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The map label for this gene is ftsI [H]

Identifier: 218708480

GI number: 218708480

Start: 452809

End: 454566

Strand: Direct

Name: ftsI [H]

Synonym: VS_0444

Alternate gene names: 218708480

Gene position: 452809-454566 (Clockwise)

Preceding gene: 218708479

Following gene: 218708481

Centisome position: 13.72

GC content: 47.44

Gene sequence:

>1758_bases
ATGACCGGTAAAAAGGAAAAAACACCCGCAAAAACCGTTAATGAATCAACGAAAGAGCGAGTGAAGAGCGAAAAGGATTT
GGATCCAATTCTTATTAAATGGCGTTTCAACGTTGTTATTGCTTTCGTGTTTCTAGCCTTTGCTGCACTCGTTGGCCGTG
TGGCTTACATCCAAATCATTGAACCCGATAACTTAATTCGTCAGGGCGATCTTCGCTCAGTGCGTGTTAAGGCTATTCCT
TCTGCTCGCGGTATTATCTCTGACCGCAATGGCGAGCCGCTTGCTGTGAGTGTTCCCGTTGAAGCAGTATGGGCCGACCC
AAAAACGATTTTCGATAAAAATGGCATGGCCCAGATTGATCGTTGGTATGCGTTAGCCGATGTACTTGGCCTACAGCGAC
AATCGATGATCGATAAGATCTCTAGCAATAAATCCCGTCGATTTATTTATCTACAAAGACAAGTTAGCCCTGCGATGGCT
AAGTATATCCGTGAACTTAAGCTGGTGGGTGTGGGCCTAAAAGCGGAATCTCGACGTTACTACCCTGCTGGTGAAGTCAG
TGCACACCTTATCGGTGTGACCGGAATTGATGGGCACGGCCTGGAAGGGGTTGAACGCAGTTACGATAAATGGCTTACGG
GCGAAGCAGGCAAGCGAACGATTCGTAAAGACCGCTACGGACGCGTTGTCGAAAACATTGCGTTAGAAGAACGCGAAGAA
GGCAAACCACTCGAACTCACCATCGATCAACGATTGCAGGCGATAGCCTATCGAGCGATTAAGCAAGCGGTGGCCGATCA
TAAAGCGACCTCAGGCTCTGCAGTATTACTCGATGTGAAAACGGGCGCTGTGTTAGCCATGGTCAATGCACCGTCTTACA
ACCCGAACAACCGCTCTGATTTACAAAGCTTTAAAATGCGAAACCGCGTGCTGACCGATGCTATGGAGCCCGGCTCAACA
GTGAAACCTTTTGTGGTGCTCGCCGCATTAGAAAATGGTACAGCTGATGCGAAATCTATTATTGATACGGGTAATGGCAT
CATGCAAATTGGAGGTAGCCGAGTACGTGATACCTCTAAAGTGGGCAAGGCTGATTTAGCCTTGATCCTTAAAAAATCAA
GTAACATCGGCGTTGCGAAATTAGCGCTTGATATGCCGCTTGAAGCGTTACTTGGTATGTACAGTTCGGTTGGTTTAGGC
GAAATGTCTGGGCTAAATCTCGTGGGTGAAACGAGTGGTATTTTCCCTAACCGTCGCCGTTGGTCTAAGTTCGAAATCGC
GACGCTATCGTTTGGTTATGGCTTATCTGTGACCCCGCTTCAGTTGGCTCATGCTTATGCAACGTTAGCCAACAAAGGCA
TGTATGAACCGATTCATATCATTAAAAGCAACGACCAAGACTTCTCAAAGCAGATCATCAAACGTGAAAATGCAGAGATG
GTATTGCAAATGTTAGAAGGCGTGACTCAAAAGGGCGGAACTGCAACCAGAGCCGCTGTTCCGGGTTATCGAGTTGCGGC
AAAAACGGGTACATCTCGTAAAGCCGCTGCGGGTGGCTATAGTGATGAGTATATTGCTATAACGTCGGGTTTTGCTCCAG
TCAGCGATCCAAGAGTAGCTCTGGTTGTCGTAGTCAATGAGCCGCAAGGTGACCTTTACTATGGCGGTTCTGTTGCTGCC
CCCGTTTTTTCTGAAATCATGAAGGGGGCACTGCAAATACTCAATGTCCCTGCTGATGAAAACAAGTTTCAAGAATAG

Upstream 100 bases:

>100_bases
AGACGGCGCTAGCAGAACACAGCCGCGTTCAAGCATCGGCAAAAAGAGAGCTAGACATGAAACGTCCAGACTCCGACAAA
GAAGTTGTGATCACACTGAA

Downstream 100 bases:

>100_bases
AGCCAATCAGGATTCAATATGAGTAATAGCCTCACGCTGTCATCTTTACTTTCTCCTTGGGGGGACTTTAGTTCACTTGA
GCTAGATGCGATTGTTGTTG

Product: peptidoglycan synthetase ftsI precursor

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MTGKKEKTPAKTVNESTKERVKSEKDLDPILIKWRFNVVIAFVFLAFAALVGRVAYIQIIEPDNLIRQGDLRSVRVKAIP
SARGIISDRNGEPLAVSVPVEAVWADPKTIFDKNGMAQIDRWYALADVLGLQRQSMIDKISSNKSRRFIYLQRQVSPAMA
KYIRELKLVGVGLKAESRRYYPAGEVSAHLIGVTGIDGHGLEGVERSYDKWLTGEAGKRTIRKDRYGRVVENIALEEREE
GKPLELTIDQRLQAIAYRAIKQAVADHKATSGSAVLLDVKTGAVLAMVNAPSYNPNNRSDLQSFKMRNRVLTDAMEPGST
VKPFVVLAALENGTADAKSIIDTGNGIMQIGGSRVRDTSKVGKADLALILKKSSNIGVAKLALDMPLEALLGMYSSVGLG
EMSGLNLVGETSGIFPNRRRWSKFEIATLSFGYGLSVTPLQLAHAYATLANKGMYEPIHIIKSNDQDFSKQIIKRENAEM
VLQMLEGVTQKGGTATRAAVPGYRVAAKTGTSRKAAAGGYSDEYIAITSGFAPVSDPRVALVVVVNEPQGDLYYGGSVAA
PVFSEIMKGALQILNVPADENKFQE

Sequences:

>Translated_585_residues
MTGKKEKTPAKTVNESTKERVKSEKDLDPILIKWRFNVVIAFVFLAFAALVGRVAYIQIIEPDNLIRQGDLRSVRVKAIP
SARGIISDRNGEPLAVSVPVEAVWADPKTIFDKNGMAQIDRWYALADVLGLQRQSMIDKISSNKSRRFIYLQRQVSPAMA
KYIRELKLVGVGLKAESRRYYPAGEVSAHLIGVTGIDGHGLEGVERSYDKWLTGEAGKRTIRKDRYGRVVENIALEEREE
GKPLELTIDQRLQAIAYRAIKQAVADHKATSGSAVLLDVKTGAVLAMVNAPSYNPNNRSDLQSFKMRNRVLTDAMEPGST
VKPFVVLAALENGTADAKSIIDTGNGIMQIGGSRVRDTSKVGKADLALILKKSSNIGVAKLALDMPLEALLGMYSSVGLG
EMSGLNLVGETSGIFPNRRRWSKFEIATLSFGYGLSVTPLQLAHAYATLANKGMYEPIHIIKSNDQDFSKQIIKRENAEM
VLQMLEGVTQKGGTATRAAVPGYRVAAKTGTSRKAAAGGYSDEYIAITSGFAPVSDPRVALVVVVNEPQGDLYYGGSVAA
PVFSEIMKGALQILNVPADENKFQE
>Mature_584_residues
TGKKEKTPAKTVNESTKERVKSEKDLDPILIKWRFNVVIAFVFLAFAALVGRVAYIQIIEPDNLIRQGDLRSVRVKAIPS
ARGIISDRNGEPLAVSVPVEAVWADPKTIFDKNGMAQIDRWYALADVLGLQRQSMIDKISSNKSRRFIYLQRQVSPAMAK
YIRELKLVGVGLKAESRRYYPAGEVSAHLIGVTGIDGHGLEGVERSYDKWLTGEAGKRTIRKDRYGRVVENIALEEREEG
KPLELTIDQRLQAIAYRAIKQAVADHKATSGSAVLLDVKTGAVLAMVNAPSYNPNNRSDLQSFKMRNRVLTDAMEPGSTV
KPFVVLAALENGTADAKSIIDTGNGIMQIGGSRVRDTSKVGKADLALILKKSSNIGVAKLALDMPLEALLGMYSSVGLGE
MSGLNLVGETSGIFPNRRRWSKFEIATLSFGYGLSVTPLQLAHAYATLANKGMYEPIHIIKSNDQDFSKQIIKRENAEMV
LQMLEGVTQKGGTATRAAVPGYRVAAKTGTSRKAAAGGYSDEYIAITSGFAPVSDPRVALVVVVNEPQGDLYYGGSVAAP
VFSEIMKGALQILNVPADENKFQE

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=550, Percent_Identity=51.4545454545455, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1786854, Length=615, Percent_Identity=26.6666666666667, Blast_Score=152, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63703; Mature: 63572

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKKEKTPAKTVNESTKERVKSEKDLDPILIKWRFNVVIAFVFLAFAALVGRVAYIQII
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEEE
EPDNLIRQGDLRSVRVKAIPSARGIISDRNGEPLAVSVPVEAVWADPKTIFDKNGMAQID
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCHHEEECCCHHHHCCCCCHHHH
RWYALADVLGLQRQSMIDKISSNKSRRFIYLQRQVSPAMAKYIRELKLVGVGLKAESRRY
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHEECCCCCCCCC
YPAGEVSAHLIGVTGIDGHGLEGVERSYDKWLTGEAGKRTIRKDRYGRVVENIALEEREE
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GKPLELTIDQRLQAIAYRAIKQAVADHKATSGSAVLLDVKTGAVLAMVNAPSYNPNNRSD
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCCCCCHHH
LQSFKMRNRVLTDAMEPGSTVKPFVVLAALENGTADAKSIIDTGNGIMQIGGSRVRDTSK
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCCHHH
VGKADLALILKKSSNIGVAKLALDMPLEALLGMYSSVGLGEMSGLNLVGETSGIFPNRRR
CCCCCEEEEEECCCCCCEEEEEHHCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCC
WSKFEIATLSFGYGLSVTPLQLAHAYATLANKGMYEPIHIIKSNDQDFSKQIIKRENAEM
CCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCHHH
VLQMLEGVTQKGGTATRAAVPGYRVAAKTGTSRKAAAGGYSDEYIAITSGFAPVSDPRVA
HHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEE
LVVVVNEPQGDLYYGGSVAAPVFSEIMKGALQILNVPADENKFQE
EEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TGKKEKTPAKTVNESTKERVKSEKDLDPILIKWRFNVVIAFVFLAFAALVGRVAYIQII
CCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEEE
EPDNLIRQGDLRSVRVKAIPSARGIISDRNGEPLAVSVPVEAVWADPKTIFDKNGMAQID
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCHHEEECCCHHHHCCCCCHHHH
RWYALADVLGLQRQSMIDKISSNKSRRFIYLQRQVSPAMAKYIRELKLVGVGLKAESRRY
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHEECCCCCCCCC
YPAGEVSAHLIGVTGIDGHGLEGVERSYDKWLTGEAGKRTIRKDRYGRVVENIALEEREE
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GKPLELTIDQRLQAIAYRAIKQAVADHKATSGSAVLLDVKTGAVLAMVNAPSYNPNNRSD
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCCCCCHHH
LQSFKMRNRVLTDAMEPGSTVKPFVVLAALENGTADAKSIIDTGNGIMQIGGSRVRDTSK
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCCHHH
VGKADLALILKKSSNIGVAKLALDMPLEALLGMYSSVGLGEMSGLNLVGETSGIFPNRRR
CCCCCEEEEEECCCCCCEEEEEHHCCHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCC
WSKFEIATLSFGYGLSVTPLQLAHAYATLANKGMYEPIHIIKSNDQDFSKQIIKRENAEM
CCEEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCHHH
VLQMLEGVTQKGGTATRAAVPGYRVAAKTGTSRKAAAGGYSDEYIAITSGFAPVSDPRVA
HHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEE
LVVVVNEPQGDLYYGGSVAAPVFSEIMKGALQILNVPADENKFQE
EEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]