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The map label for this gene is tlpA [H]

Identifier: 218708313

GI number: 218708313

Start: 247590

End: 249470

Strand: Reverse

Name: tlpA [H]

Synonym: VS_0251

Alternate gene names: 218708313

Gene position: 249470-247590 (Counterclockwise)

Preceding gene: 218708314

Following gene: 218708312

Centisome position: 7.56

GC content: 47.32

Gene sequence:

>1881_bases
TTGAGACATACTATTAAGTTCAAAATTCAGATCGCTATCGCGGTTATTATTGCCGTCGTAAGTGGCGCTCAAGCTTGGAT
ATCTGTTAATCAGCTTACTCAAGAAACTGAAGTCGCGATCAACCAACAGGTGAAAAACGTGAGTGTTGGTACGACGAACT
ACATTGCCGATTGGTTATCAATCCGCAGTGATATGATGCTTGCCAATGAATCGACCATTTCAAGCAATAGCAACTCTGAT
CGCGAGTTATTGATCACCAAGCAAGCCGGGCAATTCTTGTCTGTTTATGCAGGATTCAGTGATGGCAGTATAGCTTATGG
CGACAAGGCTGAGGATTGGCCAGCAGACTACGACCCACGATCCCGCCCTTGGTATAAAGATGCAAACGCGATATCCGAAC
TCATCATTACCGAACCTTATCAAGATTTTGACGGCAGCATTGTCATCAGTTTCGCTAAAGCATTTAATGGTGAAAGACAG
GGGGTTATCGCGGCAGACTTAACCGTAACCAGCATTATTGATACCGTACTCAATGTAAAACTCGATAATGACGGTTTTGC
TTTTTTAGTCGACGGTAATAACAACATCGTCGCCTACAGTGATGAAGAGTTGAGTCAGAAACCACTGACGAATTTGAACC
CTGAGCTAACGGTCGACAAAGTATCACAACTGCTCCAAAACCAAATGATCACGACGTTAACTTGGCCTGGTCAAGGCGAT
AAAATGGTCTACATCGCTAACGTTCCGAATACCGATTGGTCATTGGGTATTGTGATCGATAAAGAAATGGCATTTTCTGC
GGTATCCGATGCCATTCAATTTATCACGCTTACCTCTTTGATTTTATACATCGTCATTTCGATTGCGAGCACAATGGTGA
TTAACCGCTTGCTGCACCCACTGCAAACATTGTCTGAAGCACTGACTCAGCTTGCTCAAGGCAGAGGCGACCTGACTCAG
CGTATTGATATCAAGCGCATGGATGAAATTGGCAAACTTGCCGAGCTCGTGAACCAGTTCTTGAGCCAGATGCAAAGCAT
GCTTAAGGGCGTAATCGAGCACAGTCACGACTTAAACAACCATGCGGAAAAAGCCAATCAACTGGCTACGCAATCTTCGA
TTCGAGTCGAGAATCAACAAAACGACATCAACCAAATTGCGACTGCGATTCATGAAATGTCCGCCACCGCAGCTGAAGTG
GCCAGCCATGCCGAATTAACCGCCTCCGCTTCTCAGGCATCCGCTACCGCTTGTAACGAAGGCCAAGAGGTTATCCAACA
AAACCGCGATGCGATTACAGGCCTTGCAACTCAGGTTGAAGATGCAGCCAATGTTATTCGTGAATTAGAGAGTAATGCTC
AAAGCATCAACCAGATCCTATCCACCATTCAAGGCATTGCCGAACAGACCAACCTGTTGGCATTGAATGCCGCGATTGAA
GCCGCTCGTGCGGGTGAACAAGGTCGTGGATTTGCCGTTGTCGCCGATGAAGTCCGAGTGCTCAGCCAAAGAACGCATGG
CTCGACCGAAGAAATCCGCGTGATGATTGATACGCTGCAGAAAAATACCGAACATGCCGTTGAAAGCATGACCACCAGCA
CTCAACTGGCAGAGAACAGCGTTGGCTTCGCAGAACAAGCTCATGGCAGCCTGACTAAGATCACTCAGGCAATCACTGAA
ATCAACGATATGGCGCTGCAAATAGCGAGTGCTGCGGAAGAGCAACGCGCGGTCAGCGAAGACATCAGCCGTAATACGCA
AGGAATCAAGGATGCATCTGATGACCTTGCACAGCAAGCTGAAAGCAGTCGCAATAGCTCAAATGAAATGAGTAGCGCTG
CCGAGTCGATGCGCCAGGACGTGGAGCGCTTTAAGGTATAG

