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The map label for this gene is thrC [H]

Identifier: 218708520

GI number: 218708520

Start: 510158

End: 511441

Strand: Direct

Name: thrC [H]

Synonym: VS_0485

Alternate gene names: 218708520

Gene position: 510158-511441 (Clockwise)

Preceding gene: 218708519

Following gene: 218708528

Centisome position: 15.46

GC content: 45.56

Gene sequence:

>1284_bases
ATGAAGCTGTACAACATCAAAGAAAACGATGAGCAAGTCTCTTTTGGCCAAGCCGTTCGTCAAGGTCTAGGTCGTAATCA
AGGTCTATTTTTCCCATCAGAGCTGCCTAAGTTCGATGACATCGATGCACTACTTGCAGAGGACTTTGTCCCTCGTAGTT
CAAAGATTCTTTCTGCTCTAATTGGTGATGAGTTACCAAAAGAACAGATCGATCAACTAGTGGATGCGGCATTCCAATTC
CCAGCACCGATCAACCAAGTGAAAGACGGTGTTTACGCACTTGAACTGTTTCACGGTCCAACGTTAGCATTTAAAGATTT
CGGTGGCCGTTTTATGGCTCAATCTTTGGCTGCGGTTTCTGATGGCGGTCAAATCACAATCTTAACGGCAACATCGGGTG
ATACTGGCGCTGCGGTTGCACACGCATTCTACGGCATGGAAAACATCAACGTTGTTATCCTATACCCGAAAGGCAAGATC
AGCCCACTGCAAGAAAAGCTATTCTGTACGCTAGGTAAGAACATTCACACTGTAGCGATTGATGGCGATTTTGATGCGTG
TCAGGCACTCGTAAAAGACGCGTTTGACGACGCTGAATTGCGTAAAGAAATTGGCTTAAACTCAGCAAACTCAATCAACA
TCAGCCGTTTGATGGCTCAGATCTGTTATTACTTTGAGGCGGCTTCTCAGCTAACCAAAGAGCAACGTGAAAATCTGGTT
ATCTCTGTACCAAGTGGTAACTTTGGTAACCTAACTGCGGGTCTATTAGCGAAAGCGCTAGGCTTACCGGTTAAACGCTT
CATTGCAGCAACCAACGAAAACGACACGGTTCCCCGTTACCTAGAAACAGGTCAATGGGATCCAAAACCAACGGTTGCGA
CAACATCGAACGCGATGGACGTGAGCCAACCAAACAACTGGCCACGTATCGAAGAGCTTTGCCAACTGAAAGGTTGGGGA
CTGGATACTTTGGGTAAAGGTAAAGTATCTGATGAGCAGAGTGCTGAATCAGTACGTGATCTAAAAGCTCAAGGTTACCT
GTGTGAACCTCATGGTGCGATTGCTTACCGTCTATTGGAAGAGCAACTGCAAGAGAACGAAACTGGTCTGTTCTTGTGTA
CTGCACACCCAGCGAAATTCAAAGAAGTGGTTGATGATATTTTAGGTACGGATATTGAACTGCCAGGCCCGCTAGCAAAA
CACGCGGCGATGAAGTTGTTATCTGAAGATCTTGATAATGATTTTGAAGCGCTAAAAGTAGTGCTTCGTCGAGTTCAACC
GTAA

Upstream 100 bases:

>100_bases
TTGCACGCTGGTTAGAACAAAACTACGTACAAAATGAAGAAGGATTCGTCCACGTTTGTCGCTTAGATAAACAAGGTTCG
ATCGTTACAGGAAGTGAGTT

Downstream 100 bases:

>100_bases
CTTACATCTATATTGTTTGTCTTGTACGTAAAATACGCTGACGATTATTAGTAAGCCAGTAACGCAAGTTGCTGGCTTTT
TTCATGCATCTCATTTGGCG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPSELPKFDDIDALLAEDFVPRSSKILSALIGDELPKEQIDQLVDAAFQF
PAPINQVKDGVYALELFHGPTLAFKDFGGRFMAQSLAAVSDGGQITILTATSGDTGAAVAHAFYGMENINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAIDGDFDACQALVKDAFDDAELRKEIGLNSANSINISRLMAQICYYFEAASQLTKEQRENLV
ISVPSGNFGNLTAGLLAKALGLPVKRFIAATNENDTVPRYLETGQWDPKPTVATTSNAMDVSQPNNWPRIEELCQLKGWG
LDTLGKGKVSDEQSAESVRDLKAQGYLCEPHGAIAYRLLEEQLQENETGLFLCTAHPAKFKEVVDDILGTDIELPGPLAK
HAAMKLLSEDLDNDFEALKVVLRRVQP

