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The map label for this gene is csrD [H]

Identifier: 218708364

GI number: 218708364

Start: 317177

End: 319192

Strand: Direct

Name: csrD [H]

Synonym: VS_0324

Alternate gene names: 218708364

Gene position: 317177-319192 (Clockwise)

Preceding gene: 218708363

Following gene: 218708365

Centisome position: 9.61

GC content: 41.77

Gene sequence:

>2016_bases
ATGAGATATACCCCGACACTAAAATTGAGCACTCGATTGGTCGCATTTGTCACCGTGATAGTGATCAGTGCGATGTTCAT
CCTTTTTATTGGTGGCACACTCTCCTTTAAGCGTATAGGACAGGAATATTTAGATCATTATTTGGTTGGCATTGTTGACG
TCGTAGATAAAGAGATGGAAGATCCAGATGCTGCGTATTCAATGCAACGTTGGATGCCGAAGATGTTGCAGGCAAGCAAT
ATCGTTGAGATGAAGCTTTCAAACAAAACCGGTATCGTTTACCGATTTAAAGACACCTCACCACAAATTGATCCAAACCG
CCTCTATGAAAGAAGCTTCATTTTAGATCGAAATGAAGGCTATCAAATCGAATTTAAAGCACTCCCCCCTTATATTGGTT
ACAACTACTCGATTGAAGCGATGTGGTCGATTACTTTGGCGGTGGCATTGATCCTTTTTTGTTTGGCTCGCGGTGTTCGC
TGGTTAAAAGAACAGTTAATGGGATCAGAGATTTTGGAAGAGCGAGGGAGAATGATCCTTGCTGGGCAGGTAGAGGCTTA
TTCAAAAGGGGACGAGCGAGAATGGCCTTATACGGCAAGTGAGGCGCTTGATGTACTGATTGAAGAGTTGAAAGATGCAC
GCCAAGAGCGAAGTCGCTTTGATACTTTTATTCGTACCCATACTTTTCTAGATAAGCTCACTGGTACAGCCAACCGAGTA
CTATTTGATAACAAACTTGAATCTGTACTGCATGAAAGTGGCGCTCGTGGAGGCGTTTTACTGATACGTATCGACGAGTG
GGAACAAGTTCGAGATGCCAATGACAAGCAGATCACCGACGGATTTATTATTGAAGTAGGTGAAGTATTGTCGAATATTG
TTCAGCGTTATCCCGATGTCATTTTTTCTCGCTATTACGAAGCAGACTTTGCCGTATTTATTCCGCATCAAGGAACAAAG
GATATTGCGACGTTGGCTGCTCAATGTTTAAGGCAATTAGATAAATTGACTCCGCCGGAGCCTTTGGAATCAGATAATTG
GTGCCATATTGGTGTGACAATGTATACCGAAGGTGAACGCCATAGCCAAATTATGGATGAAACGGAAACGGCGTTAAAGA
GCGCTCAGTTAGAGCGTATTAATAACTGGAGCCGTTACCCAAAAGAAAATAAAAGTGAGATAGACAGAGGCAGTGTTCGC
TGGAGAACATTACTTGATAAAGCCTTGCTACCTGAAAATTTAGTAATCTTTGCTCAGCGGTGTTATCTTATGCCGGATTC
AGGTCAAGCTAATGAATTGCATAAAGAAATATTTGTTAGAATTCAAGATCCAGACAAAGGTCTATTGAAATCTTCTCGCT
TTATGTCTGCGGTAGAACAAGTCGGTTATCAAGCTCAAATGGATCAATCGGTTTTGACGGTTTTGTTTAAGCCGCTGAAA
GTATCAACACAGCTTGTCAATTATTCGGTGAACTTGAGTGTCACTCCGTTTGCAAATAAATCACATTTTAAATGGTTCAG
AAGTGAGTTGTTACAGCTCTCTGCTCAGCATCGTTCTCAGCTTGCTTTTGAGTTTTCAGAAGGCCATCTAATTACTCACC
TTGATTATATGCGACCAGTGGCGAAGATGTTACGAGGGTTAGGGTGTAAAGTGGTGGTTGGCCAAGCTGGGCGTACCATT
GTTAGCACTCATTATATCAAGGATTTGAAGGTTGACTATATTAAGCTTCATCGAAGTTTGGTAAAGAAAATCGATCAAAG
GCATGAAAACCAACTGTTTGTTCGAAGTCTGATTGGAGCATGCGGTGATTCTCCAACTGAAGTGATCGCGGTCGGAGTTG
AGACAAAGCAAGAAAAGAATACCTTGATAGAGTTAGGCATTAACGGTTATCAAGGGAGATATTTCGACGAAGAACAACAA
ATAATTCCCTTGCCTACTCAAGGGGAAAAGACAGTGAAAGCTGAATCCGTTGTAAAAGTCGGTCGAAGAAATCGATGGCG
TAAGAGTAATAGTTAA

