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The map label for this gene is guaB [H]

Identifier: 218708650

GI number: 218708650

Start: 651012

End: 652475

Strand: Direct

Name: guaB [H]

Synonym: VS_0628

Alternate gene names: 218708650

Gene position: 651012-652475 (Clockwise)

Preceding gene: 218708648

Following gene: 218708651

Centisome position: 19.73

GC content: 47.4

Gene sequence:

>1464_bases
ATGCTAAGAATTGCCAAAGAAGCGCTGACATTCGACGACGTACTGCTAGTGCCAGCACACTCCACCGTTCTCCCTAATAC
AGCTGATCTTCGCACTCAGTTGACGAAGAATATTTCCCTAAACATCCCAATGATCTCTGCATCGATGGATACTGTGACAG
AAGCTCGCCTAGCGATTGCACTGGCACAAGAAGGCGGAATAGGCTTCATTCATAAGAACATGTCTATTGAACAGCAAGCT
GAAATGGTTCGCCAGGTTAAAATTTACGAAGCAGGTGTGGTTTCTCACCCTGTTACTGTAAACCCTGACGCGACAATCGC
TGATGTTGTAGCTCTTACTCAAAAACACGGCTTCGCCGGTTTCCCTGTTGTTACTGAAACAAACGAACTTGTTGGTATTA
TTACTGGCCGTGACGTTCGCTTTGTGACTGACCTTTCTAAGAAAGTTGACGTAGTAATGACGCCTAAAGCTCGCCTTGCT
TCTGTTAAAGAAGGTGCAACTCGTGAAGAAGTTCAAGAGAAAATGCACGAAGCGCGTGTTGAAAAAGTTCTTGTTGTAAA
TGATGACTTCCAACTTACGGGAATGATCACTGCAAAAGATTTCCACAAAGCAGAACGTAAACCAAACGCTTGTAAAGATG
AGCGCGGCAGCCTACGTGTAGGTGCAGCTGTTGGTGCTGGTGCTGGTAACGAAGAGCGCGTTGCTGCTCTAGTTGAAGCT
GGCGTAGACGTTCTACTTATCGACTCTTCACACGGTCACTCTGAAGGCGTACTTAACCGTATCCGCGATACGCGTGCTGC
ATACCCTGACCTACAAATTATCGGTGGTAACGTAGCAACTGGCGCTGGCGCTCGTGCTCTTATCGAAGCGGGTGTTAGTG
CGGTTAAAGTGGGTATCGGCCCGGGTTCAATCTGTACGACTCGCATCGTTACTGGTGTTGGTGTTCCTCAAGTAACAGCA
ATTGCAGACGCAGCTGAAGTAGCAAACGAATACGGTATTCCAGTAATCGCAGATGGCGGCATCCGCTTCTCTGGCGATAT
CTGTAAAGCTATCGTTGCTGGCGCATCTTGTGTGATGGTTGGTTCAATGTTCGCGGGTACTGAAGAAGCACCGGGTGAAG
TTATCCTTTACAACGGTCGTTCTTACAAGTCTTACCGTGGTATGGGTTCTCTTGGCGCTATGTCTCAAGGTTCTTCTGAC
CGTTACTTCCAATCTGATAACGCTGCAGACAAGCTTGTTCCAGAAGGTATTGAAGGTCGTATCGCATACAAAGGTCGTCT
AAAAGAGATCGTTCACCAACAGATGGGCGGTTTACGCTCAAGCATGGGCCTAACGGGTTCTGCAACTGTTGAAGACATGC
GTACTAAAGCTGAGTTTGTTCGTATCTCTGGTGCGGGCATGAAAGAATCTCACGTACACGATGTTCAAATCACGAAAGAA
GCACCTAACTACCGTTTAGGTTAA

Upstream 100 bases:

>100_bases
TCCAAATGCAGTTTGATTTTCCTTAATTGGCTGCCCTCATTAGGCGAAACGATGAGATTGGATTGTTTCTTTTTACTCCT
ATTATTGTGAGATATTGCAA

Downstream 100 bases:

>100_bases
TAATACGTCCAAACGTTTGAATAATGTGCTGATTTAGTCGGCACATTAATATACCAATCGTAGTAAATAACTGATCATCC
TAGCTTGTTAAAAACCTCGA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EMVRQVKIYEAGVVSHPVTVNPDATIADVVALTQKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKARLA
SVKEGATREEVQEKMHEARVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDERGSLRVGAAVGAGAGNEERVAALVEA
GVDVLLIDSSHGHSEGVLNRIRDTRAAYPDLQIIGGNVATGAGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQVTA
IADAAEVANEYGIPVIADGGIRFSGDICKAIVAGASCVMVGSMFAGTEEAPGEVILYNGRSYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATVEDMRTKAEFVRISGAGMKESHVHDVQITKE
APNYRLG

Sequences:

