLRLLNRHARKLS
CCCCCCCCCCEEEEEEECCCEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTEAGERFFNECSPLLQRLSSTAEELTDVCKGASGKIRITAPSNLTKRMMMPMFSEFMTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
YPDINIELMMNNQADQLDPTEWDVIFRVGPQRDSSLIARKISEVKDILIASPDYLAKNPA
CCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCC
PSHAEELANHSLLKGYPLIKWQLSNSNEETVVNSEKGRFNANALNVVRQACSEGLGITLM
CHHHHHHHCCHHHCCCCEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEEEC
PDVMIREYIEDGSLVQVLEDWSANPRDIYMLYNHKDHLPEKVRLFIDFVIAYHIH
HHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]