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The map label for this gene is guaA [H]

Identifier: 218708651

GI number: 218708651

Start: 652854

End: 654407

Strand: Direct

Name: guaA [H]

Synonym: VS_0629

Alternate gene names: 218708651

Gene position: 652854-654407 (Clockwise)

Preceding gene: 218708650

Following gene: 218708652

Centisome position: 19.79

GC content: 45.43

Gene sequence:

>1554_bases
ATGACTAAAAATATTCATGACCAACGTATTCTAATTCTGGACTTCGGTTCTCAATACACACAGCTAGTAGCTCGTCGTAT
TCGTGAGATCGGTGTTTACTGTGAACTTTGGAGCTGGGACGTAGAAGAAGCGGATATTCGTGAATTCAATCCAGACGGTA
TCATCCTATCTGGTGGCCCTGAAAGTGTAACGGAAGAGAATTCTCCACGTGCACCTCAGTACGTATTTGATTCAGGTGTT
CCTGTCTTCGGTATCTGCTACGGCATGCAAACGATGGCTGAGCAACTTGGCGGTAAAGTAGCAACGTCTACTGAGCGCGA
GTTCGGCTACGCTGCTGTACAAGTGACAGGTGAATCTGCACTTTTCGCTGACCTTGAGACAACTCAAGATGTTTGGATGA
GCCACGGTGACAAAGTGGTTGAAATCCCTGCTGATTTCACAAAAATTGCAGAGACAGATACTTGCCCATACGCTGCAATG
GCAAACGAAGAGAAGAAATACTACGGTGTTCAATTCCACCCAGAAGTAACGCACACTAAAAACGGCCTAAAAATGCTTGA
GAACTTCGTTCTTAACGCGTGTGGTTGTGAAGGTCTGTGGACTTCAGCGTCTATCATTGAAGATGCAGTTGCACGTATTA
AAGAGCAAGTAGGTGACGATGAAGTTATCCTTGGTCTTTCTGGTGGTGTTGATTCATCAGTCGTAGCAATGCTTGCTCAC
CGCGCTATCGGCGACAAACTGACATGTGTATTTGTAGATAACGGCCTTCTTCGTTTAAACGAAGGTGAGCAGGTTATGGA
GATGTTTGGTGACCAATTCGGCCTAAACATCATTAAAGTTGATGCGGAAGATCGTTTCCTTGACGCTCTGGAAGGCGAAG
CTGAACCAGAAGCGAAACGTAAGATCATCGGTCACGTATTCGTAGATATCTTCGACGAAGAGTCTAAGAAACTGAAGAAT
GCTAAATGGCTTGCTCAGGGTACTATCTACCCAGACGTAATCGAGTCTGCAGCATCTAAGACAGGTAAAGCACACGTAAT
CAAATCTCACCACAACGTTGGTGGCCTTCCTGATGATATGGAAATGGGCCTTGTTGAGCCTCTACGTGAGCTGTTTAAAG
ATGAAGTACGTAAGATCGGCCTAGAGCTTGGTCTTCCATACAACATGCTTTACCGCCACCCATTCCCAGGTCCAGGTCTA
GGTGTTCGTGTACTTGGTGAAGTGAAGAAAGAGTACTGTGATTTACTGCGTCGTGCTGATGCTATCTTCATTGAAGAGCT
TCACGCTGCTGACCTTTACCACAAAGTATCTCAAGCATTCACGGTATTCCTACCTGTACGTTCAGTTGGCGTAATGGGCG
ATGGCCGTAAGTACGATTGGGTTGTATCTCTACGTGCAGTAGAAACTATCGACTTCATGACTGCTCACTGGGCACACTTA
CCATACGACTTCCTAGGTAAGGTATCTAACCGTATTATCAACGAAGTTAACGGCATTTCACGTGTTGTTTACGATATTTC
TGGTAAACCACCAGCAACTATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
AAGATAACCAACGAAAACGTTTGCTTTATTTCTTGAAGAGTTAATCAGAGGTGAGTAAACTCGCCTCCGTTTTATCACAT
AGCCAATAAGACTGCTTACA

Downstream 100 bases:

>100_bases
TCTCTTAGAGATTTAACCAGTTTTGATTAAGATCTTAAGCCTCGAACTCAGTTCGGGGCTTTTTTCTTTCTGACTCAGGG
TATTAAAAGCTTATAGCTGA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MTKNIHDQRILILDFGSQYTQLVARRIREIGVYCELWSWDVEEADIREFNPDGIILSGGPESVTEENSPRAPQYVFDSGV
PVFGICYGMQTMAEQLGGKVATSTEREFGYAAVQVTGESALFADLETTQDVWMSHGDKVVEIPADFTKIAETDTCPYAAM
ANEEKKYYGVQFHPEVTHTKNGLKMLENFVLNACGCEGLWTSASIIEDAVARIKEQVGDDEVILGLSGGVDSSVVAMLAH
RAIGDKLTCVFVDNGLLRLNEGEQVMEMFGDQFGLNIIKVDAEDRFLDALEGEAEPEAKRKIIGHVFVDIFDEESKKLKN
AKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGL
GVRVLGEVKKEYCDLLRRADAIFIEELHAADLYHKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHL
PYDFLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

Sequences:

>Translated_517_residues
MTKNIHDQRILILDFGSQYTQLVARRIREIGVYCELWSWDVEEADIREFNPDGIILSGGPESVTEENSPRAPQYVFDSGV
PVFGICYGMQTMAEQLGGKVATSTEREFGYAAVQVTGESALFADLETTQDVWMSHGDKVVEIPADFTKIAETDTCPYAAM
ANEEKKYYGVQFHPEVTHTKNGLKMLENFVLNACGCEGLWTSASIIEDAVARIKEQVGDDEVILGLSGGVDSSVVAMLAH
RAIGDKLTCVFVDNGLLRLNEGEQVMEMFGDQFGLNIIKVDAEDRFLDALEGEAEPEAKRKIIGHVFVDIFDEESKKLKN
AKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGL
GVRVLGEVKKEYCDLLRRADAIFIEELHAADLYHKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHL
PYDFLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
>Mature_516_residues
TKNIHDQRILILDFGSQYTQLVARRIREIGVYCELWSWDVEEADIREFNPDGIILSGGPESVTEENSPRAPQYVFDSGVP
VFGICYGMQTMAEQLGGKVATSTEREFGYAAVQVTGESALFADLETTQDVWMSHGDKVVEIPADFTKIAETDTCPYAAMA
NEEKKYYGVQFHPEVTHTKNGLKMLENFVLNACGCEGLWTSASIIEDAVARIKEQVGDDEVILGLSGGVDSSVVAMLAHR
AIGDKLTCVFVDNGLLRLNEGEQVMEMFGDQFGLNIIKVDAEDRFLDALEGEAEPEAKRKIIGHVFVDIFDEESKKLKNA
KWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDMEMGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLG
VRVLGEVKKEYCDLLRRADAIFIEELHAADLYHKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLP
YDFLGKVSNRIINEVNGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=554, Percent_Identity=36.101083032491, Blast_Score=301, Evalue=8e-82,
Organism=Escherichia coli, GI1788854, Length=525, Percent_Identity=81.1428571428571, Blast_Score=894, Evalue=0.0,
Organism=Caenorhabditis elegans, GI133901714, Length=568, Percent_Identity=35.387323943662, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71992717, Length=568, Percent_Identity=35.387323943662, Blast_Score=302, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI71992710, Length=568, Percent_Identity=35.387323943662, Blast_Score=302, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6323873, Length=515, Percent_Identity=49.126213592233, Blast_Score=521, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322638, Length=231, Percent_Identity=26.8398268398268, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281365319, Length=555, Percent_Identity=36.7567567567568, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57574; Mature: 57443

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNIHDQRILILDFGSQYTQLVARRIREIGVYCELWSWDVEEADIREFNPDGIILSGGP
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHCCCCCEEEECCCC
ESVTEENSPRAPQYVFDSGVPVFGICYGMQTMAEQLGGKVATSTEREFGYAAVQVTGESA
CCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCHHCCEEEEEEECCCE
LFADLETTQDVWMSHGDKVVEIPADFTKIAETDTCPYAAMANEEKKYYGVQFHPEVTHTK
EEEECHHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCHHHCCCCCCEECEEECCCCCCCH
NGLKMLENFVLNACGCEGLWTSASIIEDAVARIKEQVGDDEVILGLSGGVDSSVVAMLAH
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
RAIGDKLTCVFVDNGLLRLNEGEQVMEMFGDQFGLNIIKVDAEDRFLDALEGEAEPEAKR
HHCCCCEEEEEECCCEEEECCCHHHHHHHCHHHCCEEEEECCCHHHHHHHCCCCCCHHHH
KIIGHVFVDIFDEESKKLKNAKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDM
HHHHHHHHHHHCHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHH
EMGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRAD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AIFIEELHAADLYHKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHL
HHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHC
PYDFLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
CHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC
>Mature Secondary Structure 
TKNIHDQRILILDFGSQYTQLVARRIREIGVYCELWSWDVEEADIREFNPDGIILSGGP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHCCCCCEEEECCCC
ESVTEENSPRAPQYVFDSGVPVFGICYGMQTMAEQLGGKVATSTEREFGYAAVQVTGESA
CCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCHHCCEEEEEEECCCE
LFADLETTQDVWMSHGDKVVEIPADFTKIAETDTCPYAAMANEEKKYYGVQFHPEVTHTK
EEEECHHHHHHHHCCCCEEEECCCHHHHHHCCCCCCCHHHCCCCCCEECEEECCCCCCCH
NGLKMLENFVLNACGCEGLWTSASIIEDAVARIKEQVGDDEVILGLSGGVDSSVVAMLAH
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHH
RAIGDKLTCVFVDNGLLRLNEGEQVMEMFGDQFGLNIIKVDAEDRFLDALEGEAEPEAKR
HHCCCCEEEEEECCCEEEECCCHHHHHHHCHHHCCEEEEECCCHHHHHHHCCCCCCHHHH
KIIGHVFVDIFDEESKKLKNAKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDDM
HHHHHHHHHHHCHHHHHHHCCCEEECCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHH
EMGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEYCDLLRRAD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AIFIEELHAADLYHKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHL
HHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHC
PYDFLGKVSNRIINEVNGISRVVYDISGKPPATIEWE
CHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA