| Definition | Vibrio splendidus LGP32 chromosome 1, complete genome. |
|---|---|
| Accession | NC_011753 |
| Length | 3,299,303 |
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The map label for this gene is thrA [H]
Identifier: 218708518
GI number: 218708518
Start: 506728
End: 509187
Strand: Direct
Name: thrA [H]
Synonym: VS_0483
Alternate gene names: 218708518
Gene position: 506728-509187 (Clockwise)
Preceding gene: 218708516
Following gene: 218708519
Centisome position: 15.36
GC content: 47.2
Gene sequence:
>2460_bases ATGCGCGTTTTAAAGTTTGGAGGTTCATCATTAGCTGATGCAGATCGTTTTTTACGAGCGGCTGATATCATCGCTAATAA TGCCCAGCAAGAAGAGCTAGCCGTTGTACTATCGGCTCCAGGAAAAACAACCAATAAGTTGGTCGCTGTTATTGAAGCTG CACTGAAAAACGGTGAAGCTGACACACAGATTTCAGAGATCGAATCATCATTTTCTGCACTGTTTGCAGAGATTCAAGCG GTATTGCCGTCAGTAGATGGCTCTGCGTTTCAAGAGCAAGTCGATACCTCTCTTGCTCAACTTAAGCAGTTCGTGAATGG TATTAACCTACTGGGCATGTGCCCGAATCACGTAAATGCTCGTATCATTAGTAAAGGTGAGCGAGTTTCAATCCAGTTAA TGAAAGCGGTACTGGAAGCGAAAGGCCAACCAGCAAGCCTGATTGACCCTGTGGAATACCTCTATGCTCAAGGTGATCAT CTTGAAGCTATGGTGGATGTGGATGTTTCAACTCAGAACTTCCGCCAATCACCGCTTCCTAAAGGTCACGTAAATATCAT GCCGGGCTTTACTGCTGGTAATGAAAAAGGCGAGCTAGTAACGCTTGGCCGTAACGGCTCTGACTACTCAGCTGCAGTTC TAGCGGCATGTCTACGTGCTGATTGCTGTGAGATTTGGACTGACGTCGATGGCGTTTACAACTGTGACCCACGCTTAGTG GATGATGCCCGTCTTCTTAAATCACTCAGCTACCAAGAAGCGATGGAGCTTTCTTACTTCGGCGCTTCAGTTCTACACCC GAAAACAATCGCACCTATCGCACAATTCCATATTCCATGTCTGATCAAAAACAGCTTCAACCCACAGGGCGCAGGCACTT TGATTGGCCAAGACACTGGCGAAGATAACCTAGCGATCAAAGGTATCACTACGCTAAGTGACCTAACGATGGTTAACGTA TCAGGTCCAGGAATGAAGGGCATGGTAGGCATGGCAAGTCGTGTATTCGGCGCGATGTCTTCTGCAGGCGTTTCTATTGT CCTTATTACTCAATCTTCTTCTGAGTACAGCATCAGCTTCTGTATTGAATCGGCTGACAAAGTGAAAGCGAAGCAAGTGT TATCAGATGCGTTTGAACTCGAACTTAAAGATGGCCTATTAGAGCCAGTTGAGTTCATGGATGATGTTGCGATTGTGACG CTGGTGGGTGACGGTATGCGTACATCACGTGGCGTTGCTTCTCAGTTCTTCTCTTCTTTAGCTGAAGTGAACGTTAACAT CGTTGCTATTGCTCAAGGCTCTTCAGAGCGCGCTATCTCTGCGGTTATCCCGGAAGATAAAATCTCAGAAGCAATCAAAG CGTGTCATGAAAACCTATTTAACTCTAAGCACTTCCTTGACGTCTTCGTTGTCGGTGTTGGCGGTGTTGGTGGTGAGCTT GTTGACCAGATCCAACGTCAACAAGGCAAACTGGCTGAAAAAGGCATCGTGATTCGCGTATGTGGTTTAGCAAACAGCAA AGGCTTGCTGCTAGACAGCGATGGTCTACCGCTAGAACAGTGGCGTGATCGTATGTCGAGTGCGACAGAAGAGTTTAGCC TAGCGCGTTTAGCGGCACTTGTTCAACGTAATCACATCATCAACCCTGTGTTGGTTGATTGTACGTCTAGCGAAGGTATT GCAGGACAATACGCAGATTTCCTAGCGGCTGGTTTCCACGTTGTAACACCAAACAAAAAAGCCAACACAGCAAGCATGGC TTACTACCATCAGCTTCGTGAAGTGGCGCGTAACTCTCGTCGTAAGTTGATGTACGAGACAACAGTAGGCGCAGGTCTAC CCGTAATCGAAAACTTACAGAACCTAATCTCTGCAGGTGATGAGCTTGAGAAGTTCAACGGTATTCTTTCTGGTTCACTG TCTTACATCTTCGGTAAGCTGGATGAGGGTATGACACTCAGCCAAGCAACCAACATTGCTAAAGATAACGGCTTCACTGA