Sequences:

>Translated_427_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPSELPKFDDIDALLAEDFVPRSSKILSALIGDELPKEQIDQLVDAAFQF
PAPINQVKDGVYALELFHGPTLAFKDFGGRFMAQSLAAVSDGGQITILTATSGDTGAAVAHAFYGMENINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAIDGDFDACQALVKDAFDDAELRKEIGLNSANSINISRLMAQICYYFEAASQLTKEQRENLV
ISVPSGNFGNLTAGLLAKALGLPVKRFIAATNENDTVPRYLETGQWDPKPTVATTSNAMDVSQPNNWPRIEELCQLKGWG
LDTLGKGKVSDEQSAESVRDLKAQGYLCEPHGAIAYRLLEEQLQENETGLFLCTAHPAKFKEVVDDILGTDIELPGPLAK
HAAMKLLSEDLDNDFEALKVVLRRVQP
>Mature_427_residues
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPSELPKFDDIDALLAEDFVPRSSKILSALIGDELPKEQIDQLVDAAFQF
PAPINQVKDGVYALELFHGPTLAFKDFGGRFMAQSLAAVSDGGQITILTATSGDTGAAVAHAFYGMENINVVILYPKGKI
SPLQEKLFCTLGKNIHTVAIDGDFDACQALVKDAFDDAELRKEIGLNSANSINISRLMAQICYYFEAASQLTKEQRENLV
ISVPSGNFGNLTAGLLAKALGLPVKRFIAATNENDTVPRYLETGQWDPKPTVATTSNAMDVSQPNNWPRIEELCQLKGWG
LDTLGKGKVSDEQSAESVRDLKAQGYLCEPHGAIAYRLLEEQLQENETGLFLCTAHPAKFKEVVDDILGTDIELPGPLAK
HAAMKLLSEDLDNDFEALKVVLRRVQP

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=418, Percent_Identity=30.1435406698565, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI153792148, Length=422, Percent_Identity=29.1469194312796, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1786185, Length=428, Percent_Identity=67.5233644859813, Blast_Score=568, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319901, Length=448, Percent_Identity=33.0357142857143, Blast_Score=213, Evalue=4e-56,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46721; Mature: 46721

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPSELPKFDDIDALLAEDFVPRSSKILSAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCHHHHHHHH
IGDELPKEQIDQLVDAAFQFPAPINQVKDGVYALELFHGPTLAFKDFGGRFMAQSLAAVS
HCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCEEHHHCCCHHHHHHHHHHC
DGGQITILTATSGDTGAAVAHAFYGMENINVVILYPKGKISPLQEKLFCTLGKNIHTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
DGDFDACQALVKDAFDDAELRKEIGLNSANSINISRLMAQICYYFEAASQLTKEQRENLV
CCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
ISVPSGNFGNLTAGLLAKALGLPVKRFIAATNENDTVPRYLETGQWDPKPTVATTSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEECCCCCC
VSQPNNWPRIEELCQLKGWGLDTLGKGKVSDEQSAESVRDLKAQGYLCEPHGAIAYRLLE
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHH
EQLQENETGLFLCTAHPAKFKEVVDDILGTDIELPGPLAKHAAMKLLSEDLDNDFEALKV
HHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
VLRRVQP
HHHHCCC
>Mature Secondary Structure
MKLYNIKENDEQVSFGQAVRQGLGRNQGLFFPSELPKFDDIDALLAEDFVPRSSKILSAL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHCCCCHHHHHHHH
IGDELPKEQIDQLVDAAFQFPAPINQVKDGVYALELFHGPTLAFKDFGGRFMAQSLAAVS
HCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCEEHHHCCCHHHHHHHHHHC
DGGQITILTATSGDTGAAVAHAFYGMENINVVILYPKGKISPLQEKLFCTLGKNIHTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEE
DGDFDACQALVKDAFDDAELRKEIGLNSANSINISRLMAQICYYFEAASQLTKEQRENLV
CCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
ISVPSGNFGNLTAGLLAKALGLPVKRFIAATNENDTVPRYLETGQWDPKPTVATTSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEECCCCCC
VSQPNNWPRIEELCQLKGWGLDTLGKGKVSDEQSAESVRDLKAQGYLCEPHGAIAYRLLE
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHH
EQLQENETGLFLCTAHPAKFKEVVDDILGTDIELPGPLAKHAAMKLLSEDLDNDFEALKV
HHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
VLRRVQP
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]