Upstream 100 bases:

>100_bases
CTTTAAATATAACGACACTAGACACCTAGCAGAGACACATCCGTTCGCAATCCAACGCGTCGCTGTCATTAGCCTTTTAT
CCAAGAAGGAGGGATAAACC

Downstream 100 bases:

>100_bases
TGCGACTCAAGCAAAGCAAGTGAACCACACCACCGAGCGACAGCTGACATAAACTAATAACTGAAACAAAGTAGTTCTTT
CATAAGAATCACTTTGTTCT

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MRHTIKFKIQIAIAVIIAVVSGAQAWISVNQLTQETEVAINQQVKNVSVGTTNYIADWLSIRSDMMLANESTISSNSNSD
RELLITKQAGQFLSVYAGFSDGSIAYGDKAEDWPADYDPRSRPWYKDANAISELIITEPYQDFDGSIVISFAKAFNGERQ
GVIAADLTVTSIIDTVLNVKLDNDGFAFLVDGNNNIVAYSDEELSQKPLTNLNPELTVDKVSQLLQNQMITTLTWPGQGD
KMVYIANVPNTDWSLGIVIDKEMAFSAVSDAIQFITLTSLILYIVISIASTMVINRLLHPLQTLSEALTQLAQGRGDLTQ
RIDIKRMDEIGKLAELVNQFLSQMQSMLKGVIEHSHDLNNHAEKANQLATQSSIRVENQQNDINQIATAIHEMSATAAEV
ASHAELTASASQASATACNEGQEVIQQNRDAITGLATQVEDAANVIRELESNAQSINQILSTIQGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRVLSQRTHGSTEEIRVMIDTLQKNTEHAVESMTTSTQLAENSVGFAEQAHGSLTKITQAITE
INDMALQIASAAEEQRAVSEDISRNTQGIKDASDDLAQQAESSRNSSNEMSSAAESMRQDVERFKV

Sequences:

>Translated_626_residues
MRHTIKFKIQIAIAVIIAVVSGAQAWISVNQLTQETEVAINQQVKNVSVGTTNYIADWLSIRSDMMLANESTISSNSNSD
RELLITKQAGQFLSVYAGFSDGSIAYGDKAEDWPADYDPRSRPWYKDANAISELIITEPYQDFDGSIVISFAKAFNGERQ
GVIAADLTVTSIIDTVLNVKLDNDGFAFLVDGNNNIVAYSDEELSQKPLTNLNPELTVDKVSQLLQNQMITTLTWPGQGD
KMVYIANVPNTDWSLGIVIDKEMAFSAVSDAIQFITLTSLILYIVISIASTMVINRLLHPLQTLSEALTQLAQGRGDLTQ
RIDIKRMDEIGKLAELVNQFLSQMQSMLKGVIEHSHDLNNHAEKANQLATQSSIRVENQQNDINQIATAIHEMSATAAEV
ASHAELTASASQASATACNEGQEVIQQNRDAITGLATQVEDAANVIRELESNAQSINQILSTIQGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRVLSQRTHGSTEEIRVMIDTLQKNTEHAVESMTTSTQLAENSVGFAEQAHGSLTKITQAITE
INDMALQIASAAEEQRAVSEDISRNTQGIKDASDDLAQQAESSRNSSNEMSSAAESMRQDVERFKV
>Mature_626_residues
MRHTIKFKIQIAIAVIIAVVSGAQAWISVNQLTQETEVAINQQVKNVSVGTTNYIADWLSIRSDMMLANESTISSNSNSD
RELLITKQAGQFLSVYAGFSDGSIAYGDKAEDWPADYDPRSRPWYKDANAISELIITEPYQDFDGSIVISFAKAFNGERQ
GVIAADLTVTSIIDTVLNVKLDNDGFAFLVDGNNNIVAYSDEELSQKPLTNLNPELTVDKVSQLLQNQMITTLTWPGQGD
KMVYIANVPNTDWSLGIVIDKEMAFSAVSDAIQFITLTSLILYIVISIASTMVINRLLHPLQTLSEALTQLAQGRGDLTQ
RIDIKRMDEIGKLAELVNQFLSQMQSMLKGVIEHSHDLNNHAEKANQLATQSSIRVENQQNDINQIATAIHEMSATAAEV
ASHAELTASASQASATACNEGQEVIQQNRDAITGLATQVEDAANVIRELESNAQSINQILSTIQGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRVLSQRTHGSTEEIRVMIDTLQKNTEHAVESMTTSTQLAENSVGFAEQAHGSLTKITQAITE
INDMALQIASAAEEQRAVSEDISRNTQGIKDASDDLAQQAESSRNSSNEMSSAAESMRQDVERFKV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=451, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI2367378, Length=306, Percent_Identity=30.718954248366, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788195, Length=279, Percent_Identity=31.1827956989247, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1787690, Length=337, Percent_Identity=27.5964391691395, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1789453, Length=418, Percent_Identity=26.555023923445, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 68181; Mature: 68181

