Click here to switch to the map view.

The map label for this gene is tyrA [H]

Identifier: 218708582

GI number: 218708582

Start: 570863

End: 571990

Strand: Direct

Name: tyrA [H]

Synonym: VS_0548

Alternate gene names: 218708582

Gene position: 570863-571990 (Clockwise)

Preceding gene: 218708581

Following gene: 218708586

Centisome position: 17.3

GC content: 44.41

Gene sequence:

>1128_bases
ATGGCCGTTGAACTGAACGAATTACGCGACCAAATCGATGCTGTCGATAAACAAATGTTGGATTTACTGGCTCAACGACT
GGCTCTAGTAGAGAAAGTCGGTGAAGTAAAAAGTGAACATGGTTTACCTATTTATGTACCGGAACGTGAAGCCGCGATGT
TGGCATCTCGTCGTCAAGAAGCCGAGAAAATAGGAGTACCACCGCAGTTAATCGAAGATATTTTACGTCGTACGATGCGT
GAGTCTTATGCCAGTGAAAAAGATTCTGGTTTTAAGTGCCTTAACCCTGATTTGCGTTCAGTGGTTATCGTTGGTGGTAA
TGGTCAACTAGGTGGTCTGTTTGGCCGTATGTTCAAGCTTTCTGGCTACGAAGTGAAAATCCTTGGCAGCCAAGATTGGG
ATCGAGCCGATGAGATTTTAGATAATGCTGGCCTTGTGGTTGTTACGGTTCCAATTCACCTGACAGAAGGTGTGATTGCG
AAGTTGGGTAACCTACCAAGTGATTGTATTCTGTGTGATCTGACGTCGATAAAATCAAAGCCTCTACAAGCTATGTTAGA
CATGCACCAAGGCCCTGTGGTTGGATTACACCCAATGTTTGGTCCTGATGTTCCAAGCCTTGCGAAACAAGTGATTGTTT
ACAGTGATGGGCGTAGTTCTGAAAGCTATCAATGGTTGCTGAATCAATTTGGTATTTGGGGCGCGAGCCTTTGCCAGATG
GATGCTGCGGAACACGATCACGGCATGACTCTGATTCAAGCTCTTCGTCACTTCACTTCTTTTGCTTACGGATTGCACTT
GAGTAAAGAGAACCCGAATATCGATCAGCTTCTGAAGTTAAGCTCGCCAATCTACCGACTTGAGATTGCGATGGTTGGTC
GTCTGTTTGCTCAAGACCCGAACTTGTACGGTGATATCATTCTTTCTTCAGATGAGAACATTGAGATGATTCGACGTTTC
CATAGTCGTTTCGGTGAAGCATTGGAAATCTTGGATGGGAAAGATAAAGCTAAATTCGTTGATAGCTTTAATCAAGTCAG
TGGTTGGTTTGGCGACTACTCGCAGCAGTTCTTGCAAGAGAGCCAAAGTCTTCTAAAACAAGCACATGACTCGATTCATC
GTGGTTAA

Upstream 100 bases:

>100_bases
GTGCCTCATCTAATGGGGCATTTTAAGATCTGTTGCTAACGAACCTGCATCAGTGCGGGCTTTTAGATTGGCACGGGCTT
ATAGATGAGTAAGGAATAAA

Downstream 100 bases:

>100_bases
TACGATGTGAAGTCATAAAAAAGAGCGACCATTTGGTCGCTCTTTTTGTTTGTGCTGAACGCTATGAAAGCATTTGGTCT
ACTGTAGGCTAAAAGCAATT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MAVELNELRDQIDAVDKQMLDLLAQRLALVEKVGEVKSEHGLPIYVPEREAAMLASRRQEAEKIGVPPQLIEDILRRTMR
ESYASEKDSGFKCLNPDLRSVVIVGGNGQLGGLFGRMFKLSGYEVKILGSQDWDRADEILDNAGLVVVTVPIHLTEGVIA
KLGNLPSDCILCDLTSIKSKPLQAMLDMHQGPVVGLHPMFGPDVPSLAKQVIVYSDGRSSESYQWLLNQFGIWGASLCQM
DAAEHDHGMTLIQALRHFTSFAYGLHLSKENPNIDQLLKLSSPIYRLEIAMVGRLFAQDPNLYGDIILSSDENIEMIRRF
HSRFGEALEILDGKDKAKFVDSFNQVSGWFGDYSQQFLQESQSLLKQAHDSIHRG

Sequences:

>Translated_375_residues
MAVELNELRDQIDAVDKQMLDLLAQRLALVEKVGEVKSEHGLPIYVPEREAAMLASRRQEAEKIGVPPQLIEDILRRTMR
ESYASEKDSGFKCLNPDLRSVVIVGGNGQLGGLFGRMFKLSGYEVKILGSQDWDRADEILDNAGLVVVTVPIHLTEGVIA
KLGNLPSDCILCDLTSIKSKPLQAMLDMHQGPVVGLHPMFGPDVPSLAKQVIVYSDGRSSESYQWLLNQFGIWGASLCQM
DAAEHDHGMTLIQALRHFTSFAYGLHLSKENPNIDQLLKLSSPIYRLEIAMVGRLFAQDPNLYGDIILSSDENIEMIRRF
HSRFGEALEILDGKDKAKFVDSFNQVSGWFGDYSQQFLQESQSLLKQAHDSIHRG
>Mature_374_residues
AVELNELRDQIDAVDKQMLDLLAQRLALVEKVGEVKSEHGLPIYVPEREAAMLASRRQEAEKIGVPPQLIEDILRRTMRE
SYASEKDSGFKCLNPDLRSVVIVGGNGQLGGLFGRMFKLSGYEVKILGSQDWDRADEILDNAGLVVVTVPIHLTEGVIAK
LGNLPSDCILCDLTSIKSKPLQAMLDMHQGPVVGLHPMFGPDVPSLAKQVIVYSDGRSSESYQWLLNQFGIWGASLCQMD
AAEHDHGMTLIQALRHFTSFAYGLHLSKENPNIDQLLKLSSPIYRLEIAMVGRLFAQDPNLYGDIILSSDENIEMIRRFH
SRFGEALEILDGKDKAKFVDSFNQVSGWFGDYSQQFLQESQSLLKQAHDSIHRG

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=371, Percent_Identity=65.2291105121294, Blast_Score=513, Evalue=1e-147,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 41849; Mature: 41718

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVELNELRDQIDAVDKQMLDLLAQRLALVEKVGEVKSEHGLPIYVPEREAAMLASRRQE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
AEKIGVPPQLIEDILRRTMRESYASEKDSGFKCLNPDLRSVVIVGGNGQLGGLFGRMFKL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHC
SGYEVKILGSQDWDRADEILDNAGLVVVTVPIHLTEGVIAKLGNLPSDCILCDLTSIKSK
CCCEEEEECCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCHHEEEEHHHHCCC
PLQAMLDMHQGPVVGLHPMFGPDVPSLAKQVIVYSDGRSSESYQWLLNQFGIWGASLCQM
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHH
DAAEHDHGMTLIQALRHFTSFAYGLHLSKENPNIDQLLKLSSPIYRLEIAMVGRLFAQDP
HHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCC
NLYGDIILSSDENIEMIRRFHSRFGEALEILDGKDKAKFVDSFNQVSGWFGDYSQQFLQE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SQSLLKQAHDSIHRG
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVELNELRDQIDAVDKQMLDLLAQRLALVEKVGEVKSEHGLPIYVPEREAAMLASRRQE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHH
AEKIGVPPQLIEDILRRTMRESYASEKDSGFKCLNPDLRSVVIVGGNGQLGGLFGRMFKL
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCEEEEECCCCCHHHHHHHHHHC
SGYEVKILGSQDWDRADEILDNAGLVVVTVPIHLTEGVIAKLGNLPSDCILCDLTSIKSK
CCCEEEEECCCCCHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCHHEEEEHHHHCCC
PLQAMLDMHQGPVVGLHPMFGPDVPSLAKQVIVYSDGRSSESYQWLLNQFGIWGASLCQM
HHHHHHHHCCCCEEEECCCCCCCHHHHHHHEEEECCCCCCHHHHHHHHHHCCCHHHHHHH
DAAEHDHGMTLIQALRHFTSFAYGLHLSKENPNIDQLLKLSSPIYRLEIAMVGRLFAQDP
HHHCCCCHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCC
NLYGDIILSSDENIEMIRRFHSRFGEALEILDGKDKAKFVDSFNQVSGWFGDYSQQFLQE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SQSLLKQAHDSIHRG
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1512561 [H]