>Translated_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EMVRQVKIYEAGVVSHPVTVNPDATIADVVALTQKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKARLA
SVKEGATREEVQEKMHEARVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDERGSLRVGAAVGAGAGNEERVAALVEA
GVDVLLIDSSHGHSEGVLNRIRDTRAAYPDLQIIGGNVATGAGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQVTA
IADAAEVANEYGIPVIADGGIRFSGDICKAIVAGASCVMVGSMFAGTEEAPGEVILYNGRSYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATVEDMRTKAEFVRISGAGMKESHVHDVQITKE
APNYRLG
>Mature_487_residues
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIALAQEGGIGFIHKNMSIEQQA
EMVRQVKIYEAGVVSHPVTVNPDATIADVVALTQKHGFAGFPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKARLA
SVKEGATREEVQEKMHEARVEKVLVVNDDFQLTGMITAKDFHKAERKPNACKDERGSLRVGAAVGAGAGNEERVAALVEA
GVDVLLIDSSHGHSEGVLNRIRDTRAAYPDLQIIGGNVATGAGARALIEAGVSAVKVGIGPGSICTTRIVTGVGVPQVTA
IADAAEVANEYGIPVIADGGIRFSGDICKAIVAGASCVMVGSMFAGTEEAPGEVILYNGRSYKSYRGMGSLGAMSQGSSD
RYFQSDNAADKLVPEGIEGRIAYKGRLKEIVHQQMGGLRSSMGLTGSATVEDMRTKAEFVRISGAGMKESHVHDVQITKE
APNYRLG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=40.0826446280992, Blast_Score=341, Evalue=1e-93,
Organism=Homo sapiens, GI217035146, Length=463, Percent_Identity=41.2526997840173, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI156616279, Length=463, Percent_Identity=41.2526997840173, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI34328930, Length=463, Percent_Identity=41.2526997840173, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI34328928, Length=463, Percent_Identity=41.2526997840173, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI217035152, Length=452, Percent_Identity=41.5929203539823, Blast_Score=332, Evalue=3e-91,
Organism=Homo sapiens, GI217035148, Length=463, Percent_Identity=40.3887688984881, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI217035150, Length=463, Percent_Identity=38.0129589632829, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=36.1788617886179, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=34.8178137651822, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=34.8178137651822, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=34.8178137651822, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=34.8178137651822, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=81.7248459958932, Blast_Score=749, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=34.841628959276, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=37, Blast_Score=284, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=40.0473933649289, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=36.1344537815126, Blast_Score=154, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=39.5652173913043, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6322012, Length=483, Percent_Identity=38.3022774327122, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6323464, Length=443, Percent_Identity=41.0835214446953, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=40.5325443786982, Blast_Score=263, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=101, Percent_Identity=39.6039603960396, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=39.0495867768595, Blast_Score=321, Evalue=7e-88,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=39.0495867768595, Blast_Score=321, Evalue=7e-88,
Organism=Drosophila melanogaster, GI28571163, Length=442, Percent_Identity=39.5927601809955, Blast_Score=288, Evalue=6e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51535; Mature: 51535

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEECEEEECCHHHHHHHHEEEE
LAQEGGIGFIHKNMSIEQQAEMVRQVKIYEAGVVSHPVTVNPDATIADVVALTQKHGFAG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCCC
FPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKARLASVKEGATREEVQEKMHEARV
CCEEECCCCEEEEEECCCEEEEEHHCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
EKVLVVNDDFQLTGMITAKDFHKAERKPNACKDERGSLRVGAAVGAGAGNEERVAALVEA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLNRIRDTRAAYPDLQIIGGNVATGAGARALIEAGVSAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQVTAIADAAEVANEYGIPVIADGGIRFSGDICKAIVAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHHEEH
GSMFAGTEEAPGEVILYNGRSYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
IAYKGRLKEIVHQQMGGLRSSMGLTGSATVEDMRTKAEFVRISGAGMKESHVHDVQITKE
EEEHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEECC
APNYRLG
CCCCCCC
>Mature Secondary Structure
MLRIAKEALTFDDVLLVPAHSTVLPNTADLRTQLTKNISLNIPMISASMDTVTEARLAIA
CCEEHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHCCEEEECEEEECCHHHHHHHHEEEE
LAQEGGIGFIHKNMSIEQQAEMVRQVKIYEAGVVSHPVTVNPDATIADVVALTQKHGFAG
EECCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCCC
FPVVTETNELVGIITGRDVRFVTDLSKKVDVVMTPKARLASVKEGATREEVQEKMHEARV
CCEEECCCCEEEEEECCCEEEEEHHCCCCEEEECCHHHHHHHHCCCCHHHHHHHHHHHHH
EKVLVVNDDFQLTGMITAKDFHKAERKPNACKDERGSLRVGAAVGAGAGNEERVAALVEA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHC
GVDVLLIDSSHGHSEGVLNRIRDTRAAYPDLQIIGGNVATGAGARALIEAGVSAVKVGIG
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHCCCCEEEEECC
PGSICTTRIVTGVGVPQVTAIADAAEVANEYGIPVIADGGIRFSGDICKAIVAGASCVMV
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECHHHHHHHHCCCHHEEH
GSMFAGTEEAPGEVILYNGRSYKSYRGMGSLGAMSQGSSDRYFQSDNAADKLVPEGIEGR
HHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCE
IAYKGRLKEIVHQQMGGLRSSMGLTGSATVEDMRTKAEFVRISGAGMKESHVHDVQITKE
EEEHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHEEEEECCCCCCCCCEEEEEECC
APNYRLG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]