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS50192 T_SNARE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHTIKFKIQIAIAVIIAVVSGAQAWISVNQLTQETEVAINQQVKNVSVGTTNYIADWLS
CCCEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IRSDMMLANESTISSNSNSDRELLITKQAGQFLSVYAGFSDGSIAYGDKAEDWPADYDPR
HHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEHEECCCCCCEECCCCCCCCCCCCCCC
SRPWYKDANAISELIITEPYQDFDGSIVISFAKAFNGERQGVIAADLTVTSIIDTVLNVK
CCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCCCEEEEHHHHHHHHHHHHEEE
LDNDGFAFLVDGNNNIVAYSDEELSQKPLTNLNPELTVDKVSQLLQNQMITTLTWPGQGD
ECCCCEEEEEECCCCEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCC
KMVYIANVPNTDWSLGIVIDKEMAFSAVSDAIQFITLTSLILYIVISIASTMVINRLLHP
CEEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQTLSEALTQLAQGRGDLTQRIDIKRMDEIGKLAELVNQFLSQMQSMLKGVIEHSHDLNN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
HAEKANQLATQSSIRVENQQNDINQIATAIHEMSATAAEVASHAELTASASQASATACNE
HHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVIQQNRDAITGLATQVEDAANVIRELESNAQSINQILSTIQGIAEQTNLLALNAAIE
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEHHHHHH
AARAGEQGRGFAVVADEVRVLSQRTHGSTEEIRVMIDTLQKNTEHAVESMTTSTQLAENS
HHHCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VGFAEQAHGSLTKITQAITEINDMALQIASAAEEQRAVSEDISRNTQGIKDASDDLAQQA
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ESSRNSSNEMSSAAESMRQDVERFKV
HHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRHTIKFKIQIAIAVIIAVVSGAQAWISVNQLTQETEVAINQQVKNVSVGTTNYIADWLS
CCCEEEEEHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
IRSDMMLANESTISSNSNSDRELLITKQAGQFLSVYAGFSDGSIAYGDKAEDWPADYDPR
HHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEHEECCCCCCEECCCCCCCCCCCCCCC
SRPWYKDANAISELIITEPYQDFDGSIVISFAKAFNGERQGVIAADLTVTSIIDTVLNVK
CCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCCCEEEEHHHHHHHHHHHHEEE
LDNDGFAFLVDGNNNIVAYSDEELSQKPLTNLNPELTVDKVSQLLQNQMITTLTWPGQGD
ECCCCEEEEEECCCCEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCC
KMVYIANVPNTDWSLGIVIDKEMAFSAVSDAIQFITLTSLILYIVISIASTMVINRLLHP
CEEEEEECCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQTLSEALTQLAQGRGDLTQRIDIKRMDEIGKLAELVNQFLSQMQSMLKGVIEHSHDLNN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
HAEKANQLATQSSIRVENQQNDINQIATAIHEMSATAAEVASHAELTASASQASATACNE
HHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVIQQNRDAITGLATQVEDAANVIRELESNAQSINQILSTIQGIAEQTNLLALNAAIE
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEHHHHHH
AARAGEQGRGFAVVADEVRVLSQRTHGSTEEIRVMIDTLQKNTEHAVESMTTSTQLAENS
HHHCCCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VGFAEQAHGSLTKITQAITEINDMALQIASAAEEQRAVSEDISRNTQGIKDASDDLAQQA
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
ESSRNSSNEMSSAAESMRQDVERFKV
HHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]