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The map label for this gene is gltP [H]

Identifier: 218708671

GI number: 218708671

Start: 675216

End: 676490

Strand: Direct

Name: gltP [H]

Synonym: VS_0650

Alternate gene names: 218708671

Gene position: 675216-676490 (Clockwise)

Preceding gene: 218708670

Following gene: 218708672

Centisome position: 20.47

GC content: 45.57

Gene sequence:

>1275_bases
ATGGACAAATCGCTCTCAAGTAAGATTTTTGTAGGCTTGTTTGCCGGCCTACTTATTGGTACTGCTATTCAGTACCTATT
CAACGGTATTGCAGTATTTGATACTTACCTGCTAGGTCTAGCAGAAGGTGTCGGTGGTATGTTTGTCTCTTTGATCAAAC
TATTGGTTGTTCCACTGGTATACGTATCTATCGTTTGCGGAATTGTTGAATTGAAAGACATCCGTTCTTTCGGTCGCCTA
GGTGGTAAAACTTTTGCTCTTTACATTATCAACACCATCATCGCGATTTCTGCAGCCCTAACTGTTGGCCTTATTTTCCA
ACCGGGTGCTGGTGCAGATTTAGCCGGAACGATCTCTGAGACAGTTCAACTAACAACAACTGAAACTCCAGATATCTTCT
CTCTTGTTGTGAACATCGTTCCTAGCAACCCAGTTCAGGCGTTTGCAAGCGGCGACATGCTACAGATCATCTTCATGGCA
ATTTTGACTGGTCTTGCTATTCAGGCTCTTGATTCACGTGGCGGTCCAGCGATCAAAACGTTCAAGATGGCTAACGAAAT
CATGATGAAGCTTATCGGCCTGGTAATGAGCTTGGCACCATTTGGTGTATTCGCTCTGATGATTCAACTAGGTGCGACAC
TGAACGCCGAGACACTTATGTCTGTAGCGGGCTACGTAGCGCTTGTTGTTGCGATGCTAGTGTTCTGGATTTTCTTCTTC
TACCCAATGATGGTTGGTATCGCGACAGGTATTACGCCTAAGCAATTCCTACGTGCAACTCGTGAGCAAATCCTTTTCTC
ACTATCGACGGCAAGTTCGAACGCGACTATCCCAGTAACAATGCGCACTCTAACTGAAAAGCTTGGTGTATCAAGATCTG
TGGCTGGTTTCGGTGTTCCGCTGGGTGCGACAATGAACATGTCTGGTGTCTCTATCTACATCGCACTAGCGACAATGTTC
GTAGCAAACGCATTCGGTCAACCAATCAACACTGCTGACATCTTTACTCTGGGTCTAACTATCTTGCTACTGTCTATCGG
TGCTGGTGGTGTTCCAGGTGGTGGTGTTGTAATGGTAGGTGTTCTATTGCACCAACTAGGTTTACCACCAGAAGGTCTAG
CTATCATTGCTGCGGTAGACCGTATCAACGATATGTTCTGTACTTCTTCTAACGTAGTGGGTGATACCGCGGTTAACACT
ATCGTTGCTAAGTCTGAAGGCGAAATCGGCGTTGAAACAAACGAAGAAGCTGAGCTAAAGAAAGCAGAAGCGTAA

Upstream 100 bases:

>100_bases
TGTTATCTTTGTATGTAAAATCCACTGCGATATAGCGATTTAACTCGCATATATAACTATAAAAGTACAAATTTCAAACA
CAACAAACTGGAGAAGAACG

Downstream 100 bases:

>100_bases
TCAGAGATTTTCCTCTATAGATGAAATCTAAGTGGAAAGCCTGAATAGACAAACGGAGCCTAAGTGGCTCCGTTTTTTAT
TGGGTGATAACCCCAGTTAC

Product: sodium/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MDKSLSSKIFVGLFAGLLIGTAIQYLFNGIAVFDTYLLGLAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIRSFGRL
GGKTFALYIINTIIAISAALTVGLIFQPGAGADLAGTISETVQLTTTETPDIFSLVVNIVPSNPVQAFASGDMLQIIFMA
ILTGLAIQALDSRGGPAIKTFKMANEIMMKLIGLVMSLAPFGVFALMIQLGATLNAETLMSVAGYVALVVAMLVFWIFFF
YPMMVGIATGITPKQFLRATREQILFSLSTASSNATIPVTMRTLTEKLGVSRSVAGFGVPLGATMNMSGVSIYIALATMF
VANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVGVLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNT
IVAKSEGEIGVETNEEAELKKAEA

Sequences:

>Translated_424_residues
MDKSLSSKIFVGLFAGLLIGTAIQYLFNGIAVFDTYLLGLAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIRSFGRL
GGKTFALYIINTIIAISAALTVGLIFQPGAGADLAGTISETVQLTTTETPDIFSLVVNIVPSNPVQAFASGDMLQIIFMA
ILTGLAIQALDSRGGPAIKTFKMANEIMMKLIGLVMSLAPFGVFALMIQLGATLNAETLMSVAGYVALVVAMLVFWIFFF
YPMMVGIATGITPKQFLRATREQILFSLSTASSNATIPVTMRTLTEKLGVSRSVAGFGVPLGATMNMSGVSIYIALATMF
VANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVGVLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNT
IVAKSEGEIGVETNEEAELKKAEA
>Mature_424_residues
MDKSLSSKIFVGLFAGLLIGTAIQYLFNGIAVFDTYLLGLAEGVGGMFVSLIKLLVVPLVYVSIVCGIVELKDIRSFGRL
GGKTFALYIINTIIAISAALTVGLIFQPGAGADLAGTISETVQLTTTETPDIFSLVVNIVPSNPVQAFASGDMLQIIFMA
ILTGLAIQALDSRGGPAIKTFKMANEIMMKLIGLVMSLAPFGVFALMIQLGATLNAETLMSVAGYVALVVAMLVFWIFFF
YPMMVGIATGITPKQFLRATREQILFSLSTASSNATIPVTMRTLTEKLGVSRSVAGFGVPLGATMNMSGVSIYIALATMF
VANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVGVLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNT
IVAKSEGEIGVETNEEAELKKAEA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=401, Percent_Identity=30.4239401496259, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI40254478, Length=442, Percent_Identity=27.8280542986425, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI169790839, Length=443, Percent_Identity=26.1851015801354, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI4827012, Length=284, Percent_Identity=31.6901408450704, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI194239697, Length=257, Percent_Identity=31.9066147859922, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI5032093, Length=383, Percent_Identity=29.7650130548303, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI66773030, Length=393, Percent_Identity=26.2086513994911, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI223468566, Length=284, Percent_Identity=30.6338028169014, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI223468564, Length=256, Percent_Identity=30.859375, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI301601644, Length=141, Percent_Identity=36.8794326241135, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI262359914, Length=369, Percent_Identity=24.6612466124661, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1790514, Length=416, Percent_Identity=33.4134615384615, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789947, Length=380, Percent_Identity=30, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1788024, Length=403, Percent_Identity=27.5434243176179, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1789473, Length=237, Percent_Identity=30.379746835443, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71983106, Length=399, Percent_Identity=29.5739348370927, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71983099, Length=399, Percent_Identity=29.5739348370927, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=384, Percent_Identity=29.9479166666667, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71996953, Length=427, Percent_Identity=25.7611241217799, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=421, Percent_Identity=24.7030878859857, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI193206654, Length=401, Percent_Identity=26.4339152119701, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=395, Percent_Identity=27.0886075949367, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24583025, Length=421, Percent_Identity=25.8907363420428, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17137668, Length=421, Percent_Identity=25.8907363420428, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24583023, Length=421, Percent_Identity=25.8907363420428, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI281360481, Length=427, Percent_Identity=23.4192037470726, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281360483, Length=433, Percent_Identity=23.5565819861432, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137666, Length=433, Percent_Identity=23.5565819861432, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44314; Mature: 44314

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSLSSKIFVGLFAGLLIGTAIQYLFNGIAVFDTYLLGLAEGVGGMFVSLIKLLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVSIVCGIVELKDIRSFGRLGGKTFALYIINTIIAISAALTVGLIFQPGAGADLAGTISE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHH
TVQLTTTETPDIFSLVVNIVPSNPVQAFASGDMLQIIFMAILTGLAIQALDSRGGPAIKT
CEEEEECCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
FKMANEIMMKLIGLVMSLAPFGVFALMIQLGATLNAETLMSVAGYVALVVAMLVFWIFFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YPMMVGIATGITPKQFLRATREQILFSLSTASSNATIPVTMRTLTEKLGVSRSVAGFGVP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
LGATMNMSGVSIYIALATMFVANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVG
CCCEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNTIVAKSEGEIGVETNEEAELK
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCCCCHHHHH
KAEA
HCCC
>Mature Secondary Structure
MDKSLSSKIFVGLFAGLLIGTAIQYLFNGIAVFDTYLLGLAEGVGGMFVSLIKLLVVPLV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVSIVCGIVELKDIRSFGRLGGKTFALYIINTIIAISAALTVGLIFQPGAGADLAGTISE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHH
TVQLTTTETPDIFSLVVNIVPSNPVQAFASGDMLQIIFMAILTGLAIQALDSRGGPAIKT
CEEEEECCCCHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
FKMANEIMMKLIGLVMSLAPFGVFALMIQLGATLNAETLMSVAGYVALVVAMLVFWIFFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
YPMMVGIATGITPKQFLRATREQILFSLSTASSNATIPVTMRTLTEKLGVSRSVAGFGVP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHCCCCCCCCCCCC
LGATMNMSGVSIYIALATMFVANAFGQPINTADIFTLGLTILLLSIGAGGVPGGGVVMVG
CCCEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VLLHQLGLPPEGLAIIAAVDRINDMFCTSSNVVGDTAVNTIVAKSEGEIGVETNEEAELK
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCCCCCCCCHHHHH
KAEA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]