GCCGGATCCTCGTGATGATCTGTCTGGTATGGACGTTGCGCGTAAGCTGCTTATTCTTGCTCGTGAAGCGGGTATGGCAC TTGAGCTTGAAGATGTTGAAGTTGACCAAGCATTGCCACCGGGTTTTGATGACTCAGGTACAGTTGACGAGTTCATGGCT CGCTTGCCAGAAGCGGATGCATACTTCAAAGAGCAGTCAGCTATCGCAGCAGAAGAAGGCAAAGTACTTCGTTATGTGGG TGAGATCGCGGAAGGTAAATGTAAGGTTCGTATCGCAGCTGTTGATGGCGATGACCCAATGTTTAAGATTAAAGATGGCG AGAACGCTCTGGCATTCTACAGCCGTTACTACCAGCCAATCCCACTCGTTCTGCGTGGCTACGGTGCAGGTACTGAAGTT ACAGCAGCAGGCGTATTCTCTGATGTGATGCGTACTCTTGGTTGGAAATTAGGAGTTTAG
Upstream 100 bases:
>100_bases TTGGGGCAGGCTGCTAAGTAACGGATTTTAAAAAAAAGGCCTGTATCCAACAAGATACAGGCCTTTTTTTGTACCATTTT TATGACTTATGGAGAAAGGG
Downstream 100 bases:
>100_bases GAATGAGTTCAAGTGATATGGATGTTGTCGTTTATGCTCCTGCATCAATCGGCAATGTCAGTGTAGGTTTTGATGTGCTG GGGGCCGCTGTGTCTCCAGT
Product: bifunctional aspartokinase I/homeserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 819; Mature: 819
Protein sequence:
>819_residues MRVLKFGGSSLADADRFLRAADIIANNAQQEELAVVLSAPGKTTNKLVAVIEAALKNGEADTQISEIESSFSALFAEIQA VLPSVDGSAFQEQVDTSLAQLKQFVNGINLLGMCPNHVNARIISKGERVSIQLMKAVLEAKGQPASLIDPVEYLYAQGDH LEAMVDVDVSTQNFRQSPLPKGHVNIMPGFTAGNEKGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLSDLTMVNV SGPGMKGMVGMASRVFGAMSSAGVSIVLITQSSSEYSISFCIESADKVKAKQVLSDAFELELKDGLLEPVEFMDDVAIVT LVGDGMRTSRGVASQFFSSLAEVNVNIVAIAQGSSERAISAVIPEDKISEAIKACHENLFNSKHFLDVFVVGVGGVGGEL VDQIQRQQGKLAEKGIVIRVCGLANSKGLLLDSDGLPLEQWRDRMSSATEEFSLARLAALVQRNHIINPVLVDCTSSEGI AGQYADFLAAGFHVVTPNKKANTASMAYYHQLREVARNSRRKLMYETTVGAGLPVIENLQNLISAGDELEKFNGILSGSL SYIFGKLDEGMTLSQATNIAKDNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPGFDDSGTVDEFMA RLPEADAYFKEQSAIAAEEGKVLRYVGEIAEGKCKVRIAAVDGDDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTEV TAAGVFSDVMRTLGWKLGV
Sequences:
>Translated_819_residues MRVLKFGGSSLADADRFLRAADIIANNAQQEELAVVLSAPGKTTNKLVAVIEAALKNGEADTQISEIESSFSALFAEIQA VLPSVDGSAFQEQVDTSLAQLKQFVNGINLLGMCPNHVNARIISKGERVSIQLMKAVLEAKGQPASLIDPVEYLYAQGDH LEAMVDVDVSTQNFRQSPLPKGHVNIMPGFTAGNEKGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLSDLTMVNV SGPGMKGMVGMASRVFGAMSSAGVSIVLITQSSSEYSISFCIESADKVKAKQVLSDAFELELKDGLLEPVEFMDDVAIVT LVGDGMRTSRGVASQFFSSLAEVNVNIVAIAQGSSERAISAVIPEDKISEAIKACHENLFNSKHFLDVFVVGVGGVGGEL VDQIQRQQGKLAEKGIVIRVCGLANSKGLLLDSDGLPLEQWRDRMSSATEEFSLARLAALVQRNHIINPVLVDCTSSEGI AGQYADFLAAGFHVVTPNKKANTASMAYYHQLREVARNSRRKLMYETTVGAGLPVIENLQNLISAGDELEKFNGILSGSL SYIFGKLDEGMTLSQATNIAKDNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPGFDDSGTVDEFMA RLPEADAYFKEQSAIAAEEGKVLRYVGEIAEGKCKVRIAAVDGDDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTEV TAAGVFSDVMRTLGWKLGV >Mature_819_residues MRVLKFGGSSLADADRFLRAADIIANNAQQEELAVVLSAPGKTTNKLVAVIEAALKNGEADTQISEIESSFSALFAEIQA VLPSVDGSAFQEQVDTSLAQLKQFVNGINLLGMCPNHVNARIISKGERVSIQLMKAVLEAKGQPASLIDPVEYLYAQGDH LEAMVDVDVSTQNFRQSPLPKGHVNIMPGFTAGNEKGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTGEDNLAIKGITTLSDLTMVNV SGPGMKGMVGMASRVFGAMSSAGVSIVLITQSSSEYSISFCIESADKVKAKQVLSDAFELELKDGLLEPVEFMDDVAIVT LVGDGMRTSRGVASQFFSSLAEVNVNIVAIAQGSSERAISAVIPEDKISEAIKACHENLFNSKHFLDVFVVGVGGVGGEL VDQIQRQQGKLAEKGIVIRVCGLANSKGLLLDSDGLPLEQWRDRMSSATEEFSLARLAALVQRNHIINPVLVDCTSSEGI AGQYADFLAAGFHVVTPNKKANTASMAYYHQLREVARNSRRKLMYETTVGAGLPVIENLQNLISAGDELEKFNGILSGSL SYIFGKLDEGMTLSQATNIAKDNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPGFDDSGTVDEFMA RLPEADAYFKEQSAIAAEEGKVLRYVGEIAEGKCKVRIAAVDGDDPMFKIKDGENALAFYSRYYQPIPLVLRGYGAGTEV TAAGVFSDVMRTLGWKLGV
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=62.1951219512195, Blast_Score=1040, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=822, Percent_Identity=32.360097323601, Blast_Score=367, Evalue=1e-102, Organism=Escherichia coli, GI1790455, Length=461, Percent_Identity=29.5010845986985, Blast_Score=164, Evalue=1e-41, Organism=Saccharomyces cerevisiae, GI6322599, Length=340, Percent_Identity=35.2941176470588, Blast_Score=174, Evalue=4e-44, Organism=Saccharomyces cerevisiae, GI6320893, Length=405, Percent_Identity=28.641975308642, Blast_Score=157, Evalue=6e-39,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 87902; Mature: 87902
Theoretical pI: Translated: 4.52; Mature: 4.52
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLKFGGSSLADADRFLRAADIIANNAQQEELAVVLSAPGKTTNKLVAVIEAALKNGEA CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC DTQISEIESSFSALFAEIQAVLPSVDGSAFQEQVDTSLAQLKQFVNGINLLGMCPNHVNA CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCE RIISKGERVSIQLMKAVLEAKGQPASLIDPVEYLYAQGDHLEAMVDVDVSTQNFRQSPLP EEECCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHCCCCCEEEEEEECCCHHHHHCCCCC KGHVNIMPGFTAGNEKGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV CCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTG HHHHHHHHHCHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCC EDNLAIKGITTLSDLTMVNVSGPGMKGMVGMASRVFGAMSSAGVSIVLITQSSSEYSISF CCCEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEE CIESADKVKAKQVLSDAFELELKDGLLEPVEFMDDVAIVTLVGDGMRTSRGVASQFFSSL EECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHH AEVNVNIVAIAQGSSERAISAVIPEDKISEAIKACHENLFNSKHFLDVFVVGVGGVGGEL HHCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHH VDQIQRQQGKLAEKGIVIRVCGLANSKGLLLDSDGLPLEQWRDRMSSATEEFSLARLAAL HHHHHHHHCCHHHCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH VQRNHIINPVLVDCTSSEGIAGQYADFLAAGFHVVTPNKKANTASMAYYHQLREVARNSR HHHCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH RKLMYETTVGAGLPVIENLQNLISAGDELEKFNGILSGSLSYIFGKLDEGMTLSQATNIA HEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHH KDNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPGFDDSGTVDEFMA HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHH RLPEADAYFKEQSAIAAEEGKVLRYVGEIAEGKCKVRIAAVDGDDPMFKIKDGENALAFY HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEEEEECCCCCEEEEECCCCHHHHH SRYYQPIPLVLRGYGAGTEVTAAGVFSDVMRTLGWKLGV HHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCHHCCC >Mature Secondary Structure MRVLKFGGSSLADADRFLRAADIIANNAQQEELAVVLSAPGKTTNKLVAVIEAALKNGEA CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCC DTQISEIESSFSALFAEIQAVLPSVDGSAFQEQVDTSLAQLKQFVNGINLLGMCPNHVNA CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCE RIISKGERVSIQLMKAVLEAKGQPASLIDPVEYLYAQGDHLEAMVDVDVSTQNFRQSPLP EEECCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHCCCCCEEEEEEECCCHHHHHCCCCC KGHVNIMPGFTAGNEKGELVTLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYNCDPRLV CCCEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC DDARLLKSLSYQEAMELSYFGASVLHPKTIAPIAQFHIPCLIKNSFNPQGAGTLIGQDTG HHHHHHHHHCHHHHHHHHHCCCHHCCCHHHHHHHHHCCCEEEECCCCCCCCEEEEECCCC EDNLAIKGITTLSDLTMVNVSGPGMKGMVGMASRVFGAMSSAGVSIVLITQSSSEYSISF CCCEEEEEEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEE CIESADKVKAKQVLSDAFELELKDGLLEPVEFMDDVAIVTLVGDGMRTSRGVASQFFSSL EECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHH AEVNVNIVAIAQGSSERAISAVIPEDKISEAIKACHENLFNSKHFLDVFVVGVGGVGGEL HHCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHH VDQIQRQQGKLAEKGIVIRVCGLANSKGLLLDSDGLPLEQWRDRMSSATEEFSLARLAAL HHHHHHHHCCHHHCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH VQRNHIINPVLVDCTSSEGIAGQYADFLAAGFHVVTPNKKANTASMAYYHQLREVARNSR HHHCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH RKLMYETTVGAGLPVIENLQNLISAGDELEKFNGILSGSLSYIFGKLDEGMTLSQATNIA HEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHH KDNGFTEPDPRDDLSGMDVARKLLILAREAGMALELEDVEVDQALPPGFDDSGTVDEFMA HCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHH RLPEADAYFKEQSAIAAEEGKVLRYVGEIAEGKCKVRIAAVDGDDPMFKIKDGENALAFY HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCEEEEEEEEECCCCCEEEEECCCCHHHHH SRYYQPIPLVLRGYGAGTEVTAAGVFSDVMRTLGWKLGV HHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8423151 [H]