Upstream 100 bases:

>100_bases
CTTTTTGTTACCTACAATTCTTAACGCTTTATTTACAACGTCAATTTATAGTATAAGTAGCAATACGGTATAATGTGAGT
TGAAAAGGATTTCGTTATTC

Downstream 100 bases:

>100_bases
GCATGAATTTTAAAGCGATTTTAGACAACATAAAGCCAACGAATAATAACGGTAGTTCTCAAGTTGTCCTTTTGGGCAAT
GATACCGTTTATATTTCATC

Product: regulatory protein CsrD

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 671; Mature: 671

Protein sequence:

>671_residues
MRYTPTLKLSTRLVAFVTVIVISAMFILFIGGTLSFKRIGQEYLDHYLVGIVDVVDKEMEDPDAAYSMQRWMPKMLQASN
IVEMKLSNKTGIVYRFKDTSPQIDPNRLYERSFILDRNEGYQIEFKALPPYIGYNYSIEAMWSITLAVALILFCLARGVR
WLKEQLMGSEILEERGRMILAGQVEAYSKGDEREWPYTASEALDVLIEELKDARQERSRFDTFIRTHTFLDKLTGTANRV
LFDNKLESVLHESGARGGVLLIRIDEWEQVRDANDKQITDGFIIEVGEVLSNIVQRYPDVIFSRYYEADFAVFIPHQGTK
DIATLAAQCLRQLDKLTPPEPLESDNWCHIGVTMYTEGERHSQIMDETETALKSAQLERINNWSRYPKENKSEIDRGSVR
WRTLLDKALLPENLVIFAQRCYLMPDSGQANELHKEIFVRIQDPDKGLLKSSRFMSAVEQVGYQAQMDQSVLTVLFKPLK
VSTQLVNYSVNLSVTPFANKSHFKWFRSELLQLSAQHRSQLAFEFSEGHLITHLDYMRPVAKMLRGLGCKVVVGQAGRTI
VSTHYIKDLKVDYIKLHRSLVKKIDQRHENQLFVRSLIGACGDSPTEVIAVGVETKQEKNTLIELGINGYQGRYFDEEQQ
IIPLPTQGEKTVKAESVVKVGRRNRWRKSNS

Sequences:

>Translated_671_residues
MRYTPTLKLSTRLVAFVTVIVISAMFILFIGGTLSFKRIGQEYLDHYLVGIVDVVDKEMEDPDAAYSMQRWMPKMLQASN
IVEMKLSNKTGIVYRFKDTSPQIDPNRLYERSFILDRNEGYQIEFKALPPYIGYNYSIEAMWSITLAVALILFCLARGVR
WLKEQLMGSEILEERGRMILAGQVEAYSKGDEREWPYTASEALDVLIEELKDARQERSRFDTFIRTHTFLDKLTGTANRV
LFDNKLESVLHESGARGGVLLIRIDEWEQVRDANDKQITDGFIIEVGEVLSNIVQRYPDVIFSRYYEADFAVFIPHQGTK
DIATLAAQCLRQLDKLTPPEPLESDNWCHIGVTMYTEGERHSQIMDETETALKSAQLERINNWSRYPKENKSEIDRGSVR
WRTLLDKALLPENLVIFAQRCYLMPDSGQANELHKEIFVRIQDPDKGLLKSSRFMSAVEQVGYQAQMDQSVLTVLFKPLK
VSTQLVNYSVNLSVTPFANKSHFKWFRSELLQLSAQHRSQLAFEFSEGHLITHLDYMRPVAKMLRGLGCKVVVGQAGRTI
VSTHYIKDLKVDYIKLHRSLVKKIDQRHENQLFVRSLIGACGDSPTEVIAVGVETKQEKNTLIELGINGYQGRYFDEEQQ
IIPLPTQGEKTVKAESVVKVGRRNRWRKSNS
>Mature_671_residues
MRYTPTLKLSTRLVAFVTVIVISAMFILFIGGTLSFKRIGQEYLDHYLVGIVDVVDKEMEDPDAAYSMQRWMPKMLQASN
IVEMKLSNKTGIVYRFKDTSPQIDPNRLYERSFILDRNEGYQIEFKALPPYIGYNYSIEAMWSITLAVALILFCLARGVR
WLKEQLMGSEILEERGRMILAGQVEAYSKGDEREWPYTASEALDVLIEELKDARQERSRFDTFIRTHTFLDKLTGTANRV
LFDNKLESVLHESGARGGVLLIRIDEWEQVRDANDKQITDGFIIEVGEVLSNIVQRYPDVIFSRYYEADFAVFIPHQGTK
DIATLAAQCLRQLDKLTPPEPLESDNWCHIGVTMYTEGERHSQIMDETETALKSAQLERINNWSRYPKENKSEIDRGSVR
WRTLLDKALLPENLVIFAQRCYLMPDSGQANELHKEIFVRIQDPDKGLLKSSRFMSAVEQVGYQAQMDQSVLTVLFKPLK
VSTQLVNYSVNLSVTPFANKSHFKWFRSELLQLSAQHRSQLAFEFSEGHLITHLDYMRPVAKMLRGLGCKVVVGQAGRTI
VSTHYIKDLKVDYIKLHRSLVKKIDQRHENQLFVRSLIGACGDSPTEVIAVGVETKQEKNTLIELGINGYQGRYFDEEQQ
IIPLPTQGEKTVKAESVVKVGRRNRWRKSNS

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=659, Percent_Identity=31.1077389984825, Blast_Score=336, Evalue=3e-93,
Organism=Escherichia coli, GI1787541, Length=448, Percent_Identity=24.1071428571429, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788849, Length=244, Percent_Identity=22.1311475409836, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 77081; Mature: 77081

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYTPTLKLSTRLVAFVTVIVISAMFILFIGGTLSFKRIGQEYLDHYLVGIVDVVDKEME
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPDAAYSMQRWMPKMLQASNIVEMKLSNKTGIVYRFKDTSPQIDPNRLYERSFILDRNEG
CCHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHEEECCCC
YQIEFKALPPYIGYNYSIEAMWSITLAVALILFCLARGVRWLKEQLMGSEILEERGRMIL
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AGQVEAYSKGDEREWPYTASEALDVLIEELKDARQERSRFDTFIRTHTFLDKLTGTANRV
EECCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LFDNKLESVLHESGARGGVLLIRIDEWEQVRDANDKQITDGFIIEVGEVLSNIVQRYPDV
EEHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IFSRYYEADFAVFIPHQGTKDIATLAAQCLRQLDKLTPPEPLESDNWCHIGVTMYTEGER
HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCH
HSQIMDETETALKSAQLERINNWSRYPKENKSEIDRGSVRWRTLLDKALLPENLVIFAQR
HHHHHHHHHHHHHHHHHHHHHCHHCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHEEEHH
CYLMPDSGQANELHKEIFVRIQDPDKGLLKSSRFMSAVEQVGYQAQMDQSVLTVLFKPLK
HEECCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VSTQLVNYSVNLSVTPFANKSHFKWFRSELLQLSAQHRSQLAFEFSEGHLITHLDYMRPV
HHEEHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEHHHHHHHH
AKMLRGLGCKVVVGQAGRTIVSTHYIKDLKVDYIKLHRSLVKKIDQRHENQLFVRSLIGA
HHHHHCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CGDSPTEVIAVGVETKQEKNTLIELGINGYQGRYFDEEQQIIPLPTQGEKTVKAESVVKV
CCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHH
GRRNRWRKSNS
HHHCCCCCCCC
>Mature Secondary Structure
MRYTPTLKLSTRLVAFVTVIVISAMFILFIGGTLSFKRIGQEYLDHYLVGIVDVVDKEME
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
DPDAAYSMQRWMPKMLQASNIVEMKLSNKTGIVYRFKDTSPQIDPNRLYERSFILDRNEG
CCHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHEEECCCC
YQIEFKALPPYIGYNYSIEAMWSITLAVALILFCLARGVRWLKEQLMGSEILEERGRMIL
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
AGQVEAYSKGDEREWPYTASEALDVLIEELKDARQERSRFDTFIRTHTFLDKLTGTANRV
EECCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
LFDNKLESVLHESGARGGVLLIRIDEWEQVRDANDKQITDGFIIEVGEVLSNIVQRYPDV
EEHHHHHHHHHHCCCCCCEEEEEECCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IFSRYYEADFAVFIPHQGTKDIATLAAQCLRQLDKLTPPEPLESDNWCHIGVTMYTEGER
HHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCH
HSQIMDETETALKSAQLERINNWSRYPKENKSEIDRGSVRWRTLLDKALLPENLVIFAQR
HHHHHHHHHHHHHHHHHHHHHCHHCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHEEEHH
CYLMPDSGQANELHKEIFVRIQDPDKGLLKSSRFMSAVEQVGYQAQMDQSVLTVLFKPLK
HEECCCCCCHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VSTQLVNYSVNLSVTPFANKSHFKWFRSELLQLSAQHRSQLAFEFSEGHLITHLDYMRPV
HHEEHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEHHHHHHHH
AKMLRGLGCKVVVGQAGRTIVSTHYIKDLKVDYIKLHRSLVKKIDQRHENQLFVRSLIGA
HHHHHCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CGDSPTEVIAVGVETKQEKNTLIELGINGYQGRYFDEEQQIIPLPTQGEKTVKAESVVKV
CCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHH
GRRNRWRKSNS
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]